Inosine triphosphate (BioDeep_00000001622)

 

Secondary id: BioDeep_00000405212

natural product human metabolite PANOMIX_OTCML-2023 Endogenous Chemicals and Drugs


代谢物信息卡片


({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-hydroxy-9H-purin-9-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid

化学式: C10H15N4O14P3 (507.979764)
中文名称: 肌苷-5'-三磷酸
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 1.54%

分子结构信息

SMILES: C([C@@H]1[C@H]([C@H]([C@H](n2cnc3c2nc[nH]c3=O)O1)O)O)OP(=O)(O)OP(=O)(O)OP(=O)(O)O
InChI: InChI=1S/C10H15N4O14P3/c15-6-4(1-25-30(21,22)28-31(23,24)27-29(18,19)20)26-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17/h2-4,6-7,10,15-16H,1H2,(H,21,22)(H,23,24)(H,11,12,17)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1

描述信息

Inosine triphosphate (ITP) is an intermediate in the purine metabolism pathway. Relatively high levels of ITP in red cells are found in individuals as result of deficiency of inosine triphosphatase (EC 3.1.3.56, ITPase) ITPase is a cytosolic nucleoside triphosphate pyrophosphohydrolase specific for ITP catalysis to inosine monophosphate (IMP) and deoxy-inosine triphosphate (dITP) to deoxy-inosine monophosphate. ITPase deficiency is not associated with any defined pathology other than the characteristic and abnormal accumulation of ITP in red blood cells. Nevertheless, ITPase deficiency may have pharmacogenomic implications, and the abnormal metabolism of 6-mercaptopurine in ITPase-deficient patients may lead to thiopurine drug toxicity. ITPases function is not clearly understood but possible roles for ITPase could be to prevent the accumulation of rogue nucleotides which would be otherwise incorporated into DNA and RNA, or compete with nucleotides such as GTP in signalling processes. (PMID : 170291, 1204209, 17113761, 17924837) [HMDB]
Inosine triphosphate (ITP) is an intermediate in the purine metabolism pathway. Relatively high levels of ITP in red cells are found in individuals as result of deficiency of inosine triphosphatase (EC 3.1.3.56, ITPase) ITPase is a cytosolic nucleoside triphosphate pyrophosphohydrolase specific for ITP catalysis to inosine monophosphate (IMP) and deoxy-inosine triphosphate (dITP) to deoxy-inosine monophosphate. ITPase deficiency is not associated with any defined pathology other than the characteristic and abnormal accumulation of ITP in red blood cells. Nevertheless, ITPase deficiency may have pharmacogenomic implications, and the abnormal metabolism of 6-mercaptopurine in ITPase-deficient patients may lead to thiopurine drug toxicity. ITPases function is not clearly understood but possible roles for ITPase could be to prevent the accumulation of rogue nucleotides which would be otherwise incorporated into DNA and RNA, or compete with nucleotides such as GTP in signalling processes. (PMID: 170291, 1204209, 17113761, 17924837).

同义名列表

23 个代谢物同义名

({[({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-hydroxy-9H-purin-9-yl)oxolan-2-yl]methoxy}(hydroxy)phosphoryl)oxy](hydroxy)phosphoryl}oxy)phosphonic acid; ({[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-hydroxypurin-9-yl)oxolan-2-yl]methoxy(hydroxy)phosphoryl}oxy(hydroxy)phosphoryl)oxyphosphonic acid; [[(2R,3S,4R,5R)-3,4-dihydroxy-5-(6-oxo-3H-purin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate; O(5)-(Tetrahydroxytriphosphoryl)inosine; Inosine 5-(tetrahydrogen triphosphate); Inosine-5-triphosphate trisodium salt; Inosine 5(tetrahydrogen triphosphate); Inosine tripolyphosphoric acid; 2-Inosine-5-triphosphoric acid; Inosine 5-triphosphoric acid; Inosine triphosphoric acid; 2-Inosine-5-triphosphate; Inosine tripolyphosphate; Inosine 5-triphosphate; Inosine 5-triphopshate; Triphosphate, inosine; Inosine triphosphate; SCHEMBL4356292; Inosine 5; 5-ITP; ITP; ITT; Inosine triphosphate(ITP)



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

61 个相关的代谢反应过程信息。

Reactome(12)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(2)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(46)

PharmGKB(0)

2 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Henryk Straube, Jannis Straube, Jannis Rinne, Lisa Fischer, Markus Niehaus, Claus-Peter Witte, Marco Herde. An inosine triphosphate pyrophosphatase safeguards plant nucleic acids from aberrant purine nucleotides. The New phytologist. 2023 03; 237(5):1759-1775. doi: 10.1111/nph.18656. [PMID: 36464781]
  • Shu-Yan Liu, Dai Yuan, Rui-Jie Sun, Jing-Jing Zhu, Ning-Ning Shan. Significant reductions in apoptosis-related proteins (HSPA6, HSPA8, ITGB3, YWHAH, and PRDX6) are involved in immune thrombocytopenia. Journal of thrombosis and thrombolysis. 2021 May; 51(4):905-914. doi: 10.1007/s11239-020-02310-5. [PMID: 33047245]
  • Jun-Xiu Liu, Huan-Xin Zhang, De-Peng Li, Wei-Wei Xing, Hu-Jun Li, Wei Chen, Hai Cheng, Jiang Cao, Zhen-Yu Li, Zhi-Ling Yan, Kai-Lin Xu. [Curative Efficacy of Rituximab for ITP Patients with Different Sensitivity to Hormone]. Zhongguo shi yan xue ye xue za zhi. 2019 Oct; 27(5):1602-1606. doi: 10.19746/j.cnki.issn.1009-2137.2019.05.037. [PMID: 31607319]
  • You-Ping Liao, Yu-Xia Liu, Qing-Zhao Li, Guo-Yu Hu. [Effect of Decitabine on Megakaryocyte Culture of Steroid-resistant ITP Patients]. Zhongguo shi yan xue ye xue za zhi. 2015 Aug; 23(4):1092-6. doi: 10.7534/j.issn.1009-2137.2015.04.036. [PMID: 26314452]
  • Hoang Hai, Akihiro Tamori, Masaru Enomoto, Hiroyasu Morikawa, Sawako Uchida-Kobayashi, Hideki Fujii, Atsushi Hagihara, Etsushi Kawamura, Le Thi Thanh Thuy, Yasuhito Tanaka, Norifumi Kawada. Relationship between inosine triphosphate genotype and outcome of extended therapy in hepatitis C virus patients with a late viral response to pegylated-interferon and ribavirin. Journal of gastroenterology and hepatology. 2014 Jan; 29(1):201-7. doi: 10.1111/jgh.12376. [PMID: 23980585]
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