4-Aminohex-5-ynoic acid (BioDeep_00000179317)

   

human metabolite blood metabolite


代谢物信息卡片


4-Amino-5-hexynoic acid

化学式: C6H9NO2 (127.0633)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(blood) 85.71%

分子结构信息

SMILES: C#CC(CCC(=O)O)N
InChI: InChI=1S/C6H9NO2/c1-2-5(7)3-4-6(8)9/h1,5H,3-4,7H2,(H,8,9)

描述信息

D004791 - Enzyme Inhibitors

同义名列表

6 个代谢物同义名

4-Amino-5-hexynoic acid; 4-Aminohex-5-ynoic acid; gamma-Acetylenic gaba; gamma-Acetylenic-gaba; 4-Aminohex-5-ynoate; 4-Aminohexynoate



数据库引用编号

5 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 13 ADRA1A, CA1, CA2, CA3, CHAT, DBH, DDC, HTT, KYAT1, OAT, ODC1, TBCE, TH
Endosome membrane 1 HTT
Endoplasmic reticulum membrane 1 DRD1
Nucleus 6 ADRA1A, CHAT, DRD1, HTT, TCF15, TH
autophagosome 1 HTT
cytosol 12 ADRA1A, CA1, CA2, CA3, CHAT, DDC, GPT, HTT, KYAT1, ODC1, SST, TH
dendrite 3 DRD2, HTT, TH
nucleoplasm 3 ADRA1A, HTT, OAT
RNA polymerase II transcription regulator complex 1 TCF15
Cell membrane 5 ADRA1A, CA2, DRD1, DRD2, HTT
Cell projection, axon 1 TH
Multi-pass membrane protein 4 ADRA1A, DRD1, DRD2, HTT
Golgi apparatus membrane 1 DRD2
Synapse 4 CHAT, DBH, DRD2, HTT
glutamatergic synapse 2 DRD1, DRD2
Golgi apparatus 1 HTT
Golgi membrane 1 DRD2
neuronal cell body 1 SST
presynaptic membrane 3 DRD1, DRD2, HTT
smooth endoplasmic reticulum 1 TH
synaptic vesicle 1 TH
Cytoplasm, cytosol 1 KYAT1
acrosomal vesicle 1 DRD2
plasma membrane 5 ADRA1A, CA2, DRD1, DRD2, HTT
synaptic vesicle membrane 1 DRD2
terminal bouton 1 TH
Membrane 1 DBH
axon 3 DRD2, HTT, TH
caveola 1 ADRA1A
extracellular exosome 4 CA1, CA2, DDC, GPT
endoplasmic reticulum 2 DBH, HTT
extracellular space 2 DBH, SST
perinuclear region of cytoplasm 2 HTT, TH
mitochondrion 4 ABAT, KYAT1, OAT, TH
protein-containing complex 1 HTT
intracellular membrane-bounded organelle 2 ADRA1A, DBH
Secreted 2 DBH, SST
extracellular region 2 DBH, SST
cytoplasmic side of plasma membrane 1 TH
Mitochondrion matrix 1 OAT
mitochondrial matrix 2 ABAT, OAT
centriolar satellite 1 DBH
ciliary membrane 2 DRD1, DRD2
Nucleus membrane 1 ADRA1A
nuclear membrane 1 ADRA1A
dendritic spine 2 DRD1, DRD2
perikaryon 2 DRD2, TH
cytoplasmic vesicle 1 TH
Melanosome membrane 1 TH
Early endosome 1 HTT
apical part of cell 1 CA2
Single-pass type II membrane protein 1 DBH
postsynaptic membrane 3 DRD1, DRD2, HTT
Cytoplasm, perinuclear region 1 TH
Membrane raft 1 HTT
Cell junction, focal adhesion 1 HTT
Cytoplasm, cytoskeleton 1 TBCE
focal adhesion 1 HTT
microtubule 1 TBCE
GABA-ergic synapse 3 DRD1, DRD2, SST
Cell projection, dendritic spine 1 DRD1
lateral plasma membrane 1 DRD2
Late endosome 1 HTT
Cell projection, neuron projection 1 HTT
neuron projection 3 CHAT, HTT, TH
cilium 2 DRD1, DRD2
chromatin 1 TCF15
centriole 1 HTT
non-motile cilium 2 DRD1, DRD2
sperm flagellum 1 DRD2
Endomembrane system 1 HTT
Membrane, caveola 1 ADRA1A
Cytoplasmic vesicle membrane 1 HTT
Cell projection, dendrite 1 DRD1
myelin sheath 1 CA2
secretory granule lumen 1 DBH
secretory granule membrane 1 DBH
axon terminus 1 DRD2
endocytic vesicle 1 DRD2
neuronal dense core vesicle 1 SST
ribonucleoprotein complex 1 TBCE
dopaminergic synapse 1 DRD2
Cytoplasmic vesicle, secretory vesicle membrane 1 DBH
postsynaptic cytosol 1 HTT
Cell projection, cilium membrane 1 DRD1
presynaptic cytosol 1 HTT
ribosome 1 TBCE
Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen 1 DBH
chromaffin granule lumen 1 DBH
transport vesicle membrane 1 DBH
inclusion body 1 HTT
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
[Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen 1 DBH
Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane 1 DBH
chromaffin granule membrane 1 DBH
G protein-coupled receptor complex 2 DRD1, DRD2
serotonergic synapse 1 HTT
[Huntingtin]: Cytoplasm 1 HTT
[Huntingtin, myristoylated N-terminal fragment]: Cytoplasmic vesicle, autophagosome 1 HTT
4-aminobutyrate transaminase complex 1 ABAT


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • W Löscher, D Hörstermann. Differential effects of vigabatrin, gamma-acetylenic GABA, aminooxyacetic acid, and valproate on levels of various amino acids in rat brain regions and plasma. Naunyn-Schmiedeberg's archives of pharmacology. 1994 Mar; 349(3):270-8. doi: 10.1007/bf00169293. [PMID: 8208305]
  • C A Wilson, M D James, A J Leigh. Role of gamma-aminobutyric acid in the zona incerta in the control of luteinizing hormone release and ovulation. Neuroendocrinology. 1990 Oct; 52(4):354-60. doi: 10.1159/000125607. [PMID: 2124661]
  • T D Elich, A F McDonagh, L A Palma, J C Lagarias. Phytochrome chromophore biosynthesis. Treatment of tetrapyrrole-deficient Avena explants with natural and non-natural bilatrienes leads to formation of spectrally active holoproteins. The Journal of biological chemistry. 1989 Jan; 264(1):183-9. doi: ". [PMID: 2909515]
  • W Löscher. Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils. Pharmacology, biochemistry, and behavior. 1986 Apr; 24(4):1007-13. doi: 10.1016/0091-3057(86)90449-1. [PMID: 3086900]
  • J Fiók, Z Acs, G B Makara, S L Erdö. Site of gamma-aminobutyric acid (GABA)-mediated inhibition of growth hormone secretion in the rat. Neuroendocrinology. 1984 Dec; 39(6):510-6. doi: 10.1159/000124031. [PMID: 6151130]
  • L Debeljuk, M D Díaz, V M Maines, A Seilicovich. Prolonged treatment with gamma-aminobutyric acid (GABA)-mimetic substances in prepubertal male rats. Archives of andrology. 1983 Jun; 10(3):239-43. doi: 10.3109/01485018308987572. [PMID: 6882089]
  • K D Haegele, J Schoun, R G Alken, N D Huebert. Determination of the R(-)- and S(+)-enantiomers of gamma-vinyl-gamma-aminobutyric acid in human body fluids by gas chromatography--mass spectrometry. Journal of chromatography. 1983 May; 274(?):103-10. doi: 10.1016/s0378-4347(00)84413-8. [PMID: 6874815]
  • J Fiók, Z Acs, E Stark. Possible inhibitory influence of gamma-aminobutyric acid on growth hormone secretion in the rat. The Journal of endocrinology. 1981 Dec; 91(3):391-7. doi: 10.1677/joe.0.0910391. [PMID: 7328370]
  • A O Donoso, M B Zárate. Changes in prolactin release caused by GABA and endogenous GABA increase in rats. Brain research bulletin. 1981 Oct; 7(4):359-64. doi: 10.1016/0361-9230(81)90029-0. [PMID: 7296305]
  • R Olsen, M Hørder. Decreased alanine aminotransferase activity in serum of man during gamma-acetylenic-GABA treatment. Scandinavian journal of clinical and laboratory investigation. 1980 Jun; 40(4):393-5. doi: 10.3109/00365518009092660. [PMID: 7414257]