Clavulanate (BioDeep_00000015949)

 

Secondary id: BioDeep_00000006271

natural product


代谢物信息卡片


Clavulanic Acid - Dark Web Drugs

化学式: C8H9NO5 (199.0481)
中文名称: 克拉维酸
谱图信息: 最多检出来源 Homo sapiens(blood) 20.22%

分子结构信息

SMILES: C(=C\1/[C@H](C(=O)O)N2C(=O)C[C@H]2O1)\CO
InChI: InChI=1S/C8H9NO5/c10-2-1-4-7(8(12)13)9-5(11)3-6(9)14-4/h1,6-7,10H,2-3H2,(H,12,13)/b4-1+/t6-,7-/m1/s1

描述信息

Antibiotic isolated from Streptomyces clavuligerus. It acts as a suicide inhibitor of bacterial beta-lactamase enzymes.
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D065093 - beta-Lactamase Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D002969 - Clavulanic Acids
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D047090 - beta-Lactams
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D007769 - Lactams
C2140 - Adjuvant > C183118 - Beta-lactamase Inhibitor
D004791 - Enzyme Inhibitors

同义名列表

6 个代谢物同义名

Isoclavulanic acid; Clavulanate; Clavulanic acid; Clavulanic Acid - Dark Web Drugs; Isoclavulanic acid; Clavulanic acid



数据库引用编号

30 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

279 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 2 ALB, PTPN22
Peripheral membrane protein 2 CYP27A1, RDX
Endosome membrane 2 HLA-A, HLA-DRB1
Endoplasmic reticulum membrane 4 CD4, HLA-A, HLA-DRB1, MOXD1
Mitochondrion membrane 1 CYP27A1
Nucleus 2 ALB, PTPN22
cytosol 4 ALB, GPT, PTPN22, SLC22A7
centrosome 1 ALB
Cell membrane 8 CD4, HLA-A, HLA-DRB1, RDX, SLC1A2, SLC1A3, SLC22A7, TNF
Cytoplasmic side 1 RDX
Cleavage furrow 1 RDX
lamellipodium 1 RDX
Early endosome membrane 2 HLA-A, HLA-DRB1
Multi-pass membrane protein 3 SLC1A2, SLC1A3, SLC22A7
Synapse 1 SLC1A3
cell surface 6 HLA-A, HLA-DRB1, SLC1A2, SLC1A3, TNF, TNR
glutamatergic synapse 2 SLC1A2, TNR
Golgi apparatus 2 ALB, HLA-A
Golgi membrane 2 HLA-A, HLA-DRB1
lysosomal membrane 2 HLA-A, HLA-DRB1
mitochondrial inner membrane 1 CYP27A1
neuronal cell body 2 SLC1A3, TNF
presynaptic membrane 1 SLC1A2
plasma membrane 9 CD4, HLA-A, HLA-DRB1, IGHE, RDX, SLC1A2, SLC1A3, SLC22A7, TNF
Membrane 6 HLA-A, HLA-DRB1, RDX, SLC1A2, SLC1A3, SLC22A7
apical plasma membrane 2 RDX, SLC22A7
basolateral plasma membrane 1 SLC22A7
extracellular exosome 5 ALB, GPT, HLA-A, HLA-DRB1, RDX
Lysosome membrane 2 HLA-A, HLA-DRB1
endoplasmic reticulum 2 ALB, HLA-A
extracellular space 11 ALB, COL2A1, CRP, HLA-A, HLA-DRB1, IGHE, IL10, MOXD1, RDX, TNF, TNR
perinuclear region of cytoplasm 2 PTPN22, SLC1A3
Schaffer collateral - CA1 synapse 1 TNR
adherens junction 1 RDX
mitochondrion 1 CYP27A1
protein-containing complex 1 ALB
filopodium 1 RDX
Single-pass type I membrane protein 5 CD4, HLA-A, HLA-DRB1, IGHE, MOXD1
Secreted 5 ALB, COL2A1, CRP, HTRA3, IL10
extracellular region 8 ALB, COL2A1, CRP, HTRA3, IGHE, IL10, TNF, TNR
cytoplasmic side of plasma membrane 1 PTPN22
Single-pass membrane protein 2 HLA-A, HLA-DRB1
mitochondrial matrix 1 CYP27A1
anchoring junction 1 ALB
external side of plasma membrane 4 CD4, HLA-A, HLA-DRB1, TNF
Secreted, extracellular space, extracellular matrix 2 COL2A1, TNR
T-tubule 1 RDX
cytoplasmic vesicle 1 SLC1A3
midbody 1 RDX
Early endosome 1 CD4
apical part of cell 1 RDX
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 SLC1A2
Apical cell membrane 1 SLC22A7
Mitochondrion inner membrane 1 CYP27A1
Membrane raft 4 CD4, SLC1A2, TNF, TNR
Cytoplasm, cytoskeleton 1 RDX
focal adhesion 1 RDX
axolemma 1 SLC1A2
basement membrane 1 COL2A1
collagen trimer 1 COL2A1
collagen-containing extracellular matrix 2 COL2A1, TNR
intermediate filament 1 HLA-DRB1
neuron projection 1 SLC1A3
ciliary basal body 1 ALB
IgE immunoglobulin complex 1 IGHE
Late endosome membrane 1 HLA-DRB1
cell projection 1 RDX
phagocytic cup 1 TNF
phagocytic vesicle membrane 2 HLA-A, HLA-DRB1
cell periphery 1 RDX
cytoskeleton 1 RDX
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 1 SLC22A7
[Isoform 2]: Cell membrane 1 IGHE
Recycling endosome membrane 2 HLA-A, HLA-DRB1
microvillus 1 RDX
Cell projection, stereocilium 1 RDX
Cell projection, microvillus 1 RDX
cell body 1 SLC1A2
basal plasma membrane 2 SLC1A3, SLC22A7
trans-Golgi network membrane 1 HLA-DRB1
secretory granule membrane 1 MOXD1
endoplasmic reticulum lumen 3 ALB, CD4, COL2A1
cortical actin cytoskeleton 1 RDX
platelet alpha granule lumen 1 ALB
endocytic vesicle membrane 1 HLA-DRB1
endoplasmic reticulum exit site 1 HLA-A
immunological synapse 1 HLA-DRB1
perineuronal net 1 TNR
ER to Golgi transport vesicle membrane 2 HLA-A, HLA-DRB1
cell tip 1 RDX
clathrin-coated endocytic vesicle membrane 2 CD4, HLA-DRB1
lumenal side of endoplasmic reticulum membrane 2 HLA-A, HLA-DRB1
MHC class I peptide loading complex 1 HLA-A
[Isoform 1]: Cytoplasm, cytosol 1 SLC22A7
[Isoform 3]: Cell membrane 1 IGHE
astrocyte projection 1 SLC1A2
Golgi medial cisterna 1 HLA-A
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD4
[Isoform 1]: Secreted 1 IGHE
IgE B cell receptor complex 1 IGHE
immunoglobulin complex, circulating 1 IGHE
MHC class I protein complex 1 HLA-A
Autolysosome membrane 1 HLA-DRB1
MHC class II protein complex 2 HLA-A, HLA-DRB1
transport vesicle membrane 1 HLA-DRB1
collagen type II trimer 1 COL2A1
collagen type XI trimer 1 COL2A1
neuron projection terminus 1 SLC1A2
tenascin complex 1 TNR
stereocilium base 1 RDX
membrane protein complex 2 SLC1A2, SLC1A3
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
[Isoform 2]: Basolateral cell membrane 1 SLC22A7


文献列表

  • Naglaa F S Awad, Marwa I Abd El-Hamid, Nehal M Nabil, Maram M Tawakol, Samah Eid, Mayasar I Al-Zaban, Heba Farouk, Shadi A Zakai, Amr Elkelish, Mona S Ibrahim, Hanim A Mahmoud, Sanaa M Salem, Hala M Ismail, Rehab I Hamed. Multidrug resistant and multivirulent avian bacterial pathogens: tackling experimental leg disorders using phytobiotics and antibiotics alone or in combination. Poultry science. 2023 Nov; 102(11):102889. doi: 10.1016/j.psj.2023.102889. [PMID: 37666144]
  • Vinod Kumar, Anu Radha, Varsha Sharma, Nagaraju Nekkala, Saurabh Saran. Utilization of xylose enriched extract from spent lemongrass hydrolysate for clavulanic acid production using Streptomyces clavuligerus (MTCC 1142). Bioresource technology. 2023 Sep; 384(?):129268. doi: 10.1016/j.biortech.2023.129268. [PMID: 37286045]
  • Nagwa A Shoeib, Lamiaa A Al-Madboly, Amany E Ragab. In vitro and in silico β-lactamase inhibitory properties and phytochemical profile of Ocimum basilicum cultivated in central delta of Egypt. Pharmaceutical biology. 2022 Dec; 60(1):1969-1980. doi: 10.1080/13880209.2022.2127791. [PMID: 36226757]
  • Winnie Bao, Mira Koro, Gabriel W Loh, Ana Ortiz. Urinary Tract Infections in Long-term Care: Evaluation of Uropathogens, Antibiotic Susceptibility, and Empiric Treatment. The Senior care pharmacist. 2022 Jun; 37(6):232-243. doi: 10.4140/tcp.n.2022.232. [PMID: 35610764]
  • Milo Gatti, Michele Fusaroli, Emanuel Raschi, Irene Capelli, Elisabetta Poluzzi, Fabrizio De Ponti. Crystal nephropathy and amoxicillin: insights from international spontaneous reporting systems. Journal of nephrology. 2022 04; 35(3):1017-1027. doi: 10.1007/s40620-021-01191-y. [PMID: 34762277]
  • Petar D Petrov, Polina Soluyanova, Sonia Sánchez-Campos, José V Castell, Ramiro Jover. Molecular mechanisms of hepatotoxic cholestasis by clavulanic acid: Role of NRF2 and FXR pathways. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2021 Dec; 158(?):112664. doi: 10.1016/j.fct.2021.112664. [PMID: 34767876]
  • André Birgy, Fouad Madhi, Camille Jung, Corinne Levy, Aurélie Cointe, Philippe Bidet, Claire Amaris Hobson, Stéphane Bechet, Elsa Sobral, Hoang Vuthien, Agnès Ferroni, Saïd Aberrane, Gaëlle Cuzon, Laetitia Beraud, Vincent Gajdos, Elise Launay, Didier Pinquier, Hervé Haas, Marie Desmarest, Marie-Aliette Dommergues, Robert Cohen, Stéphane Bonacorsi. Clavulanate combinations with mecillinam, cefixime or cefpodoxime against ESBL-producing Enterobacterales frequently associated with blaOXA-1 in a paediatric population with febrile urinary tract infections. The Journal of antimicrobial chemotherapy. 2021 10; 76(11):2839-2846. doi: 10.1093/jac/dkab289. [PMID: 34453533]
  • S Ognenovska, Z Chen, C Mukerjee, K H Moore, K J Mansfield. Bacterial colonization of bladder urothelial cells in women with refractory Detrusor Overactivity: the effects of antibiotic therapy. Pathogens and disease. 2021 07; 79(6):. doi: 10.1093/femspd/ftab031. [PMID: 34143186]
  • Kehinde C Mofolorunsho, Hannah O Ocheni, Ruth F Aminu, Cornelius A Omatola, Olabisi O Olowonibi. Prevalence and antimicrobial susceptibility of extended-spectrum beta lactamases-producing Escherichia coli and Klebsiella pneumoniae isolated in selected hospitals of Anyigba, Nigeria. African health sciences. 2021 Jun; 21(2):505-512. doi: 10.4314/ahs.v21i2.4. [PMID: 34795702]
  • Sînziana Cristea, Elke H J Krekels, Karel Allegaert, Peter De Paepe, Annick de Jaeger, Pieter De Cock, Catherijne A J Knibbe. Estimation of Ontogeny Functions for Renal Transporters Using a Combined Population Pharmacokinetic and Physiology-Based Pharmacokinetic Approach: Application to OAT1,3. The AAPS journal. 2021 05; 23(3):65. doi: 10.1208/s12248-021-00595-9. [PMID: 33948771]
  • Kristina Putecova, Katerina Nedbalcova, Iva Bartejsova, Monika Zouharova, Katarina Matiaskova, Kamil Stastny. Mass spectrometric identification and quantification of the antibiotic clavulanic acid in broiler chicken plasma and meat as a necessary analytical tool in finding ways to increase the effectiveness of currently used antibiotics in the treatment of broiler chickens. Analytical and bioanalytical chemistry. 2021 May; 413(13):3561-3571. doi: 10.1007/s00216-021-03307-6. [PMID: 33851228]
  • Muhammad Asim, Farooq Ahmad, Mohammed Akhtar. Florid Interstitial Hemorrhages: A Novel Feature of Amoxicillin-Clavulanate-Induced Acute Tubulointerstitial Nephritis. The American journal of case reports. 2021 Mar; 22(?):e928989. doi: 10.12659/ajcr.928989. [PMID: 33716294]
  • Jennifer Gregory, Bichtram Huynh, Brittany Tayler, Chaitali Korgaonkar-Cherala, Gina Garrison, Ashar Ata, Paul Sorum. High-Dose vs Standard-Dose Amoxicillin Plus Clavulanate for Adults With Acute Sinusitis: A Randomized Clinical Trial. JAMA network open. 2021 03; 4(3):e212713. doi: 10.1001/jamanetworkopen.2021.2713. [PMID: 33755168]
  • Kate KuKanich, Kallie Woodruff, Zackery Bieberly, Mark G Papich, Butch KuKanich. Evaluation of urine concentrations of amoxicillin and clavulanate in cats. Journal of veterinary internal medicine. 2021 Jan; 35(1):456-461. doi: 10.1111/jvim.15991. [PMID: 33280171]
  • Moli Wang, Yanxia Gao, Xueli Liu, Jing Zhang, Qiang Wang, Junshan Chang, Lantong Zhang. Determination and pharmacokinetic analysis of ticarcillin disodium-clavulanate potassium for injection in rat plasma by UPLC-ESI-MS/MS. The Journal of international medical research. 2020 Dec; 48(12):300060520967822. doi: 10.1177/0300060520967822. [PMID: 33356736]
  • Timothy J Davies, Nicole Stoesser, Anna E Sheppard, Manal Abuoun, Philip Fowler, Jeremy Swann, T Phuong Quan, David Griffiths, Alison Vaughan, Marcus Morgan, Hang T T Phan, Katie J Jeffery, Monique Andersson, Matt J Ellington, Oskar Ekelund, Neil Woodford, Amy J Mathers, Robert A Bonomo, Derrick W Crook, Tim E A Peto, Muna F Anjum, A Sarah Walker. Reconciling the Potentially Irreconcilable? Genotypic and Phenotypic Amoxicillin-Clavulanate Resistance in Escherichia coli. Antimicrobial agents and chemotherapy. 2020 05; 64(6):. doi: 10.1128/aac.02026-19. [PMID: 32205351]
  • Wenxia Zhang, Yan Guo, Yang Yang, Dong Dong, Yonggui Zheng, Demei Zhu, Fupin Hu. Study of In Vitro Synergistic Bactericidal Activity of Dual β-Lactam Antibiotics Against KPC-2-Producing Klebsiella pneumoniae. Microbial drug resistance (Larchmont, N.Y.). 2020 Mar; 26(3):204-210. doi: 10.1089/mdr.2019.0126. [PMID: 31553260]
  • Veneta Simon, Sreerag K V, R Sasikumar, S K Kanthlal. In Vitro Protective Effect of Ascorbic Acid Against Antibiotic-Induced Hepatotoxicity. Current drug discovery technologies. 2020; 17(3):357-364. doi: 10.2174/1570163816666190204122007. [PMID: 30714529]
  • Ewan M Harrison, Xiaoliang Ba, Francesc Coll, Beth Blane, Olivier Restif, Henry Carvell, Claudio U Köser, Dorota Jamrozy, Sandra Reuter, Andrew Lovering, Nicholas Gleadall, Katherine L Bellis, Anne-Catrin Uhlemann, Franklin D Lowy, Ruth C Massey, Inês R Grilo, Rita Sobral, Jesper Larsen, Anders Rhod Larsen, Carina Vingsbo Lundberg, Julian Parkhill, Gavin K Paterson, Matthew T G Holden, Sharon J Peacock, Mark A Holmes. Genomic identification of cryptic susceptibility to penicillins and β-lactamase inhibitors in methicillin-resistant Staphylococcus aureus. Nature microbiology. 2019 10; 4(10):1680-1691. doi: 10.1038/s41564-019-0471-0. [PMID: 31235959]
  • Zhuoer Xie, L Edwin Gonzalez, Christina R Ferreira, Anna Vorsilak, Dylan Frabutt, Tiago J P Sobreira, Michael Pugia, R Graham Cooks. Multiple Reaction Monitoring Profiling (MRM-Profiling) of Lipids To Distinguish Strain-Level Differences in Microbial Resistance in Escherichia coli. Analytical chemistry. 2019 09; 91(17):11349-11354. doi: 10.1021/acs.analchem.9b02465. [PMID: 31398004]
  • Nekane Barbero, Rubén Fernández-Santamaría, Cristobalina Mayorga, Ángela Martin-Serrano, María Salas, Gador Bogas, Francisco Nájera, Dolores Pérez-Sala, Ezequiel Pérez-Inestrosa, Tahia D Fernandez, María I Montañez, María J Torres. Identification of an antigenic determinant of clavulanic acid responsible for IgE-mediated reactions. Allergy. 2019 08; 74(8):1490-1501. doi: 10.1111/all.13761. [PMID: 30829415]
  • Kamilia Abdelraouf, Sean M Stainton, David P Nicolau. In Vivo Pharmacodynamic Profile of Ceftibuten-Clavulanate Combination against Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae in the Murine Thigh Infection Model. Antimicrobial agents and chemotherapy. 2019 07; 63(7):. doi: 10.1128/aac.00145-19. [PMID: 31061165]
  • Elizabeth T Cirulli, Paola Nicoletti, Karen Abramson, Raul J Andrade, Einar S Bjornsson, Naga Chalasani, Robert J Fontana, Pär Hallberg, Yi Ju Li, M Isabel Lucena, Nanye Long, Mariam Molokhia, Matthew R Nelson, Joseph A Odin, Munir Pirmohamed, Thorunn Rafnar, Jose Serrano, Kári Stefánsson, Andrew Stolz, Ann K Daly, Guruprasad P Aithal, Paul B Watkins. A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury. Gastroenterology. 2019 05; 156(6):1707-1716.e2. doi: 10.1053/j.gastro.2019.01.034. [PMID: 30664875]
  • Annet E Heuvelink, Maaike A Gonggrijp, Rianne G J Buter, Carlijn C Ter Bogt-Kappert, Gerdien van Schaik, Annet G J Velthuis, Theo J G M Lam. Prevalence of extended-spectrum and AmpC β-lactamase-producing Escherichia coli in Dutch dairy herds. Veterinary microbiology. 2019 May; 232(?):58-64. doi: 10.1016/j.vetmic.2019.04.005. [PMID: 31030845]
  • Yusuf S Althobaiti, Fahad S Alshehri, Alqassem Y Hakami, Alaa M Hammad, Youssef Sari. Effects of Clavulanic Acid Treatment on Reinstatement to Methamphetamine, Glial Glutamate Transporters, and mGluR 2/3 Expression in P Rats Exposed to Ethanol. Journal of molecular neuroscience : MN. 2019 Jan; 67(1):1-15. doi: 10.1007/s12031-018-1194-z. [PMID: 30471010]
  • Dagan Osborne Lonsdale, Jeffrey Lipman, Amelia Livermore, Brett McWhinney, Jacobus P J Ungerer, Jason A Roberts. Amoxicillin-Clavulanate Dosing in the Intensive Care Unit: The Additive Effect of Renal Replacement Therapy in a Patient with Normal Kidney Function. Chemotherapy. 2019; 64(4):173-176. doi: 10.1159/000505057. [PMID: 31940615]
  • Celia Rousseau, Lionel Piroth, Vincent Pernin, Elisabeth Cassuto, Isabelle Etienne, Ahmed Jeribi, Nassim Kamar, Claire Pouteil-Noble, Christiane Mousson. Actinomycosis: An infrequent disease in renal transplant recipients?. Transplant infectious disease : an official journal of the Transplantation Society. 2018 Dec; 20(6):e12970. doi: 10.1111/tid.12970. [PMID: 30055044]
  • Bai Wei, Min Kang, Hyung-Kwan Jang. Evaluation of potassium clavulanate supplementation of Bolton broth for enrichment and detection of Campylobacter from chicken. PloS one. 2018; 13(10):e0205324. doi: 10.1371/journal.pone.0205324. [PMID: 30356296]
  • Alejandro Hoberman, Jack L Paradise, Howard E Rockette, Jong-Hyeon Jeong, Diana H Kearney, Sonika Bhatnagar, Timothy R Shope, Gysella Muñiz, Judith M Martin, Marcia Kurs-Lasky, MaryAnn Haralam, Marcia A Pope, Jennifer P Nagg, Wenchen Zhao, Mohammad Kowser Miah, Jan Beumer, Raman Venkataramanan, Nader Shaikh. Reduced-Concentration Clavulanate for Young Children with Acute Otitis Media. Antimicrobial agents and chemotherapy. 2017 07; 61(7):. doi: 10.1128/aac.00238-17. [PMID: 28438923]
  • J Lee, S C Ji, B Kim, S Yi, K H Shin, J Y Cho, K S Lim, S H Lee, S H Yoon, J Y Chung, K S Yu, H S Park, S H Kim, I J Jang. Exploration of Biomarkers for Amoxicillin/Clavulanate-Induced Liver Injury: Multi-Omics Approaches. Clinical and translational science. 2017 05; 10(3):163-171. doi: 10.1111/cts.12425. [PMID: 27785887]
  • A Ochoa-Aguilar, M A Sotomayor-Sobrino, R Jaimez, R Rodríguez, R Plancarte-Sánchez, R Ventura-Martinez. Antiallodynic Activity of Ceftriaxone and Clavulanic Acid in Acute Administration is Associated with Serum TNF-α Modulation and Activation of Dopaminergic and Opioidergic Systems. Drug development research. 2017 03; 78(2):105-115. doi: 10.1002/ddr.21381. [PMID: 28345130]
  • Toufic A Kabbani, Kumar Pallav, Scot E Dowd, Javier Villafuerte-Galvez, Rohini R Vanga, Natalia E Castillo, Joshua Hansen, Melinda Dennis, Daniel A Leffler, Ciarán P Kelly. Prospective randomized controlled study on the effects of Saccharomyces boulardii CNCM I-745 and amoxicillin-clavulanate or the combination on the gut microbiota of healthy volunteers. Gut microbes. 2017 01; 8(1):17-32. doi: 10.1080/19490976.2016.1267890. [PMID: 27973989]
  • Raju Bhandari, Narayan Dutt Pant, Asia Poudel, Mukunda Sharma. Assessment of the effectiveness of three different cephalosporin/clavulanate combinations for the phenotypic confirmation of extended-spectrum beta-lactamase producing bacteria isolated from urine samples at National Public Health Laboratory, Kathmandu, Nepal. BMC research notes. 2016 08; 9(?):390. doi: 10.1186/s13104-016-2192-2. [PMID: 27488224]
  • Yaxin Fan, Xiaojie Wu, Miao Zhao, Beining Guo, Guoying Cao, Jicheng Yu, Yuancheng Chen, Jing Zhang. Rapid and Simultaneous Quantitation of Amoxicillin and Clavulanic Acid in Human Plasma and Urine by Ultra-Performance Liquid Chromatography Tandem Mass Spectrometry and Its Application to a Pharmacokinetic Study. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2016; 32(12):1269-1276. doi: 10.2116/analsci.32.1269. [PMID: 27941254]
  • Pieter A J G De Cock, Joseph F Standing, Charlotte I S Barker, Annick de Jaeger, Evelyn Dhont, Mieke Carlier, Alain G Verstraete, Joris R Delanghe, Hugo Robays, Peter De Paepe. Augmented renal clearance implies a need for increased amoxicillin-clavulanic acid dosing in critically ill children. Antimicrobial agents and chemotherapy. 2015 Nov; 59(11):7027-35. doi: 10.1128/aac.01368-15. [PMID: 26349821]
  • Sophia Lionaki, Konstantinos Panagiotellis, Demetrios Moris, George Daikos, Mina Psyhogiou, Spiridon Vernadakis, Georgios Zavos, John N Boletis. Clostridium difficile infection among kidney transplant recipients: frequency, clinical presentation, and outcome. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 2015 Mar; 123(3):234-9. doi: 10.1111/apm.12348. [PMID: 25556694]
  • Fernando Pineda, Adriana Ariza, Cristobalina Mayorga, Francisca Arribas, Rosario González-Mendiola, Natalia Blanca-López, Galicia Davila, Nieves Cabañes, Gabriela Canto, José Julio Laguna, Carlos Senent, Per Stahl-Skov, Ricardo Palacios, Miguel Blanca, María José Torres. Role of Histamine Release Test for the Evaluation of Patients with Immediate Hypersensitivity Reactions to Clavulanic Acid. International archives of allergy and immunology. 2015; 168(4):233-40. doi: 10.1159/000443274. [PMID: 26894754]
  • Teresa Jackowska, Jakub Chwiećko, Piotr Hartmann. [The etiology of urinary tract infections and antimicrobial susceptibility: study based on children hospitalized in 2012]. Developmental period medicine. 2014 Oct; 18(4):470-6. doi: NULL. [PMID: 25874786]
  • Frida Gustafsson, Alison J Foster, Sunil Sarda, Matthew H Bridgland-Taylor, J Gerry Kenna. A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans. Toxicological sciences : an official journal of the Society of Toxicology. 2014 Jan; 137(1):189-211. doi: 10.1093/toxsci/kft223. [PMID: 24085192]
  • Juanhong Zhang, Yinfu Wang, Hua Xie, Rong Wang, Zhengping Jia, Xiandong Men, Liting Xu, Qiang Zhang. Pharmacokinetics study of amoxycillin and clavulanic acid (8:1)--a new combination in healthy Chinese adult male volunteers using the LC-MS/MS method. Cell biochemistry and biophysics. 2013 Apr; 65(3):363-72. doi: 10.1007/s12013-012-9440-4. [PMID: 23109176]
  • Anil Dubala, Janaki Sankarachari Krishnan Nagarajan, Chandran Sathish Vimal, Renjith George. Simultaneous quantification of cefpodoxime proxetil and clavulanic acid in human plasma by LC-MS using solid phase extraction with application to pharmacokinetic studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2013 Mar; 921-922(?):49-55. doi: 10.1016/j.jchromb.2013.01.018. [PMID: 23434877]
  • Tuba Celik, Dilek Yuksel, Mustafa Kosker, Elif Betul Turkoglu. Unilateral acute dacryocystitis associated with oculoglandular tularemia: a case report. Seminars in ophthalmology. 2013 Mar; 28(2):91-3. doi: 10.3109/08820538.2012.760624. [PMID: 23448564]
  • Yoram Fleissig, Eran Regev, Hadas Lehman. Sunitinib related osteonecrosis of jaw: a case report. Oral surgery, oral medicine, oral pathology and oral radiology. 2012 Mar; 113(3):e1-3. doi: 10.1016/j.tripleo.2011.06.023. [PMID: 22676833]
  • Takehiko Sho, Tetsuro Muratani, Yukihiro Mizokami, Ryoichi Hamasuna, Naoki Fujimoto, Tetsuro Matsumoto. Mechanism of resistance of a highly carbapenem-resistant Klebsiella oxytoca isolate and comparison of susceptibility to five carbapenems. International journal of antimicrobial agents. 2012 Mar; 39(3):268-9. doi: 10.1016/j.ijantimicag.2011.11.009. [PMID: 22226923]
  • Sarah Dawson, Simone Stahl, Nikki Paul, Jane Barber, J Gerald Kenna. In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans. Drug metabolism and disposition: the biological fate of chemicals. 2012 Jan; 40(1):130-8. doi: 10.1124/dmd.111.040758. [PMID: 21965623]
  • Gina Chun Kost, Senthil Selvaraj, Young Bok Lee, Deog Joong Kim, Chang-Ho Ahn, Brij B Singh. Clavulanic acid increases dopamine release in neuronal cells through a mechanism involving enhanced vesicle trafficking. Neuroscience letters. 2011 Oct; 504(2):170-175. doi: 10.1016/j.neulet.2011.09.032. [PMID: 21964384]
  • Zu-wen Lin, Yuan Li, Wei-juan Song, Hai-yan Hu, Ying Zeng, Bai-hong Xu. [Simultaneous determination of serum concentrations of amoxicillin and clavulanate potassium in human blood using high-performance liquid chromatography]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2011 Jun; 31(6):1069-71. doi: NULL. [PMID: 21690072]
  • Samia Réjiba, Paola Sandra Mercuri, Pablo Power, Amel Kechrid. Emergence and dominance of CTX-M-15 extended spectrum beta-lactamase among Escherichia coli isolates from children. Microbial drug resistance (Larchmont, N.Y.). 2011 Jun; 17(2):135-40. doi: 10.1089/mdr.2010.0098. [PMID: 21288137]
  • Biljana Cirić, Dusan Jandrić, Vesna Kilibarda, Jasmina Jović-Stosić, Viktorija Dragojević-Simić, Slavica Vucinić. [Simultaneous determination of amoxicillin and clavulanic acid in the human plasma by high performance liquid chromatography-mass spectrometry (UPLC/MS)]. Vojnosanitetski pregled. 2010 Nov; 67(11):887-92. doi: 10.2298/vsp1011887c. [PMID: 21268924]
  • F Hasanpour, Ali A Ensafi, T Khayamian. Simultaneous chemiluminescence determination of amoxicillin and clavulanic acid using least squares support vector regression. Analytica chimica acta. 2010 Jun; 670(1-2):44-50. doi: 10.1016/j.aca.2010.05.001. [PMID: 20685415]
  • Zaichang Yang, Yule Niu, Yi Le, Xiaoyan Ma, Chong Qiao. Beta-lactamase inhibitory component from the roots of Fissistigma cavaleriei. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2010 Feb; 17(2):139-41. doi: 10.1016/j.phymed.2009.08.003. [PMID: 19747808]
  • Dongeun Yong, Mark A Toleman, Christian G Giske, Hyun S Cho, Kristina Sundman, Kyungwon Lee, Timothy R Walsh. Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India. Antimicrobial agents and chemotherapy. 2009 Dec; 53(12):5046-54. doi: 10.1128/aac.00774-09. [PMID: 19770275]
  • Alejandro Beceiro, Rafael López-Rojas, Juan Domínguez-Herrera, Fernando Docobo-Pérez, Germán Bou, Jerónimo Pachón. In vitro activity and in vivo efficacy of clavulanic acid against Acinetobacter baumannii. Antimicrobial agents and chemotherapy. 2009 Oct; 53(10):4298-304. doi: 10.1128/aac.00320-09. [PMID: 19635957]
  • Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance. Journal of medicinal chemistry. 2009 Aug; 52(15):4844-52. doi: 10.1021/jm900403j. [PMID: 19445515]
  • Cornelia B Landersdorfer, Martina Kinzig, Jürgen B Bulitta, Friedrich F Hennig, Ulrike Holzgrabe, Fritz Sörgel, Johannes Gusinde. Bone penetration of amoxicillin and clavulanic acid evaluated by population pharmacokinetics and Monte Carlo simulation. Antimicrobial agents and chemotherapy. 2009 Jun; 53(6):2569-78. doi: 10.1128/aac.01119-08. [PMID: 19307356]
  • Anna Engelbrektson, Joshua R Korzenik, Arlyn Pittler, Mary E Sanders, Todd R Klaenhammer, Gregory Leyer, Christopher L Kitts. Probiotics to minimize the disruption of faecal microbiota in healthy subjects undergoing antibiotic therapy. Journal of medical microbiology. 2009 May; 58(Pt 5):663-670. doi: 10.1099/jmm.0.47615-0. [PMID: 19369530]
  • S S Hoskote, Veena R Iyer, V M Kothari, Darshana A Sanghvi. Bilateral anterior cerebral artery infarction following viper bite. The Journal of the Association of Physicians of India. 2009 Jan; 57(?):67-9. doi: NULL. [PMID: 19753762]
  • G Efthimiou, A E Thumser, C A Avignone-Rossa. A novel finding that Streptomyces clavuligerus can produce the antibiotic clavulanic acid using olive oil as a sole carbon source. Journal of applied microbiology. 2008 Dec; 105(6):2058-64. doi: 10.1111/j.1365-2672.2008.03975.x. [PMID: 19120651]
  • R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals. 2008 Jul; 36(7):1385-405. doi: 10.1124/dmd.108.020479. [PMID: 18426954]
  • Djalal Meziane-Cherif, Thierry Lambert, Marine Dupêchez, Patrice Courvalin, Marc Galimand. Genetic and biochemical characterization of OXA-63, a new class D beta-lactamase from Brachyspira pilosicoli BM4442. Antimicrobial agents and chemotherapy. 2008 Apr; 52(4):1264-8. doi: 10.1128/aac.00684-07. [PMID: 18212108]
  • Egidia Miftode, Olivia Dorneanu, D Leca, Andra Teodor, Doina Mihalache, O Filip, V Luca. [Antimicrobial resistance profile of E. coli and Klebsiella spp. from urine in the Infectious Diseases Hospital Iaşi]. Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi. 2008 Apr; 112(2):478-82. doi: NULL. [PMID: 19295023]
  • Tim Reyns, Sandra De Boever, Siegrid De Baere, Patrick De Backer, Siska Croubels. Tissue depletion of amoxicillin and its major metabolites in pigs: influence of the administration route and the simultaneous dosage of clavulanic acid. Journal of agricultural and food chemistry. 2008 Jan; 56(2):448-54. doi: 10.1021/jf072398p. [PMID: 18163566]
  • T Prado, W C Pereira, D M Silva, L M Seki, A P D'A Carvalho, M D Asensi. Detection of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae in effluents and sludge of a hospital sewage treatment plant. Letters in applied microbiology. 2008 Jan; 46(1):136-41. doi: 10.1111/j.1472-765x.2007.02275.x. [PMID: 17983431]
  • T Reyns, S De Boever, K Baert, S Croubels, S Schauvliege, F Gasthuys, P De Backer. Disposition and oral bioavailability of amoxicillin and clavulanic acid in pigs. Journal of veterinary pharmacology and therapeutics. 2007 Dec; 30(6):550-5. doi: 10.1111/j.1365-2885.2007.00910.x. [PMID: 17991223]
  • L Alou, L Aguilar, D Sevillano, M J Giménez, N González, O Echeverría, M Torrico, J E Martín, L Valdés, J Prieto. Levofloxacin vs. azithromycin pharmacodynamic activity against S. pneumoniae and H. influenzae with decreased susceptibility to amoxicillin/clavulanic acid. Journal of chemotherapy (Florence, Italy). 2007 Dec; 19(6):670-2. doi: 10.1179/joc.2007.19.6.670. [PMID: 18230548]
  • Seyed Mohsen Foroutan, Afshin Zarghi, Alireza Shafaati, Arash Khoddam, Hooman Movahed. Simultaneous determination of amoxicillin and clavulanic acid in human plasma by isocratic reversed-phase HPLC using UV detection. Journal of pharmaceutical and biomedical analysis. 2007 Nov; 45(3):531-4. doi: 10.1016/j.jpba.2007.06.019. [PMID: 17686600]
  • M Torrico, L Aguilar, N González, M J Giménez, O Echeverría, F Cafini, D Sevillano, L Alou, P Coronel, J Prieto. influence of TEM-1 beta-lactamase on the pharmacodynamic activity of simulated total versus free-drug serum concentrations of cefditoren (400 milligrams) versus amoxicillin-clavulanic acid (2,000/125 milligrams) against Haemophilus influenzae strains exhibiting an N526K mutation in the ftsI gene. Antimicrobial agents and chemotherapy. 2007 Oct; 51(10):3699-706. doi: 10.1128/aac.01530-06. [PMID: 17664320]
  • Alyssa R McIntyre, Neil S Lipman. Amoxicillin-clavulanic acid and trimethoprim- sulfamethoxazole in rodent feed and water: effects of compounding on antibiotic stability. Journal of the American Association for Laboratory Animal Science : JAALAS. 2007 Sep; 46(5):26-32. doi: NULL. [PMID: 17877324]
  • Tim Reyns, Sandra De Boever, Siegrid De Baere, Patrick De Backer, Siska Croubels. Quantitative analysis of clavulanic acid in porcine tissues by liquid chromatography combined with electrospray ionization tandem mass spectrometry. Analytica chimica acta. 2007 Aug; 597(2):282-9. doi: 10.1016/j.aca.2007.06.056. [PMID: 17683740]
  • Richard Borrows, Gary Chusney, Marina Loucaidou, Anthony James, Jen Van Tromp, Tom Cairns, Megan Griffith, Nadey Hakim, Adam McLean, Andrew Palmer, Vassilios Papalois, David Taube. The magnitude and time course of changes in mycophenolic acid 12-hour predose levels during antibiotic therapy in mycophenolate mofetil-based renal transplantation. Therapeutic drug monitoring. 2007 Feb; 29(1):122-6. doi: 10.1097/ftd.0b013e31803111d5. [PMID: 17304160]
  • Wirongrong Chierakul, Jinda Wangboonskul, Thida Singtoroj, Wirichada Pongtavornpinyo, Jennifer M Short, Bina Maharjan, Vanaporn Wuthiekanun, David A B Dance, Prapit Teparrukkul, Niklas Lindegardh, Sharon J Peacock, Nicholas P Day, Wipada Chaowagul, Nicholas J White. Pharmacokinetic and pharmacodynamic assessment of co-amoxiclav in the treatment of melioidosis. The Journal of antimicrobial chemotherapy. 2006 Dec; 58(6):1215-20. doi: 10.1093/jac/dkl389. [PMID: 17003061]
  • Tim Reyns, Siegrid De Baere, Siska Croubels, Patrick De Backer. Determination of clavulanic acid in calf plasma by liquid chromatography tandem mass spectrometry. Journal of mass spectrometry : JMS. 2006 Nov; 41(11):1414-20. doi: 10.1002/jms.1106. [PMID: 17051520]
  • P Crispino, F Iacopini, R Pica, A Consolazio, A Bella, C Cassieri, F Nardi, P Paoluzi. Beta-lactamase inhibition with clavulanic acid supplementing standard amoxycillin-based triple therapy does not increase Helicobacter pylori eradication rate. Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 2005 Nov; 37(11):826-31. doi: 10.1016/j.dld.2005.07.010. [PMID: 16169304]
  • Suranjana Arora, Manjusri Bal. AmpC beta-lactamase producing bacterial isolates from Kolkata hospital. The Indian journal of medical research. 2005 Sep; 122(3):224-33. doi: NULL. [PMID: 16251779]
  • Kashif Manzoor, Saif Khan, Ejaz Ahmed, Fazal Akhter, Mohamad Mubarak, Syed Ali Anwar Naqvi, Adibul Hasan Rizvi. Crescentic glomerulonephritis associated with bacterial endocarditis--antibiotics alone may be sufficient. A case report. JPMA. The Journal of the Pakistan Medical Association. 2005 Aug; 55(8):352-4. doi: NULL. [PMID: 16164165]
  • Carrnen Ponte, Matilde Gracia, Maria-José Giménez, Lorenzo Aguilar, Carmen Martínez Maín, Yolanda Carpintero, Lorena Huelves, Antonio Carcas, Gemma del Prado, Francisco Soriano. Urinary concentrations and bactericidal activity against amoxicillin-nonsusceptible strains of Escherichia coli with single-dose, oral, sustained-release amoxicillin/clavulanic acid: a phase I, open-label, noncomparative clinical trial in healthy volunteers. Clinical therapeutics. 2005 Jul; 27(7):1043-9. doi: 10.1016/j.clinthera.2005.07.001. [PMID: 16154483]
  • Valerie Berry, Jennifer Hoover, Christine Singley, Gary Woodnutt. Comparative bacteriological efficacy of pharmacokinetically enhanced amoxicillin-clavulanate against Streptococcus pneumoniae with elevated amoxicillin MICs and Haemophilus influenzae. Antimicrobial agents and chemotherapy. 2005 Mar; 49(3):908-15. doi: 10.1128/aac.49.3.908-915.2005. [PMID: 15728883]
  • Amparo Sánchez Navarro. New formulations of amoxicillin/clavulanic acid: a pharmacokinetic and pharmacodynamic review. Clinical pharmacokinetics. 2005; 44(11):1097-115. doi: 10.2165/00003088-200544110-00001. [PMID: 16231964]
  • Kyung-Hwan Yoon, So-Young Lee, Won Kim, Jong-Sei Park, Hie-Joon Kim. Simultaneous determination of amoxicillin and clavulanic acid in human plasma by HPLC-ESI mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2004 Dec; 813(1-2):121-7. doi: 10.1016/j.jchromb.2004.09.018. [PMID: 15556524]
  • Inga Odenholt, Otto Cars, Elisabeth Löwdin. Pharmacodynamic studies of amoxicillin against Streptococcus pneumoniae: comparison of a new pharmacokinetically enhanced formulation (2000 mg twice daily) with standard dosage regimens. The Journal of antimicrobial chemotherapy. 2004 Dec; 54(6):1062-6. doi: 10.1093/jac/dkh484. [PMID: 15563517]
  • Gianluca Averono, Massimo Olina, Matteo Basile, Marco Bagnati, Alessia Uglietti, Pietro Luigi Garavelli, Giorgio Bellomo, Francesco Pia. [Amoxicillin in tonsillectomy: preliminary data on the evaluation of serum and tissue concentrations]. Recenti progressi in medicina. 2004 Jun; 95(6):314-5. doi: NULL. [PMID: 15248415]
  • Han-Gon Choi, H Won Jun, Dae-Duk Kim, Hongkee Sah, Bong Kyu Yoo, Chul Soon Yong. Simultaneous determination of cefatrizine and clavulanic acid in dog plasma by HPLC. Journal of pharmaceutical and biomedical analysis. 2004 Apr; 35(1):221-31. doi: 10.1016/j.jpba.2004.01.010. [PMID: 15030898]
  • José María Aguado-García, José Emilio Martín-Herrero, Carlos Lumbreras-Bermejo. [Bacterial resistance and pharmacodynamics as the basis for prescribing antibiotics in respiratory infections]. Enfermedades infecciosas y microbiologia clinica. 2004 Apr; 22(4):230-7. doi: 10.1157/13059054. [PMID: 15056440]
  • Vincent B Young, Thomas M Schmidt. Antibiotic-associated diarrhea accompanied by large-scale alterations in the composition of the fecal microbiota. Journal of clinical microbiology. 2004 Mar; 42(3):1203-6. doi: 10.1128/jcm.42.3.1203-1206.2004. [PMID: 15004076]
  • Carmen Ponte, Araceli Parra, Carlos Cenjor, Marta Garcia-Olmos, Maria Jose Gimenez, Lorenzo Aguilar, Antonio Carcas, Francisco Soriano. Does acetaminophen interfere in the antibiotic treatment of acute otitis media caused by a penicillin-resistant pneumococcus strain? A gerbil model. Pediatric research. 2003 Dec; 54(6):913-8. doi: 10.1203/01.pdr.0000090931.94785.da. [PMID: 12930908]
  • Chonghua Li, Qiuming Geng, David P Nicolau, Charles H Nightingale. Simultaneous determination of ticarcillin and clavulanate in rabbit serum and tissue cage fluid by liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2003 Sep; 794(2):227-36. doi: 10.1016/s1570-0232(03)00456-2. [PMID: 12954375]
  • T B Vree, E Dammers, E Van Duuren. Variable absorption of clavulanic acid after an oral dose of 25 mg/kg of Clavubactin and Synulox in healthy dogs. Journal of veterinary pharmacology and therapeutics. 2003 Jun; 26(3):165-71. doi: 10.1046/j.1365-2885.2003.00476.x. [PMID: 12755899]
  • Tom B Vree, Erik Dammers, Peter S Exler. Identical pattern of highly variable absorption of clavulanic acid from four different oral formulations of co-amoxiclav in healthy subjects. The Journal of antimicrobial chemotherapy. 2003 Feb; 51(2):373-8. doi: 10.1093/jac/dkg082. [PMID: 12562705]
  • Guillaume Hoizey, Denis Lamiable, Carole Frances, Thierry Trenque, Matthieu Kaltenbach, Jacky Denis, Hervé Millart. Simultaneous determination of amoxicillin and clavulanic acid in human plasma by HPLC with UV detection. Journal of pharmaceutical and biomedical analysis. 2002 Oct; 30(3):661-6. doi: 10.1016/s0731-7085(02)00289-3. [PMID: 12367691]
  • E Löwdin, O Cars, I Odenholt. Pharmacodynamics of amoxicillin/clavulanic acid against Haemophilus influenzae in an in vitro kinetic model: a comparison of different dosage regimens including a pharmacokinetically enhanced formulation. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2002 Oct; 8(10):646-53. doi: 10.1046/j.1469-0691.2002.00441.x. [PMID: 12390283]
  • Ahmed Ameur, Mohamed Lezrek, Hassan Boumdin, Amoqrane Beddouch. [Focal bacterial nephritis: diagnosis and treatment]. Progres en urologie : journal de l'Association francaise d'urologie et de la Societe francaise d'urologie. 2002 Jun; 12(3):479-81. doi: NULL. [PMID: 12189761]
  • Tom B Vree, Erik Dammers, Eri van Duuren. Variable absorption of clavulanic acid after an oral dose of 25 mg/kg of Clavubactin and Synulox in healthy cats. TheScientificWorldJournal. 2002 May; 2(?):1369-78. doi: 10.1100/tsw.2002.287. [PMID: 12805922]
  • V Murbach, N Dhoyen, L Linger, H Monteil, F Jehl. Evidence for a true post-beta-lactamase-inhibitor effect of clavulanic acid against Klebsiella pneumoniae and Haemophilus influenzae. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2001 Dec; 7(12):661-5. doi: 10.1046/j.1469-0691.2001.00336.x. [PMID: 11843906]
  • A A Neves, D A Pereira, L M Vieira, J C Menezes. Real time monitoring biomass concentration in Streptomyces clavuligerus cultivations with industrial media using a capacitance probe. Journal of biotechnology. 2001 Nov; 84(1):45-52. doi: 10.1016/s0168-1656(00)00325-4. [PMID: 11035186]
  • K L Mealey. Penicillins and beta-lactamase inhibitor combinations. Journal of the American Veterinary Medical Association. 2001 Jun; 218(12):1893-6. doi: 10.2460/javma.2001.218.1893. [PMID: 11417732]
  • C M Kaye, A Allen, S Perry, M McDonagh, M Davy, K Storm, N Bird, O Dewit. The clinical pharmacokinetics of a new pharmacokinetically enhanced formulation of amoxicillin/clavulanate. Clinical therapeutics. 2001 Apr; 23(4):578-84. doi: 10.1016/s0149-2918(01)80061-8. [PMID: 11354391]
  • A A Neves, L M Vieira, J C Menezes. Effects of preculture variability on clavulanic acid fermentation. Biotechnology and bioengineering. 2001 Mar; 72(6):628-33. doi: 10.1002/1097-0290(20010320)72:6<628::aid-bit1028>3.0.co;2-l. [PMID: 11460254]
  • H Sourgens, H Steinbrede, J S Verschoor, M A Bertola, B Rayer. Bioequivalence study of a novel Solutab tablet formulation of amoxicillin/clavulanic acid versus the originator film-coated tablet. International journal of clinical pharmacology and therapeutics. 2001 Feb; 39(2):75-82. doi: 10.5414/cpp39075. [PMID: 11270805]
  • S D Van Camp, M G Papich, M D Whitacre. Administration of ticarcillin in combination with clavulanic acid intravenously and intrauterinely to clinically normal oestrous mares. Journal of veterinary pharmacology and therapeutics. 2000 Dec; 23(6):373-8. doi: 10.1046/j.1365-2885.2000.00297.x. [PMID: 11168915]