albendazole S-oxide (BioDeep_00000001761)

 

Secondary id: BioDeep_00000397472

human metabolite natural product


代谢物信息卡片


N-[6-(propane-1-sulfinyl)-1H-1,3-benzodiazol-2-yl]methoxycarboximidic acid

化学式: C12H15N3O3S (281.083408)
中文名称: 氧阿苯达唑, 阿苯哒唑亚砜
谱图信息: 最多检出来源 Homo sapiens(blood) 1.53%

分子结构信息

SMILES: CCCS(=O)C1=CC2=C(C=C1)N=C(N2)N=C(O)OC
InChI: InChI=1S/C12H15N3O3S/c1-3-6-19(17)8-4-5-9-10(7-8)14-11(13-9)15-12(16)18-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)

描述信息

Albendazole s-oxide is part of the Steroid hormone biosynthesis, Linoleic acid metabolism, Retinol metabolism, and Bile secretion pathways. It is a substrate for: Cytochrome P450 3A4.
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
C254 - Anti-Infective Agent > C276 - Antiparasitic Agent > C250 - Antihelminthic Agent

同义名列表

12 个代谢物同义名

N-[6-(propane-1-sulfinyl)-1H-1,3-benzodiazol-2-yl]methoxycarboximidic acid; N-[5-(propane-1-sulfinyl)-3H-1,3-benzodiazol-2-yl]methoxycarboximidic acid; Albendazole sulfoxide, monohydrochloride; (+-)-Albendazole sulphoxide; (+-)-Albendazole sulfoxide; Albendazole sulphoxide; Albendazole sulfoxide; Albendazole sulfone; albendazole S-oxide; Albendazole oxide; Ricobendazole; Rycobendazole



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • María Celeste Nicolao, Christian Rodriguez Rodrigues, Magalí B Coccimiglio, Camila Ledo, Guillermo H Docena, Andrea C Cumino. Characterization of protein cargo of Echinococcus granulosus extracellular vesicles in drug response and its influence on immune response. Parasites & vectors. 2023 Jul; 16(1):255. doi: 10.1186/s13071-023-05854-6. [PMID: 37516852]
  • Cengiz Gokbulut, Veli Y Cirak, Suleyman Aypak, Hamdi Avci, Selim Sekkin, Hande S Yalinkilinc, Buket Boga, Erol Ayaz. In vivo exposure of Albendazole sulphoxide by Haemonchus contortus and correlation between plasma and target tissue or gastrointestinal content dispositions in goats. Journal of veterinary pharmacology and therapeutics. 2021 Sep; 44(5):799-807. doi: 10.1111/jvp.12974. [PMID: 33893651]
  • Maximo Pettarin, Michael B Bolger, Maja Chronowska, Edmund S Kostewicz. A combined in vitro in-silico approach to predict the oral bioavailability of borderline BCS Class II/IV weak base albendazole and its main metabolite albendazole sulfoxide. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2020 Dec; 155(?):105552. doi: 10.1016/j.ejps.2020.105552. [PMID: 32937212]
  • Ebrahim Alipanahpour Dil, Arash Asfaram, Hamedreza Javadian. A new approach for microextraction of trace albendazole sulfoxide drug from the samples of human plasma and urine, and water by the molecularly imprinted polymer nanoparticles combined with HPLC. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Nov; 1158(?):122249. doi: 10.1016/j.jchromb.2020.122249. [PMID: 33059159]
  • Morgan A A Riggan, Gabriel Perreault, Anita Wen, Veronica Raco, Susi Vassallo, Roy Gerona, Robert S Hoffman. Case Report: Analytically Confirmed Severe Albenzadole Overdose Presenting with Alopecia and Pancytopenia. The American journal of tropical medicine and hygiene. 2020 01; 102(1):177-179. doi: 10.4269/ajtmh.19-0198. [PMID: 31701853]
  • Gianfranco Arroyo, Javier A Bustos, Andres G Lescano, Isidro Gonzales, Herbert Saavedra, Silvia Rodriguez, E Javier Pretell, Pierina S Bonato, Vera L Lanchote, Osvaldo M Takayanagui, John Horton, Armando E Gonzalez, Robert H Gilman, Hector H Garcia. Albendazole Sulfoxide Plasma Levels and Efficacy of Antiparasitic Treatment in Patients With Parenchymal Neurocysticercosis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2019 11; 69(11):1996-2002. doi: 10.1093/cid/ciz085. [PMID: 30715265]
  • Andi Dian Permana, Ismaiel A Tekko, Helen O McCarthy, Ryan F Donnelly. New HPLC-MS method for rapid and simultaneous quantification of doxycycline, diethylcarbamazine and albendazole metabolites in rat plasma and organs after concomitant oral administration. Journal of pharmaceutical and biomedical analysis. 2019 Jun; 170(?):243-253. doi: 10.1016/j.jpba.2019.03.047. [PMID: 30947125]
  • Jessica D Schulz, Anna Neodo, Jean T Coulibaly, Jennifer Keiser. Pharmacokinetics of Albendazole, Albendazole Sulfoxide, and Albendazole Sulfone Determined from Plasma, Blood, Dried-Blood Spots, and Mitra Samples of Hookworm-Infected Adolescents. Antimicrobial agents and chemotherapy. 2019 04; 63(4):. doi: 10.1128/aac.02489-18. [PMID: 30745388]
  • C Canton, L Ceballos, M P Domínguez, L Moreno, C Fiel, G Bernat, C Farías, C Lanusse, L Alvarez. Pharmaco-parasitological evaluation of the ricobendazole plus levamisole nematodicidal combination in cattle. Journal of veterinary pharmacology and therapeutics. 2018 Feb; 41(1):83-91. doi: 10.1111/jvp.12438. [PMID: 28695609]
  • Jui J Pandya, Mallika Sanyal, Pranav S Shrivastav. Simultaneous densitometric determination of anthelmintic drug albendazole and its metabolite albendazole sulfoxide by HPTLC in human plasma and pharmaceutical formulations. Biomedical chromatography : BMC. 2017 Sep; 31(9):. doi: 10.1002/bmc.3947. [PMID: 28178374]
  • Noemi Cowan, Charles Meier, Anna Neodo, Jennifer Keiser. Exposure of Heligmosomoides polygyrus and Trichuris muris to albendazole, albendazole sulfoxide, mebendazole and oxantel pamoate in vitro and in vivo to elucidate the pathway of drug entry into these gastrointestinal nematodes. International journal for parasitology. Drugs and drug resistance. 2017 08; 7(2):159-173. doi: 10.1016/j.ijpddr.2017.03.005. [PMID: 28371660]
  • Candela Canton, Laura Ceballos, César Fiel, Laura Moreno, Pablo Domingo Yagüez, Gisele Bernat, Carlos Lanusse, Luis Alvarez. Resistant nematodes in cattle: Pharmaco-therapeutic assessment of the ivermectin- ricobendazole combination. Veterinary parasitology. 2017 Jan; 234(?):40-48. doi: 10.1016/j.vetpar.2016.12.021. [PMID: 28115181]
  • Marziyeh Naseri, Abolfazl Akbarzadeh, Adel Spotin, Nagibeh Asl Rahnemaii Akbari, Mahmoud Mahami-Oskouei, Ehsan Ahmadpour. Scolicidal and apoptotic activities of albendazole sulfoxide and albendazole sulfoxide-loaded PLGA-PEG as a novel nanopolymeric particle against Echinococcus granulosus protoscoleces. Parasitology research. 2016 Dec; 115(12):4595-4603. doi: 10.1007/s00436-016-5250-8. [PMID: 27623699]
  • Cíntia A J Pereira, Laura L S Oliveira, Aytube L Coaglio, Fernanda S O Santos, Rodolfo S M Cezar, Tiago Mendes, Fernando L P Oliveira, Gustavo Conzensa, Walter S Lima. Anti-helminthic activity of Momordica charantia L. against Fasciola hepatica eggs after twelve days of incubation in vitro. Veterinary parasitology. 2016 Sep; 228(?):160-166. doi: 10.1016/j.vetpar.2016.08.025. [PMID: 27692319]
  • Felix Lötsch, Judith Naderer, Tomislava Skuhala, Mirjam Groger, Herbert Auer, Klaus Kaczirek, Fredrik Waneck, Michael Ramharter. Intra-cystic concentrations of albendazole-sulphoxide in human cystic echinococcosis: a systematic review and analysis of individual patient data. Parasitology research. 2016 Aug; 115(8):2995-3001. doi: 10.1007/s00436-016-5054-x. [PMID: 27085708]
  • Nihal Saraner, Güler Yağmur Özkan, Berrak Güney, Erkin Alkan, Nihan Burul-Bozkurt, Onursal Sağlam, Ezgi Fikirdeşici, Mevlüt Yıldırım. Determination of albendazole sulfoxide in human plasma by using liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Jun; 1022(?):1-5. doi: 10.1016/j.jchromb.2016.03.024. [PMID: 27060508]
  • Dilek Aksit, Hande Sultan Yalinkilinc, Selim Sekkin, Murat Boyacioğlu, Veli Yilgor Cirak, Erol Ayaz, Cengiz Gokbulut. Comparative pharmacokinetics and bioavailability of albendazole sulfoxide in sheep and goats, and dose-dependent plasma disposition in goats. BMC veterinary research. 2015 May; 11(?):124. doi: 10.1186/s12917-015-0442-5. [PMID: 26012791]
  • L E Fazzio, R O Sánchez, N Streitenberger, W R Galvan, C J Giudici, E J Gimeno. The effect of anthelmintic resistance on the productivity in feedlot cattle. Veterinary parasitology. 2014 Dec; 206(3-4):240-5. doi: 10.1016/j.vetpar.2014.10.010. [PMID: 25468022]
  • Chia-Wen Hsu, Jinghua Zhao, Ruili Huang, Jui-Hua Hsieh, Jon Hamm, Xiaoqing Chang, Keith Houck, Menghang Xia. Quantitative high-throughput profiling of environmental chemicals and drugs that modulate farnesoid X receptor. Scientific reports. 2014 Sep; 4(?):6437. doi: 10.1038/srep06437. [PMID: 25257666]
  • Wen Liang, Xin-Chun Wang, Xiang-Wei Wu, Shi-Jie Zhang, Hong Sun, Xin Ma, Xin-Yu Peng. [Efficacy of albendazole chitosan microspheres against Echinococcus granulosus infection in mice]. Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases. 2014 Jun; 32(3):188-92. doi: . [PMID: 25223052]
  • Sandra Halwachs, Louise Wassermann, Walther Honscha. A novel MDCKII in vitro model for assessing ABCG2-drug interactions and regulation of ABCG2 transport activity in the caprine mammary gland by environmental pollutants and pesticides. Toxicology in vitro : an international journal published in association with BIBRA. 2014 Apr; 28(3):432-41. doi: 10.1016/j.tiv.2013.12.015. [PMID: 24389113]
  • Tomislava Skuhala, Vladimir Trkulja, Mislav Runje, Dalibor Vukelic, Bosko Desnica. Albendazolesulphoxide concentrations in plasma and hydatid cyst and prediction of parasitological and clinical outcomes in patients with liver hydatidosis caused by Echinococcus granulosus. Croatian medical journal. 2014 Apr; 55(2):146-55. doi: 10.3325/cmj.2014.55.146. [PMID: 24778101]
  • Gonzalo Suarez, Luis Alvarez, Daniel Castells, Laura Moreno, Pietro Fagiolino, Carlos Lanusse. Evaluation of pharmacological interactions after administration of a levamisole, albendazole and ivermectin triple combination in lambs. Veterinary parasitology. 2014 Mar; 201(1-2):110-9. doi: 10.1016/j.vetpar.2013.12.015. [PMID: 24462508]
  • M Bistoletti, L Alvarez, C Lanusse, L Moreno. Effects of feeding on the plasma disposition kinetics of the anthelmintic albendazole in laying hens. British poultry science. 2014; 55(6):824-9. doi: 10.1080/00071668.2014.958058. [PMID: 25159169]
  • Sara Ahmadnia, Mohammad Moazeni, Soliman Mohammadi-Samani, Ahmad Oryan. In vivo evaluation of the efficacy of albendazole sulfoxide and albendazole sulfoxide loaded solid lipid nanoparticles against hydatid cyst. Experimental parasitology. 2013 Oct; 135(2):314-9. doi: 10.1016/j.exppara.2013.07.017. [PMID: 23912040]
  • Maria Anete Lallo, Lidiana F Vidoto da Costa, João Manoel de Castro. Effect of three drugs against Encephalitozoon cuniculi infection in immunosuppressed mice. Antimicrobial agents and chemotherapy. 2013 Jul; 57(7):3067-71. doi: 10.1128/aac.00157-13. [PMID: 23612191]
  • Kathrin Eckardt, Johanna Kaltenhäuser, Caroline Kilb, Andrea Seiler, Ralf Stahlmann. Relative potency of albendazole and its sulfoxide metabolite in two in vitro tests for developmental toxicity: the rat whole embryo culture and the mouse embryonic stem cell test. Reproductive toxicology (Elmsford, N.Y.). 2012 Nov; 34(3):378-84. doi: 10.1016/j.reprotox.2012.05.037. [PMID: 22652462]
  • L Alvarez, G Suárez, L Ceballos, L Moreno, C Lanusse. Dose-dependent systemic exposure of albendazole metabolites in lambs. Journal of veterinary pharmacology and therapeutics. 2012 Aug; 35(4):365-72. doi: 10.1111/j.1365-2885.2011.01326.x. [PMID: 21819410]
  • Zaijian Li, Cuilan Chen, Diyun Ai, Chunmei Wang, Jing Li, Yuanhua Qi, Weixue Yi, Hongchun Shen, Jiyue Cao. Pharmacokinetics and tissue residues of hydrochloric acid albendazole sulfoxide and its metabolites in crucian carp (Carassius auratus) after oral administration. Environmental toxicology and pharmacology. 2012 Mar; 33(2):197-204. doi: 10.1016/j.etap.2011.12.001. [PMID: 22227164]
  • Iliana González-Hernández, María Isabel Ruiz-Olmedo, Graciela Cárdenas, Helgi Jung-Cook. A simple LC-MS/MS method to determine plasma and cerebrospinal fluid levels of albendazole metabolites (albendazole sulfoxide and albendazole sulfone) in patients with neurocysticercosis. Biomedical chromatography : BMC. 2012 Feb; 26(2):267-72. doi: 10.1002/bmc.1659. [PMID: 21721022]
  • Kuldeep Sharma, Murugesh Kandaswamy, Chandan Mithra, Ashok Kumar Meena, Sanjeev Giri, Sriram Rajagopal, Ramesh Mullangi. Highly sensitive LC-MS/MS-ESI method for simultaneous quantitation of albendazole and ricobendazole in rat plasma and its application to a rat pharmacokinetic study. Biomedical chromatography : BMC. 2012 Feb; 26(2):247-55. doi: 10.1002/bmc.1654. [PMID: 21633966]
  • Tomasz Grabowski, Jerzy Jan Jaroszewski, Anna Swierczewska, Renata Sawicka, Tomasz Maślanka, Włodzimierz Markiewicz, Hubert Ziółkowski. Application of ultra-performance columns in high-performance liquid chromatography for determination of albendazole and its metabolites in turkeys. Biomedical chromatography : BMC. 2011 Oct; 25(10):1159-67. doi: 10.1002/bmc.1588. [PMID: 21294142]
  • Doaa A Yones, Gamal A Taher, Zedan Z Ibraheim. In vitro effects of some herbs used in Egyptian traditional medicine on viability of protoscolices of hydatid cysts. The Korean journal of parasitology. 2011 Sep; 49(3):255-63. doi: 10.3347/kjp.2011.49.3.255. [PMID: 22072825]
  • Hector H Garcia, Andres G Lescano, Vera L Lanchote, E Javier Pretell, Isidro Gonzales, Javier A Bustos, Osvaldo M Takayanagui, Pierina S Bonato, John Horton, Herbert Saavedra, Armando E Gonzalez, Robert H Gilman. Pharmacokinetics of combined treatment with praziquantel and albendazole in neurocysticercosis. British journal of clinical pharmacology. 2011 Jul; 72(1):77-84. doi: 10.1111/j.1365-2125.2011.03945.x. [PMID: 21332573]
  • Xinle Zhu, Shuhuai Wang, Qi Liu, Qian Xu, Congmin Zhang, Shixin Xu, Xia Wang, Dan Li, Haiyan Hu. Simultaneous determination of benzimidazoles and their metabolites in plasma using high-performance liquid chromatography/tandem mass spectrometry: application to pharmacokinetic studies in rabbits. Journal of AOAC International. 2011 May; 94(3):839-46. doi: . [PMID: 21797012]
  • Miriam Teruel, Jaqueline Dercole, Rodolfo Catalano. Evaluation of potential embryo toxicity of albendazole sulphoxide in CF1 mice. Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al. 2011 Apr; 35(1):29-33. doi: . [PMID: 21667669]
  • A Dib, S Palma, G Suárez, C Farías, P Cabrera, S Castro, D Allemandi, L Moreno, C Lanusse, S Sánchez Bruni. Albendazole sulphoxide kinetic disposition after treatment with different formulations in dogs. Journal of veterinary pharmacology and therapeutics. 2011 Apr; 34(2):136-41. doi: 10.1111/j.1365-2885.2010.01203.x. [PMID: 21395604]
  • Zimei Wu, Ian G Tucker, Majid Razzak, Lin Yang, Keith McSporran, Natalie J Medlicott. Absorption and tissue tolerance of ricobendazole in the presence of hydroxypropyl-beta-cyclodextrin following subcutaneous injection in sheep. International journal of pharmaceutics. 2010 Sep; 397(1-2):96-102. doi: 10.1016/j.ijpharm.2010.07.002. [PMID: 20621175]
  • Tusharmouli Mukherjee, Fotios M Plakogiannis. Development and oral bioavailability assessment of a supersaturated self-microemulsifying drug delivery system (SMEDDS) of albendazole. The Journal of pharmacy and pharmacology. 2010 Sep; 62(9):1112-20. doi: 10.1111/j.2042-7158.2010.01149.x. [PMID: 20796189]
  • Mohammad H Pourgholami, Zhao Y Cai, Stephanie W L Chu, Peter Galettis, David L Morris. The influence of ovarian cancer induced peritoneal carcinomatosis on the pharmacokinetics of albendazole in nude mice. Anticancer research. 2010 Feb; 30(2):423-8. doi: . [PMID: 20332449]
  • N Castro, C Márquez-Caraveo, R C Brundage, D González-Esquivel, A M Suárez, F Góngora, A Jara, J Urizar, J M Lanao, H Jung. Population pharmacokinetics of albendazole in patients with neurocysticercosis. International journal of clinical pharmacology and therapeutics. 2009 Nov; 47(11):679-85. doi: . [PMID: 19840532]
  • Ahmed M Abdel-tawab, Mark Bradley, Essam A Ghazaly, John Horton, Maged el-Setouhy. Albendazole and its metabolites in the breast milk of lactating women following a single oral dose of albendazole. British journal of clinical pharmacology. 2009 Nov; 68(5):737-42. doi: 10.1111/j.1365-2125.2009.03524.x. [PMID: 19916998]
  • Mesküre Capan, Sebastian Keltner, Florian Thalhammer, Stefan Winkler, Walter Jäger, Markus Zeitlinger, Michael Ramharter. Intra-cystic drug concentration of albendazole sulphoxide in patients with Echinococcus granulosus cysts. The American journal of tropical medicine and hygiene. 2009 Oct; 81(4):712-3. doi: 10.4269/ajtmh.2009.09-0234. [PMID: 19815892]
  • Bettencourt P S Capece, Guillermo L Virkel, Carlos E Lanusse. Enantiomeric behaviour of albendazole and fenbendazole sulfoxides in domestic animals: pharmacological implications. Veterinary journal (London, England : 1997). 2009 Sep; 181(3):241-50. doi: 10.1016/j.tvjl.2008.11.010. [PMID: 19124257]
  • C Gokbulut, V Y Cirak, B Senlik, F Yildirim, Q A McKellar. Pharmacological assessment of netobimin as a potential anthelmintic for use in horses: plasma disposition, faecal excretion and efficacy. Research in veterinary science. 2009 Jun; 86(3):514-20. doi: 10.1016/j.rvsc.2008.10.001. [PMID: 19022462]
  • B P S Capece, S M S Afonso, R Lazáro, M Harun, C Godoy, G Castells, C Cristòfol. Effect of age and gender in the pharmacokinetics of albendazole and albendazole sulphoxide enantiomers in goats. Research in veterinary science. 2009 Jun; 86(3):498-502. doi: 10.1016/j.rvsc.2008.08.002. [PMID: 18805559]
  • Uwe Muenster, Birgit Grieshop, Karsten Ickenroth, Mark Jean Gnoth. Characterization of substrates and inhibitors for the in vitro assessment of Bcrp mediated drug-drug interactions. Pharmaceutical research. 2008 Oct; 25(10):2320-6. doi: 10.1007/s11095-008-9632-1. [PMID: 18523872]
  • Bettencourt P S Capece, Gloria Castells, Carlo Godoy, Margarita Arboix, Carles Cristòfol. Pharmacokinetics of albendazole sulfoxide enantiomers administered in racemic form and separately in rats. Veterinary journal (London, England : 1997). 2008 Aug; 177(2):297-9. doi: 10.1016/j.tvjl.2007.04.011. [PMID: 17566773]
  • Kátia Roberta A Belaz, Quezia B Cass, Regina V Oliveira. Determination of albendazole metabolites by direct injection of bovine plasma and multidimensional achiral-chiral high performance liquid chromatography. Talanta. 2008 Jun; 76(1):146-53. doi: 10.1016/j.talanta.2008.02.013. [PMID: 18585256]
  • A K Dubey, P K Sanyal, K M Koley, P L Chaudhary, K Mukherjee, S C Mandal, S Pal. Kinetic disposition of albendazole in goats subclinically infected with gastrointestinal nematodes vis-à-vis naive animals following oral and intraruminal administration. Journal of helminthology. 2008 Mar; 82(1):17-23. doi: 10.1017/s0022149x07870817. [PMID: 18053296]
  • Pierina Sueli Bonato, Anderson Rodrigo Moraes de Oliveira, Fernando José Malagueño de Santana, Bruno José Dumet Fernandes, Vera Lucia Lanchote, Armando E Gonzalez, Hector H Garcia, Osvaldo Massaiti Takayanagui. Simultaneous determination of albendazole metabolites, praziquantel and its metabolite in plasma by high-performance liquid chromatography-electrospray mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2007 Jun; 44(2):558-63. doi: 10.1016/j.jpba.2006.11.020. [PMID: 17169522]
  • Francisca Palomares-Alonso, Juan Carlos Piliado, Guadalupe Palencia, Alma Ortiz-Plata, Helgi Jung-Cook. Efficacy of nitazoxanide, tizoxanide and tizoxanide/albendazole sulphoxide combination against Taenia crassiceps cysts. The Journal of antimicrobial chemotherapy. 2007 Feb; 59(2):212-8. doi: 10.1093/jac/dkl463. [PMID: 17114175]
  • Zhao-Yan Cai, Peter Galettis, Ying Lu, David L Morris, Mohammad H Pourgholami. Pharmacokinetics of albendazole in New Zealand white rabbits: oral versus intraperitoneal administration. Anticancer research. 2007 Jan; 27(1A):417-22. doi: . [PMID: 17352262]
  • Giuseppe Cringoli, Laura Rinaldi, Vincenzo Veneziano, Claudio Genchi. A dual anthelmintic treatment strategic scheme for the control of fasciolosis in dairy sheep farms. Parasitology research. 2006 Nov; 99(6):700-5. doi: 10.1007/s00436-006-0223-y. [PMID: 16738889]
  • C Gokbulut, V Y Cirak, B Senlik. Plasma disposition and faecal excretion of netobimin metabolites and enantiospecific disposition of albendazole sulphoxide produced in ewes. Veterinary research communications. 2006 Oct; 30(7):791-805. doi: 10.1007/s11259-006-3336-y. [PMID: 17004041]
  • Mivis M Pulido, Antonio J Molina, Gracia Merino, Gracia Mendoza, Julio G Prieto, Ana I Alvarez. Interaction of enrofloxacin with breast cancer resistance protein (BCRP/ABCG2): influence of flavonoids and role in milk secretion in sheep. Journal of veterinary pharmacology and therapeutics. 2006 Aug; 29(4):279-87. doi: 10.1111/j.1365-2885.2006.00744.x. [PMID: 16846465]
  • F Göngora-Rivera, J L Soto-Hernández, D González Esquivel, H J Cook, C Márquez-Caraveo, R Hernández Dávila, J Santos-Zambrano. Albendazole trial at 15 or 30 mg/kg/day for subarachnoid and intraventricular cysticercosis. Neurology. 2006 Feb; 66(3):436-8. doi: 10.1212/01.wnl.0000195887.63124.dc. [PMID: 16382035]
  • M J Stear, O Abuagob, M Benothman, S C Bishop, G Innocent, A Kerr, S Mitchell. Variation among faecal egg counts following natural nematode infection in Scottish Blackface lambs. Parasitology. 2006 Feb; 132(Pt 2):275-80. doi: 10.1017/s0031182005009029. [PMID: 16209724]
  • E A Formentini, N Mestorino, J O Errecalde. Pharmacokinetics of ricobendazole after its intravenous, intraruminal and subcutaneous administration in sheep. Veterinary research communications. 2005 Oct; 29(7):595-608. doi: 10.1007/s11259-005-3304-y. [PMID: 16142607]
  • Zimei Wu, Natalie J Medlicott, Majid Razzak, Ian G Tucker. Development and optimization of a rapid HPLC method for analysis of ricobendazole and albendazole sulfone in sheep plasma. Journal of pharmaceutical and biomedical analysis. 2005 Sep; 39(1-2):225-32. doi: 10.1016/j.jpba.2005.03.010. [PMID: 15878252]
  • Dimitrios J Fletouris, Elias P Papapanagiotou, Dimitrios S Nakos, Ioannis E Psomas. Highly sensitive ion pair liquid chromatographic determination of albendazole marker residue in animal tissues. Journal of agricultural and food chemistry. 2005 Feb; 53(4):893-8. doi: 10.1021/jf048459q. [PMID: 15712994]
  • V L Lanchote, O M Takayanagui, F H Mateus. Enantioselective renal excretion of albendazole metabolites in patients with neurocysticercosis. Chirality. 2004 Oct; 16(8):520-5. doi: 10.1002/chir.20071. [PMID: 15290687]
  • G C Batzias, E Theodosiadou, G A Delis. Quantitative determination of albendazole metabolites in sheep spermatozoa and seminal plasma by liquid chromatographic analysis with fluorescence detection. Journal of pharmaceutical and biomedical analysis. 2004 Sep; 35(5):1191-202. doi: 10.1016/j.jpba.2004.03.023. [PMID: 15336364]
  • O S Anziani, V Suarez, A A Guglielmone, O Warnke, H Grande, G C Coles. Resistance to benzimidazole and macrocyclic lactone anthelmintics in cattle nematodes in Argentina. Veterinary parasitology. 2004 Aug; 122(4):303-6. doi: 10.1016/j.vetpar.2004.05.018. [PMID: 15262008]
  • Xiaoyan Chen, Liyan Zhao, Haiyan Xu, Dafang Zhong. Simultaneous determination of albendazole and its major active metabolite in human plasma using a sensitive and specific liquid chromatographic-tandem mass spectrometric method. Journal of pharmaceutical and biomedical analysis. 2004 Jun; 35(4):829-36. doi: 10.1016/j.jpba.2004.02.022. [PMID: 15193727]
  • Georgios C Batzias, Georgios A Delis. Reversed-phase liquid chromatographic method with fluorescence detection for the simultaneous determination of albendazole sulphoxide, albendazole sulphone and albendazole 2-aminosulphone in sheep plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Jun; 805(2):267-74. doi: 10.1016/j.jchromb.2004.03.012. [PMID: 15135100]
  • K Pengsaa, K Na-Bangchang, K Limkittikul, K Kabkaew, K Lapphra, C Sirivichayakul, P Wisetsing, C Pojjaroen-Anant, P Chanthavanich, A Subchareon. Pharmacokinetic investigation of albendazole and praziquantel in Thai children infected with Giardia intestinalis. Annals of tropical medicine and parasitology. 2004 Jun; 98(4):349-57. doi: 10.1179/000349804225003398. [PMID: 15228716]
  • Jitka Caslavska, Wolfgang Thormann. Monitoring of drugs and metabolites in body fluids by capillary electrophoresis with XeHg lamp-based and laser-induced fluorescence detection. Electrophoresis. 2004 Jun; 25(10-11):1623-31. doi: 10.1002/elps.200305821. [PMID: 15188250]
  • Marianne Stettler, Jean François Rossignol, Renate Fink, Mirjam Walker, Bruno Gottstein, Michael Merli, Regula Theurillat, Wolfgang Thormann, Eric Dricot, Rudi Segers, Andrew Hemphill. Secondary and primary murine alveolar echinococcosis: combined albendazole/nitazoxanide chemotherapy exhibits profound anti-parasitic activity. International journal for parasitology. 2004 Apr; 34(5):615-24. doi: 10.1016/j.ijpara.2004.01.006. [PMID: 15064126]
  • Reema Sarin, A P Dash, V K Dua. Albendazole sulphoxide concentrations in plasma of endemic normals from a lymphatic filariasis endemic region using liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Jan; 799(2):233-8. doi: 10.1016/j.jchromb.2003.10.040. [PMID: 14670741]
  • Osvaldo Massaiti Takayanagui. Therapy for neurocysticercosis. Expert review of neurotherapeutics. 2004 Jan; 4(1):129-39. doi: 10.1586/14737175.4.1.129. [PMID: 15853623]
  • A Goudah. Aspects of the pharmacokinetics of albendazole sulphoxide in sheep. Veterinary research communications. 2003 Oct; 27(7):555-66. doi: 10.1023/a:1026008010899. [PMID: 14609267]
  • Gracia Merino, Antonio J Molina, José L García, Mivis M Pulido, Julio G Prieto, Ana I Alvarez. Ginseng increases intestinal elimination of albendazole sulfoxide in the rat. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2003 Sep; 136(1):9-15. doi: 10.1016/s1532-0456(03)00145-5. [PMID: 14522595]
  • G Merino, A J Molina, J L García, M M Pulido, J G Prieto, A I Alvarez. Effect of clotrimazole on microsomal metabolism and pharmacokinetics of albendazole. The Journal of pharmacy and pharmacology. 2003 Jun; 55(6):757-64. doi: 10.1211/002235703765951357. [PMID: 12841935]
  • B P S Capece, M Navarro, T Arcalis, G Castells, L Toribio, F Perez, A Carretero, J Ruberte, M Arboix, C Cristòfol. Albendazole sulphoxide enantiomers in pregnant rats' embryo concentrations and developmental toxicity. Veterinary journal (London, England : 1997). 2003 May; 165(3):266-75. doi: 10.1016/s1090-0233(02)00158-2. [PMID: 12672373]
  • Pierina Sueli Bonato, Vera Lucia Lanchote, Osvaldo Massaiti Takayanagui. Simultaneous liquid chromatography-tandem mass spectrometric determination of albendazole sulfoxide and albendazole sulfone in plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Jan; 783(1):237-45. doi: 10.1016/s1570-0232(02)00665-7. [PMID: 12450544]
  • M L Mottier, L I Alvarez, M A Pis, C E Lanusse. Transtegumental diffusion of benzimidazole anthelmintics into Moniezia benedeni: correlation with their octanol-water partition coefficients. Experimental parasitology. 2003 Jan; 103(1-2):1-7. doi: 10.1016/s0014-4894(03)00060-2. [PMID: 12810040]
  • Dennis Kitzman, Kuei-Ju Cheng, Lawrence Fleckenstein. HPLC assay for albendazole and metabolites in human plasma for clinical pharmacokinetic studies. Journal of pharmaceutical and biomedical analysis. 2002 Oct; 30(3):801-13. doi: 10.1016/s0731-7085(02)00382-5. [PMID: 12367706]
  • A Mirfazaelian, S Dadashzadeh, M R Rouini. Effect of gender in the disposition of albendazole metabolites in humans. European journal of clinical pharmacology. 2002 Sep; 58(6):403-8. doi: 10.1007/s00228-002-0488-8. [PMID: 12242599]
  • O M Takayanagui, P S Bonato, S A C Dreossi, V L Lanchote. Enantioselective distribution of albendazole metabolites in cerebrospinal fluid of patients with neurocysticercosis. British journal of clinical pharmacology. 2002 Aug; 54(2):125-30. doi: 10.1046/j.1365-2125.2002.01634.x. [PMID: 12207631]
  • Wang Mingjie, Xiao Shuhua, Chai Junjie, Liang Bin, Fu Cheng, Shen Weixia, Peter Hotez. Albendazole-soybean oil emulsion for the treatment of human cystic echinococcosis: evaluation of bioavailability and bioequivalence. Acta tropica. 2002 Aug; 83(2):177-81. doi: 10.1016/s0001-706x(02)00096-7. [PMID: 12088859]
  • Vera L Lanchote, Fabíola S Garcia, Sônia A C Dreossi, Osvaldo Massaiti Takayanagui. Pharmacokinetic interaction between albendazole sulfoxide enantiomers and antiepileptic drugs in patients with neurocysticercosis. Therapeutic drug monitoring. 2002 Jun; 24(3):338-45. doi: 10.1097/00007691-200206000-00003. [PMID: 12021623]
  • B P S Capece, R Pérez, A Andaluz, F Pérez, F Garcia, G Castells, M Arboix, C Cristòfol. Placental transfer of albendazole sulphoxide enantiomers in sheep. Veterinary journal (London, England : 1997). 2002 Mar; 163(2):155-60. doi: 10.1053/tvjl.2001.0628. [PMID: 12093190]
  • M P Marques, O M Takayanagui, V L Lanchote. Albendazole metabolism in patients with neurocysticercosis: antipyrine as a multifunctional marker drug of cytochrome P450. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2002 Feb; 35(2):261-9. doi: 10.1590/s0100-879x2002000200016. [PMID: 11847531]
  • Wolfgang Thormann, Francine Prost, Andrea Procházková. Capillary electrophoresis with (R)-(--)-N-(3,5-dinitrobenzoyl)-alpha-phenylglycine as chiral selector for separation of albendazole sulfoxide enantiomers and their analysis in human plasma. Journal of pharmaceutical and biomedical analysis. 2002 Jan; 27(3-4):555-67. doi: 10.1016/s0731-7085(01)00650-1. [PMID: 11755756]
  • H D Solana, J M Sallovitz, C E Lanusse, J A Rodriguez. Enantioselective binding of albendazole sulphoxide to cytosolic proteins from helminth parasites. Methods and findings in experimental and clinical pharmacology. 2002 Jan; 24(1):7-13. doi: 10.1358/mf.2002.24.1.677121. [PMID: 11980387]
  • E A Formentini, O N Mestorino, E L Mariño, J O Errecalde. Pharmacokinetics of ricobendazole in calves. Journal of veterinary pharmacology and therapeutics. 2001 Jun; 24(3):199-202. doi: 10.1046/j.1365-2885.2001.00328.x. [PMID: 11442798]
  • C Cristofol, G Virkel, L Alvarez, S Sánchez, M Arboix, C Lanusse. Albendazole sulphoxide enantiomeric ratios in plasma and target tissues after intravenous administration of ricobendazole to cattle. Journal of veterinary pharmacology and therapeutics. 2001 Apr; 24(2):117-24. doi: 10.1046/j.1365-2885.2001.00320.x. [PMID: 11442786]
  • J L García-Llamazares, G Merino-Pelaez, O Larrode-Pellicer, P A Redondo-Cardeña, J G Prieto-Fernández, A I Alvarez-de-Felipe. Pharmacokinetics of netobimin and microsomal metabolism of albendazole in infected gerbils with Echinococcus granulosus. Parasitology research. 2001 Feb; 87(2):107-11. doi: 10.1007/s004360000309. [PMID: 11206105]
  • C Cristòfol, G Virkel, L Alvarez, M Arboix, C E Lanusse. Comparative disposition of ricobendazole enantiomers after intravenous and subcutaneous administration of a racemic formulation to calves. Biopharmaceutics & drug disposition. 2000 Nov; 21(8):303-11. doi: 10.1002/bdd.246. [PMID: 11514949]
  • S Sánchez, L Alvarez, J Sallovitz, C Lanusse. Enhanced plasma and target tissue availabilities of albendazole and albendazole sulphoxide in fasted calves: evaluation of different fasting intervals. Journal of veterinary pharmacology and therapeutics. 2000 Aug; 23(4):193-201. doi: 10.1046/j.1365-2885.2000.00265.x. [PMID: 11126322]
  • B P Capece, G Castells, F Pérez, M Arboix, C Cristòfol. Pharmacokinetic behaviour of albendazole sulphoxide enantiomers in male and female sheep. Veterinary research communications. 2000 Jul; 24(5):339-48. doi: 10.1023/a:1006496122684. [PMID: 10868551]
  • A Procházková, M Chouki, R Theurillat, W Thormann. Therapeutic drug monitoring of albendazole: determination of albendazole, albendazole sulfoxide, and albendazole sulfone in human plasma using nonaqueous capillary electrophoresis. Electrophoresis. 2000 Mar; 21(4):729-36. doi: 10.1002/(sici)1522-2683(20000301)21:4<729::aid-elps729>3.0.co;2-m. [PMID: 10733213]
  • P Alonso-Villalobos, M M Martinez-Grueiro. The in vitro secretion of acetylcholinesterase by adult stages of Heligmosomoides polygyrus: the effects of broad-spectrum anthelmintics. Journal of veterinary medicine. B, Infectious diseases and veterinary public health. 2000 Feb; 47(1):1-8. doi: 10.1046/j.1439-0450.2000.00318.x. [PMID: 10780168]
  • D Singh, P K Sanyal, C P Swarnkar, F A Khan, P S Bhagwan. Influence of diet type and pretreatment fasting on the disposition kinetics of albendazole in sheep. Veterinary research communications. 1999 Jun; 23(4):229-40. doi: 10.1023/a:1006201226391. [PMID: 10461800]
  • M P Marques, O M Takayanagui, P S Bonato, S R Santos, V L Lanchote. Enantioselective kinetic disposition of albendazole sulfoxide in patients with neurocysticercosis. Chirality. 1999; 11(3):218-23. doi: 10.1002/(sici)1520-636x(1999)11:3<218::aid-chir8>3.0.co;2-g. [PMID: 10079501]
  • L Domínguez, E Savio, J Saldaña, A Malanga, D Quevedo, C Camarote, A Ochoa, P Fagiolino. Lipidic matrix of albendazole sulphoxide: is it an alternative for systemic infections?. Bollettino chimico farmaceutico. 1998 Nov; 137(10):383-6. doi: NULL. [PMID: 9880943]
  • C E Lanusse, G L Virkel, S F Sanchez, L I Alvarez, A L Lifschitz, F Imperiale, A Monfrinotti. Ricobendazole kinetics and availability following subcutaneous administration of a novel injectable formulation to calves. Research in veterinary science. 1998 Jul; 65(1):5-10. doi: 10.1016/s0034-5288(98)90019-4. [PMID: 9769065]
  • V L Lanchote, M P Marques, O M Takayanagui, R de Carvalho, F O Paias, P S Bonato. Simultaneous determination of albendazole sulfoxide enantiomers and albendazole sulfone in plasma. Journal of chromatography. B, Biomedical sciences and applications. 1998 May; 709(2):273-9. doi: 10.1016/s0378-4347(98)00082-6. [PMID: 9657224]