7,8,17-trihydroxy-4,9,11,13,15,19-docosahexaenoic acid (BioDeep_00000175132)
human metabolite blood metabolite
代谢物信息卡片
7,8,17-Trihydroxy-4,9,11,13,15,19-docosahexaenoic acid
化学式: C22H32O5 (376.2249622)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC=CCC(O)C=CC=CC=CC=CC(O)C(O)CC=CCCC(O)=O
InChI: InChI=1S/C22H32O5/c1-2-3-9-14-19(23)15-10-6-4-5-7-11-16-20(24)21(25)17-12-8-13-18-22(26)27/h3-12,15-16,19-21,23-25H,2,13-14,17-18H2,1H3,(H,26,27)
数据库引用编号
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wenyan Zhang, Suwas Bhandari, Yajun Ding, Jun Luo, Bo Feng, Yating Jiang, Ting Chen, Jinling Wei, Xiaodong Pan, Haixu Weng, Zhangna Ding, Jie Chen, Xi Chen, Yuqiang Gong, Hui Li, Shengwei Jin, Yu Hao. Polyunsaturated fatty acid-derived lipid mediator Resolvin D1 alleviates sepsis-induced disseminated intravascular coagulation via Caspase-1/Gasdermin D pyroptotic pathway.
Clinical nutrition (Edinburgh, Scotland).
2024 Jun; 43(6):1372-1383. doi:
10.1016/j.clnu.2024.04.020. [PMID: 38678822] - Jhony Robson de Oliveira, Aline Beatriz Mahler Pereira, Henrique Ismarsi de Souza, Wanessa Maria Dos Santos, Thaís Sorares Farnesi de Assunção, Fernanda Bernadelli de Vito, Helio Moraes de Souza, Paulo Roberto da Silva, Marcos Vinicius da Silva, Virmondes Rodrigues Junior, Alexandre Paula Rogerio. Anti-inflammatory actions of aspirin-triggered resolvin D1 (AT-RvD1) in bronchial epithelial cells stimulated by cigarette smoke extract.
Prostaglandins & other lipid mediators.
2024 Jun; 172(?):106833. doi:
10.1016/j.prostaglandins.2024.106833. [PMID: 38460760] - Siyuan Zhu, Jingbo Liu, Qi Wang, Yong Yang, Lei Du, Xiaoyu Qiu, Renli Qi, Jing Wang. Resolvin D1 alleviates apoptosis triggered by endoplasmic reticulum stress in IPEC-J2 cells.
BMC veterinary research.
2024 Apr; 20(1):125. doi:
10.1186/s12917-023-03820-z. [PMID: 38561794] - Cheng Wei, Jishou Zhang, Shanshan Peng, Jianfang Liu, Yao Xu, Mengmeng Zhao, Shuwan Xu, Wei Pan, Zheng Yin, Zihui Zheng, Juan-Juan Qin, Jun Wan, Menglong Wang. Resolvin D1 attenuates Ang II-induced hypertension in mice by inhibiting the proliferation, migration and phenotypic transformation of vascular smooth muscle cells by blocking the RhoA/mitogen-activated protein kinase pathway.
Journal of hypertension.
2023 Nov; ?(?):. doi:
10.1097/hjh.0000000000003610. [PMID: 37937508] - Giulia Ferri, Matteo Serano, Elisa Isopi, Matteo Mucci, Domenico Mattoscio, Romina Pecce, Feliciano Protasi, Marcus A Mall, Mario Romano, Antonio Recchiuti. Resolvin D1 improves airway inflammation and exercise capacity in cystic fibrosis lung disease.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2023 Nov; 37(11):e23233. doi:
10.1096/fj.202301495r. [PMID: 37823221] - Wenjun Li, Hailey M Shepherd, Yuriko Terada, Ashley E Shay, Amit I Bery, Andrew E Gelman, Kory J Lavine, Charles N Serhan, Daniel Kreisel. Resolvin D1 prevents injurious neutrophil swarming in transplanted lungs.
Proceedings of the National Academy of Sciences of the United States of America.
2023 08; 120(31):e2302938120. doi:
10.1073/pnas.2302938120. [PMID: 37487095] - Lei Li, Shu-Qi Cheng, Yu-Qin Sun, Jian-Bing Yu, Xin-Xin Huang, Yin-Feng Dong, Juan Ji, Xi-Yue Zhang, Gang Hu, Xiu-Lan Sun. Resolvin D1 reprograms energy metabolism to promote microglia to phagocytize neutrophils after ischemic stroke.
Cell reports.
2023 Jun; 42(6):112617. doi:
10.1016/j.celrep.2023.112617. [PMID: 37285269] - Wei Xiong, Han Wang, Hongyan Zhang, Yanmei Xing, Wenli Gao, Lengfeng Chen, Lixin Chen, Zhongliang Dai. Resolvin D1 attenuates depressive-like behavior in LPS-challenged mice by promoting microglial autophagy.
Inflammopharmacology.
2023 Apr; ?(?):. doi:
10.1007/s10787-023-01234-9. [PMID: 37103692] - Cristina P B Melo, Priscila Saito, Renata M Martinez, Larissa Staurengo-Ferrari, Ingrid C Pinto, Camilla C A Rodrigues, Stephanie Badaro-Garcia, Josiane A Vignoli, Marcela M Baracat, Allan J C Bussmann, Sandra R Georgetti, Waldiceu A Verri, Rubia Casagrande. Aspirin-Triggered Resolvin D1 (AT-RvD1) Protects Mouse Skin against UVB-Induced Inflammation and Oxidative Stress.
Molecules (Basel, Switzerland).
2023 Mar; 28(5):. doi:
10.3390/molecules28052417. [PMID: 36903662] - Changqing Sun, Wuyang Zheng, Ling Liang, Ziguan Zhang, Zuheng Liu, Wenchao Sun, Jianwei Zhou, Weitong Qiao, Qiang Xie, Rong Tang. Acute Coronary Syndrome May be Associated with Decreased Resolvin D1-to-Leukotriene B4 Ratio.
International heart journal.
2023 Jan; ?(?):. doi:
10.1536/ihj.22-361. [PMID: 36682769] - Noy Pinto, Yehuda Klein, Eilon David, David Polak, Daniel Steinberg, Gilad Mizrahi, Yasmin Khoury, Yechezkel Barenholz, Stella Chaushu. Resolvin D1 improves allograft osteointegration and directly enhances osteoblasts differentiation.
Frontiers in immunology.
2023; 14(?):1086930. doi:
10.3389/fimmu.2023.1086930. [PMID: 36923414] - Rafael F Guilherme, José Bruno N F Silva, Ingrid Waclawiack, Vanderlei S Fraga-Junior, Thaís O Nogueira, Cyntia Pecli, Carlla A Araújo-Silva, Nathalia S Magalhães, Felipe S Lemos, Carlos A Bulant, Pablo J Blanco, Rafaela Serra, Erik Svensjö, Júlio Scharfstein, João A Moraes, Claudio Canetti, Claudia F Benjamim. Pleiotropic antifibrotic actions of aspirin-triggered resolvin D1 in the lungs.
Frontiers in immunology.
2023; 14(?):886601. doi:
10.3389/fimmu.2023.886601. [PMID: 36960058] - Menglong Wang, Wei Pan, Cheng Wei, Jianfang Liu, Jishou Zhang, Junping Yu, Mengmeng Zhao, Shuwan Xu, Jing Ye, Zhen Wang, Di Ye, Yongqi Feng, Yao Xu, Jun Wan. The Anti-Inflammatory Mediator 17(R)-Resolvin D1 Attenuates Pressure Overload-Induced Cardiac Hypertrophy and Fibrosis.
Drug design, development and therapy.
2023; 17(?):3073-3083. doi:
10.2147/dddt.s421894. [PMID: 37849783] - Victoria Leroy, Jun Cai, Zhenxiao Tu, Alexander McQuiston, Simrun Sharma, Amir Emtiazjoo, Carl Atkinson, Gilbert R Upchurch, Ashish K Sharma. Resolution of post-lung transplant ischemia-reperfusion injury is modulated via Resolvin D1-FPR2 and Maresin 1-LGR6 signaling.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
2022 Dec; ?(?):. doi:
10.1016/j.healun.2022.12.013. [PMID: 36628837] - Ahmed E Zarrough, Hatice Hasturk, Danielle N Stephens, Thomas E Van Dyke, Alpdogan Kantarci. Resolvin D1 modulates periodontal ligament fibroblast function.
Journal of periodontology.
2022 Nov; ?(?):. doi:
10.1002/jper.22-0462. [PMID: 36416879] - Amanda C Filiberto, Zachary Ladd, Victoria Leroy, Gang Su, Craig T Elder, Eric Y Pruitt, Sara E Hensley, Guanyi Lu, Joseph B Hartman, Ali Zarrinpar, Ashish K Sharma, Gilbert R Upchurch. Resolution of inflammation via RvD1/FPR2 signaling mitigates Nox2 activation and ferroptosis of macrophages in experimental abdominal aortic aneurysms.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2022 11; 36(11):e22579. doi:
10.1096/fj.202201114r. [PMID: 36183323] - Xiaofeng Jiang, Jing Liu, Si Li, Yingfei Qiu, Xiaoli Wang, Xiaoli He, Torbjørn Ø Pedersen, Kamal Mustafa, Ying Xue, Manal Mustafa, Alpdogan Kantarci, Zhe Xing. The effect of resolvin D1 on bone regeneration in a rat calvarial defect model.
Journal of tissue engineering and regenerative medicine.
2022 11; 16(11):987-997. doi:
10.1002/term.3345. [PMID: 35980287] - Jiazheng Cai, Jing Liu, Jing Yan, Xuexia Lu, Xiaoli Wang, Si Li, Kamal Mustafa, Huihui Wang, Ying Xue, Manal Mustafa, Alpdogan Kantarci, Zhe Xing. Impact of Resolvin D1 on the inflammatory phenotype of periodontal ligament cell response to hypoxia.
Journal of periodontal research.
2022 Oct; 57(5):1034-1042. doi:
10.1111/jre.13044. [PMID: 35944267] - Cui Zeng, Xinghuang Liu, Danping Xiong, Kaifang Zou, Tao Bai. Resolvin D1 Prevents Epithelial-to-Mesenchymal Transition and Reduces Collagen Deposition by Stimulating Autophagy in Intestinal Fibrosis.
Digestive diseases and sciences.
2022 10; 67(10):4749-4759. doi:
10.1007/s10620-021-07356-w. [PMID: 35013877] - Sangmin Lee, Sangyoon Kim, Sunghee Park, Jieun Lee, Hak-Sun Yu. Effect of resolvin D1 on experimental bacterial keratitis to prevent corneal scar.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie.
2022 Oct; 260(10):3293-3302. doi:
10.1007/s00417-022-05686-7. [PMID: 35522296] - Tiago H Zaninelli, Victor Fattori, Telma Saraiva-Santos, Stephanie Badaro-Garcia, Larissa Staurengo-Ferrari, Ketlem C Andrade, Nayara A Artero, Camila R Ferraz, Mariana M Bertozzi, Fernanda Rasquel-Oliveira, Marilia F Manchope, Flávio A Amaral, Mauro M Teixeira, Sergio M Borghi, Michael S Rogers, Rubia Casagrande, Waldiceu A Verri. RvD1 disrupts nociceptor neuron and macrophage activation and neuroimmune communication, reducing pain and inflammation in gouty arthritis in mice.
British journal of pharmacology.
2022 09; 179(18):4500-4515. doi:
10.1111/bph.15897. [PMID: 35716378] - Ali Roohbakhsh, Leila Etemad, Gholamreza Karimi. Resolvin D1: A key endogenous inhibitor of neuroinflammation.
BioFactors (Oxford, England).
2022 Sep; 48(5):1005-1026. doi:
10.1002/biof.1891. [PMID: 36176016] - Mei Yang, Xian-Qi Song, Mei Han, Hui Liu. The role of Resolvin D1 in liver diseases.
Prostaglandins & other lipid mediators.
2022 06; 160(?):106634. doi:
10.1016/j.prostaglandins.2022.106634. [PMID: 35292355] - Sang Yoon Kim, Ji Eun Lee. Resolvin D1 Inhibits Corneal Inflammation in Staphylococcus Aureus Keratitis.
Ocular immunology and inflammation.
2022 May; ?(?):1-8. doi:
10.1080/09273948.2022.2070504. [PMID: 35522258] - Inês Ferreira, Filipa Falcato, Narcisa Bandarra, Amélia P Rauter. Resolvins, Protectins, and Maresins: DHA-Derived Specialized Pro-Resolving Mediators, Biosynthetic Pathways, Synthetic Approaches, and Their Role in Inflammation.
Molecules (Basel, Switzerland).
2022 Mar; 27(5):. doi:
10.3390/molecules27051677. [PMID: 35268778] - Manoj Manickam, Sangeetha Meenakshisundaram, Thanigaimalai Pillaiyar. Activating endogenous resolution pathways by soluble epoxide hydrolase inhibitors for the management of COVID-19.
Archiv der Pharmazie.
2022 Mar; 355(3):e2100367. doi:
10.1002/ardp.202100367. [PMID: 34802171] - Qin Qin, Kai Hu, Zifang He, Feifei Chen, Wenwen Zhang, Yajun Liu, Zhenggao Xie. Resolvin D1 protects against Aspergillus fumigatus keratitis in diabetes by blocking the MAPK-NF-κB pathway.
Experimental eye research.
2022 03; 216(?):108941. doi:
10.1016/j.exer.2022.108941. [PMID: 35077754] - Cui Zeng, Xinghuang Liu, Siran Zhu, Danping Xiong, Liangru Zhu, Xiaohua Hou, Kaifang Zou, Tao Bai. Resolvin D1 ameliorates hepatic steatosis by remodeling the gut microbiota and restoring the intestinal barrier integrity in DSS-induced chronic colitis.
International immunopharmacology.
2022 Feb; 103(?):108500. doi:
10.1016/j.intimp.2021.108500. [PMID: 34974401] - Alexander S Kim, Evan C Werlin, Hideo Kagaya, Mian Chen, Bian Wu, Giorgio Mottola, Masood Jan, Michael S Conte. 17R/S-Benzo-RvD1, a synthetic resolvin D1 analogue, attenuates neointimal hyperplasia in a rat model of acute vascular injury.
PloS one.
2022; 17(2):e0264217. doi:
10.1371/journal.pone.0264217. [PMID: 35226675] - Bohan Wang, Jingchao Wei, Qi Huangfu, Fei Gao, Lanxin Qin, Jiao Zhong, Jiaming Wen, Zhangqun Ye, Xiaoqi Yang, Haoran Liu. Identification of Resolvin D1 and Protectin D1 as Potential Therapeutic Agents for Treating Kidney Stones.
Oxidative medicine and cellular longevity.
2022; 2022(?):4345037. doi:
10.1155/2022/4345037. [PMID: 35251472] - Ellen C Keeley, Han J Li, Christopher R Cogle, Eileen M Handberg, C Noel Bairey Merz, Carl J Pepine. Specialized Proresolving Mediators in Symptomatic Women With Coronary Microvascular Dysfunction (from the Women's Ischemia Trial to Reduce Events in Nonobstructive CAD [WARRIOR] Trial).
The American journal of cardiology.
2022 01; 162(?):1-5. doi:
10.1016/j.amjcard.2021.09.015. [PMID: 34728061] - Luiza Oliveira Perucci, Kelerson Mauro de Castro Pinto, Sirlaine Pio Gomes da Silva, Eura Martins Lage, Patrícia Gonçalves Teixeira, Alexandre Simões Barbosa, Patrícia Nessralla Alpoim, Lirlândia Pires de Sousa, André Talvani, Luci Maria SantAna Dusse. Longitudinal assessment of leukotriene B4, lipoxin A4, and resolvin D1 plasma levels in pregnant women with risk factors for preeclampsia.
Clinical biochemistry.
2021 Dec; 98(?):24-28. doi:
10.1016/j.clinbiochem.2021.09.002. [PMID: 34492288] - Francisco Olivares-Silva, Nicole De Gregorio, Jenaro Espitia-Corredor, Claudio Espinoza, Raúl Vivar, David Silva, José Miguel Osorio, Sergio Lavandero, Concepción Peiró, Carlos Sánchez-Ferrer, Guillermo Díaz-Araya. Resolvin-D1 attenuation of angiotensin II-induced cardiac inflammation in mice is associated with prevention of cardiac remodeling and hypertension.
Biochimica et biophysica acta. Molecular basis of disease.
2021 12; 1867(12):166241. doi:
10.1016/j.bbadis.2021.166241. [PMID: 34400298] - Habil Yücel, Alper Tunga Özdemir. Low LXA4, RvD1 and RvE1 levels may be an indicator of the development of hypertension.
Prostaglandins, leukotrienes, and essential fatty acids.
2021 11; 174(?):102365. doi:
10.1016/j.plefa.2021.102365. [PMID: 34740030] - Claudio Gemperle, Syndi Tran, Mattia Schmid, Nicole Rimann, Jacqueline Marti-Jaun, Ivan Hartling, Paulina Wawrzyniak, Martin Hersberger. Resolvin D1 reduces inflammation in co-cultures of primary human macrophages and adipocytes by triggering macrophages.
Prostaglandins, leukotrienes, and essential fatty acids.
2021 11; 174(?):102363. doi:
10.1016/j.plefa.2021.102363. [PMID: 34740032] - Jing Song, Rongxin Sun, Yuanyuan Zhang, Ying Fu, Dong Zhao. Role of the Specialized Pro-resolving Mediator Resolvin D1 in Hashimoto's Thyroiditis.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association.
2021 Nov; 129(11):791-797. doi:
10.1055/a-1345-0173. [PMID: 33465800] - José Bruno N F Silva, Thayanne B B Calcia, Cyntia P Silva, Rafael F Guilherme, Fernando Almeida-Souza, Felipe S Lemos, Kátia S Calabrese, Celso Caruso-Neves, Josiane S Neves, Claudia F Benjamim. ATRvD1 Attenuates Renal Tubulointerstitial Injury Induced by Albumin Overload in Sepsis-Surviving Mice.
International journal of molecular sciences.
2021 Oct; 22(21):. doi:
10.3390/ijms222111634. [PMID: 34769064] - Bruno Sada Salerno, Aline Beatriz Mahler Pereira, Henrique Ismarsi de Souza, Mario Leon Silva-Vergara, Bruce David Levy, Alexandre Paula Rogerio. Anti-inflammatory actions of aspirin-triggered resolvin D1 (AT-RvD1) in bronchial epithelial cells infected with Cryptococcus neoformans.
Inflammopharmacology.
2021 Oct; 29(5):1603-1612. doi:
10.1007/s10787-021-00855-2. [PMID: 34405339] - Eluisa Perna, Javier Aguilera-Lizarraga, Morgane V Florens, Piyush Jain, Stavroula A Theofanous, Nikita Hanning, Joris G De Man, Maya Berg, Benedicte De Winter, Yeranddy A Alpizar, Karel Talavera, Pieter Vanden Berghe, Mira Wouters, Guy Boeckxstaens. Effect of resolvins on sensitisation of TRPV1 and visceral hypersensitivity in IBS.
Gut.
2021 07; 70(7):1275-1286. doi:
10.1136/gutjnl-2020-321530. [PMID: 33023902] - Maria Consiglia Trotta, Sami Gharbia, Hildegard Herman, Bianca Mladin, Andrei Hermenean, Cornel Balta, Coralia Cotoraci, Victor Eduard Peteu, Carlo Gesualdo, Francesco Petrillo, Marilena Galdiero, Roberto Alfano, Mihaela Gherghiceanu, Michele D'Amico, Settimio Rossi, Anca Hermenean. Sex and Age-Related Differences in Neuroinflammation and Apoptosis in Balb/c Mice Retina Involve Resolvin D1.
International journal of molecular sciences.
2021 Jun; 22(12):. doi:
10.3390/ijms22126280. [PMID: 34208040] - Regina Sordi, Fausto Chiazza, Debora Collotta, Giuseppe Migliaretti, Romain A Colas, Paul Vulliamy, Karim Brohi, Jesmond Dalli, Massimo Collino, Christoph Thiemermann. Resolvin D1 Attenuates the Organ Injury Associated With Experimental Hemorrhagic Shock.
Annals of surgery.
2021 05; 273(5):1012-1021. doi:
10.1097/sla.0000000000003407. [PMID: 31188196] - Ha-Na Lee, Yeon-Seo Choi, Seong Hoon Kim, Xiancai Zhong, Wonki Kim, Joon Sung Park, Soma Saeidi, Byung Woo Han, Nayoung Kim, Hye Seung Lee, Yoon Jin Choi, Jeong-Heum Baek, Hye-Kyung Na, Young-Joon Surh. Resolvin D1 suppresses inflammation-associated tumorigenesis in the colon by inhibiting IL-6-induced mitotic spindle abnormality.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 05; 35(5):e21432. doi:
10.1096/fj.202002392r. [PMID: 33794029] - Domenico Mattoscio, Elisa Isopi, Alessia Lamolinara, Sara Patruno, Alessandro Medda, Federica De Cecco, Susanna Chiocca, Manuela Iezzi, Mario Romano, Antonio Recchiuti. Resolvin D1 reduces cancer growth stimulating a protective neutrophil-dependent recruitment of anti-tumor monocytes.
Journal of experimental & clinical cancer research : CR.
2021 Apr; 40(1):129. doi:
10.1186/s13046-021-01937-3. [PMID: 33845864] - Antonio Recchiuti, Sara Patruno, Domenico Mattoscio, Elisa Isopi, Antonella Pomilio, Alessia Lamolinara, Manuela Iezzi, Romina Pecce, Mario Romano. Resolvin D1 and D2 reduce SARS-CoV-2-induced inflammatory responses in cystic fibrosis macrophages.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 04; 35(4):e21441. doi:
10.1096/fj.202001952r. [PMID: 33749902] - Tariq A Bhat, Suresh Gopi Kalathil, Paul N Bogner, Paul V Lehmann, Thomas H Thatcher, Patricia J Sime, Yasmin Thanavala. AT-RvD1 Mitigates Secondhand Smoke-Exacerbated Pulmonary Inflammation and Restores Secondhand Smoke-Suppressed Antibacterial Immunity.
Journal of immunology (Baltimore, Md. : 1950).
2021 03; 206(6):1348-1360. doi:
10.4049/jimmunol.2001228. [PMID: 33558371] - Venkata K Yellepeddi, Kaustubh Parashar, Spencer M Dean, Kevin M Watt, Jonathan E Constance, Olga J Baker. Predicting Resolvin D1 Pharmacokinetics in Humans with Physiologically-Based Pharmacokinetic Modeling.
Clinical and translational science.
2021 03; 14(2):683-691. doi:
10.1111/cts.12930. [PMID: 33202089] - Maha Fathy Elmasry, Eman Hassan, Laila Ahmed Rashed, Dalia Mohamed Abdel Halim. Role of resolvin D1 in psoriasis before and after narrowband ultraviolet B phototherapy: A case-control study.
Dermatologic therapy.
2021 03; 34(2):e14879. doi:
10.1111/dth.14879. [PMID: 33586174] - Siresha Bathina, Undurti N Das. Resolvin D1 Decreases Severity of Streptozotocin-Induced Type 1 Diabetes Mellitus by Enhancing BDNF Levels, Reducing Oxidative Stress, and Suppressing Inflammation.
International journal of molecular sciences.
2021 Feb; 22(4):. doi:
10.3390/ijms22041516. [PMID: 33546300] - Francesco Palmas, Jennifer Clarke, Romain A Colas, Esteban A Gomez, Aoife Keogh, Maria Boylan, Natalie McEvoy, Oliver J McElvaney, Oisin McElvaney, Razi Alalqam, Noel G McElvaney, Gerard F Curley, Jesmond Dalli. Dysregulated plasma lipid mediator profiles in critically ill COVID-19 patients.
PloS one.
2021; 16(8):e0256226. doi:
10.1371/journal.pone.0256226. [PMID: 34437568] - Tao Cheng, Shuai Ding, Shanshan Liu, Xiaojing Li, Xiaojun Tang, Lingyun Sun. Resolvin D1 Improves the Treg/Th17 Imbalance in Systemic Lupus Erythematosus Through miR-30e-5p.
Frontiers in immunology.
2021; 12(?):668760. doi:
10.3389/fimmu.2021.668760. [PMID: 34093566] - Takuya Kuzumoto, Tetsuya Tanigawa, Akira Higashimori, Hiroyuki Kitamura, Yuji Nadatani, Koji Otani, Shusei Fukunaga, Shuhei Hosomi, Fumio Tanaka, Noriko Kamata, Yasuaki Nagami, Koichi Taira, Toshio Watanabe, Yasuhiro Fujiwara. Protective role of resolvin D1, a pro-resolving lipid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage.
PloS one.
2021; 16(5):e0250862. doi:
10.1371/journal.pone.0250862. [PMID: 33945545] - Pedro-Antonio Regidor, Anna Mueller, Manuela Sailer, Fernando Gonzalez Santos, Jose Miguel Rizo, Fernando Moreno Egea. Chronic Inflammation in PCOS: The Potential Benefits of Specialized Pro-Resolving Lipid Mediators (SPMs) in the Improvement of the Resolutive Response.
International journal of molecular sciences.
2020 Dec; 22(1):. doi:
10.3390/ijms22010384. [PMID: 33396555] - Tariq A Bhat, Suresh Gopi Kalathil, Austin Miller, Thomas H Thatcher, Patricia J Sime, Yasmin Thanavala. Specialized Proresolving Mediators Overcome Immune Suppression Induced by Exposure to Secondhand Smoke.
Journal of immunology (Baltimore, Md. : 1950).
2020 12; 205(11):3205-3217. doi:
10.4049/jimmunol.2000711. [PMID: 33115852] - Iryna A Khasabova, Mikhail Y Golovko, Svetlana A Golovko, Donald A Simone, Sergey G Khasabov. Intrathecal administration of Resolvin D1 and E1 decreases hyperalgesia in mice with bone cancer pain: Involvement of endocannabinoid signaling.
Prostaglandins & other lipid mediators.
2020 12; 151(?):106479. doi:
10.1016/j.prostaglandins.2020.106479. [PMID: 32745525] - Francesco Petrillo, Maria Consiglia Trotta, Claudio Bucolo, Anca Hermenean, Arianna Petrillo, Rosa Maisto, Gorizio Pieretti, Michela Pietropaolo, Franca Ferraraccio, Caterina Gagliano, Marilena Galdiero, Michele D'Amico. Resolvin D1 attenuates the inflammatory process in mouse model of LPS-induced keratitis.
Journal of cellular and molecular medicine.
2020 11; 24(21):12298-12307. doi:
10.1111/jcmm.15633. [PMID: 33058526] - Rabia Bilge Özgül Özdemir, Özgül Soysal Gündüz, Alper Tunga Özdemir, Özgür Akgül. Low levels of pro-resolving lipid mediators lipoxin-A4, resolvin-D1 and resolvin-E1 in patients with rheumatoid arthritis.
Immunology letters.
2020 11; 227(?):34-40. doi:
10.1016/j.imlet.2020.08.006. [PMID: 32818598] - Jiahuan Li, Xiaoling Deng, Tao Bai, Shuhan Wang, Qianqian Jiang, Keshu Xu. Resolvin D1 mitigates non-alcoholic steatohepatitis by suppressing the TLR4-MyD88-mediated NF-κB and MAPK pathways and activating the Nrf2 pathway in mice.
International immunopharmacology.
2020 Nov; 88(?):106961. doi:
10.1016/j.intimp.2020.106961. [PMID: 33182038] - Pongsatorn Meesawatsom, Gareth Hathway, Andrew Bennett, Dumitru Constantin-Teodosiu, Victoria Chapman. Spinal neuronal excitability and neuroinflammation in a model of chemotherapeutic neuropathic pain: targeting the resolution pathways.
Journal of neuroinflammation.
2020 Oct; 17(1):316. doi:
10.1186/s12974-020-01997-w. [PMID: 33097087] - Weiting Chen, Hui Wang, Zhengquan Wang, Changwei Zhao, Jiefeng Xu, Qijiang Chen. Resolvin D1 Improves Post-Resuscitation Cardiac and Cerebral Outcomes in A Porcine Model of Cardiac Arrest.
Shock (Augusta, Ga.).
2020 10; 54(4):548-554. doi:
10.1097/shk.0000000000001528. [PMID: 32080063] - Nan Chiang, Charles N Serhan. Specialized pro-resolving mediator network: an update on production and actions.
Essays in biochemistry.
2020 09; 64(3):443-462. doi:
10.1042/ebc20200018. [PMID: 32885825] - James F Markworth, Lemuel A Brown, Eunice Lim, Carolyn Floyd, Jacqueline Larouche, Jesus A Castor-Macias, Kristoffer B Sugg, Dylan C Sarver, Peter Cd Macpherson, Carol Davis, Carlos A Aguilar, Krishna Rao Maddipati, Susan V Brooks. Resolvin D1 supports skeletal myofiber regeneration via actions on myeloid and muscle stem cells.
JCI insight.
2020 09; 5(18):. doi:
10.1172/jci.insight.137713. [PMID: 32750044] - Menglong Wang, Menglin Liu, Jishou Zhang, Jianfang Liu, Jing Ye, Yao Xu, Zhen Wang, Di Ye, Mengmeng Zhao, Jun Wan. Resolvin D1 protects against sepsis-induced cardiac injury in mice.
BioFactors (Oxford, England).
2020 Sep; 46(5):766-776. doi:
10.1002/biof.1668. [PMID: 32668503] - Keishi Miyazawa, Hisanori Fukunaga, Yasuko Tatewaki, Yumi Takano, Shuzo Yamamoto, Tatsushi Mutoh, Yasuyuki Taki. Alzheimer's Disease and Specialized Pro-Resolving Lipid Mediators: Do MaR1, RvD1, and NPD1 Show Promise for Prevention and Treatment?.
International journal of molecular sciences.
2020 Aug; 21(16):. doi:
10.3390/ijms21165783. [PMID: 32806612] - Siresha Bathina, Naveen K V Gundala, Poorani Rhenghachar, Sailaja Polavarapu, Anasuya D Hari, Monika Sadananda, Undurti N Das. Resolvin D1 Ameliorates Nicotinamide-streptozotocin-induced Type 2 Diabetes Mellitus by its Anti-inflammatory Action and Modulating PI3K/Akt/mTOR Pathway in the Brain.
Archives of medical research.
2020 08; 51(6):492-503. doi:
10.1016/j.arcmed.2020.05.002. [PMID: 32451116] - Małgorzata Szczuko, Dariusz Kotlęga, Joanna Palma, Agnieszka Zembroń-Łacny, Anna Tylutka, Monika Gołąb-Janowska, Arleta Drozd. Lipoxins, RevD1 and 9, 13 HODE as the most important derivatives after an early incident of ischemic stroke.
Scientific reports.
2020 07; 10(1):12849. doi:
10.1038/s41598-020-69831-0. [PMID: 32732956] - Maja Payrits, Ádám Horváth, Tünde Biró-Sütő, János Erostyák, Géza Makkai, Éva Sághy, Krisztina Pohóczky, Angéla Kecskés, Miklós Kecskés, János Szolcsányi, Zsuzsanna Helyes, Éva Szőke. Resolvin D1 and D2 Inhibit Transient Receptor Potential Vanilloid 1 and Ankyrin 1 Ion Channel Activation on Sensory Neurons via Lipid Raft Modification.
International journal of molecular sciences.
2020 Jul; 21(14):. doi:
10.3390/ijms21145019. [PMID: 32708653] - Dalia G Mostafa, Huda H Satti. Resolvin D1 Prevents the Impairment in the Retention Memory and Hippocampal Damage in Rats Fed a Corn Oil-Based High Fat Diet by Upregulation of Nrf2 and Downregulation and Inactivation of p66Shc.
Neurochemical research.
2020 Jul; 45(7):1576-1591. doi:
10.1007/s11064-020-03022-1. [PMID: 32253649] - Xueshu Tao, Michael S Lee, Christopher R Donnelly, Ru-Rong Ji. Neuromodulation, Specialized Proresolving Mediators, and Resolution of Pain.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics.
2020 07; 17(3):886-899. doi:
10.1007/s13311-020-00892-9. [PMID: 32696274] - Brian E Sansbury, Xiaofeng Li, Blenda Wong, Andreas Patsalos, Nikolas Giannakis, Michael J Zhang, Laszlo Nagy, Matthew Spite. Myeloid ALX/FPR2 regulates vascularization following tissue injury.
Proceedings of the National Academy of Sciences of the United States of America.
2020 06; 117(25):14354-14364. doi:
10.1073/pnas.1918163117. [PMID: 32513697] - Jeevan B Gc, Christopher T Szlenk, Jin Gao, Xinyue Dong, Zhenjia Wang, Senthil Natesan. Molecular Dynamics Simulations Provide Insight into the Loading Efficiency of Proresolving Lipid Mediators Resolvin D1 and D2 in Cell Membrane-Derived Nanovesicles.
Molecular pharmaceutics.
2020 06; 17(6):2155-2164. doi:
10.1021/acs.molpharmaceut.0c00299. [PMID: 32374613] - Kaustubh Parashar, Fabian Schulte, Markus Hardt, Olga J Baker. Sex-mediated elevation of the specialized pro-resolving lipid mediator levels in a Sjögren's syndrome mouse model.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2020 06; 34(6):7733-7744. doi:
10.1096/fj.201902196r. [PMID: 32277856] - Aline L Horta, Tere Williams, Bing Han, Yanfen Ma, Ana Paula J Menezes, Vincent Tu, André Talvani, Louis M Weiss, Huan Huang. Resolvin D1 Administration Is Beneficial in Trypanosoma cruzi Infection.
Infection and immunity.
2020 05; 88(6):. doi:
10.1128/iai.00052-20. [PMID: 32152197] - Dominika Maciejewska, Arleta Drozd, Karolina Skonieczna-Żydecka, Marta Skórka-Majewicz, Karolina Dec, Karolina Jakubczyk, Anna Pilutin, Ewa Stachowska. Eicosanoids in Nonalcoholic Fatty Liver Disease (NAFLD) Progression. Do Serum Eicosanoids Profile Correspond with Liver Eicosanoids Content during NAFLD Development and Progression?.
Molecules (Basel, Switzerland).
2020 Apr; 25(9):. doi:
10.3390/molecules25092026. [PMID: 32349225] - Meriem Sekheri, Driss El Kebir, Natalie Edner, János G Filep. 15-Epi-LXA4 and 17-epi-RvD1 restore TLR9-mediated impaired neutrophil phagocytosis and accelerate resolution of lung inflammation.
Proceedings of the National Academy of Sciences of the United States of America.
2020 04; 117(14):7971-7980. doi:
10.1073/pnas.1920193117. [PMID: 32205444] - Venkata Kashyap Yellepeddi, Olga J Baker. Predictive modeling of aspirin-triggered resolvin D1 pharmacokinetics for the study of Sjögren's syndrome.
Clinical and experimental dental research.
2020 04; 6(2):225-235. doi:
10.1002/cre2.260. [PMID: 32250566] - Weiwei Sun, Jinglan Ma, Han Zhao, Chipeng Xiao, Hao Zhong, Hanzhi Ling, Zhen Xie, Qingqing Tian, Huaijun Chen, Tingting Zhang, Mu Chen, Shengwei Jin, Jianguang Wang. Resolvin D1 suppresses pannus formation via decreasing connective tissue growth factor caused by upregulation of miRNA-146a-5p in rheumatoid arthritis.
Arthritis research & therapy.
2020 03; 22(1):61. doi:
10.1186/s13075-020-2133-2. [PMID: 32216830] - Mirosław Dróżdż, Joanna Gdula-Argasińska, Grażyna Biesiada, Artur Jurczyszyn, William Perucki, Paweł Wołkow, Agnieszka Borys, Katarzyna Sroczyńska, Anna Zając, Tadeusz Librowski, Aleksander Garlicki, Jacek Czepiel. Clostridium difficile caused changes in fatty acids profile and resolvin D1 content in plasma of infected patients.
European journal of gastroenterology & hepatology.
2020 03; 32(3):318-324. doi:
10.1097/meg.0000000000001600. [PMID: 31714390] - Luiza Oliveira Perucci, Talita Adriana Pereira Santos, Patrícia Campi Santos, Lívia Cristina Ribeiro Teixeira, Patrícia Nessralla Alpoim, Karina Braga Gomes, Lirlândia Pires Sousa, Luci Maria Sant'Ana Dusse, André Talvani. Pre-eclampsia is associated with reduced resolvin D1 and maresin 1 to leukotriene B4 ratios in the plasma.
American journal of reproductive immunology (New York, N.Y. : 1989).
2020 02; 83(2):e13206. doi:
10.1111/aji.13206. [PMID: 31679164] - Giorgio Mottola, Evan C Werlin, Bian Wu, Mian Chen, Anuran Chatterjee, Melinda S Schaller, Michael S Conte. Oral Resolvin D1 attenuates early inflammation but not intimal hyperplasia in a rat carotid angioplasty model.
Prostaglandins & other lipid mediators.
2020 02; 146(?):106401. doi:
10.1016/j.prostaglandins.2019.106401. [PMID: 31841663] - Burcu Kok Kendirlioglu, Pelin Unalan Ozpercin, Ozge Yuksel Oksuz, Sule Sozen, Refik Cihnioglu, Tevfik Kalelioglu, Mehmet Cem Ilnem, Nesrin Karamustafalioglu. Resolvin D1 as a novel anti-inflammatory marker in manic, depressive and euthymic states of bipolar disorder.
Nordic journal of psychiatry.
2020 Feb; 74(2):83-88. doi:
10.1080/08039488.2019.1673480. [PMID: 31575320] - Yan Guo, You-Hui Tu, Xu Wu, Shuang Ji, Ji-Long Shen, Hui-Mei Wu, Guang-He Fei. ResolvinD1 Protects the Airway Barrier Against Injury Induced by Influenza A Virus Through the Nrf2 Pathway.
Frontiers in cellular and infection microbiology.
2020; 10(?):616475. doi:
10.3389/fcimb.2020.616475. [PMID: 33643931] - Miriam Madrid, Malinalli Brianza-Padilla, Juan C Echeverría, Rolando Rivera-González, Rafael Bojalil. The Severity of Neurological Dysfunction in Preschool Children, Secondary to Damage Generated During the Perinatal Period, is Associated With a Pro-Inflammatory Pattern of Serum Molecules.
Frontiers in immunology.
2020; 11(?):595309. doi:
10.3389/fimmu.2020.595309. [PMID: 33584663] - Anjyu Ikeda, Akari Muroki, Chie Suzuki, Yoshihito Shimazu, Mamoru Takeda. Resolvin D1 suppresses inflammation-induced hyperexcitability of nociceptive trigeminal neurons associated with mechanical hyperalgesia.
Brain research bulletin.
2020 01; 154(?):61-67. doi:
10.1016/j.brainresbull.2019.11.002. [PMID: 31722251] - Elisa Isopi, Domenico Mattoscio, Marilina Codagnone, Veronica Cecilia Mari, Alessia Lamolinara, Sara Patruno, Marco D'Aurora, Eleonora Cianci, Annalisa Nespoli, Sara Franchi, Valentina Gatta, Marc Dubourdeau, Paolo Moretti, Maria Di Sabatino, Manuela Iezzi, Mario Romano, Antonio Recchiuti. Resolvin D1 Reduces Lung Infection and Inflammation Activating Resolution in Cystic Fibrosis.
Frontiers in immunology.
2020; 11(?):581. doi:
10.3389/fimmu.2020.00581. [PMID: 32528461] - Hua-Wei Zhang, Qian Wang, Hong-Xia Mei, Sheng-Xing Zheng, Abdullahi Mohamed Ali, Qi-Xing Wu, Yang Ye, Hao-Ran Xu, Shu-Yang Xiang, Sheng-Wei Jin. RvD1 ameliorates LPS-induced acute lung injury via the suppression of neutrophil infiltration by reducing CXCL2 expression and release from resident alveolar macrophages.
International immunopharmacology.
2019 Nov; 76(?):105877. doi:
10.1016/j.intimp.2019.105877. [PMID: 31522017] - Ying Xiong, Zhixiu Song, Yun Gu, Yuhang Qin, Jiangfei Wei, Jinlu Lu, Yan Zhu. Effect of chiropractic manipulation on disrupted epithelium barrier and its mechanism of specialized pro-resolving mediators in a spleen-deficiency murine model.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2019 10; 39(5):678-684. doi:
. [PMID: 32186117] - C N Serhan, X de la Rosa, C Jouvene. Novel mediators and mechanisms in the resolution of infectious inflammation: evidence for vagus regulation.
Journal of internal medicine.
2019 09; 286(3):240-258. doi:
10.1111/joim.12871. [PMID: 30565762] - Rui Liu, Zhenkun Li, Qiang Wang. Resolvin D1 Attenuates Myocardial Infarction in a Rodent Model with the Participation of the HMGB1 Pathway.
Cardiovascular drugs and therapy.
2019 08; 33(4):399-406. doi:
10.1007/s10557-019-06884-y. [PMID: 31280453] - Jung-Woo Kang, Hyo-Sun Choi, Jun-Kyu Shin, Sun-Mee Lee. Resolvin D1 activates the sphingosine-1-phosphate signaling pathway in murine livers with ischemia/reperfusion injury.
Biochemical and biophysical research communications.
2019 07; 514(4):1058-1065. doi:
10.1016/j.bbrc.2019.05.041. [PMID: 31097221] - Prahalathan Pichavaram, Arul M Mani, Nikhlesh K Singh, Gadiparthi N Rao. Cholesterol crystals promote endothelial cell and monocyte interactions via H2O2-mediated PP2A inhibition, NFκB activation and ICAM1 and VCAM1 expression.
Redox biology.
2019 06; 24(?):101180. doi:
10.1016/j.redox.2019.101180. [PMID: 31022672] - Liankang Sun, Yufeng Wang, Liang Wang, Bowen Yao, Tianxiang Chen, Qing Li, Zhikui Liu, Runkun Liu, Yongshen Niu, Tao Song, Qingguang Liu, Kangsheng Tu. Resolvin D1 prevents epithelial-mesenchymal transition and reduces the stemness features of hepatocellular carcinoma by inhibiting paracrine of cancer-associated fibroblast-derived COMP.
Journal of experimental & clinical cancer research : CR.
2019 Apr; 38(1):170. doi:
10.1186/s13046-019-1163-6. [PMID: 30999932] - J Xia, J Y Xue, J Du, G W Wu, X T Hu, Q F Zhao. [Role and related mechanism of resolvin D1 in lung ischemia reperfusion injury in rats].
Zhonghua yi xue za zhi.
2019 Apr; 99(14):1111-1115. doi:
10.3760/cma.j.issn.0376-2491.2019.14.015. [PMID: 30982262] - Vasundhara Kain, Ganesh V Halade. Immune responsive resolvin D1 programs peritoneal macrophages and cardiac fibroblast phenotypes in diversified metabolic microenvironment.
Journal of cellular physiology.
2019 04; 234(4):3910-3920. doi:
10.1002/jcp.27165. [PMID: 30191990] - Houda Abir Benabdoun, Merve Kulbay, Elsa-Patricia Rondon, Francis Vallières, Qin Shi, Julio Fernandes, Hassan Fahmi, Mohamed Benderdour. In vitro and in vivo assessment of the proresolutive and antiresorptive actions of resolvin D1: relevance to arthritis.
Arthritis research & therapy.
2019 03; 21(1):72. doi:
10.1186/s13075-019-1852-8. [PMID: 30867044] - Dan Ye, Feng-Ying Wang, Zuo-Yan Liu, Yong Liu. [Resolvin D1 Reduces Cerulein and Lipopolysaccharide-induced Severe Acute Pancreatitis in Mice Fracture Patients].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2019 Mar; 50(2):215-218. doi:
NULL. [PMID: 31106542] - Xiao Hu, Yuanyuan Liang, Hongyu Zhao, Min Zhao. Effects of AT-RvD1 on paraquat-induced acute renal injury in mice.
International immunopharmacology.
2019 Feb; 67(?):231-238. doi:
10.1016/j.intimp.2018.12.029. [PMID: 30562684] - Jørn Eivind Tungen, Lisa Gerstmann, Anders Vik, Roberta De Matteis, Romain Alexandre Colas, Jesmond Dalli, Nan Chiang, Charles Nicholas Serhan, Markus Kalesse, Trond Vidar Hansen. Resolving Inflammation: Synthesis, Configurational Assignment, and Biological Evaluations of RvD1n-3 DPA.
Chemistry (Weinheim an der Bergstrasse, Germany).
2019 Jan; 25(6):1476-1480. doi:
10.1002/chem.201806029. [PMID: 30511787] - Antonia Rujia Sun, Xiaoxin Wu, Bohao Liu, Yang Chen, Charles W Armitage, Avinash Kollipara, Ross Crawford, Kenneth W Beagley, Xinzhan Mao, Yin Xiao, Indira Prasadam. Pro-resolving lipid mediator ameliorates obesity induced osteoarthritis by regulating synovial macrophage polarisation.
Scientific reports.
2019 01; 9(1):426. doi:
10.1038/s41598-018-36909-9. [PMID: 30674985] - Alessandro Matte, Antonio Recchiuti, Enrica Federti, Bérengère Koehl, Thomas Mintz, Wassim El Nemer, Pierre-Louis Tharaux, Valentine Brousse, Immacolata Andolfo, Alessia Lamolinara, Olga Weinberg, Angela Siciliano, Paul C Norris, Ian R Riley, Achille Iolascon, Charles N Serhan, Carlo Brugnara, Lucia De Franceschi. Resolution of sickle cell disease-associated inflammation and tissue damage with 17R-resolvin D1.
Blood.
2019 01; 133(3):252-265. doi:
10.1182/blood-2018-07-865378. [PMID: 30404812]