Disulfiram (BioDeep_00000017900)
Secondary id: BioDeep_00000001685
human metabolite blood metabolite natural product
代谢物信息卡片
N,N-diethyl[(diethylcarbamothioyl)disulfanyl]carbothioamide
化学式: C10H20N2S4 (296.0509)
中文名称: 二硫化四乙基秋兰姆
谱图信息:
最多检出来源 Homo sapiens(blood) 24.77%
分子结构信息
SMILES: CCN(CC)C(=S)SSC(=S)N(CC)CC
InChI: InChI=1S/C10H20N2S4/c1-5-11(6-2)9(13)15-16-10(14)12(7-3)8-4/h5-8H2,1-4H3
描述信息
A carbamate derivative used as an alcohol deterrent. It is a relatively nontoxic substance when administered alone, but markedly alters the intermediary metabolism of alcohol. When alcohol is ingested after administration of disulfiram, blood acetaldehyde concentrations are increased, followed by flushing, systemic vasodilation, respiratory difficulties, nausea, hypotension, and other symptoms (acetaldehyde syndrome). It acts by inhibiting aldehyde dehydrogenase. [PubChem]
P - Antiparasitic products, insecticides and repellents > P03 - Ectoparasiticides, incl. scabicides, insecticides and repellents > P03A - Ectoparasiticides, incl. scabicides > P03AA - Sulfur containing products
N - Nervous system > N07 - Other nervous system drugs > N07B - Drugs used in addictive disorders > N07BB - Drugs used in alcohol dependence
C274 - Antineoplastic Agent > C163758 - Targeted Therapy Agent > C2160 - Proteasome Inhibitor
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D004791 - Enzyme Inhibitors > D065086 - Acetaldehyde Dehydrogenase Inhibitors
D002491 - Central Nervous System Agents > D000427 - Alcohol Deterrents
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor
C1744 - Multidrug Resistance Modulator
C471 - Enzyme Inhibitor
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Disulfiram (Tetraethylthiuram disulfide) is a specific inhibitor of?aldehyde-dehydrogenase (ALDH1), used for the treatment of chronic alcoholism by producing an acute sensitivity to alcohol. Disulfiram inhibits gasdermin D (GSDMD) pore formation in liposomes and inflammasome-mediated pyroptosis and IL-1β secretion in human and mouse cells. Disulfiram, a copper ion carrier,?with?Cu2+ increases intracellular ROS levels and induces cuproptosis[1][2][3][4][5][6].
同义名列表
41 个代谢物同义名
N,N-diethyl[(diethylcarbamothioyl)disulfanyl]carbothioamide; Tetraethylthioperoxydicarbonic diamide, ((H2N)C(S))2S2; 1,1-Dithiobis(N,N-diethylthioformamide); Tetraethylthioperoxydicarbonic diamide; Sanofi synthelabo brand OF disulfiram; N,N,N,n-tetraethylthiuram disulphide; Bis(diethylthiocarbamoyl) disulphide; N,N,N,n-tetraethylthiuram disulfide; Bis(diethylthiocarbamoyl) disulfide; Altana pharma brand OF disulfiram; Disulfide, tetraethylthiuram; Tetraethylthiuram disulphide; Odyssey brand OF disulfiram; Tetraethylthiuran disulfide; Tetraethylthiram disulphide; Tetraethylthiuram disulfide; Allphar brand OF disulfiram; Tetraethylthiram disulfide; Orphan brand OF disulfiram; Tetraethylthiuram sulfide; Dumex brand OF disulfiram; Bohm brand OF disulfiram; Dupont fungicide 4472; Tetraethylthiuram; Disulphiram; Disulphuram; Disulfuram; disulfiram; Dupon 4472; Alcophobin; Usaf b-33; Antabuse; Dicupral; Teturam; Antabus; Anticol; Esperal; TETD; TATD; TTD; Disulfiram
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:4659
- KEGG: C01692
- PubChem: 3117
- HMDB: HMDB0014960
- DrugBank: DB00822
- ChEMBL: CHEMBL964
- Wikipedia: Disulfiram
- MeSH: Disulfiram
- chemspider: 3005
- CAS: 97-77-8
- PMhub: MS000000980
- ChEBI: CHEBI:173763
- PubChem: 4833
- NIKKAJI: J3.980B
- RefMet: Disulfiram
- medchemexpress: HY-B0240
- KNApSAcK: 173763
- LOTUS: LTS0022946
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
9 个相关的物种来源信息
- 155619 - Agaricomycetes: LTS0022946
- 5204 - Basidiomycota: LTS0022946
- 184431 - Coprinopsis: LTS0022946
- 71694 - Coprinopsis atramentaria: 10.1135/CCCC19570331
- 71694 - Coprinopsis atramentaria: LTS0022946
- 2759 - Eukaryota: LTS0022946
- 4751 - Fungi: LTS0022946
- 9606 - Homo sapiens: -
- 184208 - Psathyrellaceae: LTS0022946
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Wei Guo, Lin Jia, Ling Xie, Juliann G Kiang, Yangyang Wang, Fengfei Sun, Zunwen Lin, Enwen Wang, Yida Zhang, Peigen Huang, Ting Sun, Xiao Zhang, Zhengying Bian, Tiejun Tang, Jingtian Guo, Soldano Ferrone, Xinhui Wang. Turning anecdotal irradiation-induced anticancer immune responses into reproducible in situ cancer vaccines via disulfiram/copper-mediated enhanced immunogenic cell death of breast cancer cells.
Cell death & disease.
2024 Apr; 15(4):298. doi:
10.1038/s41419-024-06644-3. [PMID: 38678042] - Zhenhu Guo, Xiaohan Gao, Jingsong Lu, Ying Li, Zeping Jin, Abdul Fahad, Neema Ufurahi Pambe, Hirotaka Ejima, Xiaodan Sun, Xiumei Wang, Wensheng Xie, Guifeng Zhang, Lingyun Zhao. Apoptosis and Paraptosis Induced by Disulfiram-Loaded Ca2+/Cu2+ Dual-Ions Nano Trap for Breast Cancer Treatment.
ACS nano.
2024 Mar; 18(9):6975-6989. doi:
10.1021/acsnano.3c10173. [PMID: 38377439] - Ping Zhang, Chaoting Zhou, Xueying Ren, Qiangan Jing, Yan Gao, Chen Yang, Yuhuan Shen, Yi Zhou, Wanye Hu, Feifan Jin, Haifeng Xu, Lingyan Yu, Yingchao Liu, Xiangmin Tong, Yanchun Li, Ying Wang, Jing Du. Inhibiting the compensatory elevation of xCT collaborates with disulfiram/copper-induced GSH consumption for cascade ferroptosis and cuproptosis.
Redox biology.
2024 Feb; 69(?):103007. doi:
10.1016/j.redox.2023.103007. [PMID: 38150993] - Jinyan Lin, Cailin Huang, Peiyuan Wang, Yueyang He, Qiang Luo, Xiaolong Liu, Yang Li. Tumor-Microenvironment-Responsive Cerium-Enriched Copper Nanozyme with O2 Supply and Oxidative Stress Amplification for In Situ Disulfiram Chemotherapy and Chemodynamic Therapy Intensification.
Advanced healthcare materials.
2024 Jan; ?(?):e2303955. doi:
10.1002/adhm.202303955. [PMID: 38271271] - Luca Mazzei, Arundhati Paul, Michele Cianci, Marta Devodier, Davide Mandelli, Paolo Carloni, Stefano Ciurli. Kinetic and structural details of urease inactivation by thiuram disulphides.
Journal of inorganic biochemistry.
2023 Oct; 250(?):112398. doi:
10.1016/j.jinorgbio.2023.112398. [PMID: 37879152] - Meiran Chu, Xinglan An, Cong Fu, Hao Yu, Daoyu Zhang, Qi Li, Xiaxia Man, Xiangpeng Dai, Ziyi Li. Disulfiram/Copper Induce Ferroptosis in Triple-Negative Breast Cancer Cell Line MDA-MB-231.
Frontiers in bioscience (Landmark edition).
2023 08; 28(8):186. doi:
10.31083/j.fbl2808186. [PMID: 37664913] - Yanjuan Zhao, Shujin Zhu. Nrf2/HO-1 Alleviates Disulfiram/Copper-Induced Ferroptosis in Oral Squamous Cell Carcinoma.
Biochemical genetics.
2023 Jun; ?(?):. doi:
10.1007/s10528-023-10405-w. [PMID: 37286868] - Jia Guo, Jinyun Shi, Min Qin, Yan Wang, Zhidong Li, Takahiro Shoji, Toru Ikezoe, Yingbin Ge, Baohui Xu. Pharmacological Inhibition of Gasdermin D Suppresses Angiotensin II-Induced Experimental Abdominal Aortic Aneurysms.
Biomolecules.
2023 05; 13(6):. doi:
10.3390/biom13060899. [PMID: 37371479] - Cheng Ni, Zhijun Ouyang, Gaoming Li, Junjie Liu, Xueyan Cao, Linfeng Zheng, Xiangyang Shi, Rui Guo. A tumor microenvironment-responsive core-shell tecto dendrimer nanoplatform for magnetic resonance imaging-guided and cuproptosis-promoted chemo-chemodynamic therapy.
Acta biomaterialia.
2023 Apr; ?(?):. doi:
10.1016/j.actbio.2023.04.003. [PMID: 37040813] - Meng Yuan, Qian Wu, Mingyang Zhang, Minshan Lai, Wenbo Chen, Jianfeng Yang, Li Jiang, Ji Cao. Disulfiram enhances the antitumor activity of cisplatin by inhibiting the Fanconi anemia repair pathway.
Journal of Zhejiang University. Science. B.
2023 Mar; 24(3):207-220. doi:
10.1631/jzus.b2200405. [PMID: 36915997] - Xue-Xia Yuan, You-Fa Duan, Chunxiang Luo, Lu Li, Meng-Jie Yang, Ting-Yu Liu, Zhi-Rui Cao, Wenlin Huang, Xianzhang Bu, Xin Yue, Ran-Yi Liu. Disulfiram enhances cisplatin cytotoxicity by forming a novel platinum chelate Pt(DDTC)3.
Biochemical pharmacology.
2023 Mar; 211(?):115498. doi:
10.1016/j.bcp.2023.115498. [PMID: 36913990] - Jin-Pin Liu, Si-Yu Cen, Zian Xue, Tian-Xiang Wang, Yun Gao, Jia Zheng, Cheng Zhang, Junchi Hu, Shenyou Nie, Yue Xiong, Kun-Liang Guan, Hai-Xin Yuan. A Class of Disulfide Compounds Suppresses Ferroptosis by Stabilizing GPX4.
ACS chemical biology.
2022 12; 17(12):3389-3406. doi:
10.1021/acschembio.2c00445. [PMID: 36446024] - Qiaofeng Li, Yu Chao, Bo Liu, Zhisheng Xiao, Zhijuan Yang, Yuzhe Wu, Zhuang Liu. Disulfiram loaded calcium phosphate nanoparticles for enhanced cancer immunotherapy.
Biomaterials.
2022 12; 291(?):121880. doi:
10.1016/j.biomaterials.2022.121880. [PMID: 36334355] - Qiaoting Cai, Zhaoxing Sun, Sujuan Xu, Xiaoyan Jiao, Shulan Guo, Yingxiang Li, Huan Wu, Xiaofang Yu. Disulfiram ameliorates ischemia/reperfusion-induced acute kidney injury by suppressing the caspase-11-GSDMD pathway.
Renal failure.
2022 Dec; 44(1):1169-1181. doi:
10.1080/0886022x.2022.2098764. [PMID: 35837696] - Camila Meirelles S Silva, Carlos Wagner S Wanderley, Flavio Protasio Veras, Augusto Velozo Gonçalves, Mikhael Haruo Fernandes Lima, Juliana Escher Toller-Kawahisa, Giovanni Freitas Gomes, Daniele Carvalho Nascimento, Valter V Silva Monteiro, Isadora Marques Paiva, Cícero José Luíz Ramos Almeida, Diego Brito Caetité, Juliana Costa Silva, Maria Isabel Fernandes Lopes, Letícia Pastorelli Bonjorno, Marcela Cavichioli Giannini, Natalia Brasil Amaral, Maíra Nilson Benatti, Rodrigo Carvalho Santana, Luis Eduardo Alves Damasceno, Bruna Manuella Souza Silva, Ayda Henriques Schneider, Icaro Maia Santos Castro, Juan Carlo Santos Silva, Amanda Pereira Vasconcelos, Tiago Tomazini Gonçalves, Sabrina Setembre Batah, Tamara Silva Rodrigues, Victor Ferreira Costa, Marjorie Cornejo Pontelli, Ronaldo B Martins, Timna Varela Martins, Danillo Lucas Alves Espósito, Guilherme Cesar Martelossi Cebinelli, Benedito Antônio Lopes da Fonseca, Luiz Osório Silveira Leiria, Larissa Dias Cunha, Eurico Arruda, Helder I Nakaia, Alexandre Todorovic Fabro, Rene D R Oliveira, Dario S Zamboni, Paulo Louzada-Junior, Thiago Mattar Cunha, José Carlos Farias Alves-Filho, Fernando Queiroz Cunha. Gasdermin-D activation by SARS-CoV-2 triggers NET and mediate COVID-19 immunopathology.
Critical care (London, England).
2022 07; 26(1):206. doi:
10.1186/s13054-022-04062-5. [PMID: 35799268] - Jiana Huang, Peigen Chen, Yuting Xiang, Qiqi Liang, Taibao Wu, Jiawen Liu, Yanyan Zeng, Haitao Zeng, Xiaoyan Liang, Chuanchuan Zhou. Gut microbiota dysbiosis-derived macrophage pyroptosis causes polycystic ovary syndrome via steroidogenesis disturbance and apoptosis of granulosa cells.
International immunopharmacology.
2022 Jun; 107(?):108717. doi:
10.1016/j.intimp.2022.108717. [PMID: 35334358] - Mohd Aslam Saifi, Arbaz Sujat Shaikh, Venkata Rao Kaki, Chandraiah Godugu. Disulfiram prevents collagen crosslinking and inhibits renal fibrosis by inhibiting lysyl oxidase enzymes.
Journal of cellular physiology.
2022 05; 237(5):2516-2527. doi:
10.1002/jcp.30717. [PMID: 35285015] - Tian Zhang, Julie Kephart, Elizabeth Bronson, Monika Anand, Christine Daly, Ivan Spasojevic, Subha Bakthavatsalam, Katherine Franz, Hannah Berg, Georgia S Karachaliou, Olga G James, Lauren Howard, Susan Halabi, Michael R Harrison, Andrew J Armstrong, Daniel J George. Prospective clinical trial of disulfiram plus copper in men with metastatic castration-resistant prostate cancer.
The Prostate.
2022 05; 82(7):858-866. doi:
10.1002/pros.24329. [PMID: 35286730] - Chuyi Tan, Bridgette Reilly, Alok Jha, Atsushi Murao, Yongchan Lee, Max Brenner, Monowar Aziz, Ping Wang. Active Release of eCIRP via Gasdermin D Channels to Induce Inflammation in Sepsis.
Journal of immunology (Baltimore, Md. : 1950).
2022 05; 208(9):2184-2195. doi:
10.4049/jimmunol.2101004. [PMID: 35418465] - Shanshan Wei, Zijun Xiao, Jie Huang, Zhenyu Peng, Bikui Zhang, Wenqun Li. Disulfiram inhibits oxidative stress and NLRP3 inflammasome activation to prevent LPS-induced cardiac injury.
International immunopharmacology.
2022 Apr; 105(?):108545. doi:
10.1016/j.intimp.2022.108545. [PMID: 35091339] - Tereza Buchtova, Zdenek Skrott, Katarina Chroma, Jiri Rehulka, Petr Dzubak, Marian Hajduch, David Lukac, Stefanos Arampatzis, Jiri Bartek, Martin Mistrik. Cannabidiol-induced activation of the metallothionein pathway impedes anticancer effects of disulfiram and its metabolite CuET.
Molecular oncology.
2022 04; 16(7):1541-1554. doi:
10.1002/1878-0261.13114. [PMID: 34632694] - Jose M Adrover, Lucia Carrau, Juliane Daßler-Plenker, Yaron Bram, Vasuretha Chandar, Sean Houghton, David Redmond, Joseph R Merrill, Margaret Shevik, Benjamin R tenOever, Scott K Lyons, Robert E Schwartz, Mikala Egeblad. Disulfiram inhibits neutrophil extracellular trap formation and protects rodents from acute lung injury and SARS-CoV-2 infection.
JCI insight.
2022 03; 7(5):. doi:
10.1172/jci.insight.157342. [PMID: 35133984] - Chenchen Xie, Jin Yan, Siyuan Cao, Ri Liu, Baishun Sun, Ying Xie, Kaige Qu, Wenxiao Zhang, Zhankun Weng, Zuobin Wang. Bi-layered disulfiram-loaded fiber membranes with antibacterial properties for wound dressing.
Applied biochemistry and biotechnology.
2022 Mar; 194(3):1359-1372. doi:
10.1007/s12010-021-03663-0. [PMID: 34714499] - Xing Wang, Shenglan Yang, Huijing Ye, Jingqiao Chen, Lu Shi, Lujia Feng, Xiandai Wang, Te Zhang, Rongxin Chen, Wei Xiao, Huasheng Yang. Disulfiram Exerts Antiadipogenic, Anti-Inflammatory, and Antifibrotic Therapeutic Effects in an In Vitro Model of Graves' Orbitopathy.
Thyroid : official journal of the American Thyroid Association.
2022 03; 32(3):294-305. doi:
10.1089/thy.2021.0246. [PMID: 34605662] - Jie Huang, Shanshan Wei, Zhenyu Peng, Zijun Xiao, Yuanying Yang, Jiaqin Liu, Bikui Zhang, Wenqun Li. Disulfiram attenuates lipopolysaccharide-induced acute kidney injury by suppressing oxidative stress and NLRP3 inflammasome activation in mice.
The Journal of pharmacy and pharmacology.
2022 Feb; 74(2):259-267. doi:
10.1093/jpp/rgab171. [PMID: 34923585] - Jian-Wei Zhang, Yuan Xiong, Feng Wang, Fu-Mao Zhang, Xiaodi Yang, Guo-Qiang Lin, Ping Tian, Guangbo Ge, Dingding Gao. Discovery of 9,10-dihydrophenanthrene derivatives as SARS-CoV-2 3CLpro inhibitors for treating COVID-19.
European journal of medicinal chemistry.
2022 Jan; 228(?):114030. doi:
10.1016/j.ejmech.2021.114030. [PMID: 34883292] - Yawara Kawano, Takayuki Sasano, Yuichiro Arima, Saki Kushima, Kenichi Tsujita, Masao Matsuoka, Hiroyuki Hata. A novel PDK1 inhibitor, JX06, inhibits glycolysis and induces apoptosis in multiple myeloma cells.
Biochemical and biophysical research communications.
2022 01; 587(?):153-159. doi:
10.1016/j.bbrc.2021.11.102. [PMID: 34875534] - Jing Tian, Baichuan Wang, Bin Xie, Xinwei Liu, Dapeng Zhou, Xuening Hou, Liangbi Xiang. Pyroptosis inhibition alleviates potassium oxonate- and monosodium urate-induced gouty arthritis in mice.
Modern rheumatology.
2022 Jan; 32(1):221-230. doi:
10.1080/14397595.2021.1899569. [PMID: 33705241] - Juliana Almeida-Silva, Diego Silva Menezes, Juan Mateus Pereira Fernandes, Márcio Cerqueira Almeida, Deyvison Rhuan Vasco-Dos-Santos, Roberto Magalhães Saraiva, Alessandra Lifsitch Viçosa, Sandra Aurora Chavez Perez, Sônia Gumes Andrade, Ana Márcia Suarez-Fontes, Marcos André Vannier-Santos. The repositioned drugs disulfiram/diethyldithiocarbamate combined to benznidazole: Searching for Chagas disease selective therapy, preventing toxicity and drug resistance.
Frontiers in cellular and infection microbiology.
2022; 12(?):926699. doi:
10.3389/fcimb.2022.926699. [PMID: 35967878] - Peng Zheng, Chenglinzi Liu, Yaoqin Wu, Ruifeng Xu, Ying Chen, Fan Hu, Zhuo Chen, Tongcun Zhang. Quantitative proteomics analysis reveals novel insights into mechanisms of action of disulfiram (DSF).
Proteomics. Clinical applications.
2022 01; 16(1):e2100031. doi:
10.1002/prca.202100031. [PMID: 34542231] - James H McMahon, Vanessa A Evans, Jillian S Y Lau, Jori Symons, Jennifer M Zerbato, Judy Chang, Ajantha Solomon, Surekha Tennakoon, Ashanti Dantanarayana, Michelle Hagenauer, Sulggi Lee, Sarah Palmer, Katie Fisher, Namandje Bumpus, Carley J S Heck, David Burger, Guoxin Wu, Paul Zuck, Bonnie J Howell, Henrik H Zetterberg, Kaj Blennow, Magnus Gisslen, Thomas A Rasmussen, Sharon R Lewin. Neurotoxicity with high-dose disulfiram and vorinostat used for HIV latency reversal.
AIDS (London, England).
2022 01; 36(1):75-82. doi:
10.1097/qad.0000000000003091. [PMID: 34586085] - P M Emeka, H I M Ibrahim, I A Alhaider, M A Morsy, M E Mohamed. Subchronic administration of mitoxantrone and the influence of enzyme inhibitors on its induced cardiotoxicity in mice: role of NRF-2/CYP2E1.
European review for medical and pharmacological sciences.
2021 Dec; 25(24):7806-7822. doi:
10.26355/eurrev_202112_27627. [PMID: 34982442] - Yan Jia, Hui Xu, Qi Yu, Lishan Tan, Zuying Xiong. Identification and verification of vascular cell adhesion protein 1 as an immune-related hub gene associated with the tubulointerstitial injury in diabetic kidney disease.
Bioengineered.
2021 12; 12(1):6655-6673. doi:
10.1080/21655979.2021.1976540. [PMID: 34506229] - Anna Taranta, Mohamed A Elmonem, Francesco Bellomo, Ester De Leo, Sara Boenzi, Manoe J Janssen, Amer Jamalpoor, Sara Cairoli, Anna Pastore, Cristiano De Stefanis, Manuela Colucci, Laura R Rega, Isabella Giovannoni, Paola Francalanci, Lambertus P van den Heuvel, Carlo Dionisi-Vici, Bianca M Goffredo, Rosalinde Masereeuw, Elena Levtchenko, Francesco Emma. Benefits and Toxicity of Disulfiram in Preclinical Models of Nephropathic Cystinosis.
Cells.
2021 11; 10(12):. doi:
10.3390/cells10123294. [PMID: 34943802] - An-Te Ou, Jia-Xin Zhang, Yue-Fei Fang, Rong Wang, Xue-Ping Tang, Peng-Fei Zhao, Yu-Ge Zhao, Meng Zhang, Yong-Zhuo Huang. Disulfiram-loaded lactoferrin nanoparticles for treating inflammatory diseases.
Acta pharmacologica Sinica.
2021 11; 42(11):1913-1920. doi:
10.1038/s41401-021-00770-w. [PMID: 34561552] - Yidan Sun, Chunyue An, Luyan Wu, Wenhui Zeng, Jiafeng Wang, Yanfeng Wang, Jian He, Guandao Gao, Deju Ye. Degradable FeCuS-Lipid Nanoparticles Confer Ultrasound-Activated CO Release and O2-Independent Radical Production for Synergistic Therapy.
ACS nano.
2021 10; 15(10):16298-16313. doi:
10.1021/acsnano.1c05485. [PMID: 34590840] - Xueying Ren, Yanchun Li, Yi Zhou, Wanye Hu, Chen Yang, Qiangan Jing, Chaoting Zhou, Xu Wang, Jiayu Hu, Luyang Wang, Jing Yang, Hairui Wang, Haifeng Xu, Huanjuan Li, Xiangmin Tong, Ying Wang, Jing Du. Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis.
Redox biology.
2021 10; 46(?):102122. doi:
10.1016/j.redox.2021.102122. [PMID: 34482117] - Luyan Xu, Jiahui Tong, Yiran Wu, Suwen Zhao, Bo-Lin Lin. A computational evaluation of targeted oxidation strategy (TOS) for potential inhibition of SARS-CoV-2 by disulfiram and analogues.
Biophysical chemistry.
2021 09; 276(?):106610. doi:
10.1016/j.bpc.2021.106610. [PMID: 34089978] - Stefano Tamburin, Elisa Mantovani, Ernesto De Bernardis, Donato Zipeto, Fabio Lugoboni. COVID-19 and related symptoms in patients under disulfiram for alcohol use disorder.
Internal and emergency medicine.
2021 09; 16(6):1729-1731. doi:
10.1007/s11739-021-02633-y. [PMID: 33464469] - Denisa Weiser Drozdkova, Katerina Smesny Trtkova. Possible Therapeutic Potential of Disulfiram for Multiple Myeloma.
Current oncology (Toronto, Ont.).
2021 06; 28(3):2087-2096. doi:
10.3390/curroncol28030193. [PMID: 34205025] - Patrick S Thomas, Ellen M Nielsen, Catherine J Spellicy, Mark J Harding, An Ye, Michelle Patriquin, Sara C Hamon, Thomas R Kosten, David A Nielsen. The OPRD1 rs678849 variant influences outcome of disulfiram treatment for cocaine dependency in methadone-maintained patients.
Psychiatric genetics.
2021 06; 31(3):88-94. doi:
10.1097/ypg.0000000000000279. [PMID: 33953123] - Jia-Ying Zhao, Kai-Rui Feng, Feng Wang, Jian-Wei Zhang, Jay Fei Cheng, Guo-Qiang Lin, Dingding Gao, Ping Tian. A retrospective overview of PHGDH and its inhibitors for regulating cancer metabolism.
European journal of medicinal chemistry.
2021 May; 217(?):113379. doi:
10.1016/j.ejmech.2021.113379. [PMID: 33756126] - Yu Zhang, Ruicheng Zhang, Xiaohu Han. Disulfiram inhibits inflammation and fibrosis in a rat unilateral ureteral obstruction model by inhibiting gasdermin D cleavage and pyroptosis.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2021 May; 70(5):543-552. doi:
10.1007/s00011-021-01457-y. [PMID: 33851234] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Chao Li, Li Li, Tian Lan. Co-treatment with disulfiram and glycyrrhizic acid suppresses the inflammatory response of chondrocytes.
Journal of orthopaedic surgery and research.
2021 Feb; 16(1):132. doi:
10.1186/s13018-021-02262-3. [PMID: 33579316] - Abhishek Ghosh, Tathagata Mahintamani, Y P S Balhara, Fazl E Roub, Debashish Basu, Subodh Bn, S K Mattoo, Eepsita Mishra, Babita Sharma. Disulfiram Ethanol Reaction with Alcohol-Based Hand Sanitizer: An Exploratory Study.
Alcohol and alcoholism (Oxford, Oxfordshire).
2021 Jan; 56(1):42-46. doi:
10.1093/alcalc/agaa096. [PMID: 33150930] - Nathanael Fillmore, Steven Bell, Ciyue Shen, Vinh Nguyen, Jennifer La, Maureen Dubreuil, Judith Strymish, Mary Brophy, Gautam Mehta, Hao Wu, Judy Lieberman, Nhan Do, Chris Sander. Disulfiram use is associated with lower risk of COVID-19: A retrospective cohort study.
PloS one.
2021; 16(10):e0259061. doi:
10.1371/journal.pone.0259061. [PMID: 34710137] - Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue.
Archives of toxicology.
2020 12; 94(12):4037-4041. doi:
10.1007/s00204-020-02869-1. [PMID: 32808185] - Leandro Rocha Silva, Paulo Fernando da Silva Santos-Júnior, Júlia de Andrade Brandão, Letícia Anderson, Ênio José Bassi, João Xavier de Araújo-Júnior, Sílvia Helena Cardoso, Edeildo Ferreira da Silva-Júnior. Druggable targets from coronaviruses for designing new antiviral drugs.
Bioorganic & medicinal chemistry.
2020 11; 28(22):115745. doi:
10.1016/j.bmc.2020.115745. [PMID: 33007557] - Carmen Gil, Tiziana Ginex, Inés Maestro, Vanesa Nozal, Lucía Barrado-Gil, Miguel Ángel Cuesta-Geijo, Jesús Urquiza, David Ramírez, Covadonga Alonso, Nuria E Campillo, Ana Martinez. COVID-19: Drug Targets and Potential Treatments.
Journal of medicinal chemistry.
2020 11; 63(21):12359-12386. doi:
10.1021/acs.jmedchem.0c00606. [PMID: 32511912] - Peter M Meggyesy, Shashank Masaldan, Sharnel A S Clatworthy, Irene Volitakis, Daniel J Eyckens, Kathryn Aston-Mourney, Michael A Cater. Copper Ionophores as Novel Antiobesity Therapeutics.
Molecules (Basel, Switzerland).
2020 Oct; 25(21):. doi:
10.3390/molecules25214957. [PMID: 33120881] - Yi-Xiang Xu, Yun-Yuan Huang, Rong-Rong Song, Yan-Liang Ren, Xin Chen, Chao Zhang, Fei Mao, Xiao-Kang Li, Jin Zhu, Shuai-Shuai Ni, Jian Wan, Jian Li. Development of disulfide-derived fructose-1,6-bisphosphatase (FBPase) covalent inhibitors for the treatment of type 2 diabetes.
European journal of medicinal chemistry.
2020 Oct; 203(?):112500. doi:
10.1016/j.ejmech.2020.112500. [PMID: 32711108] - Yatan Pal Singh Balhara, Swarndeep Singh, Parul Narang. Effect of lockdown following COVID-19 pandemic on alcohol use and help-seeking behavior: Observations and insights from a sample of alcohol use disorder patients under treatment from a tertiary care center.
Psychiatry and clinical neurosciences.
2020 08; 74(8):440-441. doi:
10.1111/pcn.13075. [PMID: 32463127] - Jun Jacob Hu, Xing Liu, Shiyu Xia, Zhibin Zhang, Ying Zhang, Jingxia Zhao, Jianbin Ruan, Xuemei Luo, Xiwen Lou, Yang Bai, Junhong Wang, L Robert Hollingsworth, Venkat Giri Magupalli, Li Zhao, Hongbo R Luo, Justin Kim, Judy Lieberman, Hao Wu. FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation.
Nature immunology.
2020 07; 21(7):736-745. doi:
10.1038/s41590-020-0669-6. [PMID: 32367036] - Colin Brewer, Emmanuel Streel. Is Alcohol in Hand Sanitizers Absorbed Through the Skin or Lungs? Implications for Disulfiram Treatment.
Alcohol and alcoholism (Oxford, Oxfordshire).
2020 Jun; 55(4):354-356. doi:
10.1093/alcalc/agaa045. [PMID: 32400852] - Yunyuan Huang, Yixiang Xu, Rongrong Song, Shuaishuai Ni, Jiaqi Liu, Yanhong Xu, Yanliang Ren, Li Rao, Yingjie Wang, Lin Wei, Lingling Feng, Chen Su, Chao Peng, Jian Li, Jian Wan. Identification of the New Covalent Allosteric Binding Site of Fructose-1,6-bisphosphatase with Disulfiram Derivatives toward Glucose Reduction.
Journal of medicinal chemistry.
2020 06; 63(11):6238-6247. doi:
10.1021/acs.jmedchem.0c00699. [PMID: 32375478] - Jing Nan, Shaoran Zhang, Ping Zhan, Ling Jiang. Evaluation of Bronopol and Disulfiram as Potential Candidatus Liberibacter asiaticus Inosine 5'-Monophosphate Dehydrogenase Inhibitors by Using Molecular Docking and Enzyme Kinetic.
Molecules (Basel, Switzerland).
2020 May; 25(10):. doi:
10.3390/molecules25102313. [PMID: 32423116] - Francesca Rolle, Valeria Bincoletto, Elena Gazzano, Barbara Rolando, Giovanna Lollo, Barbara Stella, Chiara Riganti, Silvia Arpicco. Coencapsulation of disulfiram and doxorubicin in liposomes strongly reverses multidrug resistance in breast cancer cells.
International journal of pharmaceutics.
2020 Apr; 580(?):119191. doi:
10.1016/j.ijpharm.2020.119191. [PMID: 32142738] - Kelly C Falls-Hubert, Aimee L Butler, Kai Gui, Michael Anderson, Mengshi Li, Jeffrey M Stolwijk, Samuel N Rodman, Shane R Solst, Ann Tomanek-Chalkley, Charles C Searby, Val C Sheffield, Vanessa Sandfort, Hartmut Schmidt, Michael L McCormick, Brian R Wels, Bryan G Allen, Garry R Buettner, Michael K Schultz, Douglas R Spitz. Disulfiram causes selective hypoxic cancer cell toxicity and radio-chemo-sensitization via redox cycling of copper.
Free radical biology & medicine.
2020 04; 150(?):1-11. doi:
10.1016/j.freeradbiomed.2020.01.186. [PMID: 32032663] - Bipradas Roy, Suresh Selvaraj Palaniyandi. Aldehyde dehydrogenase 2 inhibition potentiates 4-hydroxy-2-nonenal induced decrease in angiogenesis of coronary endothelial cells.
Cell biochemistry and function.
2020 Apr; 38(3):290-299. doi:
10.1002/cbf.3468. [PMID: 31943249] - Hideki Ishii, Tomoteru Yamasaki, Joji Yui, Yiding Zhang, Masayuki Hanyu, Masanao Ogawa, Nobuki Nengaki, Atsushi B Tsuji, Yuya Terashima, Kouji Matsushima, Ming-Rong Zhang. Radiosynthesis of [thiocarbonyl-11C]disulfiram and its first PET study in mice.
Bioorganic & medicinal chemistry letters.
2020 03; 30(6):126998. doi:
10.1016/j.bmcl.2020.126998. [PMID: 32014383] - Garrett M Fitzmaurice, Stuart R Lipsitz, Roger D Weiss. Within-treatment frequency of use versus abstinence as a predictor of longitudinal post-treatment follow-up assessments of drug use.
Drug and alcohol dependence.
2020 03; 208(?):107857. doi:
10.1016/j.drugalcdep.2020.107857. [PMID: 31968301] - Olivia J Stephenson, Louis D Trombetta. Comparative effects of Mancozeb and Disulfiram-induced striated muscle myopathies in Long-Evans rats.
Environmental toxicology and pharmacology.
2020 Feb; 74(?):103300. doi:
10.1016/j.etap.2019.103300. [PMID: 31805476] - Haowen Li, Biao Liu, Hui Ao, Jingxin Fu, Yian Wang, Yue Feng, Yifei Guo, Xiangtao Wang. Soybean lecithin stabilizes disulfiram nanosuspensions with a high drug-loading content: remarkably improved antitumor efficacy.
Journal of nanobiotechnology.
2020 Jan; 18(1):4. doi:
10.1186/s12951-019-0565-0. [PMID: 31907045] - Hirofumi Yoshino, Yasutoshi Yamada, Hideki Enokida, Yoichi Osako, Masafumi Tsuruda, Kazuki Kuroshima, Takashi Sakaguchi, Satoshi Sugita, Shuichi Tatarano, Masayuki Nakagawa. Targeting NPL4 via drug repositioning using disulfiram for the treatment of clear cell renal cell carcinoma.
PloS one.
2020; 15(7):e0236119. doi:
10.1371/journal.pone.0236119. [PMID: 32667929] - Shraddha I Khairnar, Umesh B Mahajan, Kalpesh R Patil, Harun M Patel, Sachin D Shinde, Sameer N Goyal, Sateesh Belemkar, Shreesh Ojha, Chandragouda R Patil. Disulfiram and Its Copper Chelate Attenuate Cisplatin-Induced Acute Nephrotoxicity in Rats Via Reduction of Oxidative Stress and Inflammation.
Biological trace element research.
2020 Jan; 193(1):174-184. doi:
10.1007/s12011-019-01683-w. [PMID: 30825159] - Muhammad Asim Farooq, Md Aquib, Daulat Haleem Khan, Zahid Hussain, Anam Ahsan, Mirza Muhammad Faran Ashraf Baig, Dickson Pius Wande, Muhammad Masood Ahmad, Hafiz Muhammad Ahsan, Jiang Jiajie, Bo Wang. Recent advances in the delivery of disulfiram: a critical analysis of promising approaches to improve its pharmacokinetic profile and anticancer efficacy.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2019 Dec; 27(2):853-862. doi:
10.1007/s40199-019-00308-w. [PMID: 31758497] - Tatiana V Komarova, Ekaterina V Sheshukova, Ekaterina N Kosobokova, Vyacheslav S Kosorukov, Anastasia V Shindyapina, Fedor A Lipskerov, Polina S Shpudeiko, Tatiana E Byalik, Yuri L Dorokhov. The biological activity of bispecific trastuzumab/pertuzumab plant biosimilars may be drastically boosted by disulfiram increasing formaldehyde accumulation in cancer cells.
Scientific reports.
2019 11; 9(1):16168. doi:
10.1038/s41598-019-52507-9. [PMID: 31700025] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Theerapong Krajaejun, Tassanee Lohnoo, Wanta Yingyong, Thidarat Rujirawat, Yothin Kumsang, Passara Jongkhajornpong, Sirin Theerawatanasirikul, Weerayuth Kittichotirat, Onrapak Reamtong, Hanna Yolanda. The Repurposed Drug Disulfiram Inhibits Urease and Aldehyde Dehydrogenase and Prevents In Vitro Growth of the Oomycete Pythium insidiosum.
Antimicrobial agents and chemotherapy.
2019 08; 63(8):. doi:
10.1128/aac.00609-19. [PMID: 31138572] - June P Kampangkaew, Catherine J Spellicy, Ellen M Nielsen, Mark J Harding, An Ye, Sara C Hamon, Thomas R Kosten, David A Nielsen. Pharmacogenetic role of dopamine transporter (SLC6A3) variation on response to disulfiram treatment for cocaine addiction.
The American journal on addictions.
2019 07; 28(4):311-317. doi:
10.1111/ajad.12891. [PMID: 31087723] - Erlend Skaga, Ida Ø Skaga, Zanina Grieg, Cecilie J Sandberg, Iver A Langmoen, Einar O Vik-Mo. The efficacy of a coordinated pharmacological blockade in glioblastoma stem cells with nine repurposed drugs using the CUSP9 strategy.
Journal of cancer research and clinical oncology.
2019 Jun; 145(6):1495-1507. doi:
10.1007/s00432-019-02920-4. [PMID: 31028540] - Sulggi A Lee, Julian H Elliott, James McMahon, Wendy Hartogenesis, Namandje N Bumpus, Jeffrey D Lifson, Robert J Gorelick, Peter Bacchetti, Steven G Deeks, Sharon R Lewin, Radojka M Savic. Population Pharmacokinetics and Pharmacodynamics of Disulfiram on Inducing Latent HIV-1 Transcription in a Phase IIb Trial.
Clinical pharmacology and therapeutics.
2019 03; 105(3):692-702. doi:
10.1002/cpt.1220. [PMID: 30137649] - Parikshit Banerjee, Tianjiao Geng, Arpan Mahanty, Tiantian Li, Li Zong, Bo Wang. Integrating the drug, disulfiram into the vitamin E-TPGS-modified PEGylated nanostructured lipid carriers to synergize its repurposing for anti-cancer therapy of solid tumors.
International journal of pharmaceutics.
2019 Feb; 557(?):374-389. doi:
10.1016/j.ijpharm.2018.12.051. [PMID: 30610896] - Wu Chen, Wen Yang, Pengyu Chen, Yongzhuo Huang, Feng Li. Disulfiram Copper Nanoparticles Prepared with a Stabilized Metal Ion Ligand Complex Method for Treating Drug-Resistant Prostate Cancers.
ACS applied materials & interfaces.
2018 Dec; 10(48):41118-41128. doi:
10.1021/acsami.8b14940. [PMID: 30444340] - Xuezhi Zhuo, Tian Lei, Linlin Miao, Wei Chu, Xiaowen Li, Lifeng Luo, Jingxin Gou, Yu Zhang, Tian Yin, Haibing He, Xing Tang. Disulfiram-loaded mixed nanoparticles with high drug-loading and plasma stability by reducing the core crystallinity for intravenous delivery.
Journal of colloid and interface science.
2018 Nov; 529(?):34-43. doi:
10.1016/j.jcis.2018.05.057. [PMID: 29883928] - Roxanne Hastie, Louie Ye, Natalie J Hannan, Fiona C Brownfoot, Ping Cannon, Vi Nguyen, Stephen Tong, Tu'uhevaha J Kaitu'u-Lino. Disulfiram inhibits placental soluble FMS-like tyrosine kinase-1 and soluble endoglin secretion independent of the proteasome.
Pregnancy hypertension.
2018 Oct; 14(?):125-130. doi:
10.1016/j.preghy.2018.09.005. [PMID: 30527099] - Varsha K Sonawane, Umesh B Mahajan, Sachin D Shinde, Subhajit Chatterjee, Sandip S Chaudhari, Harshada A Bhangale, Shreesh Ojha, Sameer N Goyal, Chanakya N Kundu, Chandragouda R Patil. A Chemosensitizer Drug: Disulfiram Prevents Doxorubicin-Induced Cardiac Dysfunction and Oxidative Stress in Rats.
Cardiovascular toxicology.
2018 10; 18(5):459-470. doi:
10.1007/s12012-018-9458-y. [PMID: 29779119] - Linlin Miao, Jia Su, Xuezhi Zhuo, Lifeng Luo, Yihan Kong, Jingxin Gou, Tian Yin, Yu Zhang, Haibing He, Xing Tang. mPEG5k- b-PLGA2k/PCL3.4k/MCT Mixed Micelles as Carriers of Disulfiram for Improving Plasma Stability and Antitumor Effect in Vivo.
Molecular pharmaceutics.
2018 04; 15(4):1556-1564. doi:
10.1021/acs.molpharmaceut.7b01094. [PMID: 29505711] - Nena Bowman, E Martin Caravati, B Zane Horowitz, Barbara Insley Crouch. Acute pneumonitis associated with nickel carbonyl exposure in the workplace.
Clinical toxicology (Philadelphia, Pa.).
2018 03; 56(3):223-225. doi:
10.1080/15563650.2017.1355057. [PMID: 28753074] - Chang Liu, Qi Lan, Wei He, Changlu Nie, Chunjuan Zhang, Tonghua Xu, Tongying Jiang, Siling Wang. Octa-arginine modified lipid emulsions as a potential ocular delivery system for disulfiram: A study of the corneal permeation, transcorneal mechanism and anti-cataract effect.
Colloids and surfaces. B, Biointerfaces.
2017 Dec; 160(?):305-314. doi:
10.1016/j.colsurfb.2017.08.037. [PMID: 28950195] - Linsheng Liu, Chenrong Huang, Yicong Bian, Liyan Miao. GC-MS based metabolomics of CSF and blood serum: Metabolic phenotype for a rat model of cefoperazone-induced disulfiram-like reaction.
Biochemical and biophysical research communications.
2017 08; 490(3):1066-1073. doi:
10.1016/j.bbrc.2017.06.167. [PMID: 28668395] - Remco van Dijk, Sem J Aronson, Dirk R de Waart, Stan F van de Graaf, Suzanne Duijst, Jurgen Seppen, Ronald Oude Elferink, Ulrich Beuers, Piter J Bosma. Biliverdin Reductase inhibitors did not improve severe unconjugated hyperbilirubinemia in vivo.
Scientific reports.
2017 05; 7(1):1646. doi:
10.1038/s41598-017-01602-w. [PMID: 28490767] - Mohammad Najlah, Zahima Ahmed, Mohammed Iqbal, Zhipeng Wang, Patrica Tawari, Weiguang Wang, Christopher McConville. Development and characterisation of disulfiram-loaded PLGA nanoparticles for the treatment of non-small cell lung cancer.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.
2017 Mar; 112(?):224-233. doi:
10.1016/j.ejpb.2016.11.032. [PMID: 27915005] - Monika Mittal, Subhashis Pal, Shyamsundar Pal China, Konica Porwal, Kapil Dev, Richa Shrivastava, Kanumuri Siva Rama Raju, Mamunur Rashid, Arun Kumar Trivedi, Sabyasachi Sanyal, Muhammad Wahajuddin, Smrati Bhaduria, Rakesh Maurya, Naibedya Chattopadhyay. Pharmacological activation of aldehyde dehydrogenase 2 promotes osteoblast differentiation via bone morphogenetic protein-2 and induces bone anabolic effect.
Toxicology and applied pharmacology.
2017 02; 316(?):63-73. doi:
10.1016/j.taap.2016.12.013. [PMID: 28017615] - Shibing Yu, Mitchell Stephen Fourman, Adel Mahjoub, Jonathan Brendan Mandell, Jared Anthony Crasto, Nicholas Giuseppe Greco, Kurt Richard Weiss. Lung cells support osteosarcoma cell migration and survival.
BMC cancer.
2017 01; 17(1):78. doi:
10.1186/s12885-017-3047-5. [PMID: 28122543] - Qiang Huo, Jianhua Zhu, Yimin Niu, Huihui Shi, Yaxiang Gong, Yang Li, Huihui Song, Yang Liu. pH-triggered surface charge-switchable polymer micelles for the co-delivery of paclitaxel/disulfiram and overcoming multidrug resistance in cancer.
International journal of nanomedicine.
2017; 12(?):8631-8647. doi:
10.2147/ijn.s144452. [PMID: 29270012] - O Celik, A Ersahin, M Acet, N Celik, Y Baykus, R Deniz, E Ozerol, I Ozerol. Disulfiram, as a candidate NF-κB and proteasome inhibitor, prevents endometriotic implant growing in a rat model of endometriosis.
European review for medical and pharmacological sciences.
2016 10; 20(20):4380-4389. doi:
NULL. [PMID: 27831632] - Poojan Pyakurel, Eve Privman Champaloux, B Jill Venton. Fast-Scan Cyclic Voltammetry (FSCV) Detection of Endogenous Octopamine in Drosophila melanogaster Ventral Nerve Cord.
ACS chemical neuroscience.
2016 08; 7(8):1112-9. doi:
10.1021/acschemneuro.6b00070. [PMID: 27326831] - Thomas A Rasmussen, Sharon R Lewin. Shocking HIV out of hiding: where are we with clinical trials of latency reversing agents?.
Current opinion in HIV and AIDS.
2016 07; 11(4):394-401. doi:
10.1097/coh.0000000000000279. [PMID: 26974532] - Kathleen M Carroll, Charla Nich, Nancy M Petry, Dorothy A Eagan, Julia M Shi, Samuel A Ball. A randomized factorial trial of disulfiram and contingency management to enhance cognitive behavioral therapy for cocaine dependence.
Drug and alcohol dependence.
2016 Mar; 160(?):135-42. doi:
10.1016/j.drugalcdep.2015.12.036. [PMID: 26817621] - Vishal R Mali, Mandar Deshpande, Guodong Pan, Rajarajan A Thandavarayan, Suresh S Palaniyandi. Impaired ALDH2 activity decreases the mitochondrial respiration in H9C2 cardiomyocytes.
Cellular signalling.
2016 Feb; 28(2):1-6. doi:
10.1016/j.cellsig.2015.11.006. [PMID: 26577527] - Abdulla A-B Badawy, Samina Bano. Elevation of Kynurenine Metabolites in Rat Liver and Serum: A Potential Additional Mechanism of the Alcohol Aversive and Anti-cancer Effects of Disulfiram?.
Alcohol and alcoholism (Oxford, Oxfordshire).
2016 Jan; 51(1):20-6. doi:
10.1093/alcalc/agv085. [PMID: 26224731] - Guodong Pan, Mandar Deshpande, Rajarajan A Thandavarayan, Suresh Selvaraj Palaniyandi. ALDH2 Inhibition Potentiates High Glucose Stress-Induced Injury in Cultured Cardiomyocytes.
Journal of diabetes research.
2016; 2016(?):1390861. doi:
10.1155/2016/1390861. [PMID: 27882330] - Julian H Elliott, James H McMahon, Christina C Chang, Sulggi A Lee, Wendy Hartogensis, Namandje Bumpus, Rada Savic, Janine Roney, Rebecca Hoh, Ajantha Solomon, Michael Piatak, Robert J Gorelick, Jeff Lifson, Peter Bacchetti, Steven G Deeks, Sharon R Lewin. Short-term administration of disulfiram for reversal of latent HIV infection: a phase 2 dose-escalation study.
The lancet. HIV.
2015 Dec; 2(12):e520-9. doi:
10.1016/s2352-3018(15)00226-x. [PMID: 26614966] - Ling Zhang, Bin Tian, Yi Li, Tian Lei, Jia Meng, Liu Yang, Yan Zhang, Fen Chen, Haotian Zhang, Hui Xu, Yu Zhang, Xing Tang. A Copper-Mediated Disulfiram-Loaded pH-Triggered PEG-Shedding TAT Peptide-Modified Lipid Nanocapsules for Use in Tumor Therapy.
ACS applied materials & interfaces.
2015 Nov; 7(45):25147-61. doi:
10.1021/acsami.5b06488. [PMID: 26501354] - Alex G Peniche, Adam R Renslo, Peter C Melby, Bruno L Travi. Antileishmanial Activity of Disulfiram and Thiuram Disulfide Analogs in an Ex Vivo Model System Is Selectively Enhanced by the Addition of Divalent Metal Ions.
Antimicrobial agents and chemotherapy.
2015 Oct; 59(10):6463-70. doi:
10.1128/aac.05131-14. [PMID: 26239994] - Chitra Bhatia, Stephanie Oerum, James Bray, Kathryn L Kavanagh, Naeem Shafqat, Wyatt Yue, Udo Oppermann. Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships.
Chemico-biological interactions.
2015 Jun; 234(?):114-25. doi:
10.1016/j.cbi.2014.12.013. [PMID: 25526675] - Gregory M Laird, C Korin Bullen, Daniel I S Rosenbloom, Alyssa R Martin, Alison L Hill, Christine M Durand, Janet D Siliciano, Robert F Siliciano. Ex vivo analysis identifies effective HIV-1 latency-reversing drug combinations.
The Journal of clinical investigation.
2015 May; 125(5):1901-12. doi:
10.1172/jci80142. [PMID: 25822022]
