Cefalotin (BioDeep_00000006595)
Secondary id: BioDeep_00001867863
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
(6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
化学式: C16H16N2O6S2 (396.0449756)
中文名称: 头孢噻吩酸
谱图信息:
最多检出来源 Homo sapiens(blood) 4.17%
分子结构信息
SMILES: CC(=O)OCC1=C(C(=O)O)N2C(=O)C(NC(=O)Cc3cccs3)C2SC1
InChI: InChI=1S/C16H16N2O6S2/c1-8(19)24-6-9-7-26-15-12(14(21)18(15)13(9)16(22)23)17-11(20)5-10-3-2-4-25-10/h2-4,12,15H,5-7H2,1H3,(H,17,20)(H,22,23)/t12-,15-/m1/s1
描述信息
Cefalotin is only found in individuals that have used or taken this drug. It is a cephalosporin antibiotic.The bactericidal activity of cefalotin results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs). The PBPs are transpeptidases which are vital in peptidoglycan biosynthesis. Therefore, their inhibition prevents this vital cell wall compenent from being properly synthesized.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DB - First-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic
同义名列表
33 个代谢物同义名
(6R,7R)-3-[(acetyloxy)methyl]-8-oxo-7-[2-(thiophen-2-yl)acetamido]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 3-[(acetyloxy)methyl]-8-oxo-7-[(thiophen-2-ylacetyl)amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; 3-Acetoxymethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylic acid; 3-Acetoxymethyl-7-(2-thienylacetamido)-3-cephem-4-carboxylate; 7-(2-Thienylacetamido)cephalosporanic acid; 7-(2-Thienylacetamido)cephalosporanate; 7-(Thiophene-2-acetamido)cephalosporin; Normon brand OF cephalothin sodium; Spaly brand OF cephalothin sodium; Galen brand OF cephalothin sodium; Lilly brand OF cephalothin sodium; Salt, cephalothin monosodium; Monosodium salt, cephalothin; Cephalothin monosodium salt; Cefalotina sodica spaly; Cephalothin, sodium; Sodium cephalothin; Cefalotina normon; Cefalotina fabra; Cephalothinum; Cephalothin; Cefalotinum; Cefalotina; Cefalothin; Cefalotine; Cephalotin; Cefalotin; Ceftina; Keflin; Seffin; CET; CLS; Cephalothin
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:124991
- KEGG: C07761
- KEGGdrug: D07635
- PubChem: 2612
- PubChem: 6024
- HMDB: HMDB0014599
- Metlin: METLIN1638
- DrugBank: DB00456
- ChEMBL: CHEMBL617
- Wikipedia: Cephalothin
- MeSH: Cephalothin
- chemspider: 5802
- CAS: 51098-29-4
- CAS: 153-61-7
- PMhub: MS000019661
- PubChem: 9963
- PDB-CCD: CLS
- NIKKAJI: J3.273E
- RefMet: Cefalotin
- KNApSAcK: 124991
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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