Cephalothin (BioDeep_00001867863)
Main id: BioDeep_00000006595
代谢物信息卡片
Cephalothin
化学式: C16H16N2O6S2 (396.045)
中文名称: 头孢噻吩酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(=O)OCC1=C(N2C(C(C2=O)NC(=O)CC3=CC=CS3)SC1)C(=O)O
InChI: InChI=1S/C16H16N2O6S2/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23)/t12-,15-/m1/s1
描述信息
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DB - First-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
2 个代谢物同义名
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:124991
- KEGG: C07761
- KEGGdrug: D07635
- PubChem: 6024
- DrugBank: DB00456
- ChEMBL: CHEMBL617
- MeSH: Cephalothin
- CAS: 51098-29-4
- CAS: 153-61-7
- PubChem: 9963
- PDB-CCD: CLS
- NIKKAJI: J3.273E
- KNApSAcK: 124991
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Patrícia Aleixa do Nascimento, Ana Carolina Kogawa, Hérida Regina Nunes Salgado. Cephalothin: Review of Characteristics, Properties, and Status of Analytical Methods.
Journal of AOAC International.
2021 Dec; 104(6):1593-1608. doi:
10.1093/jaoacint/qsaa163. [PMID: 33252646] - Taisuke Kuroda, Yohei Minamijima, Hidekazu Niwa, Norihisa Tamura, Hiroshi Mita, Kentaro Fukuda, Masahiro Kaimachi, Yuto Suzuki, Yuki Enoki, Kazuaki Taguchi, Kazuaki Matsumoto, Pierre-Louis Toutain, Alain Bousquet-Melou, Yoshinori Kasashima. Rational dosage regimens for cephalothin and cefazolin using pharmacokinetics and pharmacodynamics analysis in healthy horses.
Equine veterinary journal.
2021 Nov; 53(6):1239-1249. doi:
10.1111/evj.13406. [PMID: 33341979] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Zhengyu Zhang, Masanori Tachikawa, Yasuo Uchida, Tetsuya Terasaki. Drug Clearance from Cerebrospinal Fluid Mediated by Organic Anion Transporters 1 (Slc22a6) and 3 (Slc22a8) at Arachnoid Membrane of Rats.
Molecular pharmaceutics.
2018 03; 15(3):911-922. doi:
10.1021/acs.molpharmaceut.7b00852. [PMID: 29436232] - Valerie Corvalán, Beatrice Hervé, Camila Sanhueza, Nicolás Martínez, María Almonacid, Sebastián De La Fuente. [Susceptibility to first-generation Cephalosporins in Enterobacteriaceae isolated from urine culture according to CLSI and EUCAST breakpoints].
Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia.
2018 ; 35(3):329-331. doi:
10.4067/s0716-10182018000300329. [PMID: 30534916] - Darren M Roberts, Dwarakanathan Ranganathan, Steven C Wallis, Julie M Varghese, Adrian Kark, Jeffrey Lipman, Jason A Roberts. Pharmacokinetics of Intraperitoneal Cefalothin and Cefazolin in Patients Being Treated for Peritoneal Dialysis-Associated Peritonitis.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.
2016 Jul; 36(4):415-20. doi:
10.3747/pdi.2015.00008. [PMID: 26764340] - Suzanne L Parker, Yarmarly C Guerra Valero, Darren M Roberts, Jeffrey Lipman, Jason A Roberts, Steven C Wallis. Determination of Cefalothin and Cefazolin in Human Plasma, Urine and Peritoneal Dialysate by UHPLC-MS/MS: application to a pilot pharmacokinetic study in humans.
Biomedical chromatography : BMC.
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Klinicka mikrobiologie a infekcni lekarstvi.
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Foodborne pathogens and disease.
2010 Nov; 7(11):1323-30. doi:
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International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.
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Medical principles and practice : international journal of the Kuwait University, Health Science Centre.
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Medycyna doswiadczalna i mikrobiologia.
2010; 62(3):231-6. doi:
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2009 Dec; 9(?):267. doi:
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Antimicrobial agents and chemotherapy.
2009 Dec; 53(12):5046-54. doi:
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Antimicrobial agents and chemotherapy.
2009 Dec; 53(12):5303-5. doi:
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Toxicology.
2009 Nov; 265(1-2):15-26. doi:
10.1016/j.tox.2009.09.003. [PMID: 19761811] - M José Figueras, Anabel Alperi, M José Saavedra, Wen-Chien Ko, Nieves Gonzalo, Maria Navarro, Antonio J Martínez-Murcia. Clinical relevance of the recently described species Aeromonas aquariorum.
Journal of clinical microbiology.
2009 Nov; 47(11):3742-6. doi:
10.1128/jcm.02216-08. [PMID: 19741075] - Andrew J Dalley, Jeffrey Lipman, Renae Deans, Bala Venkatesh, Michael Rudd, Michael S Roberts, Sheree E Cross. Tissue accumulation of cephalothin in burns: a comparative study by microdialysis of subcutaneous interstitial fluid cephalothin concentrations in burn patients and healthy volunteers.
Antimicrobial agents and chemotherapy.
2009 Jan; 53(1):210-5. doi:
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Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit.
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2008 Jul; 36(7):1385-405. doi:
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Antimicrobial agents and chemotherapy.
2008 Jul; 52(7):2473-9. doi:
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Revista da Sociedade Brasileira de Medicina Tropical.
2008 May; 41(3):277-81. doi:
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Zoonoses and public health.
2008 May; 55(4):195-205. doi:
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Applied and environmental microbiology.
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2008 Jan; 61(1):85-8. doi:
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2007 Jul; 60(1):166-9. doi:
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European journal of pharmacology.
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