(8R)-3-[(4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol (BioDeep_00000173618)
human metabolite blood metabolite Chemicals and Drugs Antibiotics
代谢物信息卡片
(8R)-3-[(4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol
化学式: C11H16N4O4 (268.1171)
中文名称: 喷司他丁
谱图信息:
最多检出来源 Mus musculus(blood) 100%
分子结构信息
SMILES: C1C(C(OC1N2C=NC3=C2NC=NCC3O)CO)O
InChI: InChI=1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)
描述信息
D000970 - Antineoplastic Agents > D000903 - Antibiotics, Antineoplastic > D005573 - Formycins
D004791 - Enzyme Inhibitors > D058892 - Adenosine Deaminase Inhibitors
同义名列表
9 个代谢物同义名
(8R)-3-[(4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydro-4H-imidazo[4,5-d][1,3]diazepin-8-ol; 3-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H,6H,7H,8H-imidazo[4,5-d][1,3]diazepin-8-ol; 2-Deoxycoformycin; 2 Deoxycoformycin; Deoxycoformycin; CO-Vidarabine; PENTOSTATIN; Nipent; Deoxycoformycin
数据库引用编号
7 个数据库交叉引用编号
- PubChem: 4739
- HMDB: HMDB0245535
- MeSH: Pentostatin
- chemspider: 4577
- CAS: 53910-25-1
- KEGG: C02267
- PubChem: 5328
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Haematologica.
1990 Jul; 75(4):375-80. doi:
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Bone marrow transplantation.
1990 Jun; 5(6):395-402. doi:
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Journal of cellular physiology.
1990 May; 143(2):344-51. doi:
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Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
1990 Apr; 8(4):721-30. doi:
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Leukemia.
1989 Oct; 3(10):718-23. doi:
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Molecular pharmacology.
1989 Jul; 36(1):185-92. doi:
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The Journal of clinical investigation.
1988 Nov; 82(5):1694-9. doi:
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Blood.
1988 Jul; 72(1):29-33. doi:
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Blood.
1988 May; 71(5):1304-9. doi:
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Medical and pediatric oncology.
1988; 16(5):327-32. doi:
10.1002/mpo.2950160507. [PMID: 3263563] - D L Marquardt, L L Walker. Inhibition of mast cell adenosine responsiveness by chronic exposure to adenosine receptor agonists.
Biochemical pharmacology.
1987 Dec; 36(24):4297-302. doi:
10.1016/0006-2952(87)90674-5. [PMID: 2825721] - D A Galton, F Brito-Babapulle. The management of myelomatosis.
European journal of haematology.
1987 Nov; 39(5):385-98. doi:
10.1111/j.1600-0609.1987.tb01445.x. [PMID: 2446915] - D de Korte, W A Haverkort, E F van Leeuwen, D Roos, A H van Gennip. Biochemical consequences of 2'-deoxycoformycin treatment in a patient with T-cell lymphoma. Some unusual findings.
Cancer.
1987 Aug; 60(4):750-5. doi:
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Molecular and cellular biochemistry.
1987 Jul; 76(1):85-91. doi:
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Cancer research.
1987 May; 47(9):2498-503. doi:
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Leukemia.
1987 Apr; 1(4):350-4. doi:
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Antimicrobial agents and chemotherapy.
1987 Jan; 31(1):21-6. doi:
10.1128/aac.31.1.21. [PMID: 3032089] - J B Johnston, R I Glazer, L Pugh, L G Israels. The treatment of hairy-cell leukaemia with 2'-deoxycoformycin.
British journal of haematology.
1986 Jul; 63(3):525-34. doi:
10.1111/j.1365-2141.1986.tb07530.x. [PMID: 3488071] - J B Johnston, A Begleiter, L Pugh, M K Leith, J A Wilkins, D J Cavers, L G Israels. Biochemical changes induced in hairy-cell leukemia following treatment with the adenosine deaminase inhibitor 2'-deoxycoformycin.
Cancer research.
1986 Apr; 46(4 Pt 2):2179-84. doi:
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Advances in experimental medicine and biology.
1986; 195 Pt A(?):223-9. doi:
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Advances in experimental medicine and biology.
1986; 195 Pt B(?):673-5. doi:
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Experientia.
1985 Oct; 41(10):1326-8. doi:
10.1007/bf01952078. [PMID: 2412878] - A Goday, H A Simmonds, G S Morris, L D Fairbanks. Human B lymphocytes and thymocytes but not peripheral blood mononuclear cells accumulate high dATP levels in conditions simulating ADA deficiency.
Biochemical pharmacology.
1985 Oct; 34(19):3561-9. doi:
10.1016/0006-2952(85)90734-8. [PMID: 3876835] - J F Henderson, C M Smith, G Zombor. Regulation of purine metabolism in lymphocytes.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.).
1985 Sep; 179(4):419-26. doi:
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Journal of cellular physiology.
1985 Aug; 124(2):226-32. doi:
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Cancer treatment reports.
1985 Jul; 69(7-8):777-82. doi:
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The American journal of pathology.
1985 Apr; 119(1):65-72. doi:
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Cancer chemotherapy and pharmacology.
1985; 14(1):49-52. doi:
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Journal of immunopharmacology.
1985; 7(3):325-41. doi:
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Annals of the New York Academy of Sciences.
1985; 451(?):123-8. doi:
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Annals of the New York Academy of Sciences.
1985; 451(?):113-22. doi:
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Cryobiology.
1984 Jun; 21(3):285-95. doi:
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Biochemical pharmacology.
1984 May; 33(10):1633-7. doi:
10.1016/0006-2952(84)90285-5. [PMID: 6610419] - D C Harris, S Lawrence, K F Bradstock, J J Carter, W G Jones. Intraglomerular thrombosis with deoxycoformycin--reversible acute renal failure.
Clinical nephrology.
1984 Mar; 21(3):194-6. doi:
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