Metyrosine (BioDeep_00001868131)

Main id: BioDeep_00000006632

 


代谢物信息卡片


alpha-methyl-L-tyrosine

化学式: C10H13NO3 (195.0895388)
中文名称: alpha-甲基-L-酪氨酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(CC1=CC=C(C=C1)O)(C(=O)O)N
InChI: InChI=1S/C10H13NO3/c1-10(11,9(13)14)6-7-2-4-8(12)5-3-7/h2-5,12H,6,11H2,1H3,(H,13,14)/t10-/m0/s1

描述信息

An L-tyrosine derivative that consists of L-tyrosine bearing an additional methyl substituent at position 2. An inhibitor of the enzyme tyrosine 3-monooxygenase, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with pheochromocytoma.
C - Cardiovascular system > C02 - Antihypertensives > C02K - Other antihypertensives > C02KB - Tyrosine hydroxylase inhibitors
C471 - Enzyme Inhibitor > C2155 - Tyrosine Hydroxylase Inhibitor
D004791 - Enzyme Inhibitors

同义名列表

2 个代谢物同义名

alpha-methyl-L-tyrosine; Metyrosine



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Lucinda M Gruber, Sina Jasim, Allison Ducharme-Smith, Toby Weingarten, William F Young, Irina Bancos. The Role for Metyrosine in the Treatment of Patients With Pheochromocytoma and Paraganglioma. The Journal of clinical endocrinology and metabolism. 2021 05; 106(6):e2393-e2401. doi: 10.1210/clinem/dgab130. [PMID: 33693908]
  • D-M Zhang, S-L Chen. Cytokine storms caused by novel coronavirus 2019 and treatment for cardiac injury. European review for medical and pharmacological sciences. 2020 12; 24(23):12527-12535. doi: 10.26355/eurrev_202012_24050. [PMID: 33336773]
  • Sergio Ortiz-Padilla, Elier Soto-Orduño, Marisa Escobar Barrios, Abril Armenta Manjarrez, Yadira Bastián, J Alfredo Mendez. Blockade of the dopaminergic neurotransmission with AMPT and reserpine induces a differential expression of genes of the dopaminergic phenotype in substantia nigra. Neuropharmacology. 2020 04; 166(?):107920. doi: 10.1016/j.neuropharm.2019.107920. [PMID: 31870855]
  • Xuemin Huang, Huanan Zhao, Wen Qiu, Jian Wang, Longhua Guo, Zhenyu Lin, Wei Pan, Yong Wu, Bin Qiu. A fluorescence signal amplification strategy for modification-free ratiometric determination of tyrosinase in situ based on the use of dual-templated copper nanoclusters. Mikrochimica acta. 2020 03; 187(4):240. doi: 10.1007/s00604-020-4186-y. [PMID: 32198661]
  • Fang Fang, Li Ding, Qing He, Ming Liu. Preoperative Management of Pheochromocytoma and Paraganglioma. Frontiers in endocrinology. 2020; 11(?):586795. doi: 10.3389/fendo.2020.586795. [PMID: 33117294]
  • Kazuhiro Takekoshi, Fumitoshi Satoh, Akiyo Tanabe, Takahiro Okamoto, Atsuhiro Ichihara, Mika Tsuiki, Takuyuki Katabami, Masatoshi Nomura, Tomoaki Tanaka, Tadashi Matsuda, Tsuneo Imai, Masanobu Yamada, Suguru Asada, Nobuyuki Kawata, Mitsuhide Naruse. Correlation between urinary fractionated metanephrines in 24-hour and spot urine samples for evaluating the therapeutic effect of metyrosine: a subanalysis of a multicenter, open-label phase I/II study. Endocrine journal. 2019 Dec; 66(12):1063-1072. doi: 10.1507/endocrj.ej19-0125. [PMID: 31511435]
  • Molly A Kwiatkowski, Gerhard Hellemann, Catherine A Sugar, Zackary A Cope, Arpi Minassian, William Perry, Mark A Geyer, Jared W Young. Dopamine transporter knockdown mice in the behavioral pattern monitor: A robust, reproducible model for mania-relevant behaviors. Pharmacology, biochemistry, and behavior. 2019 03; 178(?):42-50. doi: 10.1016/j.pbb.2017.12.007. [PMID: 29289701]
  • James J Butz, Toby N Weingarten, Alexandre N Cavalcante, Irina Bancos, William F Young, Travis J McKenzie, Darrell R Schroeder, David P Martin, Juraj Sprung. Perioperative hemodynamics and outcomes of patients on metyrosine undergoing resection of pheochromocytoma or paraganglioma. International journal of surgery (London, England). 2017 Oct; 46(?):1-6. doi: 10.1016/j.ijsu.2017.08.026. [PMID: 28803996]
  • Kabilan Thanapaalasingham, André S Pollmann, Benjamin Schelew. Failure of metyrosine therapy for preoperative management of pheochromocytoma: a case report. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 2015 Dec; 62(12):1303-7. doi: 10.1007/s12630-015-0480-2. [PMID: 26362800]
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