Cefamandole (BioDeep_00000001865)

 

Secondary id: BioDeep_00001868028

human metabolite blood metabolite Chemicals and Drugs Antibiotics


代谢物信息卡片


(6R,7R)-7-[(2R)-2-hydroxy-2-phenylacetamido]-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

化学式: C18H18N6O5S2 (462.078)
中文名称: 头孢孟多, 头孢孟多锂
谱图信息: 最多检出来源 Homo sapiens(blood) 83.33%

分子结构信息

SMILES: CN1C(=NN=N1)SCC2=C(N3C(C(C3=O)NC(=O)C(C4=CC=CC=C4)O)SC2)C(=O)O
InChI: InChI=1S/C18H18N6O5S2/c1-23-18(20-21-22-23)31-8-10-7-30-16-11(15(27)24(16)12(10)17(28)29)19-14(26)13(25)9-5-3-2-4-6-9/h2-6,11,13,16,25H,7-8H2,1H3,(H,19,26)(H,28,29)/t11-,13-,16-/m1/s1

描述信息

Cefamandole is only found in individuals that have used or taken this drug. It is a broad-spectrum cephalosporin antibiotic. The clinically used form of cefamandole is the formate ester cefamandole nafate, a prodrug which is administered parenterally. Cefamandole is no longer available in the United States.Like all beta-lactam antibiotics, cefamandole binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefamandole interferes with an autolysin inhibitor.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01D - Other beta-lactam antibacterials > J01DC - Second-generation cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002511 - Cephalosporins
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C254 - Anti-Infective Agent > C258 - Antibiotic > C260 - Beta-Lactam Antibiotic

同义名列表

20 个代谢物同义名

(6R,7R)-7-[(2R)-2-hydroxy-2-phenylacetamido]-3-{[(1-methyl-1H-1,2,3,4-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulphanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulphanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; (6R,7R)-7-{[(2R)-2-hydroxy-2-phenylacetyl]amino}-3-{[(1-methyl-1H-tetrazol-5-yl)sulfanyl]methyl}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate; 7-[(2-hydroxy-2-phenylacetyl)amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; (6R,7R)-7-(R)-Mandelamido-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-carboxylic acid; (6R,7R)-7-(R)-Mandelamido-3-(((1-methyl-1H-tetrazol-5-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-carboxylate; Cefamandole nafate; Compound 83405; L-Cefamandole; Cefamandolum; Cephamandole; Cefamandole; Cefamandol; Cephadole; Cefadole; CMD; Cefamandole; Cefamandole sodium



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 3 ALB, BPI, DAO
Peripheral membrane protein 2 DAO, RDX
Endoplasmic reticulum membrane 1 MOXD1
Nucleus 2 ALB, PPP1R10
cytosol 4 ALB, DAO, DIABLO, GPT
nuclear body 1 PPP1R10
centrosome 1 ALB
nucleoplasm 1 PPP1R10
Cell membrane 3 DAO, RDX, TNF
Cytoplasmic side 1 RDX
Cleavage furrow 1 RDX
lamellipodium 1 RDX
Multi-pass membrane protein 3 SLC15A1, SLC22A6, SLC22A8
cell surface 1 TNF
Golgi apparatus 1 ALB
neuronal cell body 1 TNF
Cytoplasm, cytosol 2 DAO, DIABLO
plasma membrane 9 DAO, F2, F7, IGHE, RDX, SLC15A1, SLC22A6, SLC22A8, TNF
presynaptic active zone 1 DAO
Membrane 5 BPI, DIABLO, RDX, SLC15A1, SLC22A6
apical plasma membrane 3 RDX, SLC15A1, SLC22A8
axon 1 CCK
basolateral plasma membrane 2 SLC22A6, SLC22A8
brush border 1 SLC15A1
caveola 1 SLC22A6
extracellular exosome 8 ALB, BPI, DAO, F2, GPT, RDX, SLC22A6, SLC22A8
endoplasmic reticulum 1 ALB
extracellular space 14 ALB, BPI, CCK, CPZ, DAO, F2, F7, IGHE, IL4, IL6, MOXD1, RDX, SCT, TNF
adherens junction 1 RDX
bicellular tight junction 1 DAO
mitochondrion 1 DIABLO
protein-containing complex 2 ALB, SLC22A6
filopodium 1 RDX
Single-pass type I membrane protein 2 IGHE, MOXD1
Secreted 8 ALB, BPI, CCK, DAO, F2, F7, IL4, IL6
extracellular region 11 ALB, BPI, CCK, DAO, F2, F7, IGHE, IL4, IL6, SCT, TNF
cytoplasmic side of plasma membrane 1 DIABLO
Extracellular side 1 DAO
anchoring junction 1 ALB
CD40 receptor complex 1 DIABLO
external side of plasma membrane 1 TNF
Secreted, extracellular space, extracellular matrix 1 CPZ
T-tubule 1 RDX
midbody 1 RDX
apical part of cell 1 RDX
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 F7
Apical cell membrane 1 SLC15A1
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 RDX
focal adhesion 1 RDX
Peroxisome 1 DAO
Peroxisome matrix 1 DAO
peroxisomal matrix 1 DAO
mitochondrial intermembrane space 1 DIABLO
collagen-containing extracellular matrix 2 F2, F7
lateral plasma membrane 1 SLC22A8
ciliary basal body 1 ALB
chromatin 1 PPP1R10
IgE immunoglobulin complex 1 IGHE
cell projection 2 DAO, RDX
phagocytic cup 1 TNF
cell periphery 1 RDX
cytoskeleton 1 RDX
centriole 1 ALB
Secreted, extracellular space 1 DAO
spindle pole 1 ALB
blood microparticle 2 ALB, F2
Basolateral cell membrane 2 SLC22A6, SLC22A8
[Isoform 2]: Cell membrane 1 IGHE
microvillus 1 RDX
Cell projection, stereocilium 1 RDX
Cell projection, microvillus 1 RDX
basal plasma membrane 1 SLC22A6
secretory granule membrane 1 MOXD1
Golgi lumen 2 F2, F7
endoplasmic reticulum lumen 4 ALB, F2, F7, IL6
cortical actin cytoskeleton 1 RDX
platelet alpha granule lumen 1 ALB
specific granule lumen 2 BPI, DAO
azurophil granule lumen 1 BPI
cell tip 1 RDX
PTW/PP1 phosphatase complex 1 PPP1R10
Basal cell membrane 1 SLC22A6
[Isoform 3]: Cell membrane 1 IGHE
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
interleukin-6 receptor complex 1 IL6
serine-type peptidase complex 1 F7
Cytoplasmic granule membrane 1 BPI
stereocilium base 1 RDX
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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