rebamipide (BioDeep_00000182871)
human metabolite blood metabolite
代谢物信息卡片
2-[(4-chlorophenyl)formamido]-3-(2-hydroxyquinolin-4-yl)propanoic acid
化学式: C19H15ClN2O4 (370.07203000000004)
中文名称: 瑞巴派特
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CC=C2C(=C1)C(=CC(=O)N2)CC(C(=O)O)NC(=O)C3=CC=C(C=C3)Cl
InChI: InChI=1S/C19H15ClN2O4/c20-13-7-5-11(6-8-13)18(24)22-16(19(25)26)9-12-10-17(23)21-15-4-2-1-3-14(12)15/h1-8,10,16H,9H2,(H,21,23)(H,22,24)(H,25,26)
描述信息
A - Alimentary tract and metabolism > A02 - Drugs for acid related disorders > A02B - Drugs for peptic ulcer and gastro-oesophageal reflux disease (gord)
C78276 - Agent Affecting Digestive System or Metabolism > C29701 - Anti-ulcer Agent
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents
D020011 - Protective Agents > D000975 - Antioxidants
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
10 个数据库交叉引用编号
- ChEBI: CHEBI:93814
- PubChem: 5042
- HMDB: HMDB0257127
- DrugBank: DB11656
- ChEMBL: CHEMBL1697771
- Wikipedia: Rebamipide
- chemspider: 4866
- CAS: 139344-42-6
- CAS: 111911-87-6
- CAS: 90098-04-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Heba S Zaky, Somaia A Abdel-Sattar, Albatoul Allam, Hebatalla I Ahmed. Further insights into the impact of rebamipide on gentamicin-induced nephrotoxicity in rats: modulation of SIRT1 and β-catenin/cyclin D1 pathways.
Drug and chemical toxicology.
2022 Jul; ?(?):1-13. doi:
10.1080/01480545.2022.2104867. [PMID: 35899710] - JooYeon Jhun, Jeonghyeon Moon, Se-Young Kim, Keun-Hyung Cho, Hyun Sik Na, JeongWon Choi, Yoon Ju Jung, Kyo Young Song, Jun-Ki Min, Mi-La Cho. Rebamipide treatment ameliorates obesity phenotype by regulation of immune cells and adipocytes.
PloS one.
2022; 17(12):e0277692. doi:
10.1371/journal.pone.0277692. [PMID: 36574392] - G H Wang, T Zuo, R Li, Z C Zuo. [Effect of rebamipide on the acute gouty arthritis in rats induced by monosodium urate crystals].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences.
2021 Aug; 53(4):716-720. doi:
. [PMID: 34393234] - Dae Woong Ko, Jung Hyun Cho, Han-Gon Choi. Development of rebamipide-loaded spray-dried microsphere using distilled water and meglumine: physicochemical characterization and pharmacokinetics in rats.
Pharmaceutical development and technology.
2021 Jul; 26(6):701-708. doi:
10.1080/10837450.2021.1924781. [PMID: 33938359] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Shinya Okawa, Yusuke Sumimoto, Kazufumi Masuda, Ken-Ichi Ogawara, Masato Maruyama, Kazutaka Higaki. Improvement of lipid solubility and oral bioavailability of a poorly water- and poorly lipid-soluble drug, rebamipide, by utilizing its counter ion and SNEDDS preparation.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2021 Apr; 159(?):105721. doi:
10.1016/j.ejps.2021.105721. [PMID: 33482317] - Rasha A Elmansy, Hanan S Seleem, Amany R Mahmoud, Emad H M Hassanein, Fares E M Ali. Rebamipide potentially mitigates methotrexate-induced nephrotoxicity via inhibition of oxidative stress and inflammation: A molecular and histochemical study.
Anatomical record (Hoboken, N.J. : 2007).
2021 03; 304(3):647-661. doi:
10.1002/ar.24482. [PMID: 32589351] - Daorui Hou, Maoyi Yang, Zhipeng Hu, Liangjun Yang. Effects of rebamipide for chronic atrophic gastritis: A protocol for systematic review and meta-analysis.
Medicine.
2020 Jun; 99(25):e20620. doi:
10.1097/md.0000000000020620. [PMID: 32569191] - In-Hwan Baek, Dong Kyoung Ha, Da-Seul Joo, Min Ji Kim. Interspecies differences on pharmacokinetics of rebamipide following oral administration to rats and dogs.
Biopharmaceutics & drug disposition.
2020 Jun; 41(6):268-272. doi:
10.1002/bdd.2247. [PMID: 32557753] - V T Ivashkin, A S Trukhmanov, M I Gonik. [Rebamipide using in gastroesophageal reflux disease treatment].
Terapevticheskii arkhiv.
2020 May; 92(4):98-104. doi:
10.26442/00403660.2020.04.000568. [PMID: 32598706] - Menghao Sun, Zheng Deng, Fei Shi, Zheng Zhou, Chenyi Jiang, Zhilu Xu, Xiaoming Cui, Wentong Li, Yifeng Jing, Bangmin Han, Weifen Zhang, Shujie Xia. Rebamipide-loaded chitosan nanoparticles accelerate prostatic wound healing by inhibiting M1 macrophage-mediated inflammation via the NF-κB signaling pathway.
Biomaterials science.
2020 Feb; 8(3):912-925. doi:
10.1039/c9bm01512d. [PMID: 31829321] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Akanksha Mishra, Sairam Krishnamurthy. Rebamipide Mitigates Impairments in Mitochondrial Function and Bioenergetics with α-Synuclein Pathology in 6-OHDA-Induced Hemiparkinson's Model in Rats.
Neurotoxicity research.
2019 Apr; 35(3):542-562. doi:
10.1007/s12640-018-9983-2. [PMID: 30610666] - Arjun Narala, Swathi Guda, Kishan Veerabrahma. Lipid Nanoemulsions of Rebamipide: Formulation, Characterization, and In Vivo Evaluation of Pharmacokinetic and Pharmacodynamic Effects.
AAPS PharmSciTech.
2019 Jan; 20(1):26. doi:
10.1208/s12249-018-1225-7. [PMID: 30604333] - Toshinori Suzuki, Akane Okuyama. Reactions of Rebamipide with Hypobromous Acid.
Chemical & pharmaceutical bulletin.
2019; 67(10):1164-1167. doi:
10.1248/cpb.c19-00384. [PMID: 31582637] - Norihiko Yokoi, Georgi As Georgiev. Tear Film-Oriented Diagnosis and Tear Film-Oriented Therapy for Dry Eye Based on Tear Film Dynamics.
Investigative ophthalmology & visual science.
2018 11; 59(14):DES13-DES22. doi:
10.1167/iovs.17-23700. [PMID: 30481801] - Lien Ngo, Hee-Doo Yoo, Phuong Tran, Hea-Young Cho, Yong-Bok Lee. Population pharmacokinetic analysis of rebamipide in healthy Korean subjects with the characterization of atypical complex absorption kinetics.
Journal of pharmacokinetics and pharmacodynamics.
2017 08; 44(4):291-303. doi:
10.1007/s10928-017-9519-z. [PMID: 28316019] - Abdallah M Gendy, Dalaal M Abdallah, Hanan S El-Abhar. The potential curative effect of rebamipide in hepatic ischemia/reperfusion injury.
Naunyn-Schmiedeberg's archives of pharmacology.
2017 Jul; 390(7):691-700. doi:
10.1007/s00210-017-1370-7. [PMID: 28361247] - JooYeon Jhun, Jeong-Eun Kwon, Se-Young Kim, Jeong-Hee Jeong, Hyun Sik Na, Eun-Kyung Kim, Seung Hoon Lee, KyungAh Jung, Jun-Ki Min, Mi-La Cho. Rebamipide ameliorates atherosclerosis by controlling lipid metabolism and inflammation.
PloS one.
2017; 12(2):e0171674. doi:
10.1371/journal.pone.0171674. [PMID: 28241014] - Wendy R Kam, Yang Liu, Juan Ding, David A Sullivan. Do Cyclosporine A, an IL-1 Receptor Antagonist, Uridine Triphosphate, Rebamipide, and/or Bimatoprost Regulate Human Meibomian Gland Epithelial Cells?.
Investigative ophthalmology & visual science.
2016 08; 57(10):4287-94. doi:
10.1167/iovs.16-19937. [PMID: 27552406] - Noriaki Abe, Hiroki Funato, Ayumu Hirata, Megumi Nakai, Michiro Iizuka, Hisashi Shiraishi, Kohei Jobu, Yusuke Yagi, Aki Kadota, Kyoko Ogi, Junko Yokota, Mitsuhiko Miyamura. [Evaluation of Gastric Mucosal Injury Model Animals of Rebamipide Formulation--Study of Therapeutic Equivalence].
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.
2016; 136(4):677-84. doi:
10.1248/yakushi.15-00014. [PMID: 27040349] - Dong Ju Son, Gyung Rak Lee, Sungil Oh, Sung Eun Lee, Won Sik Choi. Gastroprotective efficacy and safety evaluation of scoparone derivatives on experimentally induced gastric lesions in rodents.
Nutrients.
2015 Mar; 7(3):1945-64. doi:
10.3390/nu7031945. [PMID: 25781220] - Hyun Jin Kim, Jin Hyun Kim, Won Moon, Jongha Park, Seun Ja Park, Geun Am Song, Seung Hee Han, Jong Hun Lee. Rebamipide attenuates 5-Fluorouracil-induced small intestinal mucositis in a mouse model.
Biological & pharmaceutical bulletin.
2015; 38(2):179-83. doi:
10.1248/bpb.b14-00400. [PMID: 25747976] - Yoon Jeong Choi, Nayoung Kim, Ju Yup Lee, Ryoung Hee Nam, Hyun Chang, Ji Hyung Seo, Kyu Keun Kang, Hee Jin Kim, Yun Jin Choi, Hye Seung Lee, Dong Ho Lee. Protective effects of garlic extract, PMK-S005, against nonsteroidal anti-inflammatory drugs-induced acute gastric damage in rats.
Digestive diseases and sciences.
2014 Dec; 59(12):2927-34. doi:
10.1007/s10620-014-3370-5. [PMID: 25283375] - J-K Byun, S-J Moon, J-Y Jhun, E-K Kim, J-S Park, J Youn, J-K Min, S-H Park, H-Y Kim, M-L Cho. Rebamipide attenuates autoimmune arthritis severity in SKG mice via regulation of B cell and antibody production.
Clinical and experimental immunology.
2014 Oct; 178(1):9-19. doi:
10.1111/cei.12355. [PMID: 24749771] - Md Amran Hossain, Mayo Yamashita, Long Binh Vong, Yutaka Ikeda, Yukio Nagasaki. Silica-installed redox nanoparticles for novel oral nanotherapeutics - improvement in intestinal delivery with anti-inflammatory effects.
Journal of drug targeting.
2014 Aug; 22(7):638-47. doi:
10.3109/1061186x.2014.928716. [PMID: 24955616] - Dustin L Cooper, Robert C Wood, Jarrett E Wyatt, Sam Harirforoosh. Pharmacokinetic interactions between rebamipide and selected nonsteroidal anti-inflammatory drugs in rats.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2014 Mar; 53(?):28-34. doi:
10.1016/j.ejps.2013.12.002. [PMID: 24342124] - Robert C Wood, Jarrett E Wyatt, Kenny W Bullins, Angela V Hanley, Gregory A Hanley, James W Denham, Peter C Panus, Sam Harirforoosh. Effects of rebamipide on nephrotoxicity associated with selected NSAIDs in rats.
European journal of pharmacology.
2013 Nov; 720(1-3):138-46. doi:
10.1016/j.ejphar.2013.10.035. [PMID: 24365796] - Yijie Shi, Meijuan Zou, Yue An, Zhaoshuai Ji, Ping Gao, Gang Cheng. A potent preparation method combining neutralization with microfluidization for rebamipide nanosuspensions and its in vivo evaluation.
Drug development and industrial pharmacy.
2013 Jul; 39(7):996-1004. doi:
10.3109/03639045.2012.689765. [PMID: 22624728] - Kiwon Jung, Young-Won Chin, Yoon Hee Chung, Yang Hae Park, Hunseung Yoo, Dong Sun Min, Bongyong Lee, Jinwoong Kim. Anti-gastritis and wound healing effects of Momordicae Semen extract and its active component.
Immunopharmacology and immunotoxicology.
2013 Feb; 35(1):126-32. doi:
10.3109/08923973.2012.712139. [PMID: 22889079] - Jian Liu, Jianzhong Shen-Tu, Lihua Wu, Jing Dou, Qiyang Xu, Huili Zhou, Guolan Wu, Xingjiang Hu. Development of a simple LC-MS/MS method for determination of rebamipide in human plasma and its application to a bioequivalence study.
Die Pharmazie.
2012 Nov; 67(11):906-11. doi:
NULL. [PMID: 23210239] - Y Nagano, H Matsui, O Shimokawa, A Hirayama, M Tamura, Y Nakamura, T Kaneko, K Rai, H P Indo, H J Majima, I Hyodo. Rebamipide attenuates nonsteroidal anti-inflammatory drugs (NSAID) induced lipid peroxidation by the manganese superoxide dismutase (MnSOD) overexpression in gastrointestinal epithelial cells.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2012 Apr; 63(2):137-42. doi:
. [PMID: 22653900] - Fumihiko Yoshino, Ayaka Yoshida, Naofumi Umigai, Koya Kubo, Masaichi-Chang-Il Lee. Crocetin reduces the oxidative stress induced reactive oxygen species in the stroke-prone spontaneously hypertensive rats (SHRSPs) brain.
Journal of clinical biochemistry and nutrition.
2011 Nov; 49(3):182-7. doi:
10.3164/jcbn.11-01. [PMID: 22128217] - K O Ajeigbe, S B Olaleye, E O Oladejo, A O Olayanju. Effect of folic acid supplementation on oxidative gastric mucosa damage and acid secretory response in the rat.
Indian journal of pharmacology.
2011 Sep; 43(5):578-81. doi:
10.4103/0253-7613.84976. [PMID: 22022004] - Takashi Kawai, Yu Takagi, Mari Fukuzawa, Tetsuya Yamagishi, Shinya Goto. The role of trefoil factor family in apparently healthy subjects administrated gastroprotective agents for the primary prevention of gastrointestinal injuries from low-dose acetylsalicylic acid: a preliminary study.
Journal of clinical biochemistry and nutrition.
2011 Sep; 49(2):136-40. doi:
10.3164/jcbn.11-10. [PMID: 21980231] - Vismaya, Srikanta M Belagihally, Sindhu Rajashekhar, Vinay B Jayaram, Shylaja M Dharmesh, Sindhu Kanya C Thirumakudalu. Gastroprotective Properties of Karanjin from Karanja (Pongamia pinnata) Seeds; Role as Antioxidant and H, K-ATPase Inhibitor.
Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):747246. doi:
10.1093/ecam/neq027. [PMID: 21799691] - Junko Yokota, Taisuke Kitaoka, Kohei Jobu, Daisuke Takuma, Atsuhide Hamada, Masahide Onogawa, Saburo Yoshioka, Shojiro Kyotani, Mitsuhiko Miyamura. Eriobotrya japonica seed extract and deep sea water protect against indomethacin-induced gastric mucosal injury in rats.
Journal of natural medicines.
2011 Jan; 65(1):9-17. doi:
10.1007/s11418-010-0445-2. [PMID: 20640522] - Shunichi Matsuoka, Hiroshi Matsumura, Hitomi Nakamura, Shu Oshiro, Yasuo Arakawa, Junpei Hayashi, Naoki Sekine, Kazushige Nirei, Hiroaki Yamagami, Masahiro Ogawa, Noriko Nakajima, Shuichi Amaki, Naohide Tanaka, Mitsuhiko Moriyama. Zinc supplementation improves the outcome of chronic hepatitis C and liver cirrhosis.
Journal of clinical biochemistry and nutrition.
2009 Nov; 45(3):292-303. doi:
10.3164/jcbn.08-246. [PMID: 19902019] - Y Ohashi, E Aihara, H Takasuka, K Takahashi, K Takeuchi. Antral ulcers induced by alendronate, a nitrogen-containing biphophonate, in rat stomachs - prophylactic effect of rebamipide.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2009 Sep; 60(3):85-93. doi:
. [PMID: 19826186] - Shailendra Kapoor. Sjogren's syndrome: promising, new treatment options besides nizatidine.
Modern rheumatology.
2009; 19(1):100-1. doi:
10.1007/s10165-008-0124-2. [PMID: 18841440] - Nao Kinjo, Hirofumi Kawanaka, Tomohiko Akahoshi, Shohei Yamaguchi, Daisuke Yoshida, Go Anegawa, Kozo Konishi, Morimasa Tomikawa, Kazuo Tanoue, Andrzej Tarnawski, Makoto Hashizume, Yoshihiko Maehara. Significance of ERK nitration in portal hypertensive gastropathy and its therapeutic implications.
American journal of physiology. Gastrointestinal and liver physiology.
2008 Nov; 295(5):G1016-24. doi:
10.1152/ajpgi.90329.2008. [PMID: 18787063] - Bei-Bei Huang, Guo-Feng Li, Jing-Hui Luo, Lian Duan, Kishimoto Nobuaki, Yamamoto Akira. Permeabilities of rebamipide via rat intestinal membranes and its colon specific delivery using chitosan capsule as a carrier.
World journal of gastroenterology.
2008 Aug; 14(31):4928-37. doi:
10.3748/wjg.14.4928. [PMID: 18756602] - Yuji Naito, Shoji Iinuma, Nobuaki Yagi, Yoshio Boku, Eiko Imamoto, Tomohisa Takagi, Osamu Handa, Satoshi Kokura, Toshikazu Yoshikawa. Prevention of Indomethacin-Induced Gastric Mucosal Injury in Helicobacter pylori-Negative Healthy Volunteers: A Comparison Study Rebamipide vs Famotidine.
Journal of clinical biochemistry and nutrition.
2008 Jul; 43(1):34-40. doi:
10.3164/jcbn.2008041. [PMID: 18648657] - Yoshiaki Takeuchi, Maki Takahashi, Jun-ichi Fuchikami. Vulnerability of gastric mucosa to prednisolone in rats chronically exposed to cigarette smoke.
Journal of pharmacological sciences.
2008 Apr; 106(4):585-92. doi:
10.1254/jphs.fp0071606. [PMID: 18385541] - Zongbing You, Ying Dong, Xiangtian Kong, Laurel A Beckett, Regina Gandour-Edwards, Jonathan Melamed. Midkine is a NF-kappaB-inducible gene that supports prostate cancer cell survival.
BMC medical genomics.
2008 Feb; 1(?):6. doi:
10.1186/1755-8794-1-6. [PMID: 18275606] - Masayuki Kohashi, Naozumi Ishimaru, Rieko Arakaki, Yoshio Hayashi. Effective treatment with oral administration of rebamipide in a mouse model of Sjögren's syndrome.
Arthritis and rheumatism.
2008 Feb; 58(2):389-400. doi:
10.1002/art.23163. [PMID: 18240266] - Tadashi Hagiwara, Ken-ichi Mukaisho, Zhi-Qiang Ling, Takayo Sakano, Hiroyuki Sugihara, Takanori Hattori. Rebamipide contributes to reducing adverse effects of long-term administration of omeprazole in rats.
Digestive diseases and sciences.
2007 Apr; 52(4):988-94. doi:
10.1007/s10620-006-9415-7. [PMID: 17342392] - Yuji Naito, Toshikazu Yoshikawa. Oxidative stress involvement and gene expression in indomethacin-induced gastropathy.
Redox report : communications in free radical research.
2006; 11(6):243-53. doi:
10.1179/135100006x155021. [PMID: 17207306] - Tae Young Oh, Chang Yell Shin, Yong Sung Sohn, Dong Hwan Kim, Byoung Ok Ahn, Eun Bang Lee, Cho Hyun Park. Therapeutic effect of DA-9601 on chronic reflux gastritis induced by sodium taurocholate in rats.
World journal of gastroenterology.
2005 Dec; 11(47):7430-5. doi:
10.3748/wjg.v11.i47.7430. [PMID: 16437712] - Kazushi Sakurai, Toshihiro Osaka, Katsuya Yamasaki. Rebamipide reduces recurrence of experimental gastric ulcers: role of free radicals and neutrophils.
Digestive diseases and sciences.
2005 Oct; 50 Suppl 1(?):S90-6. doi:
10.1007/s10620-005-2812-5. [PMID: 16184427] - Yumiko Nagano, Hirofumi Matsui, Mutsumi Muramatsu, Osamu Shimokawa, Takeshi Shibahara, Akinori Yanaka, Akira Nakahara, Yasushi Matsuzaki, Naomi Tanaka, Yukio Nakamura. Rebamipide significantly inhibits indomethacin-induced mitochondrial damage, lipid peroxidation, and apoptosis in gastric epithelial RGM-1 cells.
Digestive diseases and sciences.
2005 Oct; 50 Suppl 1(?):S76-83. doi:
10.1007/s10620-005-2810-7. [PMID: 16184425] - Kazuhiro Katada, Norimasa Yoshida, Yutaka Isozaki, Naoya Tomatsuri, Hiroshi Ichikawa, Yuji Naito, Takeshi Okanoue, Toshikazu Yoshikawa. Prevention by rebamipide of acute reflux esophagitis in rats.
Digestive diseases and sciences.
2005 Oct; 50 Suppl 1(?):S97-S103. doi:
10.1007/s10620-005-2813-4. [PMID: 16184428] - Beom Soo Shin, Chul Hwan Kim, Yoon Sik Jun, Chi Ho Yoon, Jae Il Rho, Kang Choon Lee, Hye Seon Han, Sun Dong Yoo. Oral absorption and pharmacokinetics of rebamipide and rebamipide lysinate in rats.
Drug development and industrial pharmacy.
2004 Sep; 30(8):869-76. doi:
10.1081/ddc-200034577. [PMID: 15521332] - Tamara Matysiak-Budnik, Guillaume van Niel, Francis Mégraud, Kathryn Mayo, Claudia Bevilacqua, Valérie Gaboriau-Routhiau, Marie-Christiane Moreau, Martine Heyman. Gastric Helicobacter infection inhibits development of oral tolerance to food antigens in mice.
Infection and immunity.
2003 Sep; 71(9):5219-24. doi:
10.1128/iai.71.9.5219-5224.2003. [PMID: 12933867] - Nam Cheol Park, Hyun Jun Park, Kyeong Mi Lee, Dong Gil Shin. Free radical scavenger effect of rebamipide in sperm processing and cryopreservation.
Asian journal of andrology.
2003 Sep; 5(3):195-201. doi:
". [PMID: 12937801] - K Higuchi, T Tanigawa, M Hamaguchi, T Takashima, E Sasaki, M Shiba, K Tominaga, Y Fujiwara, N Oshitani, T Matsumoto, T Watanabe, T Arakawa. Comparison of the effects of rebamipide with those of cimetidine on chronic gastritis associated with Helicobacter pylori in Mongolian gerbils.
Alimentary pharmacology & therapeutics.
2003 Jul; 18 Suppl 1(?):1-7. doi:
10.1046/j.1365-2036.18.s1.18.x. [PMID: 12925135] - M Nakamura, Y Akiba, H Matsui, K Tsuchimoto, H Ishii. Interaction of leptin with gastric myofibroblast transdifferentiation in Helicobacter pylori-infected Mongolian gerbils: the effect of rebamipide.
Alimentary pharmacology & therapeutics.
2003 Jul; 18 Suppl 1(?):99-105. doi:
10.1046/j.1365-2036.18.s1.11.x. [PMID: 12925146] - K B Hahm, D H Kim, K M Lee, J S Lee, Y J Surh, Y B Kim, B M Yoo, J H Kim, H J Joo, Y K Cho, K T Nam, S W Cho. Effect of long-term administration of rebamipide on Helicobacter pylori infection in mice.
Alimentary pharmacology & therapeutics.
2003 Jul; 18 Suppl 1(?):24-38. doi:
10.1046/j.1365-2036.18.s1.3.x. [PMID: 12925138] - Ki Baik Hahm, Young Joon Song, Tae Young Oh, Jeong Sang Lee, Young-Joon Surh, Young Bae Kim, Byung Moo Yoo, Jin Hong Kim, Sang Uk Han, Ki Taik Nahm, Myung-Wook Kim, Dae Yong Kim, Sung Won Cho. Chemoprevention of Helicobacter pylori-associated gastric carcinogenesis in a mouse model: is it possible?.
Journal of biochemistry and molecular biology.
2003 Jan; 36(1):82-94. doi:
10.5483/bmbrep.2003.36.1.082. [PMID: 12542979] - S Shimada, K Inoue, M Kuramoto, S Suzuki, K Yamamoto, M Ogawa. Preoperative administration of rebamipide significantly lowers body temperature and circulating interleukin-6 in gastric cancer patients after gastrectomy.
Digestive surgery.
2003; 20(6):500-5. doi:
10.1159/000073645. [PMID: 14506330] - Kazunari Murakami, Ryugo Sato, Tadayoshi Okimoto, Koichiro Watanabe, Masaru Nasu, Toshio Fujioka, Masaaki Kodama, Jiro Kagawa. Influence of anti-ulcer drugs used in Japan on the result of (13)C-urea breath test for the diagnosis of Helicobacter pylori infection.
Journal of gastroenterology.
2003; 38(10):937-41. doi:
10.1007/s00535-003-1176-x. [PMID: 14614600] - Setsuo Hasegawa, Hisakuni Sekino, Osamu Matsuoka, Kazunori Saito, Hisayuki Sekino, Aki Morikawa, Kaya Uchida, Masami Koike, Junichi Azuma. Bioequivalence of rebamipide granules and tablets in healthy adult male volunteers.
Clinical drug investigation.
2003; 23(12):771-9. doi:
10.2165/00044011-200323120-00002. [PMID: 17536891] - A Farhadi, A Keshavarzian, L R Fitzpatrick, E Mutlu, Y Zhang, A Banan. Modulatory effects of plasma and colonic milieu of patients with ulcerative colitis on neutrophil reactive oxygen species production in presence of a novel antioxidant, rebamipide.
Digestive diseases and sciences.
2002 Jun; 47(6):1342-8. doi:
10.1023/a:1015382800434. [PMID: 12064811] - Taiji Akamatsu, Naoshi Nakamura, Naoyuki Furuya, Toshiki Shimizu, Akira Gotou, Kendo Kiyosawa, Tsutomu Katsuyama, Takahiko Osumi, Yukihiro Hirao, Gohatiro Miyamoto. Local gastric and serum concentrations of rebamipide following oral ingestion in healthy volunteers.
Digestive diseases and sciences.
2002 Jun; 47(6):1399-404. doi:
10.1023/a:1015347219999. [PMID: 12064818] - K Haruma, M Ito, S Kido, N Manabe, Y Kitadai, M Sumii, S Tanaka, M Yoshihara, K Chayama. Long-term rebamipide therapy improves Helicobacter pylori-associated chronic gastritis.
Digestive diseases and sciences.
2002 Apr; 47(4):862-7. doi:
10.1023/a:1014716822702. [PMID: 11991622] - Jeong Yeon Seo, Hyeyoung Kim, Jeong Taeg Seo, Kyung Hwan Kim. Oxidative stress induced cytokine production in isolated rat pancreatic acinar cells: effects of small-molecule antioxidants.
Pharmacology.
2002 Feb; 64(2):63-70. doi:
10.1159/000056152. [PMID: 11803245] - Hiroyuki Taniguchi, Eiji Yomota, Koji Nogi, Yuichi Onoda. Effects of anti-ulcer agents on ethanol-induced gastric mucosal lesions in D-galactosamine-induced hepatitis rats.
Arzneimittel-Forschung.
2002; 52(8):600-4. doi:
10.1055/s-0031-1299937. [PMID: 12236047] - H Mizoguchi, Y Ogawa, K Kanatsu, A Tanaka, S Kato, K Takeuchi. Protective effect of rebamipide on indomethacin-induced intestinal damage in rats.
Journal of gastroenterology and hepatology.
2001 Oct; 16(10):1112-9. doi:
10.1046/j.1440-1746.2001.02592.x. [PMID: 11686837] - A Masamune, M Yoshida, Y Sakai, T Shimosegawa. Rebamipide inhibits ceramide-induced interleukin-8 production in Kato III human gastric cancer cells.
The Journal of pharmacology and experimental therapeutics.
2001 Aug; 298(2):485-92. doi:
. [PMID: 11454909] - S Y Saad, T A Najjar, M O Al-Sohaibani. The effect of rebamipide on cisplatin-induced nephrotoxicity in rats.
Pharmacological research.
2000 Jul; 42(1):81-6. doi:
10.1006/phrs.2000.0662. [PMID: 10860639] - H Kim, J Y Seo, K H Kim. Inhibition of lipid peroxidation, NF-kappaB activation and IL-8 production by rebamipide in Helicobacter pylori-stimulated gastric epithelial cells.
Digestive diseases and sciences.
2000 Mar; 45(3):621-8. doi:
10.1023/a:1005474013988. [PMID: 10749342] - L R Fitzpatrick, K Sakurai, T Le. Indomethacin-induced gastric antral damage in hamsters: are neutrophils involved?.
Alimentary pharmacology & therapeutics.
1999 Feb; 13(2):195-202. doi:
10.1046/j.1365-2036.1999.00444.x. [PMID: 10102950] - K Sakurai, T Osaka, K Yamasaki. Protection by rebamipide against acetic acid-induced colitis in rats: relationship with its antioxidative activity.
Digestive diseases and sciences.
1998 Sep; 43(9 Suppl):125S-133S. doi:
. [PMID: 9753238] - K B Hahm, K J Lee, Y S Kim, J H Kim, S W Cho, H Yim, H J Joo. Quantitative and qualitative usefulness of rebamipide in eradication regimen of Helicobacter pylori.
Digestive diseases and sciences.
1998 Sep; 43(9 Suppl):192S-197S. doi:
. [PMID: 9753249] - Y Naito, T Yoshikawa, S Iinuma, N Yagi, K Matsuyama, Y Boku, T Fujii, N Yoshida, M Kondo, E Sasaki. Rebamipide protects against indomethacin-induced gastric mucosal injury in healthy volunteers in a double-blind, placebo-controlled study.
Digestive diseases and sciences.
1998 Sep; 43(9 Suppl):83S-89S. doi:
". [PMID: 9753232] - K W Hong, K E Kim, B Y Rhim, W S Lee, C D Kim. Effect of rebamipide on liver damage and increased tumor necrosis factor in a rat model of endotoxin shock.
Digestive diseases and sciences.
1998 Sep; 43(9 Suppl):154S-159S. doi:
. [PMID: 9753243] - Y Naito, T Yoshikawa, N Yoshida, M Kondo. Role of oxygen radical and lipid peroxidation in indomethacin-induced gastric mucosal injury.
Digestive diseases and sciences.
1998 Sep; 43(9 Suppl):30S-34S. doi:
. [PMID: 9753223] - S Iinuma, Y Naito, T Yoshikawa, S Takahashi, T Takemura, N Yoshida, M Kondo. In vitro studies indicating antioxidative properties of rebamipide.
Digestive diseases and sciences.
1998 Sep; 43(9 Suppl):35S-39S. doi:
. [PMID: 9753224] - K Huh, T H Kwon, S K Kim, J S Kim, U S Shin. Therapeutic effect of rebamipide on ammonia-induced gastric mucosal hemorrhagic lesion in rats.
Archives of pharmacal research.
1998 Feb; 21(1):1-5. doi:
10.1007/bf03216744. [PMID: 9875506] - S Kokura, T Yoshikawa, Y Naito, H Ichikawa, H Takano, S Takahashi, T Tomii, N Yoshida, M Kondo. Effects of rebamipide, a novel anti-ulcer agent, on gastric mucosal injury induced by platelet-activating factor in rats.
Digestive diseases and sciences.
1997 Dec; 42(12):2566-71. doi:
10.1023/a:1018829032175. [PMID: 9440637] - S Antoku, R Aramaki, H Tanaka, N Kusumoto. [Protection of cultured mammalian cells by rebamipide].
Fukuoka igaku zasshi = Hukuoka acta medica.
1997 Jun; 88(6):247-52. doi:
NULL. [PMID: 9248142] - H Ha, S H Lee, K H Kim. Effects of rebamipide in a model of experimental diabetes and on the synthesis of transforming growth factor-beta and fibronectin, and lipid peroxidation induced by high glucose in cultured mesangial cells.
The Journal of pharmacology and experimental therapeutics.
1997 Jun; 281(3):1457-62. doi:
". [PMID: 9190883] - C D Kim, K W Hong. Preventive effect of rebamipide on gastric mucosal cell damage evoked by activation of formyl-methionyl-leucyl-phenylalanine receptors of rabbit neutrophils.
The Journal of pharmacology and experimental therapeutics.
1997 Apr; 281(1):478-83. doi:
NULL. [PMID: 9103534] - K B Hahm, I S Park, Y S Kim, J H Kim, S W Cho, S I Lee, J K Youn. Role of rebamipide on induction of heat-shock proteins and protection against reactive oxygen metabolite-mediated cell damage in cultured gastric mucosal cells.
Free radical biology & medicine.
1997; 22(4):711-6. doi:
10.1016/s0891-5849(96)00406-6. [PMID: 9013134] - Y Naito, T Yoshikawa, S Iinuma, R Miyazaki, N Yagi, N Yoshida, T Osumi, Y Hirao, M Kondo. Local gastric and serum concentrations of rebamipide following oral administration to patients with chronic gastritis.
Arzneimittel-Forschung.
1996 Jul; 46(7):698-700. doi:
NULL. [PMID: 8842341] - M Son, H K Kim, W B Kim, J Yang, B K Kim. Protective effect of taurine on indomethacin-induced gastric mucosal injury.
Advances in experimental medicine and biology.
1996; 403(?):147-55. doi:
10.1007/978-1-4899-0182-8_17. [PMID: 8915352] - K Huh, U S Shin, S H Lee. The effect of rebamipide on gastric xanthine oxidase activity and type conversion in ethanol-treated rats.
Free radical biology & medicine.
1996; 20(7):967-71. doi:
10.1016/0891-5849(95)02152-3. [PMID: 8743982] - S M Lee, K H Kim. Rebamipide ameliorates hepatic dysfunction induced by ischemia/reperfusion in rats.
European journal of pharmacology.
1995 Dec; 294(1):41-6. doi:
10.1016/0014-2999(95)00507-2. [PMID: 8788414] - T Yoshikawa, Y Naito, S Nakamura, S Nishimura, T Kaneko, S Iinuma, S Takahashi, M Kondo, K Yamasaki. Effect of rebamipide on lipid peroxidation and gastric mucosal injury induced by indometacin in rats.
Arzneimittel-Forschung.
1993 Dec; 43(12):1327-30. doi:
". [PMID: 8141822] - K Ogino, T Hobara, H Ishiyama, K Yamasaki, H Kobayashi, Y Izumi, S Oka. Antiulcer mechanism of action of rebamipide, a novel antiulcer compound, on diethyldithiocarbamate-induced antral gastric ulcers in rats.
European journal of pharmacology.
1992 Feb; 212(1):9-13. doi:
10.1016/0014-2999(92)90065-c. [PMID: 1313372] - Y Shioya, T Shimizu. High-performance liquid chromatographic procedure for the determination of a new anti-gastric ulcer agent, 2-(4-chlorobenzoylamino)-3-[2(1H)-quinolinon-4-yl]propioni c acid, in human plasma and urine.
Journal of chromatography.
1988 Dec; 434(1):283-7. doi:
10.1016/0378-4347(88)80089-6. [PMID: 2854135]