Araloside_A (BioDeep_00001867503)

Main id: BioDeep_00000000436

 

PANOMIX_OTCML-2023


代谢物信息卡片


(2S,3S,4R,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-4,4,6a,6b,11,11,14b-heptamethyl-8a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3-[(2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxyoxane-2-carboxylic acid

化学式: C47H74O18 (926.4874904000001)
中文名称: 竹节参皂苷 IV, 楤木皂苷A, 木皂苷A
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1(CCC2(CCC3(C(=CCC4C3(CCC5C4(CCC(C5(C)C)OC6C(C(C(C(O6)C(=O)O)OC7C(C(C(O7)CO)O)O)O)O)C)C)C2C1)C)C(=O)OC8C(C(C(C(O8)CO)O)O)O)C
InChI: InChI=1S/C47H74O18/c1-42(2)14-16-47(41(59)65-39-33(55)30(52)28(50)23(19-48)61-39)17-15-45(6)21(22(47)18-42)8-9-26-44(5)12-11-27(43(3,4)25(44)10-13-46(26,45)7)62-40-34(56)31(53)35(36(64-40)37(57)58)63-38-32(54)29(51)24(20-49)60-38/h8,22-36,38-40,48-56H,9-20H2,1-7H3,(H,57,58)

描述信息

Chikusetsusaponin-IV is a triterpenoid saponin. It has a role as a metabolite.
Araloside A is a natural product found in Kalopanax septemlobus, Bassia muricata, and other organisms with data available.
A natural product found in Panax japonicus var. major.
Araloside A (Chikusetsusaponin IV) is a component of Panax japonicus, with low-renin-inhibitory activity, with an IC50 of 77.4 μM[1].
Araloside A (Chikusetsusaponin IV) is a component of Panax japonicus, with low-renin-inhibitory activity, with an IC50 of 77.4 μM[1].

同义名列表

10 个代谢物同义名

(2S,3S,4R,5R,6R)-6-[[(3S,4aR,6aR,6bS,8aS,12aS,14aR,14bR)-4,4,6a,6b,11,11,14b-heptamethyl-8a-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxycarbonyl-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3-[(2S,3R,4R,5S)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-4,5-dihydroxyoxane-2-carboxylic acid; beta-D-Glucopyranosiduronic acid, (3beta)-28-(beta-D-glucopyranosyloxy)-28-oxoolean-12-en-3-yl 4-O-alpha-L-arabinofuranosyl-; (3beta)-28-(beta-D-Glucopyranosyloxy)-28-oxoolean-12-en-3-yl 4-O-alpha-L-arabinofuranosyl-beta-D-glucopyranosiduronic acid; b-D-Glucopyranosiduronic acid, (3b)-28-(b-D-glucopyranosyloxy)-28-oxoolean-12-en-3-yl 4-O-a-L-arabinofuranosyl-; Chikusetsusaponin-IV; Chikusetsusaponin IV; Chikusetsusaponin 4; Araloside A; 32BF7Y358G; Araloside



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

17 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yaqin Tian, Xiuling Zhang, Meiling Du, Fengfeng Li, Manyu Xiao, Wentao Zhang. Synergistic Antioxidant Effects of Araloside A and L-Ascorbic Acid on H2O2-Induced HEK293 Cells: Regulation of Cellular Antioxidant Status. Oxidative medicine and cellular longevity. 2021; 2021(?):9996040. doi: 10.1155/2021/9996040. [PMID: 34336129]
  • Yi Tao, Surun Huang, Jizhong Yan, Baochang Cai. Determination of major components from Radix Achyranthes bidentate using ultra high performance liquid chromatography with triple quadrupole tandem mass spectrometry and an evaluation of their anti-osteoporosis effect in vitro. Journal of separation science. 2019 Jul; 42(13):2214-2221. doi: 10.1002/jssc.201900146. [PMID: 31037819]
  • Haibo He, Xiaomei Li, Haili Yu, Shu Zhu, Yumin He, Katsuko Komatsu, Dongyan Guo, Xiaoqin Li, Junzhi Wang, Huajun Luo, Daoxiang Xu, Kun Zou. Gastroprotective effect of araloside A on ethanol- and aspirin-induced gastric ulcer in mice: involvement of H+/K+-ATPase and mitochondrial-mediated signaling pathway. Journal of natural medicines. 2019 Mar; 73(2):339-352. doi: 10.1007/s11418-018-1256-0. [PMID: 30523551]
  • Dong-Yan Guo, Bing-Tao Zhai, Yang Lv, Ya-Jun Shi, Yu Fan, Lu Wang, Mei Wang. [Tissue distribution of araloside A in rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2017 Oct; 42(20):4002-4006. doi: 10.19540/j.cnki.cjcmm.20170901.011. [PMID: 29243440]
  • Keisuke Tomohara, Tomohiro Ito, Saika Onikata, Atsushi Kato, Isao Adachi. Discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under DMSO-perturbed assay conditions. Bioorganic & medicinal chemistry letters. 2017 04; 27(7):1620-1623. doi: 10.1016/j.bmcl.2017.01.083. [PMID: 28202328]
  • Sainan Li, Ying Tang, Chunming Liu, Yuchi Zhang. Development of a method to screen and isolate potential α-glucosidase inhibitors from Panax japonicus C.A. Meyer by ultrafiltration, liquid chromatography, and counter-current chromatography. Journal of separation science. 2015 Jun; 38(12):2014-23. doi: 10.1002/jssc.201500064. [PMID: 25847676]
  • Hsiu-Hui Chan, Tsong-Long Hwang, Mopur Vijaya Bhaskar Reddy, Ding-Tzai Li, Keduo Qian, Kenneth F Bastow, Kuo-Hsiung Lee, Tian-Shung Wu. Bioactive constituents from the roots of Panax japonicus var. major and development of a LC-MS/MS method for distinguishing between natural and artifactual compounds. Journal of natural products. 2011 Apr; 74(4):796-802. doi: 10.1021/np100851s. [PMID: 21417387]
  • Eun Bang Lee, Oon Ja Kim, Sam Sik Kang, Choonsik Jeong. Araloside A, an antiulcer constituent from the root bark of Aralia elata. Biological & pharmaceutical bulletin. 2005 Mar; 28(3):523-6. doi: 10.1248/bpb.28.523. [PMID: 15744082]