alpha-amanitin (BioDeep_00000175895)
human metabolite blood metabolite
代谢物信息卡片
2-[34-(Butan-2-yl)-13-(3,4-dihydroxybutan-2-yl)-2,8,11,14,22,30,33,36,39-nonahydroxy-5,27-dioxo-27-thia-3,6,12,15,25,29,32,35,38-nonaazapentacyclo[14.12.11.0,.0,.0,]nonatriaconta-2,11,14,18(26),19(24),20,22,29,32,35,38-undecaen-4-yl]ethanimidate
化学式: C39H54N10O14S (918.3542)
中文名称: α-毒伞肽
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: CCC(C)C1C(=O)NCC(=O)NC2CS(=O)C3=C(CC(C(=O)NCC(=O)N1)NC(=O)C(NC(=O)C4CC(CN4C(=O)C(NC2=O)CC(=O)N)O)C(C)C(CO)O)C5=C(N3)C=C(C=C5)O
InChI: InChI=1S/C39H54N10O14S/c1-4-16(2)31-36(60)42-11-29(55)43-25-15-64(63)38-21(20-6-5-18(51)7-22(20)46-38)9-23(33(57)41-12-30(56)47-31)44-37(61)32(17(3)27(53)14-50)48-35(59)26-8-19(52)13-49(26)39(62)24(10-28(40)54)45-34(25)58/h5-7,16-17,19,23-27,31-32,46,50-53H,4,8-15H2,1-3H3,(H2,40,54)(H,41,57)(H,42,60)(H,43,55)(H,44,61)(H,45,58)(H,47,56)(H,48,59)
描述信息
D004791 - Enzyme Inhibitors > D019384 - Nucleic Acid Synthesis Inhibitors
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins
D009676 - Noxae > D011042 - Poisons > D000546 - Amanitins
同义名列表
9 个代谢物同义名
2-[34-(Butan-2-yl)-13-(3,4-dihydroxybutan-2-yl)-2,8,11,14,22,30,33,36,39-nonahydroxy-5,27-dioxo-27-thia-3,6,12,15,25,29,32,35,38-nonaazapentacyclo[14.12.11.0,.0,.0,]nonatriaconta-2,11,14,18(26),19(24),20,22,29,32,35,38-undecaen-4-yl]ethanimidate; 2-[34-(butan-2-yl)-13-(3,4-dihydroxybutan-2-yl)-8,22-dihydroxy-2,5,11,14,27,30,33,36,39-nonaoxo-27λ⁴-thia-3,6,12,15,25,29,32,35,38-nonaazapentacyclo[14.12.11.0⁶,¹⁰.0¹⁸,²⁶.0¹⁹,²⁴]nonatriaconta-18(26),19,21,23-tetraen-4-yl]acetamide; Alpha-Amanitine; Alpha Amanitine; alpha-Amanitin; Alpha Amanitin; a-Amanitin; Α-amanitin; alpha-Amanitin
数据库引用编号
8 个数据库交叉引用编号
- PubChem: 2100
- HMDB: HMDB0248187
- MeSH: Alpha-Amanitin
- CAS: 23109-05-9
- RefMet: alpha-Amanitin
- KEGG: C08438
- PubChem: 10632
- KNApSAcK: 37415
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Li-Ying Lin, Ya-Ling Tong, Yuan-Qiang Lu. The characteristics of liver injury induced by Amanita and clinical value of α-amanitin detection.
Hepatobiliary & pancreatic diseases international : HBPD INT.
2022 Jun; 21(3):257-266. doi:
10.1016/j.hbpd.2022.01.007. [PMID: 35168873] - Xiuyao Zhang, Xinxin Cai, Xiaoyi Zhang, Ruifen Li, Yunfeng Zhao. [Highly sensitive determination of three kinds of amanitins in urine and plasma by ultra performance liquid chromatography-triple quadrupole mass spectrometry coupled with immunoaffinity column clean-up].
Se pu = Chinese journal of chromatography.
2022 May; 40(5):443-451. doi:
10.3724/sp.j.1123.2021.08018. [PMID: 35478003] - Jiale Gao, Nuoya Liu, Xiaomeng Zhang, En Yang, Yuzhu Song, Jinyang Zhang, Qinqin Han. Utilizing the DNA Aptamer to Determine Lethal α-Amanitin in Mushroom Samples and Urine by Magnetic Bead-ELISA (MELISA).
Molecules (Basel, Switzerland).
2022 Jan; 27(2):. doi:
10.3390/molecules27020538. [PMID: 35056853] - Zhengsheng Mao, Youjia Yu, Hao Sun, Yue Cao, Qiaoyan Jiang, Chunyan Chu, Yang Sun, Shuainan Huang, Jinsong Zhang, Feng Chen. Development of a simple and reliable method for α-amanitin detection in rat plasma and its application to a toxicokinetic study.
Rapid communications in mass spectrometry : RCM.
2021 Nov; 35(21):e9184. doi:
10.1002/rcm.9184. [PMID: 34472672] - Selma Ríos-Meléndez, Emmanuel Valadez-Hernández, Claudio Delgadillo, Maria L Luna-Guevara, Mario A Martínez-Núñez, Mishael Sánchez-Pérez, José L Martínez-Y-Pérez, Analilia Arroyo-Becerra, Luis Cárdenas, Martha Bibbins-Martínez, Ignacio E Maldonado-Mendoza, Miguel Angel Villalobos-López. Pseudocrossidium replicatum (Taylor) R.H. Zander is a fully desiccation-tolerant moss that expresses an inducible molecular mechanism in response to severe abiotic stress.
Plant molecular biology.
2021 Nov; 107(4-5):387-404. doi:
10.1007/s11103-021-01167-3. [PMID: 34189708] - Ria Park, Won-Gu Choi, Min Seo Lee, Yong-Yeon Cho, Joo Young Lee, Han Chang Kang, Chang Hwan Sohn, Im-Sook Song, Hye Suk Lee. Pharmacokinetics of α-amanitin in mice using liquid chromatography-high resolution mass spectrometry and in vitro drug-drug interaction potentials.
Journal of toxicology and environmental health. Part A.
2021 10; 84(20):821-835. doi:
10.1080/15287394.2021.1944942. [PMID: 34187333] - Brendan Le Daré, Pierre-Jean Ferron, Aurélien Couette, Catherine Ribault, Isabelle Morel, Thomas Gicquel. In vivo and in vitro α-amanitin metabolism studies using molecular networking.
Toxicology letters.
2021 Aug; 346(?):1-6. doi:
10.1016/j.toxlet.2021.04.006. [PMID: 33872745] - Jennifer A Kaae, Robert H Poppenga, Ashley E Hill. Physical examination, serum biochemical, and coagulation abnormalities, treatments, and outcomes for dogs with toxicosis from α-amanitin-containing mushrooms: 59 cases (2006-2019).
Journal of the American Veterinary Medical Association.
2021 Mar; 258(5):502-509. doi:
10.2460/javma.258.5.502. [PMID: 33620242] - Xiaomin Xu, Jingshun Zhang, Zengxuan Cai, Zhen Meng, Baifen Huang, Qing Chen. [Determination of trace α-amanitin in urine of mushroom poisoning patient by online solid phase extraction-liquid chromatography-tandem mass spectrometry].
Se pu = Chinese journal of chromatography.
2020 Nov; 38(11):1281-1287. doi:
10.3724/sp.j.1123.2020.03010. [PMID: 34213098] - Xiao-Min Xu, Zhen Meng, Jing-Shun Zhang, Qing Chen, Jian-Long Han. Analytical method development for α-amanitin and β-amanitin in plasma at ultra-trace level by online solid phase extraction-high performance liquid chromatography-triple quadrupole mass spectrometry and its application in poisoning events.
Journal of pharmaceutical and biomedical analysis.
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Human & experimental toxicology.
2020 Mar; 39(3):328-337. doi:
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Gene.
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2017 Oct; 1064(?):36-39. doi:
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Acta biochimica Polonica.
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Journal of chromatography. A.
2016 Aug; 1459(?):1-8. doi:
10.1016/j.chroma.2016.06.072. [PMID: 27394089] - Huihui Wu, Shanshan Tang, Zhaoqin Huang, Qian Zhou, Ping Zhang, Zuohong Chen. Hepatoprotective Effects and Mechanisms of Action of Triterpenoids from Lingzhi or Reishi Medicinal Mushroom Ganoderma lucidum (Agaricomycetes) on α-Amanitin-Induced Liver Injury in Mice.
International journal of medicinal mushrooms.
2016; 18(9):841-850. doi:
10.1615/intjmedmushrooms.v18.i9.80. [PMID: 27910775] - Tomasz Janus, Ewa Jasionowicz, Barbara Potocka-Banaś, Krzysztof Borowiak. [Amanitine determination as an example of peptide analysis in the biological samples with HPLC-MS technique].
Pomeranian journal of life sciences.
2016 ; 62(3):42-8. doi:
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2015 Sep; 103(?):55-9. doi:
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2015 Sep; 103(?):60-4. doi:
10.1016/j.toxicon.2015.06.018. [PMID: 26100667] - Juliana Garcia, Vera M Costa, Paula Baptista, Maria de Lourdes Bastos, Félix Carvalho. Quantification of alpha-amanitin in biological samples by HPLC using simultaneous UV- diode array and electrochemical detection.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2015 Aug; 997(?):85-95. doi:
10.1016/j.jchromb.2015.06.001. [PMID: 26100080] - Liming Feng, Lei Tan, He Li, Zhiguang Xu, Guixian Shen, Youwen Tang. Selective fluorescent sensing of α-amanitin in serum using carbon quantum dots-embedded specificity determinant imprinted polymers.
Biosensors & bioelectronics.
2015 Jul; 69(?):265-71. doi:
10.1016/j.bios.2015.03.005. [PMID: 25770458] - Hong Luo, Sung-Yong Hong, R Michael Sgambelluri, Evan Angelos, Xuan Li, Jonathan D Walton. Peptide macrocyclization catalyzed by a prolyl oligopeptidase involved in α-amanitin biosynthesis.
Chemistry & biology.
2014 Dec; 21(12):1610-7. doi:
10.1016/j.chembiol.2014.10.015. [PMID: 25484237] - Thomas Gicquel, Sylvie Lepage, Manon Fradin, Olivier Tribut, Bénédicte Duretz, Isabelle Morel. Amatoxins (α- and β-Amanitin) and phallotoxin (Phalloidin) analyses in urines using high-resolution accurate mass LC-MS technology.
Journal of analytical toxicology.
2014 Jul; 38(6):335-40. doi:
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Cutaneous and ocular toxicology.
2014 Jun; 33(2):154-60. doi:
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Journal of chromatography. A.
2014 Jan; 1324(?):190-7. doi:
10.1016/j.chroma.2013.11.042. [PMID: 24326132] - Chelsea L Mitchell, Michael C Saul, Liang Lei, Hairong Wei, Thomas Werner. The mechanisms underlying α-amanitin resistance in Drosophila melanogaster: a microarray analysis.
PloS one.
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Biochemistry.
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Molecular cell.
2012 Dec; 48(5):811-8. doi:
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Veterinary pathology.
2012 Nov; 49(6):1032-5. doi:
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Fungal genetics and biology : FG & B.
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