Gibberellin A4 (BioDeep_00000001647)

   

natural product PANOMIX_OTCML-2023 Plant Hormones


代谢物信息卡片


NCGC00380182-01_C19H24O5_(1R,2R,5R,8R,9S,10R,12S)-12-Hydroxy-11-methyl-6-methylene-16-oxo-15-oxapentacyclo[9.3.2.1~5,8~.0~1,10~.0~2,8~]heptadecane-9-carboxylic acid

化学式: C19H24O5 (332.1624)
中文名称: 赤霉素A4
谱图信息: 最多检出来源 Viridiplantae(plant) 12.99%

分子结构信息

SMILES: C=C([C@H]45)C[C@@](C5)([C@@H](C(O)=O)1)[C@@]([H])(CC4)[C@@](C3)(O2)[C@]([H])([C@@](C)([C@@H](O)C3)C(=O)2)1
InChI: InChI=1S/C19H24O5/c1-9-7-18-8-10(9)3-4-11(18)19-6-5-12(20)17(2,16(23)24-19)14(19)13(18)15(21)22/h10-14,20H,1,3-8H2,2H3,(H,21,22)

描述信息

A C19-gibberellin, initially identified in Gibberella fujikuroi and differing from gibberellin A1 by the substitution of the OH at C-7 (gibbane numbering) by H.
D006133 - Growth Substances > D010937 - Plant Growth Regulators > D005875 - Gibberellins
Acquisition and generation of the data is financially supported in part by CREST/JST.
CONFIDENCE Reference Standard (Level 1); INTERNAL_ID 16

同义名列表

5 个代谢物同义名

Gibberellin A4; NCGC00380182-01_C19H24O5_(1R,2R,5R,8R,9S,10R,12S)-12-Hydroxy-11-methyl-6-methylene-16-oxo-15-oxapentacyclo[9.3.2.1~5,8~.0~1,10~.0~2,8~]heptadecane-9-carboxylic acid; Gibbane-1,10-dicarboxylic acid, 2,4a-dihydroxy-1-methyl-8-methylene-, 1,4a-lactone, (1alpha,2beta,4aalpha,4bbeta,10beta)-; 4aalpha,4bbeta-Gibbane-1alpha,10beta-dicarboxylic acid, 2beta,4a-dihydroxy-1-methyl-8-methylene-, 1,4a-lactone; Gibberellin A4



数据库引用编号

42 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(3)

代谢反应

549 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(306)

INOH(0)

PlantCyc(243)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

174 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ADSS2, ARHGAP45, CAT, GLI3, PGR, TXN
Peripheral membrane protein 1 GORASP1
Endoplasmic reticulum membrane 1 HSP90B1
Nucleus 4 GLI3, HSP90B1, PGR, TXN
cytosol 8 ADSS2, ARHGAP45, CAT, GLI3, HSP90B1, PGR, TAT, TXN
nucleoplasm 3 GLI3, PGR, TXN
Cytoplasmic side 1 GORASP1
ruffle membrane 1 ARHGAP45
Golgi apparatus membrane 1 GORASP1
Golgi apparatus 1 GORASP1
Golgi membrane 1 GORASP1
lysosomal membrane 1 GAA
smooth endoplasmic reticulum 1 HSP90B1
Lysosome 1 GAA
plasma membrane 4 ARHGAP45, GAA, PGR, TPSG1
Membrane 5 ARHGAP45, CAT, GAA, HSP90B1, TPSG1
extracellular exosome 5 ADSS2, CAT, GAA, HSP90B1, TXN
Lysosome membrane 1 GAA
endoplasmic reticulum 1 HSP90B1
extracellular space 2 GH1, TPSG1
lysosomal lumen 1 GAA
perinuclear region of cytoplasm 1 HSP90B1
mitochondrion 2 ADSS2, CAT
protein-containing complex 2 CAT, HSP90B1
intracellular membrane-bounded organelle 3 CAT, GAA, GLI3
Secreted 3 GAA, GH1, TXN
extracellular region 6 ARHGAP45, CAT, GAA, GH1, HSP90B1, TXN
Single-pass membrane protein 1 TPSG1
mitochondrial outer membrane 1 PGR
mitochondrial matrix 1 CAT
nucleolus 1 GLI3
midbody 1 HSP90B1
Cell projection, ruffle membrane 1 ARHGAP45
focal adhesion 2 CAT, HSP90B1
cis-Golgi network 1 GORASP1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 HSP90B1
axoneme 1 GLI3
ciliary tip 1 GLI3
nuclear speck 1 GLI3
ciliary base 1 GLI3
cilium 1 GLI3
chromatin 1 PGR
endosome lumen 1 GH1
tertiary granule membrane 1 GAA
Melanosome 1 HSP90B1
sperm plasma membrane 1 HSP90B1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 ARHGAP45, CAT
endoplasmic reticulum lumen 1 HSP90B1
transcription repressor complex 1 GLI3
azurophil granule membrane 1 GAA
azurophil granule lumen 1 ARHGAP45
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Sarcoplasmic reticulum lumen 1 HSP90B1
ficolin-1-rich granule membrane 1 GAA
endocytic vesicle lumen 1 HSP90B1
growth hormone receptor complex 1 GH1
catalase complex 1 CAT
[Isoform 4]: Mitochondrion outer membrane 1 PGR
endoplasmic reticulum chaperone complex 1 HSP90B1
GLI-SUFU complex 1 GLI3
autolysosome lumen 1 GAA


文献列表

  • Vivek Kumar Awon, Debabrata Dutta, Saptadipa Banerjee, Soumili Pal, Gaurab Gangopadhyay. Integrated metabolomics and transcriptomics analysis highlight key pathways involved in the somatic embryogenesis of Darjeeling tea. BMC genomics. 2024 Feb; 25(1):207. doi: 10.1186/s12864-024-10119-2. [PMID: 38395740]
  • Ce Shi, Pan Luo, Yu-Ting Du, Hong Chen, Xiaorong Huang, Tian-He Cheng, An Luo, Hong-Ju Li, Wei-Cai Yang, Peng Zhao, Meng-Xiang Sun. Maternal control of suspensor programmed cell death via gibberellin signaling. Nature communications. 2019 08; 10(1):3484. doi: 10.1038/s41467-019-11476-3. [PMID: 31375676]
  • Zhong-Feng Li, Yong Guo, Lin Ou, Huilong Hong, Jun Wang, Zhang-Xiong Liu, Bingfu Guo, Lijuan Zhang, Lijuan Qiu. Identification of the dwarf gene GmDW1 in soybean (Glycine max L.) by combining mapping-by-sequencing and linkage analysis. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik. 2018 May; 131(5):1001-1016. doi: 10.1007/s00122-017-3044-8. [PMID: 29550969]
  • Chunlu Qian, Nannan Ren, Jingye Wang, Qiang Xu, Xuehao Chen, Xiaohua Qi. Effects of exogenous application of CPPU, NAA and GA4+7 on parthenocarpy and fruit quality in cucumber (Cucumis sativus L.). Food chemistry. 2018 Mar; 243(?):410-413. doi: 10.1016/j.foodchem.2017.09.150. [PMID: 29146357]
  • Raimund Nagel, Paula C G Turrini, Ryan S Nett, Jan E Leach, Valérie Verdier, Marie-Anne Van Sluys, Reuben J Peters. An operon for production of bioactive gibberellin A4 phytohormone with wide distribution in the bacterial rice leaf streak pathogen Xanthomonas oryzae pv. oryzicola. The New phytologist. 2017 May; 214(3):1260-1266. doi: 10.1111/nph.14441. [PMID: 28134995]
  • Ryan S Nett, Tiffany Contreras, Reuben J Peters. Characterization of CYP115 As a Gibberellin 3-Oxidase Indicates That Certain Rhizobia Can Produce Bioactive Gibberellin A4. ACS chemical biology. 2017 04; 12(4):912-917. doi: 10.1021/acschembio.6b01038. [PMID: 28199080]
  • Tai-ping Sun. Plant Science. Sex and the single fern. Science (New York, N.Y.). 2014 Oct; 346(6208):423-4. doi: 10.1126/science.1260948. [PMID: 25342787]
  • Junmu Tanaka, Kenji Yano, Koichiro Aya, Ko Hirano, Sayaka Takehara, Eriko Koketsu, Reynante Lacsamana Ordonio, Seung-Hyun Park, Masatoshi Nakajima, Miyako Ueguchi-Tanaka, Makoto Matsuoka. Antheridiogen determines sex in ferns via a spatiotemporally split gibberellin synthesis pathway. Science (New York, N.Y.). 2014 Oct; 346(6208):469-73. doi: 10.1126/science.1259923. [PMID: 25342803]
  • Yoshinori Sugai, Sho Miyazaki, Shinichiro Mukai, Isamu Yumoto, Masahiro Natsume, Hiroshi Kawaide. Enzymatic total synthesis of gibberellin A₄ from acetate. Bioscience, biotechnology, and biochemistry. 2011; 75(1):128-35. doi: 10.1271/bbb.100733. [PMID: 21228464]
  • Takashi Murata, Shinya Fushinobu, Masatoshi Nakajima, Osamu Asami, Takeshi Sassa, Takayoshi Wakagi, Isomaro Yamaguchi. Crystal structure of the liganded anti-gibberellin A(4) antibody 4-B8(8)/E9 Fab fragment. Biochemical and biophysical research communications. 2002 Apr; 293(1):489-96. doi: 10.1016/s0006-291x(02)00225-5. [PMID: 12054627]