BUTHIONINE SULFOXIMINE (BioDeep_00001868159)
Main id: BioDeep_00000005561
代谢物信息卡片
D,L-Buthionine-(S,R)-sulfoximine
化学式: C8H18N2O3S (222.1038078)
中文名称: D,L-蛋氨酸-(S,R)-亚磺酰亚胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCS(=N)(=O)CCC(C(=O)O)N
InChI: InChI=1S/C8H18N2O3S/c1-2-3-5-14(10,13)6-4-7(9)8(11)12/h7,10H,2-6,9H2,1H3,(H,11,12)
描述信息
D020011 - Protective Agents > D011837 - Radiation-Protective Agents
D009676 - Noxae > D000963 - Antimetabolites
D011838 - Radiation-Sensitizing Agents
D000970 - Antineoplastic Agents
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:176510
- ChEBI: CHEBI:28714
- KEGG: C04543
- PubChem: 21157
- DrugBank: DB12870
- ChEMBL: CHEMBL1627290
- ChEMBL: CHEMBL1256575
- MeSH: Buthionine Sulfoximine
- CAS: 71765-30-5
- CAS: 5072-26-4
- PubChem: 7149
- NIKKAJI: J128.583A
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Feng-Juan Li, Shouzhi Fu, Hua Ye, Yi-Han Hu, Jianxin Chen, Jamie R Privratsky, Wei Yu, Feng Dong, Russel J Reiter, Maolong Dong, Jun Guo, Jun Ren. Metallothionein Alleviates Glutathione Depletion-Induced Oxidative Cardiomyopathy through CISD1-Dependent Regulation of Ferroptosis in Murine Hearts.
The American journal of pathology.
2024 Jun; 194(6):912-926. doi:
10.1016/j.ajpath.2024.02.009. [PMID: 38417695] - Rebecca C Timson, Artem Khan, Beste Uygur, Marwa Saad, Hsi-Wen Yeh, Nicole L DelGaudio, Ross Weber, Hanan Alwaseem, Jing Gao, Chingwen Yang, Kıvanç Birsoy. Development of a mouse model expressing a bifunctional glutathione synthesizing enzyme to study glutathione limitation in vivo.
The Journal of biological chemistry.
2024 Jan; ?(?):105645. doi:
10.1016/j.jbc.2024.105645. [PMID: 38218225] - Alan Cunningham, Lieve Oudejans, Marjan Geugien, Diego A Pereira-Martins, Albertus Tj Wierenga, Ayşegül Erdem, Dominique Sternadt, Gerwin A Huls, Jan Jacob Schuringa. The 'non-essential' amino acid cysteine is required to prevent ferroptosis in acute myeloid leukemia.
Blood advances.
2023 Oct; ?(?):. doi:
10.1182/bloodadvances.2023010786. [PMID: 37906522] - Zhiping Rao, Yutian Xia, Qian Jia, Yutong Zhu, Lexuan Wang, Guohuan Liu, Xuelan Liu, Peng Yang, Pengbo Ning, Ruili Zhang, Xianghan Zhang, Chaoqiang Qiao, Zhongliang Wang. Iron-based metal-organic framework co-loaded with buthionine sulfoximine and oxaliplatin for enhanced cancer chemo-ferrotherapy via sustainable glutathione elimination.
Journal of nanobiotechnology.
2023 Aug; 21(1):265. doi:
10.1186/s12951-023-01998-w. [PMID: 37563614] - Krishnan Silja, Natarajan Selvaganabathy, Thiyagarajan Kalaiselvi, Chinnasamy Thirunavukkarasu. Inhibition of glutathione generation in hepatic steatotic rats augments oxidative stress.
Toxicology mechanisms and methods.
2023 Apr; ?(?):1-11. doi:
10.1080/15376516.2023.2202784. [PMID: 37051633] - Yufen Liao, Xin Wang, Guangyun Ran, Shiyu Zhang, Chutian Wu, Rong Tan, Ying Liu, Yan He, Ting Liu, Zhongxiu Wu, Ying Peng, Weiwei Li, Jiang Zheng. DNA damage and up-regulation of PARP-1 induced by columbin in vitro and in vivo.
Toxicology letters.
2023 Mar; 379(?):20-34. doi:
10.1016/j.toxlet.2023.03.003. [PMID: 36905973] - Hao Wu, Qian Liu, Xinyi Shan, Weihua Gao, Quan Chen. ATM orchestrates ferritinophagy and ferroptosis by phosphorylating NCOA4.
Autophagy.
2023 Feb; ?(?):1-16. doi:
10.1080/15548627.2023.2170960. [PMID: 36752571] - Shiyu Zhang, Ying Liu, Ting Liu, Jie Pan, Rong Tan, Zixia Hu, Bowen Gong, Yufen Liao, Peng Luo, Qibing Zeng, Weiwei Li, Jiang Zheng. DNA damage by reactive oxygen species resulting from metabolic activation of 8-epidiosbulbin E acetate in vitro and in vivo.
Toxicology and applied pharmacology.
2022 05; 443(?):116007. doi:
10.1016/j.taap.2022.116007. [PMID: 35367474] - Zuo Yang, Chaoqiang Qiao, Qian Jia, Zhuang Chen, Xiaofei Wang, Xuelan Liu, Ruili Zhang, Kanyi Pu, Zhongliang Wang. Redox dyshomeostasis modulation of the tumor intracellular environment through a metabolic intervention strategy for enhanced photodynamic therapy.
Theranostics.
2022; 12(14):6143-6154. doi:
10.7150/thno.75837. [PMID: 36168617] - Myriam Mireault, Yong Xiao, Benoît Barbeau, Catherine Jumarie. Cadmium affects autophagy in the human intestinal cells Caco-2 through ROS-mediated ERK activation.
Cell biology and toxicology.
2021 Sep; ?(?):. doi:
10.1007/s10565-021-09655-4. [PMID: 34580807] - Jan Klein, Elisa Horn, Mona Ernst, Tim Leykauf, Tamara Leupold, Maja Dorfner, Laura Wolf, Anastasiia Ignatova, Wolfgang Kreis, Jennifer Munkert. RNAi-mediated gene knockdown of progesterone 5β-reductases in Digitalis lanata reduces 5β-cardenolide content.
Plant cell reports.
2021 Sep; 40(9):1631-1646. doi:
10.1007/s00299-021-02707-3. [PMID: 34146141] - Wen-Juan Wang, Xia Jiang, Chang-Chun Gao, Zhi-Wei Chen. Salusin‑β participates in high glucose‑induced HK‑2 cell ferroptosis in a Nrf‑2‑dependent manner.
Molecular medicine reports.
2021 Sep; 24(3):. doi:
10.3892/mmr.2021.12313. [PMID: 34296310] - Zhihui Qin, Siyu Ou, Liping Xu, Kathleen Sorensen, Yingxue Zhang, Dan-Ping Hu, Zhe Yang, Wen-Yang Hu, Fei Chen, Gail S Prins. Design and synthesis of isothiocyanate-containing hybrid androgen receptor (AR) antagonist to downregulate AR and induce ferroptosis in GSH-Deficient prostate cancer cells.
Chemical biology & drug design.
2021 05; 97(5):1059-1078. doi:
10.1111/cbdd.13826. [PMID: 33470049] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Suneel Gupta, Sabeeh Kamil, Prashant R Sinha, Jason T Rodier, Shyam S Chaurasia, Rajiv R Mohan. Glutathione is a potential therapeutic target for acrolein toxicity in the cornea.
Toxicology letters.
2021 Apr; 340(?):33-42. doi:
10.1016/j.toxlet.2021.01.005. [PMID: 33421550] - Yeong-Chin Jou, Shou-Chieh Wang, Yuan-Chang Dia, Shou-Tsung Wang, Min-Hua Yu, Hsin-Yi Yang, Lei-Chin Chen, Cheng-Huang Shen, Yi-Wen Liu. Anti-Cancer Effects and Tumor Marker Role of Glutathione S-Transferase Mu 5 in Human Bladder Cancer.
International journal of molecular sciences.
2021 Mar; 22(6):. doi:
10.3390/ijms22063056. [PMID: 33802702] - Seong-Im Park, Jin-Ju Kim, Hyeng-Soo Kim, Young-Saeng Kim, Ho-Sung Yoon. Enhanced glutathione content improves lateral root development and grain yield in rice plants.
Plant molecular biology.
2021 Mar; 105(4-5):365-383. doi:
10.1007/s11103-020-01093-w. [PMID: 33206358] - Zeba Farooqui, Razia Sultana Mohammad, Mustafa F Lokhandwala, Anees Ahmad Banday. Nrf2 inhibition induces oxidative stress, renal inflammation and hypertension in mice.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2021 Feb; 43(2):175-180. doi:
10.1080/10641963.2020.1836191. [PMID: 33070655] - Kazuki Hayashima, Ikuo Kimura, Hironori Katoh. Role of ferritinophagy in cystine deprivation-induced cell death in glioblastoma cells.
Biochemical and biophysical research communications.
2021 02; 539(?):56-63. doi:
10.1016/j.bbrc.2020.12.075. [PMID: 33421769] - Hamit Hakan Armağan, Mustafa Nazıroğlu. Glutathione depletion induces oxidative injury and apoptosis via TRPM2 channel activation in renal collecting duct cells.
Chemico-biological interactions.
2021 Jan; 334(?):109306. doi:
10.1016/j.cbi.2020.109306. [PMID: 33309544] - Shuai Hu, Mario Sechi, Pankaj Kumar Singh, Lipeng Dai, Sean McCann, Duxin Sun, Mats Ljungman, Nouri Neamati. A Novel Redox Modulator Induces a GPX4-Mediated Cell Death That Is Dependent on Iron and Reactive Oxygen Species.
Journal of medicinal chemistry.
2020 09; 63(17):9838-9855. doi:
10.1021/acs.jmedchem.0c01016. [PMID: 32809827] - Haitao Sun, Meixia Feng, Siyu Chen, Ruizhi Wang, Yu Luo, Bo Yin, Jingchao Li, Xiaolin Wang. Near-infrared photothermal liposomal nanoantagonists for amplified cancer photodynamic therapy.
Journal of materials chemistry. B.
2020 08; 8(32):7149-7159. doi:
10.1039/d0tb01437k. [PMID: 32617545] - Kenan Yıldızhan, Mustafa Nazıroğlu. Glutathione Depletion and Parkinsonian Neurotoxin MPP+-Induced TRPM2 Channel Activation Play Central Roles in Oxidative Cytotoxicity and Inflammation in Microglia.
Molecular neurobiology.
2020 Aug; 57(8):3508-3525. doi:
10.1007/s12035-020-01974-7. [PMID: 32535761] - Shingo Oda, Nanaka Miyazaki, Koichi Tsuneyama, Tsuyoshi Yokoi. Exacerbation of gefitinib-induced liver injury by glutathione reduction in mice.
The Journal of toxicological sciences.
2020; 45(8):493-502. doi:
10.2131/jts.45.493. [PMID: 32741899] - Xie-An Yu, Mi Lu, Yingping Luo, Yiting Hu, Ying Zhang, Zhiming Xu, Shuaishuai Gong, Yunhao Wu, Xiao-Nan Ma, Bo-Yang Yu, Jiangwei Tian. A cancer-specific activatable theranostic nanodrug for enhanced therapeutic efficacy via amplification of oxidative stress.
Theranostics.
2020; 10(1):371-383. doi:
10.7150/thno.39412. [PMID: 31903126] - Linlin Hu, Fei Wu, Jie He, Lingjun Zhong, Yifan Song, Hua Shao. Cytotoxicity of safrole in HepaRG cells: studies on the role of CYP1A2-mediated ortho-quinone metabolic activation.
Xenobiotica; the fate of foreign compounds in biological systems.
2019 Dec; 49(12):1504-1515. doi:
10.1080/00498254.2019.1590882. [PMID: 30865484] - Magdalena Górny, Agnieszka Wnuk, Adrianna Kamińska, Kinga Kamińska, Grażyna Chwatko, Anna Bilska-Wilkosz, Małgorzata Iciek, Małgorzata Kajta, Zofia Rogóż, Elżbieta Lorenc-Koci. Glutathione Deficiency and Alterations in the Sulfur Amino Acid Homeostasis during Early Postnatal Development as Potential Triggering Factors for Schizophrenia-Like Behavior in Adult Rats.
Molecules (Basel, Switzerland).
2019 Nov; 24(23):. doi:
10.3390/molecules24234253. [PMID: 31766654] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Su Jung Park, Sam Seok Cho, Kyu Min Kim, Ji Hye Yang, Jae Hoon Kim, Eun Hee Jeong, Jin Won Yang, Chang Yeob Han, Sae Kwang Ku, Il Je Cho, Sung Hwan Ki. Protective effect of sestrin2 against iron overload and ferroptosis-induced liver injury.
Toxicology and applied pharmacology.
2019 09; 379(?):114665. doi:
10.1016/j.taap.2019.114665. [PMID: 31323261] - Rasmus Kold-Christensen, Karina Kragh Jensen, Emil Smedegård-Holmquist, Lambert Kristiansen Sørensen, Jakob Hansen, Karl Anker Jørgensen, Peter Kristensen, Mogens Johannsen. ReactELISA method for quantifying methylglyoxal levels in plasma and cell cultures.
Redox biology.
2019 09; 26(?):101252. doi:
10.1016/j.redox.2019.101252. [PMID: 31254735] - Akiko Matsubara, Shingo Oda, Ru Jia, Tsuyoshi Yokoi. Acute kidney injury model established by systemic glutathione depletion in mice.
Journal of applied toxicology : JAT.
2019 06; 39(6):919-930. doi:
10.1002/jat.3780. [PMID: 30768730] - Katsuhito Watanabe, Shingo Oda, Akiko Matsubara, Sho Akai, Tsuyoshi Yokoi. Establishment and characterization of a mouse model of rhabdomyolysis by coadministration of statin and fibrate.
Toxicology letters.
2019 Jun; 307(?):49-58. doi:
10.1016/j.toxlet.2019.03.001. [PMID: 30853469] - Ahmed Nadeem, Sheikh F Ahmad, Naif O Al-Harbi, Sabry M Attia, Musaad A Alshammari, Khalid S Alzahrani, Saleh A Bakheet. Increased oxidative stress in the cerebellum and peripheral immune cells leads to exaggerated autism-like repetitive behavior due to deficiency of antioxidant response in BTBR T + tf/J mice.
Progress in neuro-psychopharmacology & biological psychiatry.
2019 03; 89(?):245-253. doi:
10.1016/j.pnpbp.2018.09.012. [PMID: 30261217] - Naveen C Joshi, Andreas J Meyer, Sajid A K Bangash, Zhi-Liang Zheng, Thomas Leustek. Arabidopsis γ-glutamylcyclotransferase affects glutathione content and root system architecture during sulfur starvation.
The New phytologist.
2019 02; 221(3):1387-1397. doi:
10.1111/nph.15466. [PMID: 30368820] - Anees A Banday, Mustafa F Lokhandwala. Oxidative stress impairs cGMP-dependent protein kinase activation and vasodilator-stimulated phosphoprotein serine-phosphorylation.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2019; 41(1):5-13. doi:
10.1080/10641963.2018.1433197. [PMID: 29424564] - Sarita Khatkar, Arun Nanda, Shahid H Ansari. Comparative Evaluation of Conventional and Novel Extracts of Stem Bark of Terminalia arjuna for Antihypertensive Activity in BSO Induced Oxidative Stress based Rat Model.
Current pharmaceutical biotechnology.
2019; 20(2):157-167. doi:
10.2174/1389201020666190222185209. [PMID: 30806310] - Yuxue Zhao, Sachiko Tanaka, Bo Yuan, Kentaro Sugiyama, Kenji Onda, Anna Kiyomi, Norio Takagi, Munetoshi Sugiura, Toshihiko Hirano. Arsenic Disulfide Combined with L-Buthionine-(S, R)-Sulfoximine Induces Synergistic Antitumor Effects in Two-Dimensional and Three-Dimensional Models of MCF-7 Breast Carcinoma Cells.
The American journal of Chinese medicine.
2019; 47(5):1149-1170. doi:
10.1142/s0192415x19500599. [PMID: 31311297] - Li-Long Jiang, Yan Jiang, Dong-Sheng Zhao, Ya-Xi Fan, Qiong Yu, Ping Li, Hui-Jun Li. CYP3A Activation and Glutathione Depletion Aggravate Emodin-Induced Liver Injury.
Chemical research in toxicology.
2018 10; 31(10):1052-1060. doi:
10.1021/acs.chemrestox.8b00117. [PMID: 30203651] - Yun Sun, Yingfeng Zheng, Chunxiao Wang, Yizhi Liu. Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells.
Cell death & disease.
2018 07; 9(7):753. doi:
10.1038/s41419-018-0794-4. [PMID: 29988039] - Akiko Matsubara, Shingo Oda, Sho Akai, Koichi Tsuneyama, Tsuyoshi Yokoi. Establishment of a drug-induced rhabdomyolysis mouse model by co-administration of ciprofloxacin and atorvastatin.
Toxicology letters.
2018 Jul; 291(?):184-193. doi:
10.1016/j.toxlet.2018.04.016. [PMID: 29679711] - Yan Qin, Qianqian Zhai, Yan Li, Meng Cao, Yun Xu, Kelei Zhao, Tao Wang. Cyanidin-3-O-glucoside ameliorates diabetic nephropathy through regulation of glutathione pool.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jul; 103(?):1223-1230. doi:
10.1016/j.biopha.2018.04.137. [PMID: 29864902] - Jozef Kováčik, Sławomir Dresler, Viera Peterková, Petr Babula. Metal-induced oxidative stress in terrestrial macrolichens.
Chemosphere.
2018 Jul; 203(?):402-409. doi:
10.1016/j.chemosphere.2018.03.112. [PMID: 29627607] - János Urbancsok, Atle M Bones, Ralph Kissen. Arabidopsis mutants impaired in glutathione biosynthesis exhibit higher sensitivity towards the glucosinolate hydrolysis product allyl-isothiocyanate.
Scientific reports.
2018 06; 8(1):9809. doi:
10.1038/s41598-018-28099-1. [PMID: 29955088] - Raja Gopoju, Sravya Panangipalli, Srigiridhar Kotamraju. Metformin treatment prevents SREBP2-mediated cholesterol uptake and improves lipid homeostasis during oxidative stress-induced atherosclerosis.
Free radical biology & medicine.
2018 04; 118(?):85-97. doi:
10.1016/j.freeradbiomed.2018.02.031. [PMID: 29499335] - Shohei Yamashita, Shingo Oda, Hideko Endo, Koichi Tsuneyama, Tsuyoshi Yokoi. Neutrophil depletion protects against zomepirac-induced acute kidney injury in mice.
Chemico-biological interactions.
2018 Jan; 279(?):102-110. doi:
10.1016/j.cbi.2017.11.011. [PMID: 29154782] - Takeo Edamatsu, Ayako Fujieda, Yoshiharu Itoh. Phenyl sulfate, indoxyl sulfate and p-cresyl sulfate decrease glutathione level to render cells vulnerable to oxidative stress in renal tubular cells.
PloS one.
2018; 13(2):e0193342. doi:
10.1371/journal.pone.0193342. [PMID: 29474405] - Feroz Akhtar, Christopher A Rouse, Gabriel Catano, Marcus Montalvo, Sarah L Ullevig, Reto Asmis, Kusum Kharbanda, Shivani K Maffi. Acute maternal oxidant exposure causes susceptibility of the fetal brain to inflammation and oxidative stress.
Journal of neuroinflammation.
2017 Sep; 14(1):195. doi:
10.1186/s12974-017-0965-8. [PMID: 28962577] - Sho Akai, Shingo Oda, Tsuyoshi Yokoi. Establishment of a novel mouse model for pioglitazone-induced skeletal muscle injury.
Toxicology.
2017 05; 382(?):1-9. doi:
10.1016/j.tox.2017.03.001. [PMID: 28263783] - Jeremy A Whitson, Xiang Zhang, Mario Medvedovic, Jenny Chen, Zongbo Wei, Vincent M Monnier, Xingjun Fan. Transcriptome of the GSH-Depleted Lens Reveals Changes in Detoxification and EMT Signaling Genes, Transport Systems, and Lipid Homeostasis.
Investigative ophthalmology & visual science.
2017 05; 58(5):2666-2684. doi:
10.1167/iovs.16-21398. [PMID: 28525556] - Gao Ling Shi, Lai Qing Lou, Dao Jun Li, Zhu Bing Hu, Qing Sheng Cai. Phytochelatins play key roles for the difference in root arsenic accumulation of different Triticum aestivum cultivars in comparison with arsenate uptake kinetics and reduction.
Chemosphere.
2017 May; 175(?):192-199. doi:
10.1016/j.chemosphere.2017.02.017. [PMID: 28222373] - Naif O Al-Harbi, Ahmed Nadeem, Mushtaq A Ansari, Mohammed M Al-Harbi, Moureq R Alotaibi, Abdulaziz M S AlSaad, Sheikh F Ahmad. Psoriasis-like inflammation leads to renal dysfunction via upregulation of NADPH oxidases and inducible nitric oxide synthase.
International immunopharmacology.
2017 May; 46(?):1-8. doi:
10.1016/j.intimp.2017.02.018. [PMID: 28249219] - Mohd Javed Akhtar, Maqusood Ahamed, Hisham A Alhadlaq, Aws Alshamsan. Nanotoxicity of cobalt induced by oxidant generation and glutathione depletion in MCF-7 cells.
Toxicology in vitro : an international journal published in association with BIBRA.
2017 Apr; 40(?):94-101. doi:
10.1016/j.tiv.2016.12.012. [PMID: 28024936] - Meng-Qing Gong, Cong Wu, Xiao-Yan He, Jing-Yi Zong, Jin-Long Wu, Ren-Xi Zhuo, Si-Xue Cheng. Tumor Targeting Synergistic Drug Delivery by Self-Assembled Hybrid Nanovesicles to Overcome Drug Resistance.
Pharmaceutical research.
2017 01; 34(1):148-160. doi:
10.1007/s11095-016-2051-9. [PMID: 27738951] - Cody S Shirriff, John J Heikkila. Characterization of cadmium chloride-induced BiP accumulation in Xenopus laevis A6 kidney epithelial cells.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.
2017 Jan; 191(?):117-128. doi:
10.1016/j.cbpc.2016.10.003. [PMID: 27746171] - Dongju Lin, Kai Wang, Xiucai Guo, Huiyuan Gao, Ying Peng, Jiang Zheng. Lysine- and cysteine-based protein adductions derived from toxic metabolites of 8-epidiosbulbin E acetate.
Toxicology letters.
2016 Dec; 264(?):20-28. doi:
10.1016/j.toxlet.2016.10.007. [PMID: 27816466] - Renata Colla, Alberto Izzotti, Chiara De Ciucis, Daniela Fenoglio, Silvia Ravera, Andrea Speciale, Roberta Ricciarelli, Anna Lisa Furfaro, Alessandra Pulliero, Mario Passalacqua, Nicola Traverso, Maria Adelaide Pronzato, Cinzia Domenicotti, Barbara Marengo. Glutathione-mediated antioxidant response and aerobic metabolism: two crucial factors involved in determining the multi-drug resistance of high-risk neuroblastoma.
Oncotarget.
2016 Oct; 7(43):70715-70737. doi:
10.18632/oncotarget.12209. [PMID: 27683112] - Dan Zhu, Yudong Mei, Yujian Shi, Dekun Hu, Yong Ren, Quan Gu, Wenbiao Shen, Xin Chen, Lingxi Xu, Liqin Huang. Involvement of glutathione in β-cyclodextrin-hemin complex-induced lateral root formation in tomato seedlings.
Journal of plant physiology.
2016 Oct; 204(?):92-100. doi:
10.1016/j.jplph.2016.07.015. [PMID: 27543888] - Sudip Banerjee, Nukhet Aykin-Burns, Kimberly J Krager, Sumit K Shah, Stepan B Melnyk, Martin Hauer-Jensen, Snehalata A Pawar. Loss of C/EBPδ enhances IR-induced cell death by promoting oxidative stress and mitochondrial dysfunction.
Free radical biology & medicine.
2016 10; 99(?):296-307. doi:
10.1016/j.freeradbiomed.2016.08.022. [PMID: 27554969] - Yasuaki Uematsu, Sho Akai, Tomoaki Tochitani, Shingo Oda, Toru Yamada, Tsuyoshi Yokoi. MicroRNA-mediated Th2 bias in methimazole-induced acute liver injury in mice.
Toxicology and applied pharmacology.
2016 09; 307(?):1-9. doi:
10.1016/j.taap.2016.07.008. [PMID: 27421576] - Atsushi Iwamura, Katsuhito Watanabe, Sho Akai, Tsubasa Nishinosono, Koichi Tsuneyama, Shingo Oda, Toshiyuki Kume, Tsuyoshi Yokoi. Zomepirac Acyl Glucuronide Is Responsible for Zomepirac-Induced Acute Kidney Injury in Mice.
Drug metabolism and disposition: the biological fate of chemicals.
2016 07; 44(7):888-96. doi:
10.1124/dmd.116.069575. [PMID: 27112166] - Thotegowdanapalya C Mohan, Gabriel Castrillo, Cristina Navarro, Sonia Zarco-Fernández, Eswarayya Ramireddy, Cristian Mateo, Angel M Zamarreño, Javier Paz-Ares, Riansares Muñoz, Jose M García-Mina, Luis E Hernández, Thomas Schmülling, Antonio Leyva. Cytokinin Determines Thiol-Mediated Arsenic Tolerance and Accumulation.
Plant physiology.
2016 06; 171(2):1418-26. doi:
10.1104/pp.16.00372. [PMID: 27208271] - Sho Akai, Yasuaki Uematsu, Koichi Tsuneyama, Shingo Oda, Tsuyoshi Yokoi. Kupffer cell-mediated exacerbation of methimazole-induced acute liver injury in rats.
Journal of applied toxicology : JAT.
2016 May; 36(5):702-15. doi:
10.1002/jat.3202. [PMID: 26177832] - Weiwei Li, Dongju Lin, Huiyuan Gao, Youjun Xu, Dongya Meng, Charles Vincent Smith, Ying Peng, Jiang Zheng. Metabolic activation of furan moiety makes Diosbulbin B hepatotoxic.
Archives of toxicology.
2016 Apr; 90(4):863-72. doi:
10.1007/s00204-015-1495-8. [PMID: 25851819] - Dirleise Colle, Danúbia Bonfanti Santos, Juliana Montagna Hartwig, Marcelo Godoi, Daiane Fátima Engel, Andreza Fabro de Bem, Antonio L Braga, Marcelo Farina. Succinobucol, a Lipid-Lowering Drug, Protects Against 3-Nitropropionic Acid-Induced Mitochondrial Dysfunction and Oxidative Stress in SH-SY5Y Cells via Upregulation of Glutathione Levels and Glutamate Cysteine Ligase Activity.
Molecular neurobiology.
2016 Mar; 53(2):1280-1295. doi:
10.1007/s12035-014-9086-x. [PMID: 25619973] - Dan-Chu Chin, Chia-Chi Hsieh, Hsin-Yi Lin, Kai-Wun Yeh. A Low Glutathione Redox State Couples with a Decreased Ascorbate Redox Ratio to Accelerate Flowering in Oncidium Orchid.
Plant & cell physiology.
2016 Feb; 57(2):423-36. doi:
10.1093/pcp/pcv206. [PMID: 26738548] - Amany K Elshorbagy, Fredrik Jernerén, Cheryl L Scudamore, Fiona McMurray, Heather Cater, Tertius Hough, Roger Cox, Helga Refsum. Exploring the Lean Phenotype of Glutathione-Depleted Mice: Thiol, Amino Acid and Fatty Acid Profiles.
PloS one.
2016; 11(10):e0163214. doi:
10.1371/journal.pone.0163214. [PMID: 27788147] - Varanavasiappan Shanmugam, Yi-Wen Wang, Munkhtsetseg Tsednee, Krithika Karunakaran, Kuo-Chen Yeh. Glutathione plays an essential role in nitric oxide-mediated iron-deficiency signaling and iron-deficiency tolerance in Arabidopsis.
The Plant journal : for cell and molecular biology.
2015 Nov; 84(3):464-77. doi:
10.1111/tpj.13011. [PMID: 26333047] - Clarke P Anderson, Katherine K Matthay, John P Perentesis, Joseph P Neglia, Howard H Bailey, Judith G Villablanca, Susan Groshen, Beth Hasenauer, John M Maris, Robert C Seeger, C Patrick Reynolds. Pilot study of intravenous melphalan combined with continuous infusion L-S,R-buthionine sulfoximine for children with recurrent neuroblastoma.
Pediatric blood & cancer.
2015 Oct; 62(10):1739-46. doi:
10.1002/pbc.25594. [PMID: 26153194] - Wei Li, Ronald E Maloney, Tak Yee Aw. High glucose, glucose fluctuation and carbonyl stress enhance brain microvascular endothelial barrier dysfunction: Implications for diabetic cerebral microvasculature.
Redox biology.
2015 Aug; 5(?):80-90. doi:
10.1016/j.redox.2015.03.005. [PMID: 25867911] - H Schoeneberger, K Belz, B Schenk, S Fulda. Impairment of antioxidant defense via glutathione depletion sensitizes acute lymphoblastic leukemia cells for Smac mimetic-induced cell death.
Oncogene.
2015 Jul; 34(31):4032-43. doi:
10.1038/onc.2014.338. [PMID: 25381820] - Yi Chen, Katie L Moore, Anthony J Miller, Steve P McGrath, Jian Feng Ma, Fang-Jie Zhao. The role of nodes in arsenic storage and distribution in rice.
Journal of experimental botany.
2015 Jul; 66(13):3717-24. doi:
10.1093/jxb/erv164. [PMID: 25922485] - Patrizia Brunetti, Letizia Zanella, Angelo De Paolis, Davide Di Litta, Valentina Cecchetti, Giuseppina Falasca, Maurizio Barbieri, Maria Maddalena Altamura, Paolo Costantino, Maura Cardarelli. Cadmium-inducible expression of the ABC-type transporter AtABCC3 increases phytochelatin-mediated cadmium tolerance in Arabidopsis.
Journal of experimental botany.
2015 Jul; 66(13):3815-29. doi:
10.1093/jxb/erv185. [PMID: 25900618] - Azumi Iida, Eita Sasaki, Azusa Yano, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, Tsuyoshi Yokoi. Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats.
Drug metabolism and disposition: the biological fate of chemicals.
2015 Jul; 43(7):958-68. doi:
10.1124/dmd.115.063370. [PMID: 25870103] - Xuan Wang, Lijie Jiang, Lan Ge, Min Chen, Guang Yang, Fang Ji, Laifu Zhong, Yingjie Guan, Xiaofang Liu. Oxidative DNA damage induced by di-(2-ethylhexyl) phthalate in HEK-293 cell line.
Environmental toxicology and pharmacology.
2015 May; 39(3):1099-106. doi:
10.1016/j.etap.2015.03.016. [PMID: 25899473] - Małgorzata Wójcik, Sławomir Dresler, Andrzej Plak, Anna Tukiendorf. Naturally evolved enhanced Cd tolerance of Dianthus carthusianorum L. is not related to accumulation of thiol peptides and organic acids.
Environmental science and pollution research international.
2015 May; 22(10):7906-17. doi:
10.1007/s11356-014-3963-8. [PMID: 25510617] - Ana Angela Romero-Haro, Carlos Alonso-Alvarez. The level of an intracellular antioxidant during development determines the adult phenotype in a bird species: a potential organizer role for glutathione.
The American naturalist.
2015 Mar; 185(3):390-405. doi:
10.1086/679613. [PMID: 25674693] - Haiyan Yuan, Yongxia Zhang, Suzhen Huang, Yongheng Yang, Chunsun Gu. Effects of exogenous glutathione and cysteine on growth, lead accumulation, and tolerance of Iris lactea var. chinensis.
Environmental science and pollution research international.
2015 Feb; 22(4):2808-16. doi:
10.1007/s11356-014-3535-y. [PMID: 25212813] - Zhen Wang, Jie-Li Mao, Ying-Jun Zhao, Chuan-You Li, Cheng-Bin Xiang. L-Cysteine inhibits root elongation through auxin/PLETHORA and SCR/SHR pathway in Arabidopsis thaliana.
Journal of integrative plant biology.
2015 Feb; 57(2):186-97. doi:
10.1111/jipb.12213. [PMID: 24798139] - ZhengLin Zhao, Sang Mi Park, LiXin Guan, YiYan Wu, Jong Rok Lee, Sang Chan Kim, Young Woo Kim, RongJie Zhao. Isoliquiritigenin attenuates oxidative hepatic damage induced by carbon tetrachloride with or without buthionine sulfoximine.
Chemico-biological interactions.
2015 Jan; 225(?):13-20. doi:
10.1016/j.cbi.2014.10.030. [PMID: 25450236] - Da Wang, Lin Lin, Xin Li, Gui-Fan Sun. Effects of glutathione on the in vivo metabolism and oxidative stress of arsenic in mice.
The Journal of toxicological sciences.
2015; 40(5):577-83. doi:
10.2131/jts.40.577. [PMID: 26354374] - Toru Takeda, Yuki Fukui. Possible role of NAD-dependent glyceraldehyde-3-phosphate dehydrogenase in growth promotion of Arabidopsis seedlings by low levels of selenium.
Bioscience, biotechnology, and biochemistry.
2015; 79(10):1579-86. doi:
10.1080/09168451.2015.1045826. [PMID: 25988618] - Ebtihal H Mustafa, Huda T Mahmoud, Mariam Y Al-Hudhud, Maher Y Abdalla, Iman M Ahmad, Salem R Yasin, Ali Z Elkarmi, Lubna H Tahtamouni. 2-deoxy-D-Glucose Synergizes with Doxorubicin or L-Buthionine Sulfoximine to Reduce Adhesion and Migration of Breast Cancer Cells.
Asian Pacific journal of cancer prevention : APJCP.
2015; 16(8):3213-22. doi:
10.7314/apjcp.2015.16.8.3213. [PMID: 25921122] - Claudia Di Giacomo, Rosa Santangelo, Valeria Sorrenti, Giovanni L Volti, Rosaria Acquaviva. Neuroprotective effects of a glutathione depletor in rat post-ischemic reperfusion brain damage.
CNS & neurological disorders drug targets.
2015; 14(1):41-8. doi:
10.2174/1871527314666150116113647. [PMID: 25613502] - Qi Shen, Minjuan Zuo, Li Ma, Ye Tian, Lu Wang, Huidi Jiang, Quan Zhou, Hui Zhou, Lushan Yu, Su Zeng. Demethylation of neferine in human liver microsomes and formation of quinone methide metabolites mediated by CYP3A4 accentuates its cytotoxicity.
Chemico-biological interactions.
2014 Dec; 224(?):89-99. doi:
10.1016/j.cbi.2014.10.014. [PMID: 25451576] - Maryam Madadkar Haghjou, Louise Colville, Nicholas Smirnoff. The induction of menadione stress tolerance in the marine microalga, Dunaliella viridis, through cold pretreatment and modulation of the ascorbate and glutathione pools.
Plant physiology and biochemistry : PPB.
2014 Nov; 84(?):96-104. doi:
10.1016/j.plaphy.2014.08.024. [PMID: 25240268] - Ana C Liaudat, Luciana P Bohl, Nori G Tolosa de Talamoni, Belkys Maletto, María C Pistoresi-Palencia, Gabriela Picotto. Oxidative stress, cell cycle arrest and differentiation contribute toward the antiproliferative action of BSO and calcitriol on Caco-2 cells.
Anti-cancer drugs.
2014 Aug; 25(7):810-8. doi:
10.1097/cad.0000000000000109. [PMID: 24681551] - Fuying Du, Zhaohua Liu, Xinxiu Li, Jie Xing. Metabolic pathways leading to detoxification of triptolide, a major active component of the herbal medicine Tripterygium wilfordii.
Journal of applied toxicology : JAT.
2014 Aug; 34(8):878-84. doi:
10.1002/jat.2906. [PMID: 23836259] - Ahmed Nadeem, Nahid Siddiqui, Naif O Alharbi, Mohammad M Alharbi, Faisal Imam, Mohamed M Sayed-Ahmed. Glutathione modulation during sensitization as well as challenge phase regulates airway reactivity and inflammation in mouse model of allergic asthma.
Biochimie.
2014 Aug; 103(?):61-70. doi:
10.1016/j.biochi.2014.04.001. [PMID: 24742380] - Yan Wang, Weiwei Zhao, Junran Hao, Wentao Xu, Yunbo Luo, Weihong Wu, Zhuojun Yang, Zhihong Liang, Kunlun Huang. Changes in biosynthesis and metabolism of glutathione upon ochratoxin A stress in Arabidopsis thaliana.
Plant physiology and biochemistry : PPB.
2014 Jun; 79(?):10-8. doi:
10.1016/j.plaphy.2014.03.001. [PMID: 24662377] - Ellen Klauser, Michael Gülden, Edmund Maser, Sabine Seibert, Hasso Seibert. Additivity, antagonism, and synergy in arsenic trioxide-induced growth inhibition of C6 glioma cells: effects of genistein, quercetin and buthionine-sulfoximine.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2014 May; 67(?):212-21. doi:
10.1016/j.fct.2014.02.039. [PMID: 24632069] - L R Nigmatullina, N I Rumiantseva, Iu A Kostiukova. [Effect of D,L-buthionine-S,R-sulfoximine on the ratio of glutathione forms and the growth of tatar buckwheat calli].
Ontogenez.
2014 Jan; 45(1):50-62. doi:
". [PMID: 25720265] - Siddhartha R Bhatt, Mustafa F Lokhandwala, Anees Ahmad Banday. Vascular oxidative stress upregulates angiotensin II type I receptors via mechanisms involving nuclear factor kappa B.
Clinical and experimental hypertension (New York, N.Y. : 1993).
2014; 36(6):367-73. doi:
10.3109/10641963.2014.943402. [PMID: 25198883] - Rola Barhoumi, Youssef Mouneimne, Robert S Chapkin, Robert C Burghardt. Effects of fatty acids on benzo[a]pyrene uptake and metabolism in human lung adenocarcinoma A549 cells.
PloS one.
2014; 9(3):e90908. doi:
10.1371/journal.pone.0090908. [PMID: 24651647] - Floriane Larras, Nicole Regier, Sébastien Planchon, John Poté, Jenny Renaut, Claudia Cosio. Physiological and proteomic changes suggest an important role of cell walls in the high tolerance to metals of Elodea nuttallii.
Journal of hazardous materials.
2013 Dec; 263 Pt 2(?):575-83. doi:
10.1016/j.jhazmat.2013.10.016. [PMID: 24225582] - Hsien-Jung Chen, Chin-Shu Huang, Guan-Jhong Huang, Te-Jin Chow, Yaw-Huei Lin. NADPH oxidase inhibitor diphenyleneiodonium and reduced glutathione mitigate ethephon-mediated leaf senescence, H2O2 elevation and senescence-associated gene expression in sweet potato (Ipomoea batatas).
Journal of plant physiology.
2013 Nov; 170(17):1471-83. doi:
10.1016/j.jplph.2013.05.015. [PMID: 23834930] - Eita Sasaki, Kentaro Matsuo, Azumi Iida, Koichi Tsuneyama, Tatsuki Fukami, Miki Nakajima, Tsuyoshi Yokoi. A novel mouse model for phenytoin-induced liver injury: involvement of immune-related factors and P450-mediated metabolism.
Toxicological sciences : an official journal of the Society of Toxicology.
2013 Nov; 136(1):250-63. doi:
10.1093/toxsci/kft184. [PMID: 23986454] - Susanne Ramm, Angela Mally. Role of drug-independent stress factors in liver injury associated with diclofenac intake.
Toxicology.
2013 Oct; 312(?):83-96. doi:
10.1016/j.tox.2013.08.002. [PMID: 23939143] - Wen Hua Yang, Zhen Zhang, Yang Hu Sima, Jian Zhang, Jian Wen Wang. Glaucocalyxin A and B-induced cell death is related to GSH perturbation in human leukemia HL-60 cells.
Anti-cancer agents in medicinal chemistry.
2013 Oct; 13(8):1280-90. doi:
10.2174/18715206113139990200. [PMID: 23796245] - Hideaki Yamaguchi, Yumi Kidachi, Katsuyoshi Kamiie, Toshiro Noshita, Hironori Umetsu, Yoko Fuke, Kazuo Ryoyama. Utilization of 6-(methylsulfinyl)hexyl isothiocyanate for sensitization of tumor cells to antitumor agents in combination therapies.
Biochemical pharmacology.
2013 Aug; 86(4):458-68. doi:
10.1016/j.bcp.2013.06.008. [PMID: 23791871]