MOLINDONE (BioDeep_00001868084)
Main id: BioDeep_00000002735
代谢物信息卡片
化学式: C16H24N2O2 (276.1838)
中文名称: 3-乙基-2-甲基-5-(吗啉-4-基甲基)-1,5,6,7-四氢吲哚-4-酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC1=C(NC2=C1C(=O)C(CC2)CN3CCOCC3)C
InChI: InChI=1S/C16H24N2O2/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18/h12,17H,3-10H2,1-2H3
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AE - Indole derivatives
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
同义名列表
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Ajit Kumar, Soumitra S Datta, Stephen D Wright, Vivek A Furtado, Paul S Russell. Atypical antipsychotics for psychosis in adolescents.
The Cochrane database of systematic reviews.
2013 Oct; ?(10):CD009582. doi:
10.1002/14651858.cd009582.pub2. [PMID: 24129841] - Hongliang Jiang, Yinghe Li, Mary Pelzer, Michelle J Cannon, Christopher Randlett, Heiko Junga, Xiangyu Jiang, Qin C Ji. Determination of molindone enantiomers in human plasma by high-performance liquid chromatography-tandem mass spectrometry using macrocyclic antibiotic chiral stationary phases.
Journal of chromatography. A.
2008 May; 1192(2):230-8. doi:
10.1016/j.chroma.2008.03.048. [PMID: 18395729] - A Bagnall, M Fenton, J Kleijnen, R Lewis. Molindone for schizophrenia and severe mental illness.
The Cochrane database of systematic reviews.
2007 Jan; ?(1):CD002083. doi:
10.1002/14651858.cd002083.pub2. [PMID: 17253473] - Dwight D Flammia, Henry R Bateman, Joseph J Saady, Erik D Christensen. Tissue distribution of molidone in a multidrug overdose.
Journal of analytical toxicology.
2004 Sep; 28(6):533-6. doi:
10.1093/jat/28.6.533. [PMID: 15516311] - A Bagnall, M Fenton, R Lewis, M L Leitner, J Kleijnen. Molindone for schizophrenia and severe mental illness.
The Cochrane database of systematic reviews.
2000; ?(2):CD002083. doi:
10.1002/14651858.cd002083. [PMID: 10796464] - S I Deutsch, R B Rosse, B L Schwartz, M Banay-Schwartz, M F McCarthy, S K Johri. L-tyrosine pharmacotherapy of schizophrenia: preliminary data.
Clinical neuropharmacology.
1994 Feb; 17(1):53-62. doi:
10.1097/00002826-199402000-00006. [PMID: 8149360] - A K Pandurangi, N Narasimhachari, W G Blackard, B S Landa. Relation of serum molindone levels to serum prolactin levels and antipsychotic response.
The Journal of clinical psychiatry.
1989 Oct; 50(10):379-81. doi:
. [PMID: 2676994] - A K Pandurangi, N Narasimhachari. Rhabdomyolysis and molindone.
The Journal of clinical psychiatry.
1988 Jan; 49(1):37-8. doi:
. [PMID: 3335489] - L Glickman. Rhabdomyolysis and acute renal failure.
The Journal of clinical psychiatry.
1987 Jul; 48(7):299-300. doi:
NULL. [PMID: 3597334] - S B Johnson, W A Alvarez, J P Freinhar. A case of massive rhabdomyolysis following molindone administration.
The Journal of clinical psychiatry.
1986 Dec; 47(12):607-8. doi:
. [PMID: 3782049] - W E Fann, A F Moreira. Neuroleptic bioequivalency: tablet versus concentrate.
Journal of clinical pharmacology.
1985 May; 25(4):305-6. doi:
10.1002/j.1552-4604.1985.tb02844.x. [PMID: 2861214] - M Zetin, M Cramer, D Garber, L Plon, M Paulshock, H E Hoffman, W L Schary. Bioavailability of oral and intramuscular molindone hydrochloride in schizophrenic patients.
Clinical therapeutics.
1985; 7(2):169-75. doi:
NULL. [PMID: 3986861] - N S Shah, O D Gulati. Effect of clozapine and molindone on plasma and brain levels of mescaline in mice.
European journal of drug metabolism and pharmacokinetics.
1984 Oct; 9(4):307-9. doi:
10.1007/bf03189681. [PMID: 6532803] - K S Kendler, K L Davis. Acute and chronic effects of neuroleptic drugs on plasma and brain homovanillic acid in the rat.
Psychiatry research.
1984 Sep; 13(1):51-8. doi:
10.1016/0165-1781(84)90118-5. [PMID: 6151204] - R W Fuller, H D Snoddy. Molindone: higher doses needed to block pergolide-induced elevation of serum corticosterone than to elevate dopamine metabolites in brain.
Life sciences.
1983 Dec; 33(23):2357-61. doi:
10.1016/0024-3205(83)90270-9. [PMID: 6645804] - L E Tune, I Creese, J R DePaulo, P R Slavney, S H Snyder. Neuroleptic serum levels measured by radioreceptor assay and clinical response in schizophrenic patients.
The Journal of nervous and mental disease.
1981 Jan; 169(1):60-3. doi:
10.1097/00005053-198101000-00009. [PMID: 6108981] - R T Curnow, E J Rayfield, D T George, T V Zenser, F R DeRubertis. Altered hepatic glycogen metabolism and glucoregulatory hormones during sepsis.
The American journal of physiology.
1976 May; 230(5):1296-1301. doi:
10.1152/ajplegacy.1976.230.5.1296. [PMID: 5897]
