Fluocinolone (BioDeep_00000179114)

 

Secondary id: BioDeep_00000006396

human metabolite blood metabolite


代谢物信息卡片


1,8-difluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one

化学式: C21H26F2O6 (412.1697)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC12C=CC(=O)C=C1C(F)CC1C3CC(O)C(O)(C(=O)CO)C3(C)CC(O)C12F
InChI: InChI=1S/C21H26F2O6/c1-18-4-3-10(25)5-13(18)14(22)6-12-11-7-15(26)21(29,17(28)9-24)19(11,2)8-16(27)20(12,18)23/h3-5,11-12,14-16,24,26-27,29H,6-9H2,1-2H3

描述信息

C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid

同义名列表

4 个代谢物同义名

1,8-difluoro-13,14,17-trihydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-3,6-dien-5-one; 6,9-Difluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione; Fluocinolone; Fluocinolone



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ANG, CNTF, CYP1A1, FLNA, NR3C1, RPE65, TNFSF11, TYR, VEGFA
Peripheral membrane protein 1 CYP1A1
Endoplasmic reticulum membrane 3 CD4, CYP1A1, RPE65
Nucleus 5 ANG, FLNA, NR3C1, RPE65, VEGFA
cytosol 4 ANG, FLNA, NR3C1, SST
trans-Golgi network 1 FLNA
centrosome 1 NR3C1
nucleoplasm 1 NR3C1
Cell membrane 5 CD4, CD8A, RPE65, TNF, TNFSF11
Lipid-anchor 1 RPE65
Cell projection, growth cone 1 FLNA
Multi-pass membrane protein 2 ATP4A, C9
Synapse 1 NR3C1
cell surface 4 ICAM1, PLG, TNF, VEGFA
dendritic shaft 1 FLNA
glutamatergic synapse 2 FLNA, PLG
Golgi apparatus 1 VEGFA
growth cone 1 ANG
lysosomal membrane 1 EGF
mitochondrial inner membrane 1 CYP1A1
neuronal cell body 3 ANG, SST, TNF
postsynapse 1 FLNA
Lysosome 1 TYR
plasma membrane 11 ATP4A, C9, CD4, CD8A, EGF, FLNA, ICAM1, PLG, RPE65, TNF, TNFSF11
Membrane 9 ATP4A, C9, EGF, FLNA, ICAM1, NR3C1, RPE65, TNFSF11, VEGFA
apical plasma membrane 1 ATP4A
axon 1 CNTF
brush border 1 FLNA
extracellular exosome 6 C9, CXCL12, EGF, FLNA, ICAM1, PLG
endoplasmic reticulum 1 VEGFA
extracellular space 12 ANG, ATP4A, C9, CNTF, EGF, ICAM1, IL2, PLG, SST, TNF, TNFSF11, VEGFA
perinuclear region of cytoplasm 2 FLNA, TYR
Schaffer collateral - CA1 synapse 1 PLG
adherens junction 1 VEGFA
mitochondrion 2 CYP1A1, NR3C1
protein-containing complex 1 NR3C1
intracellular membrane-bounded organelle 2 CYP1A1, TYR
Microsome membrane 2 CYP1A1, RPE65
Single-pass type I membrane protein 4 CD4, CD8A, ICAM1, TYR
Secreted 7 ANG, C9, IL2, PLG, SST, TNFSF11, VEGFA
extracellular region 13 ANG, C9, CD8A, CNTF, CXCL12, EGF, FLNA, IL2, PLG, SST, TNF, TNFSF11, VEGFA
[Isoform 2]: Secreted 1 CD8A
mitochondrial matrix 1 NR3C1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 NR3C1
external side of plasma membrane 6 CD4, CD8A, CXCL12, ICAM1, PLG, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 2 ANG, FLNA
perikaryon 1 FLNA
Z disc 1 FLNA
nucleolus 2 ANG, FLNA
Melanosome membrane 1 TYR
Early endosome 1 CD4
cell-cell junction 1 FLNA
Golgi-associated vesicle 1 TYR
recycling endosome 1 TNF
Single-pass type II membrane protein 2 TNF, TNFSF11
Apical cell membrane 1 ATP4A
Mitochondrion inner membrane 1 CYP1A1
Membrane raft 3 CD4, ICAM1, TNF
Cytoplasm, cytoskeleton 1 FLNA
Cytoplasm, cytoskeleton, spindle 1 NR3C1
focal adhesion 2 FLNA, ICAM1
spindle 1 NR3C1
GABA-ergic synapse 1 SST
extracellular matrix 1 VEGFA
basement membrane 1 ANG
collagen-containing extracellular matrix 3 CXCL12, ICAM1, PLG
secretory granule 1 VEGFA
nuclear speck 1 NR3C1
receptor complex 1 CD8A
chromatin 1 NR3C1
axonal growth cone 1 FLNA
phagocytic cup 1 TNF
Chromosome 2 ANG, NR3C1
Cell projection, podosome 1 FLNA
podosome 1 FLNA
Nucleus, nucleolus 1 ANG
Cytoplasm, cell cortex 1 FLNA
actin filament 1 FLNA
blood microparticle 2 C9, PLG
Nucleus, nucleoplasm 1 NR3C1
Melanosome 1 TYR
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
cell body 1 RPE65
plasma membrane raft 1 CD8A
endoplasmic reticulum lumen 1 CD4
platelet alpha granule lumen 3 EGF, PLG, VEGFA
endocytic vesicle 1 ANG
immunological synapse 1 ICAM1
neuronal dense core vesicle 1 SST
[Isoform 2]: Cytoplasm 1 TNFSF11
[Tumor necrosis factor ligand superfamily member 11, soluble form]: Secreted 1 TNFSF11
clathrin-coated endocytic vesicle membrane 2 CD4, EGF
apical dendrite 1 FLNA
[Isoform 1]: Cell membrane 1 CD8A
intracellular non-membrane-bounded organelle 1 FLNA
[Isoform Alpha]: Cytoplasm 1 NR3C1
membrane attack complex 1 C9
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 2 CD4, CD8A
actin filament bundle 1 FLNA
cortical cytoskeleton 1 FLNA
Target cell membrane 1 C9
other organism cell membrane 1 C9
angiogenin-PRI complex 1 ANG
[Isoform Beta]: Nucleus 1 NR3C1
[Isoform Alpha-B]: Nucleus 1 NR3C1
glycoprotein Ib-IX-V complex 1 FLNA
Myb complex 1 FLNA
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
potassium:proton exchanging ATPase complex 1 ATP4A
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Joaquín Felipe Ramírez-Oliveros, Luciana de Abreu, Carla Tamler, Paula Vilhena, Mayara Hamilko de Barros. Microneedling with Drug Delivery (Hydroquinone 4\% Serum) as an Adjuvant Therapy for Recalcitrant Melasma. Skinmed. 2020; 18(1):38-40. doi: . [PMID: 32167455]
  • Frane Banovic, Carmen Jerry, Elizabeth Howerth. Tacrolimus therapy for dermal arteritis of the nasal philtrum refractory to surgery and anti-inflammatory therapy (doxycycline/niacinamide and topical fluocinolone) in a dog. Veterinary dermatology. 2018 Feb; 29(1):85-e35. doi: 10.1111/vde.12502. [PMID: 28990239]
  • Surya P Ayalasomayajula, Paul Ashton, Uday B Kompella. Fluocinolone inhibits VEGF expression via glucocorticoid receptor in human retinal pigment epithelial (ARPE-19) cells and TNF-alpha-induced angiogenesis in chick chorioallantoic membrane (CAM). Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. 2009 Apr; 25(2):97-103. doi: 10.1089/jop.2008.0090. [PMID: 19284324]