Ketamine (BioDeep_00000001544)

 

Secondary id: BioDeep_00000397509

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one

化学式: C13H16ClNO (237.09203559999997)
中文名称: 氯胺酮
谱图信息: 最多检出来源 Homo sapiens(natural_products) 7.69%

分子结构信息

SMILES: CNC(C2)(C(=O)CCC2)c(c1)c(Cl)ccc1
InChI: InChI=1S/C13H16ClNO/c1-15-13(9-5-4-8-12(13)16)10-6-2-3-7-11(10)14/h2-3,6-7,15H,4-5,8-9H2,1H3

描述信息

Ketamine is only found in individuals that have used or taken this drug. It is a cyclohexanone derivative used for induction of anesthesia. Its mechanism of action is not well understood, but ketamine can block NMDA receptors (receptors, N-methyl-D-aspartate) and may interact with sigma receptors. [PubChem]Ketamine has several clinically useful properties, including analgesia and less cardiorespiratory depressant effects than other anaesthetic agents, it also causes some stimulation of the cardiocascular system. Ketamine has been reported to produce general as well as local anaesthesia. It interacts with N-methyl-D-aspartate (NMDA) receptors, opioid receptors, monoaminergic receptors, muscarinic receptors and voltage sensitive Ca ion channels. Unlike other general anaesthetic agents, ketamine does not interact with GABA receptors.
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent
D002491 - Central Nervous System Agents > D000700 - Analgesics
CONFIDENCE standard compound; EAWAG_UCHEM_ID 2826
KEIO_ID K005; [MS2] KO009114
KEIO_ID K005
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

27 个代谢物同义名

2-(2-chlorophenyl)-2-(methylamino)cyclohexan-1-one; 2-(O-Chlorophenyl)-2-(methylamino)-cyclohexanone; 2-(Methylamino)-2-(2-chlorophenyl)cyclohexanone; 2-(2-Chlorophenyl)-2-(methylamino)cyclohexanone; 2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone; Ketamine hydrochloride; (S)-(-)-Ketamine; Ketamine base; (+-)-Ketamine; (S)-Ketamine; (-)-Ketamine; Ketamine HCL; DL-Ketamine; CI 581 base; L-Ketamine; Special K; Ketaminum; Calipsol; ketamine; Calypsol; Ketamina; Kalipsol; Ketanest; Ketaset; Ketalar; Tekam; NMDA



数据库引用编号

40 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Daniele Cavaleri, Ilaria Riboldi, Cristina Crocamo, Giuseppe Paglia, Giuseppe Carrà, Francesco Bartoli. Evidence from preclinical and clinical metabolomics studies on the antidepressant effects of ketamine and esketamine. Neuroscience letters. 2024 May; 831(?):137791. doi: 10.1016/j.neulet.2024.137791. [PMID: 38670523]
  • Guoweng Niu, Xiaozhu Zheng, Bigao Deng, Yong S Du, Yang Mei. The effects of prophylactic use of esketamine on postoperative depression and quality of life: a meta-analysis. Minerva anestesiologica. 2024 04; 90(4):321-329. doi: 10.23736/s0375-9393.24.17703-6. [PMID: 38498317]
  • Shijin Ma, Yuzhe Dou, Wei Wang, Ai Wei, Mengxia Lan, Jingyu Liu, Lina Yang, Mengchang Yang. Association between esketamine interventions and postpartum depression and analgesia following cesarean delivery: a systematic review and meta-analysis. American journal of obstetrics & gynecology MFM. 2024 Mar; 6(3):101241. doi: 10.1016/j.ajogmf.2023.101241. [PMID: 38262519]
  • Li Ren. The mechanistic basis for the rapid antidepressant-like effects of ketamine: From neural circuits to molecular pathways. Progress in neuro-psychopharmacology & biological psychiatry. 2024 Feb; 129(?):110910. doi: 10.1016/j.pnpbp.2023.110910. [PMID: 38061484]
  • Boran Deng, Dingding Wang, Zifeng Xie, Yongqin Wang, Li Huang, Manlin Jiang, Tu Shen. Comparison of the analgesic effect of dezocine and esketamine in combination with sufentanil respectively after laparoscopic cholecystectomy: a prospective randomized controlled study. BMC anesthesiology. 2024 Feb; 24(1):51. doi: 10.1186/s12871-024-02430-y. [PMID: 38317099]
  • Xiaofeng Lan, Haiyan Liu, Chengyu Wang, Weicheng Li, Fan Zhang, Zhibo Hu, Xiaoyu Chen, Zerui You, Yuping Ning, Yanling Zhou. Sex differences in the effects of repeated ketamine infusions on bone markers in patients with unipolar and bipolar depression. Biology of sex differences. 2024 Jan; 15(1):12. doi: 10.1186/s13293-024-00587-2. [PMID: 38287453]
  • Marina Bellot, Fernando Soria, Raul López-Arnau, Cristian Gómez-Canela, Carlos Barata. Daphnia magna an emerging environmental model of neuro and cardiotoxicity of illicit drugs. Environmental pollution (Barking, Essex : 1987). 2024 Jan; 344(?):123355. doi: 10.1016/j.envpol.2024.123355. [PMID: 38228265]
  • Zack Blumenfeld, Kallol Bera, Eero Castrén, Henry A Lester. Antidepressants enter cells, organelles, and membranes. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2024 Jan; 49(1):246-261. doi: 10.1038/s41386-023-01725-x. [PMID: 37783840]
  • Cheng Song, Dong Wang, Bin Chen. A systematic review and meta-analysis comparing the efficacy and safety of ketamine versus morphine for the treatment of acute pain. Minerva anestesiologica. 2024 Jan; 90(1-2):77-86. doi: 10.23736/s0375-9393.23.17561-4. [PMID: 37930103]
  • Fatemeh Mobinhosseini, Mahsa Salehirad, A Wallace Hayes, Majid Motaghinejad, Malak Hekmati, Sepideh Safari, Mina Gholami. Curcumin-ZnO conjugated nanoparticles confer neuroprotection against ketamine-induced neurotoxicity. Journal of biochemical and molecular toxicology. 2024 Jan; 38(1):e23611. doi: 10.1002/jbt.23611. [PMID: 38084605]
  • Bin-Sen Zhang, Xiao-Jia Zhang, Chun-Ai Wang. The efficacy and safety of esketamine in pediatric anesthesia: A systematic review and meta-analysis. Asian journal of surgery. 2023 Dec; 46(12):5661-5663. doi: 10.1016/j.asjsur.2023.08.073. [PMID: 37684126]
  • Jiao Jiao, Jin Fan, Yonggang Zhang, Lingmin Chen. Efficacy and Safety of Ketamine to Treat Cancer Pain in Adult Patients: A Systematic Review. Journal of pain and symptom management. 2023 Nov; ?(?):. doi: 10.1016/j.jpainsymman.2023.11.004. [PMID: 37972720]
  • Shylo R Johnson, Christine K Ellis, Chad K Wickham, Molly R Selleck, Amy T Gilbert. Comparison of Ketamine-Xylazine, Butorphanol-Azaperone-Medetomidine, and Nalbuphine-Medetomidine-Azaperone for Raccoon (Procyon Lotor) Immobilization. Journal of wildlife diseases. 2023 Nov; ?(?):. doi: 10.7589/jwd-d-23-00060. [PMID: 37924235]
  • Elifrances Galdino de Oliveira, Diógenes Afonso de Lima, José Carlos da Silva Júnior, Mayara Victória de Souza Barbosa, Severina Cassia de Andrade Silva, Jonata Henrique de Santana, Osmar Henrique Dos Santos Junior, Eduardo Carvalho Lira, Claudia Jacques Lagranha, Filipe Silveira Duarte, Dayane Aparecida Gomes. (R)-ketamine attenuates neurodevelopmental disease-related phenotypes in a mouse model of maternal immune activation. European archives of psychiatry and clinical neuroscience. 2023 Oct; 273(7):1501-1512. doi: 10.1007/s00406-023-01629-3. [PMID: 37249625]
  • Guofen Zhang, Quli Li, Ping Wang. The analgesic efficacy of ketamine for septorhinoplasty: a meta-analysis study. European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery. 2023 Sep; 280(9):4083-4089. doi: 10.1007/s00405-023-07933-x. [PMID: 37027028]
  • Chan Li, Jiping Zhang, Hanhe Liu, Huijie Yuan, Jianxin Cai, Manoela V Fogaça, Yuan-Wei Zhang. The synergistic mechanism of action of Dajianzhong decoction in conjunction with ketamine in the treatment of depression. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Sep; 165(?):115137. doi: 10.1016/j.biopha.2023.115137. [PMID: 37453197]
  • Tao Chen, Ling Cheng, Jingwen Ma, Jiyuan Yuan, Chao Pi, Linjin Xiong, Jinglin Chen, Huiyang Liu, Jia Tang, Yueting Zhong, Xiaomei Zhang, Zerong Liu, Ying Zuo, Hongping Shen, Yumeng Wei, Ling Zhao. Molecular mechanisms of rapid-acting antidepressants: New perspectives for developing antidepressants. Pharmacological research. 2023 Jun; 194(?):106837. doi: 10.1016/j.phrs.2023.106837. [PMID: 37379962]
  • Guo-Hua Wu, Que-Hui Guo, Xiao-Dong Xu, Jian-Chang Lin, Gui-Ting You, Cai-Hou Lin, Liang-Cheng Zhang. Ketamine exerts dual effects on the apoptosis of primary cultured hippocampal neurons from fetal rats in vitro. Metabolic brain disease. 2023 Jun; ?(?):. doi: 10.1007/s11011-023-01236-0. [PMID: 37273081]
  • Shiva Saljoughi, Hadi Kalantar, Reza Azadnasab, Mohammad Javad Khodayar. Neuroprotective effects of dimethyl fumarate against manic-like behavior induced by ketamine in rats. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Apr; ?(?):. doi: 10.1007/s00210-023-02505-6. [PMID: 37103520]
  • Cinthia Cristina Menezes da Silveira, Sabrina de Carvalho Cartágenes, Natália Harumi Corrêa Kobayashi, Sarah Viana Farias, Fábio José Coelho de Souza-Junior, Luanna Melo Pereira Fernandes, Alejandro Ferraz do Prado, Walessa Alana Bragança Aragão, Rafael Rodrigues Lima, Wallax Augusto Silva Ferreira, Edivaldo Herculano Correa de Oliveira, Fernando Augusto Rodrigues Mello Júnior, Rommel Mario Rodríguez Burbano, Enéas Andrade Fontes-Júnior, Cristiane do Socorro Ferraz Maia. One binge-type cycle of alcohol plus ketamine exposure induces emotional-like disorders associated with oxidative damage in adolescent female rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2023 Apr; 162(?):114641. doi: 10.1016/j.biopha.2023.114641. [PMID: 37023622]
  • Behnam Noorani, Ekram Ahmed Chowdhury, Faleh Alqahtani, Yeseul Ahn, Ehsan Nozohouri, Sumaih Zoubi, Dhavalkumar Patel, Laurence Wood, Juyang Huang, Muhammad Bilal Siddique, Abraham Al-Ahmad, Reza Mehvar, Ulrich Bickel. Effects of Volatile Anesthetics Versus Ketamine on Blood-Brain Barrier Permeability via Lipid-Mediated Alterations of Endothelial Cell Membranes. The Journal of pharmacology and experimental therapeutics. 2023 Feb; ?(?):. doi: 10.1124/jpet.122.001281. [PMID: 36828631]
  • Shih-Jen Tsai, Chung-Feng Kao, Tung-Ping Su, Cheng-Ta Li, Wei-Chen Lin, Chen-Jee Hong, Ya-Mei Bai, Pei-Chi Tu, Mu-Hong Chen. Cytokine- and Vascular Endothelial Growth Factor-Related Gene-Based Genome-Wide Association Study of Low-Dose Ketamine Infusion in Patients with Treatment-Resistant Depression. CNS drugs. 2023 Feb; ?(?):. doi: 10.1007/s40263-023-00989-7. [PMID: 36763263]
  • Xin-Hua Zhao, Na An, Meng-Huan Xia, Wen-Ping Liu, Qing-Qi Wang, Ji-Zhang Bao. Nootkatone Improves Chronic Unpredictable Mild Stress-Induced Depressive-Like Behaviors by Repressing NF-κB/NLRP3-Mediated Neuroinflammation. Chinese journal of integrative medicine. 2023 Jan; 29(1):37-43. doi: 10.1007/s11655-022-3725-2. [PMID: 36401752]
  • Daisy Jepkosgei Kipkemoi, Anthony Murithi Ireri, Mathew Piero Ngugi. Cognition Enhancing Potential of Aqueous Leaf Extract of Amaranthus dubius in Mice. Journal of evidence-based integrative medicine. 2023 Jan; 28(?):2515690X231211661. doi: 10.1177/2515690x231211661. [PMID: 37960857]
  • Satoshi Deyama. [Elucidation of the Mechanisms Underlying the Rapid Antidepressant Actions of Ketamine and Search for Possible Candidates for Novel Rapid-acting Antidepressants]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2023; 143(9):713-720. doi: 10.1248/yakushi.23-00111. [PMID: 37661437]
  • Yukitoshi Izumi, Fong-Fu Hsu, Charles R Conway, Peter Nagele, Steven J Mennerick, Charles F Zorumski. Nitrous Oxide, a Rapid Antidepressant, Has Ketamine-like Effects on Excitatory Transmission in the Adult Hippocampus. Biological psychiatry. 2022 12; 92(12):964-972. doi: 10.1016/j.biopsych.2022.06.016. [PMID: 36050137]
  • Tülay Ceren Ölmeztürk Karakurt, İzzet Emir, Zehra Bedir, Kezban Tuna Ozkaloglu Erdem, Halis Süleyman, Cengiz Sarıgül, Ali Sefa Mendil. Effects of carvacrol on ketamine-induced cardiac injury in rats: an experimental study. Drug and chemical toxicology. 2022 Dec; ?(?):1-6. doi: 10.1080/01480545.2022.2155664. [PMID: 36511184]
  • Chenyang Gu, Jiale Liu, Yajing Li, Qiankun Zhang, Chaoqun Lin, Jiajun Huang, Wenjie Duan, Yushu Deng, Waqas Ahmed, Rong Li, Jun Long, Ahsan Ali Khan, Lukui Chen. Comparison of ketamine/xylazine and isoflurane anesthesia on the establishment of mouse middle cerebral artery occlusion model. Experimental animals. 2022 Nov; ?(?):. doi: 10.1538/expanim.22-0131. [PMID: 36418078]
  • Yu-Hsiung Chen, Mu-Hong Chen, Han-Ting Wei, Lian-Yu Chen. Survey of substance use among adolescent drug offenders referred from juvenile courts in Taiwan: Clinical epidemiology of single versus multiple illicit substance use. Journal of the Formosan Medical Association = Taiwan yi zhi. 2022 Nov; 121(11):2257-2264. doi: 10.1016/j.jfma.2022.04.009. [PMID: 35484001]
  • Ji-Chun Zhang, Wei Yao, Kenji Hashimoto. Arketamine, a new rapid-acting antidepressant: A historical review and future directions. Neuropharmacology. 2022 11; 218(?):109219. doi: 10.1016/j.neuropharm.2022.109219. [PMID: 35977629]
  • Xinlv Chen, Shuqin Liu, Ruifen Jiang, Tiangang Luan, Gangfeng Ouyang. Rapid detection and speciation of illicit drugs via a thin-film microextraction approach for wastewater-based epidemiology study. The Science of the total environment. 2022 Oct; 842(?):156888. doi: 10.1016/j.scitotenv.2022.156888. [PMID: 35753476]
  • Sadia Afrin, Ahmed Hossain, Shelina Begum. Effects of Moringa oleifera on working memory: an experimental study with memory-impaired Wistar rats tested in radial arm maze. BMC research notes. 2022 Oct; 15(1):314. doi: 10.1186/s13104-022-06219-5. [PMID: 36192762]
  • Weizhi Xu, Faheem Maqbool, Vinod Kumar, James R Falconer, Cedric S Cui, Trent M Woodruff, Karin Borges, Andrew K Whittaker, Maree T Smith, Felicity Y Han. Sustained-release ketamine-loaded lipid-particulate system: in vivo assessment in mice. Drug delivery and translational research. 2022 10; 12(10):2518-2526. doi: 10.1007/s13346-021-01093-3. [PMID: 34802093]
  • Noah A Omeiza, Adewale G Bakre, Halimat A Abdulrahim, Happy Isibor, Precious U Ezurike, Abimbola A Sowunmi, Benneth Ben-Azu, Adegbuyi O Aderibigbe. Pretreatment with Carpolobia lutea ethanol extract prevents schizophrenia-like behavior in mice models of psychosis. Journal of ethnopharmacology. 2022 Sep; 295(?):115432. doi: 10.1016/j.jep.2022.115432. [PMID: 35659625]
  • Liqin Zhao, Hailong Zhang, Hao Cheng. Effect of a single sub-dose of ketamine on postoperative fatigue syndrome in colorectal cancer patients undergoing radical laparoscopic surgery: A double-blind, pilot study. Journal of affective disorders. 2022 Sep; 312(?):146-151. doi: 10.1016/j.jad.2022.06.029. [PMID: 35750094]
  • Simon Zhornitsky, Valérie Tourjman, Julie Pelletier, Roxane Assaf, Chiang-Shan R Li, Stéphane Potvin. Acute effects of ketamine and esketamine on cognition in healthy subjects: A meta-analysis. Progress in neuro-psychopharmacology & biological psychiatry. 2022 08; 118(?):110575. doi: 10.1016/j.pnpbp.2022.110575. [PMID: 35568275]
  • Timothy A Troppoli, Panos Zanos, Polymnia Georgiou, Todd D Gould, Uwe Rudolph, Scott M Thompson. Negative Allosteric Modulation of Gamma-Aminobutyric Acid A Receptors at α5 Subunit-Containing Benzodiazepine Sites Reverses Stress-Induced Anhedonia and Weakened Synaptic Function in Mice. Biological psychiatry. 2022 08; 92(3):216-226. doi: 10.1016/j.biopsych.2021.11.024. [PMID: 35120711]
  • Balwinder Singh, Siamak MahmoudianDehkordi, Jennifer L Vande Voort, Xianlin Han, John D Port, Mark A Frye, Rima Kaddurah-Daouk. Metabolomic signatures of intravenous racemic ketamine associated remission in treatment-resistant depression: A pilot hypothesis generating study. Psychiatry research. 2022 08; 314(?):114655. doi: 10.1016/j.psychres.2022.114655. [PMID: 35738038]
  • Hui Bai, Zhiheng Zhang, Xiangying Ma, Meilun Shen, Rouqian Li, Siyao Li, Di Qiu, Li Gao. Inhibition of the NLRP3/caspase-1 signaling cascades ameliorates ketamine-induced renal injury and pyroptosis in neonatal rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2022 Aug; 152(?):113229. doi: 10.1016/j.biopha.2022.113229. [PMID: 35679721]
  • Mirko Lehmann, Claudia Neumann, Sven Wasserthal, Achilles Delis, Johannes Schultz, René Hurlemann, Ulrich Ettinger. Ketamine increases fronto-posterior functional connectivity during meta-perceptual confidence ratings. Behavioural brain research. 2022 07; 430(?):113925. doi: 10.1016/j.bbr.2022.113925. [PMID: 35580701]
  • Li Zhu, Yin Zhang. Discovery of novel ketamine-inspired derivatives as a protective agent against renal ischemic/reperfusion injury in Wistar rats. Chemical biology & drug design. 2022 07; 100(1):13-24. doi: 10.1111/cbdd.14011. [PMID: 34923757]
  • Rauane Sousa de Moura, Isabela Plazza Bittar, Janainne Hilbig Gomes, Yan Victor Rodrigues de Oliveira, Gladsthon Divino de Sousa Filho, Glauco Cézar Fragola de Faria Soares, Eliana Martins Lima, Leandro Guimarães Franco. Plasma concentration, cardiorespiratory and analgesic effects of ketamine-fentanyl infusion in dogs submitted to mastectomy. BMC veterinary research. 2022 Jun; 18(1):225. doi: 10.1186/s12917-022-03244-1. [PMID: 35701767]
  • Aleksi J Nummela, Lauri T Laaksonen, Timo T Laitio, Roosa E Kallionpää, Jaakko W Långsjö, Joonas M Scheinin, Tero J Vahlberg, Harri T Koskela, Viljami Aittomäki, Katja J Valli, Antti Revonsuo, Mikko Niemi, Markus Perola, Harry Scheinin. Effects of dexmedetomidine, propofol, sevoflurane and S-ketamine on the human metabolome: A randomised trial using nuclear magnetic resonance spectroscopy. European journal of anaesthesiology. 2022 06; 39(6):521-532. doi: 10.1097/eja.0000000000001591. [PMID: 34534172]
  • Chih-Chuan Lin, Te-I Weng, Chip-Jin Ng, Chia-Pang Shih, Jui Hsu, Yuan-Chun Liao, Chen-Chang Yang, Cheng-Chung Fang. Emergency department visits due to new psychoactive substances and other illicit drugs in Taiwan: preliminary results of the Taiwan Emergency Department Drug Abuse Surveillance (TEDAS) project. Clinical toxicology (Philadelphia, Pa.). 2022 06; 60(6):708-715. doi: 10.1080/15563650.2022.2038793. [PMID: 35315299]
  • Pedro David Wendel-Garcia, Rolf Erlebach, Daniel Andrea Hofmaenner, Giovanni Camen, Reto Andreas Schuepbach, Christoph Jüngst, Beat Müllhaupt, Jan Bartussek, Philipp Karl Buehler, Rea Andermatt, Sascha David. Long-term ketamine infusion-induced cholestatic liver injury in COVID-19-associated acute respiratory distress syndrome. Critical care (London, England). 2022 05; 26(1):148. doi: 10.1186/s13054-022-04019-8. [PMID: 35606831]
  • Kuang-Shun Chueh, Kuan-Hua Huang, Jian-He Lu, Tai-Jui Juan, Shu-Mien Chuang, Rong-Jyh Lin, Yi-Chen Lee, Cheng-Yu Long, Mei-Chen Shen, Ting-Wei Sun, Yung-Shun Juan. Therapeutic Effect of Platelet-Rich Plasma Improves Bladder Overactivity in the Pathogenesis of Ketamine-Induced Ulcerative Cystitis in a Rat Model. International journal of molecular sciences. 2022 May; 23(10):. doi: 10.3390/ijms23105771. [PMID: 35628581]
  • Daniel Kiefer, Lukas M Müller-Wirtz, Felix Maurer, Tobias Hüppe, Alexander M Mathes, Thomas Volk, Sascha Kreuer, Tobias Fink. Intravenous propofol, ketamine (ketofol) and rocuronium after sevoflurane induction provides long lasting anesthesia in ventilated rats. Experimental animals. 2022 May; 71(2):231-239. doi: 10.1538/expanim.21-0147. [PMID: 34880161]
  • Satoshi Deyama, Makoto Kondo, Shoichi Shimada, Katsuyuki Kaneda. IGF-1 release in the medial prefrontal cortex mediates the rapid and sustained antidepressant-like actions of ketamine. Translational psychiatry. 2022 05; 12(1):178. doi: 10.1038/s41398-022-01943-9. [PMID: 35577782]
  • Ruin Moaddel, Panos Zanos, Cristan A Farmer, Bashkim Kadriu, Patrick J Morris, Jacqueline Lovett, Elia E Acevedo-Diaz, Grace W Cavanaugh, Peixiong Yuan, Mani Yavi, Craig J Thomas, Lawrence T Park, Luigi Ferrucci, Todd D Gould, Carlos A Zarate. Comparative metabolomic analysis in plasma and cerebrospinal fluid of humans and in plasma and brain of mice following antidepressant-dose ketamine administration. Translational psychiatry. 2022 05; 12(1):179. doi: 10.1038/s41398-022-01941-x. [PMID: 35501309]
  • Lichao Ye, Xueling Xiao, Yuanyuan Xu, Chen Zheng, Si Chen, Tao Luo, Zhenlong Li, Yuze Du, Yilin Yuan, Linyi Li, Bo Liu, Wei Qin, Dylan Chou. Prelimbic cortex miR-34a contributes to (2R,6R)-hydroxynorketamine-mediated antidepressant-relevant actions. Neuropharmacology. 2022 05; 208(?):108984. doi: 10.1016/j.neuropharm.2022.108984. [PMID: 35131296]
  • John James van Bockxmeer, Anthony Lau, Vishal Varshney. Ketamine-precipitated syndrome of inappropriate antidiuretic hormone secretion in a patient with persistent lumbar pain: a case report. Canadian journal of anaesthesia = Journal canadien d'anesthesie. 2022 05; 69(5):624-629. doi: 10.1007/s12630-022-02221-4. [PMID: 35233721]
  • Erik Olofsen, Jasper Kamp, Thomas K Henthorn, Monique van Velzen, Marieke Niesters, Elise Sarton, Albert Dahan. Ketamine Psychedelic and Antinociceptive Effects Are Connected. Anesthesiology. 2022 05; 136(5):792-801. doi: 10.1097/aln.0000000000004176. [PMID: 35188952]
  • Jhe-Wei Lin, Yi-Chun Lin, Jui-Ming Liu, Shing-Hwa Liu, Kai-Min Fang, Ren-Jun Hsu, Chun-Fa Huang, Kai-Yao Chang, Kuan-I Lee, Kai-Chih Chang, Chin-Chuan Su, Ya-Wen Chen. Norketamine, the Main Metabolite of Ketamine, Induces Mitochondria-Dependent and ER Stress-Triggered Apoptotic Death in Urothelial Cells via a Ca2+-Regulated ERK1/2-Activating Pathway. International journal of molecular sciences. 2022 Apr; 23(9):. doi: 10.3390/ijms23094666. [PMID: 35563057]
  • Mostafa Mohammed Elhamamsy, Ahmed Mohammed Aldemerdash, Fathi Badie Zahran, Gehan Fawzy Mahmoud Ezz, Sara Abou AlSaud, Maged Labib Boules, Mahdy Ahmed Abdelhady, Mohamed Ahmed Hamed. Effects of adding low-dose ketamine to etomidate on serum cortisol levels in critically ill cardiac patients: a randomized clinical trial. BMC anesthesiology. 2022 04; 22(1):114. doi: 10.1186/s12871-022-01654-0. [PMID: 35448950]
  • Haley F Spencer, Rina Y Berman, Martin Boese, Michael Zhang, Sharon Y Kim, Kennett D Radford, Kwang H Choi. Effects of an intravenous ketamine infusion on inflammatory cytokine levels in male and female Sprague-Dawley rats. Journal of neuroinflammation. 2022 Apr; 19(1):75. doi: 10.1186/s12974-022-02434-w. [PMID: 35379262]
  • Ning Cong, Tian Tian, Bin Hu, Fu-Shan Xue. Is addition of lidocaine to ketamine beneficial for rapid sequence endotracheal intubation in patients with septic shock?. Anaesthesia, critical care & pain medicine. 2022 04; 41(2):101023. doi: 10.1016/j.accpm.2022.101023. [PMID: 35121187]
  • Colleen Elizabeth Howing, Farzad Razi, Wael Hakmeh. Resolution of status epilepticus after ketamine administration. The American journal of emergency medicine. 2022 Apr; 54(?):328.e1-328.e2. doi: 10.1016/j.ajem.2021.10.052. [PMID: 34763960]
  • Chu-An Yang, Hsiu-Chuan Liu, Ray H Liu, Dong-Liang Lin, Shu-Pao Wu. Simultaneous Quantitation of Seven Phenethylamine-Type Drugs in Forensic Blood and Urine Samples by UHPLC-MS-MS. Journal of analytical toxicology. 2022 Mar; 46(3):246-256. doi: 10.1093/jat/bkab014. [PMID: 33575738]
  • Yusuke Mizobuchi, Kanako Miyano, Sei Manabe, Eiko Uezono, Akane Komatsu, Yui Kuroda, Miki Nonaka, Yoshikazu Matsuoka, Tetsufumi Sato, Yasuhito Uezono, Hiroshi Morimatsu. Ketamine Improves Desensitization of µ-Opioid Receptors Induced by Repeated Treatment with Fentanyl but Not with Morphine. Biomolecules. 2022 03; 12(3):. doi: 10.3390/biom12030426. [PMID: 35327617]
  • Hua Yang, Qian Zhao, Hai-Yan Chen, Wen Liu, Tong Ding, Bin Yang, Jin-Chao Song. The median effective concentration of propofol with different doses of esketamine during gastrointestinal endoscopy in elderly patients: A randomized controlled trial. British journal of clinical pharmacology. 2022 03; 88(3):1279-1287. doi: 10.1111/bcp.15072. [PMID: 34496448]
  • Wei Yao, Qianqian Cao, Shilin Luo, Lujuan He, Chun Yang, Jiaxu Chen, Qi Qi, Kenji Hashimoto, Ji-Chun Zhang. Microglial ERK-NRBP1-CREB-BDNF signaling in sustained antidepressant actions of (R)-ketamine. Molecular psychiatry. 2022 03; 27(3):1618-1629. doi: 10.1038/s41380-021-01377-7. [PMID: 34819637]
  • Luiza Spohr, Mayara Sandrielly Pereira Soares, Natália Pontes Bona, Nathalia Stark Pedra, Alethéa Gatto Barschak, Rafaela Martins Alvariz, Marcia Vizzotto, Claiton Leoneti Lencina, Francieli Moro Stefanello, Roselia Maria Spanevello. Effect of blueberry extract on energetic metabolism, levels of brain-derived neurotrophic factor, and Ca2+-ATPase activity in the hippocampus and cerebral cortex of rats submitted to ketamine-induced mania-like behavior. Metabolic brain disease. 2022 03; 37(3):835-847. doi: 10.1007/s11011-022-00904-x. [PMID: 35043268]
  • Helena M Abelaira, Thayse Rosa, Airam B de Moura, Natalia M Andrade, Nicoly S Martinello, Larissa R Maciel, Maria Eduarda M Botelho, Laura A Borba, Beatriz C Chede, Camila O Arent, Larissa Joaquim, Sandra Bonfante, Lucinéia G Danielski, Talita Tuon, Fabricia Petronilho, João Quevedo, Gislaine Z Réus. Combination of electroconvulsive stimulation with ketamine or escitalopram protects the brain against inflammation and oxidative stress induced by maternal deprivation and is critical for associated behaviors in male and female rats. Molecular neurobiology. 2022 Mar; 59(3):1452-1475. doi: 10.1007/s12035-021-02718-x. [PMID: 34994953]
  • Jaclyn N Highland, Patrick J Morris, Kylie M Konrath, Lace M Riggs, Natalie R Hagen, Panos Zanos, Chris F Powels, Ruin Moaddel, Craig J Thomas, Amy Q Wang, Todd D Gould. Hydroxynorketamine Pharmacokinetics and Antidepressant Behavioral Effects of (2,6)- and (5R)-Methyl-(2R,6R)-hydroxynorketamines. ACS chemical neuroscience. 2022 02; 13(4):510-523. doi: 10.1021/acschemneuro.1c00761. [PMID: 35113535]
  • Shiu-Dong Chung, Chellappan Praveen Rajneesh, Kuo-Chiang Chen, Huai-Ching Tai, Meng-Lin Chang, Xiao-Wen Tseng, Jai-Hong Cheng, Wei-Kung Tsai, Han-Sun Chiang, Yi-No Wu. Specific Impacts of Ketamine on Bladder Dysfunction and Associated Histological Alterations in Rats-A Time Course Validation through Transmission Electron Microscopy. International journal of molecular sciences. 2022 Feb; 23(4):. doi: 10.3390/ijms23042194. [PMID: 35216309]
  • Kennett D Radford, Rina Y Berman, Shalini Jaiswal, Sharon Y Kim, Michael Zhang, Haley F Spencer, Kwang H Choi. Enhanced Fear Memories and Altered Brain Glucose Metabolism (18F-FDG-PET) following Subanesthetic Intravenous Ketamine Infusion in Female Sprague-Dawley Rats. International journal of molecular sciences. 2022 Feb; 23(3):. doi: 10.3390/ijms23031922. [PMID: 35163844]
  • Jaclyn N Highland, Cristan A Farmer, Panos Zanos, Jacqueline Lovett, Carlos A Zarate, Ruin Moaddel, Todd D Gould. Sex-dependent metabolism of ketamine and (2R,6R)-hydroxynorketamine in mice and humans. Journal of psychopharmacology (Oxford, England). 2022 02; 36(2):170-182. doi: 10.1177/02698811211064922. [PMID: 34971525]
  • Rene Andrade Machado, Janaki Patel, Mona S Elsayed. The role of ketamine-induced beta activity in the treatment of refractory status epilepticus. Is the EEG useful to determine responder's rate? A retrospective study. Epilepsy & behavior : E&B. 2022 02; 127(?):108512. doi: 10.1016/j.yebeh.2021.108512. [PMID: 34974373]
  • Michael Weiss, Werner Siegmund. Pharmacokinetic Modeling of Ketamine Enantiomers and Their Metabolites After Administration of Prolonged-Release Ketamine With Emphasis on 2,6-Hydroxynorketamines. Clinical pharmacology in drug development. 2022 02; 11(2):194-206. doi: 10.1002/cpdd.993. [PMID: 34265182]
  • Kevin Chang, Michele Barletta, Kristen M Messenger, Daniel M Sakai, Rachel A Reed, Jane E Quandt. The effect of a ketamine constant rate infusion on cardiovascular variables in sheep anesthetized at the minimum alveolar concentration of sevoflurane that blunts adrenergic responses. American journal of veterinary research. 2022 Jan; 83(3):205-211. doi: 10.2460/ajvr.21.08.0129. [PMID: 34986114]
  • Y Yin, H Li, J Wang, Y Kong, J Chang, G Chu. Implication of microglia in ketamine-induced long-term cognitive impairment in murine pups. Human & experimental toxicology. 2022 Jan; 41(?):9603271221128739. doi: 10.1177/09603271221128739. [PMID: 36172893]
  • Minmin Chen, Yinqiu Han, Bin Que, Rong Zhou, Jianhui Gan, Xiaoyun Dong. Prophylactic Effects of Sub-anesthesia Ketamine on Cognitive Decline, Neuroinflammation, and Oxidative Stress in Elderly Mice. American journal of Alzheimer's disease and other dementias. 2022 Jan; 37(?):15333175221141531. doi: 10.1177/15333175221141531. [PMID: 36474365]
  • Thomas Gicquel, Romain Pelletier, Camille Richeval, Alexandr Gish, Florian Hakim, Pierre-Jean Ferron, Vadim Mesli, Delphine Allorge, Isabelle Morel, Jean-Michel Gaulier. Metabolite elucidation of 2-fluoro-deschloroketamine (2F-DCK) using molecular networking across three complementary in vitro and in vivo models. Drug testing and analysis. 2022 Jan; 14(1):144-153. doi: 10.1002/dta.3162. [PMID: 34515415]
  • Romain Pelletier, Brendan Le Daré, Loic Grandin, Aurélien Couette, Pierre-Jean Ferron, Isabelle Morel, Thomas Gicquel. New psychoactive substance cocktail in an intensive care intoxication case elucidated by molecular networking. Clinical toxicology (Philadelphia, Pa.). 2022 Jan; 60(1):122-125. doi: 10.1080/15563650.2021.1931693. [PMID: 34085577]
  • Daniela Fux, Moritz Metzner, Johanna Brandl, Melanie Feist, Magdalena Behrendt-Wippermann, Anne von Thaden, Christine Baumgartner. Pharmacokinetics of metamizole (dipyrone) as an add-on in calves undergoing umbilical surgery. PloS one. 2022; 17(3):e0265305. doi: 10.1371/journal.pone.0265305. [PMID: 35290991]
  • Joachim Bansbach, Julian Wenz, Kai Kaufmann, Sebastian Heinrich, Johannes Kalbhenn. Sevoflurane in combination with esketamine is an effective sedation regimen in COVID-19 patients enabling assisted spontaneous breathing even during prone positioning. Anaesthesiology intensive therapy. 2022; 54(1):23-29. doi: 10.5114/ait.2022.113950. [PMID: 35359138]
  • Huixin Li, Wei Liu, Xiaoyu Zhang, Feng Wu, Dan Sun, Zunyi Wang. Ketamine suppresses proliferation and induces ferroptosis and apoptosis of breast cancer cells by targeting KAT5/GPX4 axis. Biochemical and biophysical research communications. 2021 12; 585(?):111-116. doi: 10.1016/j.bbrc.2021.11.029. [PMID: 34800882]
  • Anaïs Sailler, Morgane Prieto, Frédéric Goulle. Successful bilateral phacoemulsification and vitrectomy in a Bennett's wallaby (Macropus rufogriseus). Journal of the American Veterinary Medical Association. 2021 12; 260(4):450-454. doi: 10.2460/javma.21.03.0165. [PMID: 34968188]
  • Johnny Aldo Tinco-Jayo, Enrique Javier Aguilar-Felices, Edwin Carlos Enciso-Roca, Jorge Luis Arroyo-Acevedo, Oscar Herrera-Calderon. Phytochemical Screening by LC-ESI-MS/MS and Effect of the Ethyl Acetate Fraction from Leaves and Stems of Jatropha macrantha Müll Arg. on Ketamine-Induced Erectile Dysfunction in Rats. Molecules (Basel, Switzerland). 2021 Dec; 27(1):. doi: 10.3390/molecules27010115. [PMID: 35011347]
  • Joshua J Solano, Lisa M Clayton, Daniel J Parks, Shayne E Polley, Patrick G Hughes, Charles H Hennekens, Richard D Shih, Scott M Alter. Prehospital Ketamine Administration for Excited Delirium with Illicit Substance Co-Ingestion and Subsequent Intubation in the Emergency Department. Prehospital and disaster medicine. 2021 Dec; 36(6):697-701. doi: 10.1017/s1049023x21000935. [PMID: 34551849]
  • Connor F Bowman, Brandon Pruitt, Jared Marx, Stephen L Thornton. Massive Iatrogenic Pediatric Ketamine Overdose With Serial Levels and Minimal Morbidity. Pediatric emergency care. 2021 Dec; 37(12):e1711-e1713. doi: 10.1097/pec.0000000000001783. [PMID: 30829847]
  • J Blair Price, Clarissa G Yates, Brooke A Morath, Sam K Van De Wakker, Nathanael J Yates, Kim Butters, Mark A Frye, Sean L McGee, Susannah J Tye. Lithium augmentation of ketamine increases insulin signaling and antidepressant-like active stress coping in a rodent model of treatment-resistant depression. Translational psychiatry. 2021 11; 11(1):598. doi: 10.1038/s41398-021-01716-w. [PMID: 34824208]
  • Sarah Nakhodchi, Naader Alizadeh. Rapid simultaneous determination of ketamine and midazolam in biological samples using ion mobility spectrometry combined by headspace solid-phase microextraction. Journal of chromatography. A. 2021 Nov; 1658(?):462609. doi: 10.1016/j.chroma.2021.462609. [PMID: 34656845]
  • Magdy Adam, Kati Salla, Riikka Aho, Laura Hänninen, Suvi Taponen, Marianna Norring, Marja Raekallio, Ann-Helena Hokkanen. A comparison of sedative effects of xylazine alone or combined with levomethadone or ketamine in calves prior to disbudding. Veterinary anaesthesia and analgesia. 2021 Nov; 48(6):906-913. doi: 10.1016/j.vaa.2021.08.004. [PMID: 34602358]
  • Hope Douglas, Klaus Hopster, Michelle Cerullo, Charlotte Hopster-Iversen, Darko Stefanovski, Bernd Driessen. The effects of flumazenil on ventilatory and recovery characteristics in horses following midazolam-ketamine induction and isoflurane anaesthesia. Equine veterinary journal. 2021 Nov; 53(6):1257-1267. doi: 10.1111/evj.13391. [PMID: 33220066]
  • Orlando Garner, Jonathan Patterson, Julieta Muñoz Mejia, Vijay Anand, Juan Deleija, Christopher Nemeh, Meghna Vallabh, Kristen A Staggers, Christopher M Howard, Sergio Enrique Treviño, Muhammad Asim Siddique, Christopher K Morgan. Impact of ketamine as an adjunct sedative in acute respiratory distress syndrome due to COVID-19 Pneumonia. Respiratory medicine. 2021 Nov; 189(?):106667. doi: 10.1016/j.rmed.2021.106667. [PMID: 34757277]
  • Lili Ying, Yuyan Chen, Zuoquan Zhong, Yajin Wu, Lufeng Hu, Congcong Wen. Effects of long-term alcohol exposure on the pharmacokinetic profiles of ketamine and norketamine in rats. Alcohol (Fayetteville, N.Y.). 2021 11; 96(?):55-61. doi: 10.1016/j.alcohol.2021.01.008. [PMID: 33549609]
  • Jiancheng Zhang, Li Ma, Yaeko Hashimoto, Xiayun Wan, Jiajing Shan, Youge Qu, Kenji Hashimoto. (R)-Ketamine ameliorates lethal inflammatory responses and multi-organ injury in mice induced by cecum ligation and puncture. Life sciences. 2021 Nov; 284(?):119882. doi: 10.1016/j.lfs.2021.119882. [PMID: 34384829]
  • Jin Qiu, Mian Xie. Influence of ketamine versus fentanyl on pain relief for pediatric orthopedic emergencies: A meta-analysis of randomized controlled studies. Medicine. 2021 Oct; 100(42):e27409. doi: 10.1097/md.0000000000027409. [PMID: 34678869]
  • Jiancheng Zhang, Li Ma, Xiayun Wan, Jiajing Shan, Youge Qu, Kenji Hashimoto. (R)-Ketamine attenuates LPS-induced endotoxin-derived delirium through inhibition of neuroinflammation. Psychopharmacology. 2021 Oct; 238(10):2743-2753. doi: 10.1007/s00213-021-05889-6. [PMID: 34313805]
  • Vincent Mallet. Reply to: 'Progressive cholangiopathy in COVID-19 patients: Other possible diagnoses than ketamine-induced cholangiopathy should be considered'. Journal of hepatology. 2021 10; 75(4):990-992. doi: 10.1016/j.jhep.2021.06.024. [PMID: 34174378]
  • Hu-Ming Chang, Po-Yu Chen, Chiu-Ping Fang, Tung-Hsia Liu, Chun-Te Wu, Yu-Chao Hsu, Hsiang-Wei Kuo, Yu-Li Liu, Ming-Chyi Huang. Increased Nectin-4 levels in chronic ketamine abusers and the relationship with lower urinary tract symptoms. Environmental toxicology and pharmacology. 2021 Oct; 87(?):103714. doi: 10.1016/j.etap.2021.103714. [PMID: 34302971]
  • Pierre Deltenre, Christophe Moreno, Eric Trépo. Progressive cholangiopathy in COVID-19 patients: Other possible diagnoses than ketamine-induced cholangiopathy should be considered. Journal of hepatology. 2021 10; 75(4):989-990. doi: 10.1016/j.jhep.2021.02.036. [PMID: 33753153]
  • Yanling Zhou, Chengyu Wang, Xiaofeng Lan, Hanqiu Li, Ziyuan Chao, Yuping Ning. Plasma inflammatory cytokines and treatment-resistant depression with comorbid pain: improvement by ketamine. Journal of neuroinflammation. 2021 Sep; 18(1):200. doi: 10.1186/s12974-021-02245-5. [PMID: 34526064]
  • Charles Verney, David Legouis, Sandrine Placier, Tiffany Migeon, Philippe Bonnin, David Buob, Juliette Hadchouel, Pierre Galichon. Anaesthesia-Induced Transcriptomic Changes in the Context of Renal Ischemia Uncovered by the Use of a Novel Clamping Device. International journal of molecular sciences. 2021 Sep; 22(18):. doi: 10.3390/ijms22189840. [PMID: 34576005]
  • Joshua D Rosenblat, Orly Lipsitz, Joshua D Di Vincenzo, Nelson B Rodrigues, Kevin Kratiuk, Mehala Subramaniapillai, Yena Lee, Anil K Arekapudi, Amir Abrishami, Edmond H Chau, Witold Szpejda, Leslie Wong, Rodrigo B Mansur, Roger S McIntyre. Real-world effectiveness of repeated ketamine infusions for treatment resistant depression during the COVID-19 pandemic. Psychiatry research. 2021 09; 303(?):114086. doi: 10.1016/j.psychres.2021.114086. [PMID: 34246008]
  • Jane Alison Hunt, Maisie Alice Lake. Reviewing the physiology, pharmacology and therapeutic uses of ketamine. Nursing standard (Royal College of Nursing (Great Britain) : 1987). 2021 09; 36(9):77-81. doi: 10.7748/ns.2021.e11737. [PMID: 34423608]
  • Andrea Barbarossa, Anisa Bardhi, Teresa Gazzotti, Giampiero Pagliuca. A critical point in chiral chromatography-mass spectrometry analysis of ketamine metabolites. Drug testing and analysis. 2021 Sep; 13(9):1689-1692. doi: 10.1002/dta.3112. [PMID: 34121336]
  • Samantha A Gerb, Ryan J Dashek, Aaron C Ericsson, Rachel Griffin, Craig L Franklin. The Effects of Ketamine on the Gut Microbiome on CD1 Mice. Comparative medicine. 2021 08; 71(4):295-301. doi: 10.30802/aalas-cm-20-000117. [PMID: 34301347]