disulfiram (BioDeep_00000001685)

Main id: BioDeep_00000017900

 

natural product


代谢物信息卡片


Disulfiram (Antabuse)

化学式: C10H20N2S4 (296.050928)
中文名称: 二硫化四乙基秋兰姆
谱图信息: 最多检出来源 Homo sapiens(blood) 66.67%

分子结构信息

SMILES: CCN(C(SSC(N(CC)CC)=S)=S)CC
InChI: InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3

描述信息

P - Antiparasitic products, insecticides and repellents > P03 - Ectoparasiticides, incl. scabicides, insecticides and repellents > P03A - Ectoparasiticides, incl. scabicides > P03AA - Sulfur containing products
N - Nervous system > N07 - Other nervous system drugs > N07B - Drugs used in addictive disorders > N07BB - Drugs used in alcohol dependence
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C2160 - Proteasome Inhibitor
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D004791 - Enzyme Inhibitors > D065086 - Acetaldehyde Dehydrogenase Inhibitors
D002491 - Central Nervous System Agents > D000427 - Alcohol Deterrents
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor
C1744 - Multidrug Resistance Modulator
C471 - Enzyme Inhibitor
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of?aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier,?with?Cu2+ increases intracellular ROS levels and induces cuproptosis[1][2][3][4][5][6].

同义名列表

4 个代谢物同义名

disulfiram; Disulfiram (Antabuse); Tetraethylthiuram disulfide; TETD



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

21 个相关的代谢反应过程信息。

Reactome(21)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Wei Guo, Lin Jia, Ling Xie, Juliann G Kiang, Yangyang Wang, Fengfei Sun, Zunwen Lin, Enwen Wang, Yida Zhang, Peigen Huang, Ting Sun, Xiao Zhang, Zhengying Bian, Tiejun Tang, Jingtian Guo, Soldano Ferrone, Xinhui Wang. Turning anecdotal irradiation-induced anticancer immune responses into reproducible in situ cancer vaccines via disulfiram/copper-mediated enhanced immunogenic cell death of breast cancer cells. Cell death & disease. 2024 Apr; 15(4):298. doi: 10.1038/s41419-024-06644-3. [PMID: 38678042]
  • Zhenhu Guo, Xiaohan Gao, Jingsong Lu, Ying Li, Zeping Jin, Abdul Fahad, Neema Ufurahi Pambe, Hirotaka Ejima, Xiaodan Sun, Xiumei Wang, Wensheng Xie, Guifeng Zhang, Lingyun Zhao. Apoptosis and Paraptosis Induced by Disulfiram-Loaded Ca2+/Cu2+ Dual-Ions Nano Trap for Breast Cancer Treatment. ACS nano. 2024 Mar; 18(9):6975-6989. doi: 10.1021/acsnano.3c10173. [PMID: 38377439]
  • Ping Zhang, Chaoting Zhou, Xueying Ren, Qiangan Jing, Yan Gao, Chen Yang, Yuhuan Shen, Yi Zhou, Wanye Hu, Feifan Jin, Haifeng Xu, Lingyan Yu, Yingchao Liu, Xiangmin Tong, Yanchun Li, Ying Wang, Jing Du. Inhibiting the compensatory elevation of xCT collaborates with disulfiram/copper-induced GSH consumption for cascade ferroptosis and cuproptosis. Redox biology. 2024 Feb; 69(?):103007. doi: 10.1016/j.redox.2023.103007. [PMID: 38150993]
  • Jinyan Lin, Cailin Huang, Peiyuan Wang, Yueyang He, Qiang Luo, Xiaolong Liu, Yang Li. Tumor-Microenvironment-Responsive Cerium-Enriched Copper Nanozyme with O2 Supply and Oxidative Stress Amplification for In Situ Disulfiram Chemotherapy and Chemodynamic Therapy Intensification. Advanced healthcare materials. 2024 Jan; ?(?):e2303955. doi: 10.1002/adhm.202303955. [PMID: 38271271]
  • Luca Mazzei, Arundhati Paul, Michele Cianci, Marta Devodier, Davide Mandelli, Paolo Carloni, Stefano Ciurli. Kinetic and structural details of urease inactivation by thiuram disulphides. Journal of inorganic biochemistry. 2023 Oct; 250(?):112398. doi: 10.1016/j.jinorgbio.2023.112398. [PMID: 37879152]
  • Meiran Chu, Xinglan An, Cong Fu, Hao Yu, Daoyu Zhang, Qi Li, Xiaxia Man, Xiangpeng Dai, Ziyi Li. Disulfiram/Copper Induce Ferroptosis in Triple-Negative Breast Cancer Cell Line MDA-MB-231. Frontiers in bioscience (Landmark edition). 2023 08; 28(8):186. doi: 10.31083/j.fbl2808186. [PMID: 37664913]
  • Yanjuan Zhao, Shujin Zhu. Nrf2/HO-1 Alleviates Disulfiram/Copper-Induced Ferroptosis in Oral Squamous Cell Carcinoma. Biochemical genetics. 2023 Jun; ?(?):. doi: 10.1007/s10528-023-10405-w. [PMID: 37286868]
  • Jia Guo, Jinyun Shi, Min Qin, Yan Wang, Zhidong Li, Takahiro Shoji, Toru Ikezoe, Yingbin Ge, Baohui Xu. Pharmacological Inhibition of Gasdermin D Suppresses Angiotensin II-Induced Experimental Abdominal Aortic Aneurysms. Biomolecules. 2023 05; 13(6):. doi: 10.3390/biom13060899. [PMID: 37371479]
  • Cheng Ni, Zhijun Ouyang, Gaoming Li, Junjie Liu, Xueyan Cao, Linfeng Zheng, Xiangyang Shi, Rui Guo. A tumor microenvironment-responsive core-shell tecto dendrimer nanoplatform for magnetic resonance imaging-guided and cuproptosis-promoted chemo-chemodynamic therapy. Acta biomaterialia. 2023 Apr; ?(?):. doi: 10.1016/j.actbio.2023.04.003. [PMID: 37040813]
  • Meng Yuan, Qian Wu, Mingyang Zhang, Minshan Lai, Wenbo Chen, Jianfeng Yang, Li Jiang, Ji Cao. Disulfiram enhances the antitumor activity of cisplatin by inhibiting the Fanconi anemia repair pathway. Journal of Zhejiang University. Science. B. 2023 Mar; 24(3):207-220. doi: 10.1631/jzus.b2200405. [PMID: 36915997]
  • Xue-Xia Yuan, You-Fa Duan, Chunxiang Luo, Lu Li, Meng-Jie Yang, Ting-Yu Liu, Zhi-Rui Cao, Wenlin Huang, Xianzhang Bu, Xin Yue, Ran-Yi Liu. Disulfiram enhances cisplatin cytotoxicity by forming a novel platinum chelate Pt(DDTC)3. Biochemical pharmacology. 2023 Mar; 211(?):115498. doi: 10.1016/j.bcp.2023.115498. [PMID: 36913990]
  • Jin-Pin Liu, Si-Yu Cen, Zian Xue, Tian-Xiang Wang, Yun Gao, Jia Zheng, Cheng Zhang, Junchi Hu, Shenyou Nie, Yue Xiong, Kun-Liang Guan, Hai-Xin Yuan. A Class of Disulfide Compounds Suppresses Ferroptosis by Stabilizing GPX4. ACS chemical biology. 2022 12; 17(12):3389-3406. doi: 10.1021/acschembio.2c00445. [PMID: 36446024]
  • Qiaofeng Li, Yu Chao, Bo Liu, Zhisheng Xiao, Zhijuan Yang, Yuzhe Wu, Zhuang Liu. Disulfiram loaded calcium phosphate nanoparticles for enhanced cancer immunotherapy. Biomaterials. 2022 12; 291(?):121880. doi: 10.1016/j.biomaterials.2022.121880. [PMID: 36334355]
  • Qiaoting Cai, Zhaoxing Sun, Sujuan Xu, Xiaoyan Jiao, Shulan Guo, Yingxiang Li, Huan Wu, Xiaofang Yu. Disulfiram ameliorates ischemia/reperfusion-induced acute kidney injury by suppressing the caspase-11-GSDMD pathway. Renal failure. 2022 Dec; 44(1):1169-1181. doi: 10.1080/0886022x.2022.2098764. [PMID: 35837696]
  • Camila Meirelles S Silva, Carlos Wagner S Wanderley, Flavio Protasio Veras, Augusto Velozo Gonçalves, Mikhael Haruo Fernandes Lima, Juliana Escher Toller-Kawahisa, Giovanni Freitas Gomes, Daniele Carvalho Nascimento, Valter V Silva Monteiro, Isadora Marques Paiva, Cícero José Luíz Ramos Almeida, Diego Brito Caetité, Juliana Costa Silva, Maria Isabel Fernandes Lopes, Letícia Pastorelli Bonjorno, Marcela Cavichioli Giannini, Natalia Brasil Amaral, Maíra Nilson Benatti, Rodrigo Carvalho Santana, Luis Eduardo Alves Damasceno, Bruna Manuella Souza Silva, Ayda Henriques Schneider, Icaro Maia Santos Castro, Juan Carlo Santos Silva, Amanda Pereira Vasconcelos, Tiago Tomazini Gonçalves, Sabrina Setembre Batah, Tamara Silva Rodrigues, Victor Ferreira Costa, Marjorie Cornejo Pontelli, Ronaldo B Martins, Timna Varela Martins, Danillo Lucas Alves Espósito, Guilherme Cesar Martelossi Cebinelli, Benedito Antônio Lopes da Fonseca, Luiz Osório Silveira Leiria, Larissa Dias Cunha, Eurico Arruda, Helder I Nakaia, Alexandre Todorovic Fabro, Rene D R Oliveira, Dario S Zamboni, Paulo Louzada-Junior, Thiago Mattar Cunha, José Carlos Farias Alves-Filho, Fernando Queiroz Cunha. Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathology. Critical care (London, England). 2022 07; 26(1):206. doi: 10.1186/s13054-022-04062-5. [PMID: 35799268]
  • Jiana Huang, Peigen Chen, Yuting Xiang, Qiqi Liang, Taibao Wu, Jiawen Liu, Yanyan Zeng, Haitao Zeng, Xiaoyan Liang, Chuanchuan Zhou. Gut microbiota dysbiosis-derived macrophage pyroptosis causes polycystic ovary syndrome via steroidogenesis disturbance and apoptosis of granulosa cells. International immunopharmacology. 2022 Jun; 107(?):108717. doi: 10.1016/j.intimp.2022.108717. [PMID: 35334358]
  • Mohd Aslam Saifi, Arbaz Sujat Shaikh, Venkata Rao Kaki, Chandraiah Godugu. Disulfiram prevents collagen crosslinking and inhibits renal fibrosis by inhibiting lysyl oxidase enzymes. Journal of cellular physiology. 2022 05; 237(5):2516-2527. doi: 10.1002/jcp.30717. [PMID: 35285015]
  • Tian Zhang, Julie Kephart, Elizabeth Bronson, Monika Anand, Christine Daly, Ivan Spasojevic, Subha Bakthavatsalam, Katherine Franz, Hannah Berg, Georgia S Karachaliou, Olga G James, Lauren Howard, Susan Halabi, Michael R Harrison, Andrew J Armstrong, Daniel J George. Prospective clinical trial of disulfiram plus copper in men with metastatic castration-resistant prostate cancer. The Prostate. 2022 05; 82(7):858-866. doi: 10.1002/pros.24329. [PMID: 35286730]
  • Chuyi Tan, Bridgette Reilly, Alok Jha, Atsushi Murao, Yongchan Lee, Max Brenner, Monowar Aziz, Ping Wang. Active Release of eCIRP via Gasdermin D Channels to Induce Inflammation in Sepsis. Journal of immunology (Baltimore, Md. : 1950). 2022 05; 208(9):2184-2195. doi: 10.4049/jimmunol.2101004. [PMID: 35418465]
  • Shanshan Wei, Zijun Xiao, Jie Huang, Zhenyu Peng, Bikui Zhang, Wenqun Li. Disulfiram inhibits oxidative stress and NLRP3 inflammasome activation to prevent LPS-induced cardiac injury. International immunopharmacology. 2022 Apr; 105(?):108545. doi: 10.1016/j.intimp.2022.108545. [PMID: 35091339]
  • Tereza Buchtova, Zdenek Skrott, Katarina Chroma, Jiri Rehulka, Petr Dzubak, Marian Hajduch, David Lukac, Stefanos Arampatzis, Jiri Bartek, Martin Mistrik. Cannabidiol-induced activation of the metallothionein pathway impedes anticancer effects of disulfiram and its metabolite CuET. Molecular oncology. 2022 04; 16(7):1541-1554. doi: 10.1002/1878-0261.13114. [PMID: 34632694]
  • Jose M Adrover, Lucia Carrau, Juliane Daßler-Plenker, Yaron Bram, Vasuretha Chandar, Sean Houghton, David Redmond, Joseph R Merrill, Margaret Shevik, Benjamin R tenOever, Scott K Lyons, Robert E Schwartz, Mikala Egeblad. Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection. JCI insight. 2022 03; 7(5):. doi: 10.1172/jci.insight.157342. [PMID: 35133984]
  • Chenchen Xie, Jin Yan, Siyuan Cao, Ri Liu, Baishun Sun, Ying Xie, Kaige Qu, Wenxiao Zhang, Zhankun Weng, Zuobin Wang. Bi-layered disulfiram-loaded fiber membranes with antibacterial properties for wound dressing. Applied biochemistry and biotechnology. 2022 Mar; 194(3):1359-1372. doi: 10.1007/s12010-021-03663-0. [PMID: 34714499]
  • Xing Wang, Shenglan Yang, Huijing Ye, Jingqiao Chen, Lu Shi, Lujia Feng, Xiandai Wang, Te Zhang, Rongxin Chen, Wei Xiao, Huasheng Yang. Disulfiram Exerts Antiadipogenic, Anti-Inflammatory, and Antifibrotic Therapeutic Effects in an In Vitro Model of Graves' Orbitopathy. Thyroid : official journal of the American Thyroid Association. 2022 03; 32(3):294-305. doi: 10.1089/thy.2021.0246. [PMID: 34605662]
  • Jie Huang, Shanshan Wei, Zhenyu Peng, Zijun Xiao, Yuanying Yang, Jiaqin Liu, Bikui Zhang, Wenqun Li. Disulfiram attenuates lipopolysaccharide-induced acute kidney injury by suppressing oxidative stress and NLRP3 inflammasome activation in mice. The Journal of pharmacy and pharmacology. 2022 Feb; 74(2):259-267. doi: 10.1093/jpp/rgab171. [PMID: 34923585]
  • Jian-Wei Zhang, Yuan Xiong, Feng Wang, Fu-Mao Zhang, Xiaodi Yang, Guo-Qiang Lin, Ping Tian, Guangbo Ge, Dingding Gao. Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CLpro inhibitors for treating COVID-19. European journal of medicinal chemistry. 2022 Jan; 228(?):114030. doi: 10.1016/j.ejmech.2021.114030. [PMID: 34883292]
  • Yawara Kawano, Takayuki Sasano, Yuichiro Arima, Saki Kushima, Kenichi Tsujita, Masao Matsuoka, Hiroyuki Hata. A novel PDK1 inhibitor, JX06, inhibits glycolysis and induces apoptosis in multiple myeloma cells. Biochemical and biophysical research communications. 2022 01; 587(?):153-159. doi: 10.1016/j.bbrc.2021.11.102. [PMID: 34875534]
  • Jing Tian, Baichuan Wang, Bin Xie, Xinwei Liu, Dapeng Zhou, Xuening Hou, Liangbi Xiang. Pyroptosis inhibition alleviates potassium oxonate- and monosodium urate-induced gouty arthritis in mice. Modern rheumatology. 2022 Jan; 32(1):221-230. doi: 10.1080/14397595.2021.1899569. [PMID: 33705241]
  • Juliana Almeida-Silva, Diego Silva Menezes, Juan Mateus Pereira Fernandes, Márcio Cerqueira Almeida, Deyvison Rhuan Vasco-Dos-Santos, Roberto Magalhães Saraiva, Alessandra Lifsitch Viçosa, Sandra Aurora Chavez Perez, Sônia Gumes Andrade, Ana Márcia Suarez-Fontes, Marcos André Vannier-Santos. The repositioned drugs disulfiram/diethyldithiocarbamate combined to benznidazole: Searching for Chagas disease selective therapy, preventing toxicity and drug resistance. Frontiers in cellular and infection microbiology. 2022; 12(?):926699. doi: 10.3389/fcimb.2022.926699. [PMID: 35967878]
  • Peng Zheng, Chenglinzi Liu, Yaoqin Wu, Ruifeng Xu, Ying Chen, Fan Hu, Zhuo Chen, Tongcun Zhang. Quantitative proteomics analysis reveals novel insights into mechanisms of action of disulfiram (DSF). Proteomics. Clinical applications. 2022 01; 16(1):e2100031. doi: 10.1002/prca.202100031. [PMID: 34542231]
  • James H McMahon, Vanessa A Evans, Jillian S Y Lau, Jori Symons, Jennifer M Zerbato, Judy Chang, Ajantha Solomon, Surekha Tennakoon, Ashanti Dantanarayana, Michelle Hagenauer, Sulggi Lee, Sarah Palmer, Katie Fisher, Namandje Bumpus, Carley J S Heck, David Burger, Guoxin Wu, Paul Zuck, Bonnie J Howell, Henrik H Zetterberg, Kaj Blennow, Magnus Gisslen, Thomas A Rasmussen, Sharon R Lewin. Neurotoxicity with high-dose disulfiram and vorinostat used for HIV latency reversal. AIDS (London, England). 2022 01; 36(1):75-82. doi: 10.1097/qad.0000000000003091. [PMID: 34586085]
  • P M Emeka, H I M Ibrahim, I A Alhaider, M A Morsy, M E Mohamed. Subchronic administration of mitoxantrone and the influence of enzyme inhibitors on its induced cardiotoxicity in mice: role of NRF-2/CYP2E1. European review for medical and pharmacological sciences. 2021 Dec; 25(24):7806-7822. doi: 10.26355/eurrev_202112_27627. [PMID: 34982442]
  • Yan Jia, Hui Xu, Qi Yu, Lishan Tan, Zuying Xiong. Identification and verification of vascular cell adhesion protein 1 as an immune-related hub gene associated with the tubulointerstitial injury in diabetic kidney disease. Bioengineered. 2021 12; 12(1):6655-6673. doi: 10.1080/21655979.2021.1976540. [PMID: 34506229]
  • Anna Taranta, Mohamed A Elmonem, Francesco Bellomo, Ester De Leo, Sara Boenzi, Manoe J Janssen, Amer Jamalpoor, Sara Cairoli, Anna Pastore, Cristiano De Stefanis, Manuela Colucci, Laura R Rega, Isabella Giovannoni, Paola Francalanci, Lambertus P van den Heuvel, Carlo Dionisi-Vici, Bianca M Goffredo, Rosalinde Masereeuw, Elena Levtchenko, Francesco Emma. Benefits and Toxicity of Disulfiram in Preclinical Models of Nephropathic Cystinosis. Cells. 2021 11; 10(12):. doi: 10.3390/cells10123294. [PMID: 34943802]
  • An-Te Ou, Jia-Xin Zhang, Yue-Fei Fang, Rong Wang, Xue-Ping Tang, Peng-Fei Zhao, Yu-Ge Zhao, Meng Zhang, Yong-Zhuo Huang. Disulfiram-loaded lactoferrin nanoparticles for treating inflammatory diseases. Acta pharmacologica Sinica. 2021 11; 42(11):1913-1920. doi: 10.1038/s41401-021-00770-w. [PMID: 34561552]
  • Yidan Sun, Chunyue An, Luyan Wu, Wenhui Zeng, Jiafeng Wang, Yanfeng Wang, Jian He, Guandao Gao, Deju Ye. Degradable FeCuS-Lipid Nanoparticles Confer Ultrasound-Activated CO Release and O2-Independent Radical Production for Synergistic Therapy. ACS nano. 2021 10; 15(10):16298-16313. doi: 10.1021/acsnano.1c05485. [PMID: 34590840]
  • Xueying Ren, Yanchun Li, Yi Zhou, Wanye Hu, Chen Yang, Qiangan Jing, Chaoting Zhou, Xu Wang, Jiayu Hu, Luyang Wang, Jing Yang, Hairui Wang, Haifeng Xu, Huanjuan Li, Xiangmin Tong, Ying Wang, Jing Du. Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis. Redox biology. 2021 10; 46(?):102122. doi: 10.1016/j.redox.2021.102122. [PMID: 34482117]
  • Luyan Xu, Jiahui Tong, Yiran Wu, Suwen Zhao, Bo-Lin Lin. A computational evaluation of targeted oxidation strategy (TOS) for potential inhibition of SARS-CoV-2 by disulfiram and analogues. Biophysical chemistry. 2021 09; 276(?):106610. doi: 10.1016/j.bpc.2021.106610. [PMID: 34089978]
  • Stefano Tamburin, Elisa Mantovani, Ernesto De Bernardis, Donato Zipeto, Fabio Lugoboni. COVID-19 and related symptoms in patients under disulfiram for alcohol use disorder. Internal and emergency medicine. 2021 09; 16(6):1729-1731. doi: 10.1007/s11739-021-02633-y. [PMID: 33464469]
  • Denisa Weiser Drozdkova, Katerina Smesny Trtkova. Possible Therapeutic Potential of Disulfiram for Multiple Myeloma. Current oncology (Toronto, Ont.). 2021 06; 28(3):2087-2096. doi: 10.3390/curroncol28030193. [PMID: 34205025]
  • Patrick S Thomas, Ellen M Nielsen, Catherine J Spellicy, Mark J Harding, An Ye, Michelle Patriquin, Sara C Hamon, Thomas R Kosten, David A Nielsen. The OPRD1 rs678849 variant influences outcome of disulfiram treatment for cocaine dependency in methadone-maintained patients. Psychiatric genetics. 2021 06; 31(3):88-94. doi: 10.1097/ypg.0000000000000279. [PMID: 33953123]
  • Jia-Ying Zhao, Kai-Rui Feng, Feng Wang, Jian-Wei Zhang, Jay Fei Cheng, Guo-Qiang Lin, Dingding Gao, Ping Tian. A retrospective overview of PHGDH and its inhibitors for regulating cancer metabolism. European journal of medicinal chemistry. 2021 May; 217(?):113379. doi: 10.1016/j.ejmech.2021.113379. [PMID: 33756126]
  • Yu Zhang, Ruicheng Zhang, Xiaohu Han. Disulfiram inhibits inflammation and fibrosis in a rat unilateral ureteral obstruction model by inhibiting gasdermin D cleavage and pyroptosis. Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 2021 May; 70(5):543-552. doi: 10.1007/s00011-021-01457-y. [PMID: 33851234]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Chao Li, Li Li, Tian Lan. Co-treatment with disulfiram and glycyrrhizic acid suppresses the inflammatory response of chondrocytes. Journal of orthopaedic surgery and research. 2021 Feb; 16(1):132. doi: 10.1186/s13018-021-02262-3. [PMID: 33579316]
  • Abhishek Ghosh, Tathagata Mahintamani, Y P S Balhara, Fazl E Roub, Debashish Basu, Subodh Bn, S K Mattoo, Eepsita Mishra, Babita Sharma. Disulfiram Ethanol Reaction with Alcohol-Based Hand Sanitizer: An Exploratory Study. Alcohol and alcoholism (Oxford, Oxfordshire). 2021 Jan; 56(1):42-46. doi: 10.1093/alcalc/agaa096. [PMID: 33150930]
  • Nathanael Fillmore, Steven Bell, Ciyue Shen, Vinh Nguyen, Jennifer La, Maureen Dubreuil, Judith Strymish, Mary Brophy, Gautam Mehta, Hao Wu, Judy Lieberman, Nhan Do, Chris Sander. Disulfiram use is associated with lower risk of COVID-19: A retrospective cohort study. PloS one. 2021; 16(10):e0259061. doi: 10.1371/journal.pone.0259061. [PMID: 34710137]
  • Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Archives of toxicology. 2020 12; 94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. [PMID: 32808185]
  • Leandro Rocha Silva, Paulo Fernando da Silva Santos-Júnior, Júlia de Andrade Brandão, Letícia Anderson, Ênio José Bassi, João Xavier de Araújo-Júnior, Sílvia Helena Cardoso, Edeildo Ferreira da Silva-Júnior. Druggable targets from coronaviruses for designing new antiviral drugs. Bioorganic & medicinal chemistry. 2020 11; 28(22):115745. doi: 10.1016/j.bmc.2020.115745. [PMID: 33007557]
  • Carmen Gil, Tiziana Ginex, Inés Maestro, Vanesa Nozal, Lucía Barrado-Gil, Miguel Ángel Cuesta-Geijo, Jesús Urquiza, David Ramírez, Covadonga Alonso, Nuria E Campillo, Ana Martinez. COVID-19: Drug Targets and Potential Treatments. Journal of medicinal chemistry. 2020 11; 63(21):12359-12386. doi: 10.1021/acs.jmedchem.0c00606. [PMID: 32511912]
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