Procainamide (BioDeep_00000001511)
Secondary id: BioDeep_00000415925
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
Bristol-myers squibb brand OF procainamide hydrochloride
化学式: C13H21N3O (235.1685)
中文名称: 4-氨基-N-(2-二乙氨基乙基)苯甲酰胺
谱图信息:
最多检出来源 Homo sapiens(blood) 5.94%
分子结构信息
SMILES: CCN(CC)CCNC(=O)C1=CC=C(C=C1)N
InChI: InChI=1S/C13H21N3O/c1-3-16(4-2)10-9-15-13(17)11-5-7-12(14)8-6-11/h5-8H,3-4,9-10,14H2,1-2H3,(H,15,17)
描述信息
Procainamide is only found in individuals that have used or taken this drug. It is a derivative of procaine with less CNS action. [PubChem]Procainamide is sodium channel blocker. It stabilizes the neuronal membrane by inhibiting the ionic fluxes required for the initiation and conduction of impulses thereby effecting local anesthetic action.
C - Cardiovascular system > C01 - Cardiac therapy > C01B - Antiarrhythmics, class i and iii > C01BA - Antiarrhythmics, class ia
D002317 - Cardiovascular Agents > D026941 - Sodium Channel Blockers > D061567 - Voltage-Gated Sodium Channel Blockers
C78274 - Agent Affecting Cardiovascular System > C47793 - Antiarrhythmic Agent
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D049990 - Membrane Transport Modulators
C93038 - Cation Channel Blocker
同义名列表
29 个代谢物同义名
Bristol-myers squibb brand OF procainamide hydrochloride; Parke davis brand OF procainamide hydrochloride; Apothecon brand OF procainamide hydrochloride; Sidmark brand OF procainamide hydrochloride; Monarch brand OF procainamide hydrochloride; Pfizer brand OF procainamide hydrochloride; Uriach brand OF procainamide hydrochloride; 4-amino-N-[2-(diethylamino)ethyl]benzamide; Apotex brand OF procainamide hydrochloride; p-Amino-N-(2-diethylaminoethyl)benzamide; p-Aminobenzoic diethylaminoethylamide; Hydrochloride, procainamide; ProcainaMide hydrochloride; Apo-procainamide; Amide, procaine; Procaine amide; Novocainamide; Procainamidum; PROCAINAMIDE; Procainamida; Procan SR; Procanbid; Pronestyl; Procamide; Novocamid; Biocoryl; Rhythmin; Procan; Procainamide
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:8428
- KEGG: C75392
- KEGG: C07401
- KEGGdrug: D08421
- PubChem: 4913
- HMDB: HMDB0015169
- Metlin: METLIN2101
- DrugBank: DB01035
- ChEMBL: CHEMBL640
- Wikipedia: Procainamide
- MeSH: Procainamide
- chemspider: 4744
- CAS: 51-06-9
- PMhub: MS000000678
- PubChem: 9605
- NIKKAJI: J4.110F
- RefMet: Procainamide
- KNApSAcK: 8428
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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10.1002/jcla.20098. [PMID: 16538644] - Brian C Geyer, Mrinalini Muralidharan, Irene Cherni, Jeffrey Doran, Samuel P Fletcher, Tama Evron, Hermona Soreq, Tsafrir S Mor. Purification of transgenic plant-derived recombinant human acetylcholinesterase-R.
Chemico-biological interactions.
2005 Dec; 157-158(?):331-4. doi:
10.1016/j.cbi.2005.10.097. [PMID: 16269140] - Carla Fenoglio, Eleonora Boncompagni, Barbara Chiavarina, Sergio Cafaggi, Michele Cilli, Maurizio Viale. Morphological and histochemical evidence of the protective effect of procainamide hydrochloride on tissue damage induced by repeated administration of low doses of cisplatin.
Anticancer research.
2005 Nov; 25(6B):4123-8. doi:
NULL. [PMID: 16309206] - Alfonso Dueñas-González, Marcela Lizano, Myrna Candelaria, Lucely Cetina, Claudia Arce, Eduardo Cervera. Epigenetics of cervical cancer. An overview and therapeutic perspectives.
Molecular cancer.
2005 Oct; 4(?):38. doi:
10.1186/1476-4598-4-38. [PMID: 16248899] - J Ablin, I Verbovetski, U Trahtemberg, S Metzger, D Mevorach. Quinidine and procainamide inhibit murine macrophage uptake of apoptotic and necrotic cells: a novel contributing mechanism of drug-induced-lupus.
Apoptosis : an international journal on programmed cell death.
2005 Oct; 10(5):1009-18. doi:
10.1007/s10495-005-1189-4. [PMID: 16151636] - P Nazare, P Massaroti, L F Duarte, D R Campos, M A M Marchioretto, G Bernasconi, S Calafatti, F A P Barros, E C Meurer, J Pedrazzoli, L A B Moraes. Validated method for determination of bromopride in human plasma by liquid chromatography--electrospray tandem mass spectrometry: application to the bioequivalence study.
Journal of mass spectrometry : JMS.
2005 Sep; 40(9):1197-202. doi:
10.1002/jms.898. [PMID: 16127659] - David N Bailey, John R Briggs. Studies of the inhibition of serum pseudocholinesterase activity in vitro by commonly used drugs.
American journal of clinical pathology.
2005 Aug; 124(2):226-8. doi:
10.1309/9x17-7kvu-1tmm-ax28. [PMID: 16040293] - Alma Chavez-Blanco, Blanca Segura-Pacheco, Enrique Perez-Cardenas, Lucia Taja-Chayeb, Lucely Cetina, Myrna Candelaria, David Cantu, Aurora Gonzalez-Fierro, Patricia Garcia-Lopez, Pilar Zambrano, Carlos Perez-Plasencia, Gustavo Cabrera, Catalina Trejo-Becerril, Enrique Angeles, Alfonso Duenas-Gonzalez. Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase I study.
Molecular cancer.
2005 Jul; 4(1):22. doi:
10.1186/1476-4598-4-22. [PMID: 16001982] - Tristan Ruysschaert, Audrey Marque, Jean-Luc Duteyrat, Sylviane Lesieur, Mathias Winterhalter, Didier Fournier. Liposome retention in size exclusion chromatography.
BMC biotechnology.
2005 May; 5(?):11. doi:
10.1186/1472-6750-5-11. [PMID: 15885140] - Naoki Ishiguro, Asami Saito, Kazutoshi Yokoyama, Makoto Morikawa, Takashi Igarashi, Ikumi Tamai. Transport of the dopamine D2 agonist pramipexole by rat organic cation transporters OCT1 and OCT2 in kidney.
Drug metabolism and disposition: the biological fate of chemicals.
2005 Apr; 33(4):495-9. doi:
10.1124/dmd.104.002519. [PMID: 15640376] - Takashi Kato, Yoshifumi Ubara, Tetsuo Tagami, Naoki Sawa, Junichi Hoshino, Tatsuya Suwabe, Takaaki Yamagata, Hideyuki Katori, Fumi Takemoto, Shigeko Hara, Shuichirou Matoba, Kenmei Takaichi. Autosomal dominant polycystic kidney disease showing rupture of a lateral ventral hernia following paralytic ileus.
Internal medicine (Tokyo, Japan).
2005 Apr; 44(4):311-4. doi:
10.2169/internalmedicine.44.311. [PMID: 15897642] - Larry A Bauer, Douglas J Black, Jennifer S Lill, Julie Garrison, Vidmantas A Raisys, Thomas M Hooton. Levofloxacin and ciprofloxacin decrease procainamide and N-acetylprocainamide renal clearances.
Antimicrobial agents and chemotherapy.
2005 Apr; 49(4):1649-51. doi:
10.1128/aac.49.4.1649-1651.2005. [PMID: 15793163] - Theofilos M Kolettis, Nikolaos Kazakos, Christos S Katsouras, Dimitra Niokou, Lamprini Pappa, Vassilios Koulouras, Panagiotis Stefanou, Constantinos Seferiadis, Vassiliki Malamou-Mitsi, Lampros K Michalis, Marios Marselos, Dimitrios A Sideris. Intrapericardial drug delivery: pharmacologic properties and long-term safety in swine.
International journal of cardiology.
2005 Mar; 99(3):415-21. doi:
10.1016/j.ijcard.2004.03.004. [PMID: 15771922] - Hiroshi Sawada, Kenji Takami, Satoru Asahi. A toxicogenomic approach to drug-induced phospholipidosis: analysis of its induction mechanism and establishment of a novel in vitro screening system.
Toxicological sciences : an official journal of the Society of Toxicology.
2005 Feb; 83(2):282-92. doi:
10.1093/toxsci/kfh264. [PMID: 15342952] - Naoko Kimura, Masahiro Okuda, Ken-ichi Inui. Metformin transport by renal basolateral organic cation transporter hOCT2.
Pharmaceutical research.
2005 Feb; 22(2):255-9. doi:
10.1007/s11095-004-1193-3. [PMID: 15783073] - Shufeng Zhou, Eli Chan, Wei Duan, Min Huang, Yu-Zong Chen. Drug bioactivation, covalent binding to target proteins and toxicity relevance.
Drug metabolism reviews.
2005; 37(1):41-213. doi:
10.1081/dmr-200028812. [PMID: 15747500] - P H Jones, K Christodoulos, N Dobbs, P Thavasu, F Balkwill, A D Blann, G J Caine, S Kumar, A J Kakkar, N Gompertz, D C Talbot, T S Ganesan, A L Harris. Combination antiangiogenesis therapy with marimastat, captopril and fragmin in patients with advanced cancer.
British journal of cancer.
2004 Jul; 91(1):30-6. doi:
10.1038/sj.bjc.6601897. [PMID: 15162145] - Guillaume Morissette, Emmanuel Moreau, René C-Gaudreault, François Marceau. Massive cell vacuolization induced by organic amines such as procainamide.
The Journal of pharmacology and experimental therapeutics.
2004 Jul; 310(1):395-406. doi:
10.1124/jpet.104.066084. [PMID: 15007104] - Inge D Wijnberg, F F T Ververs. Phenytoin sodium as a treatment for ventricular dysrhythmia in horses.
Journal of veterinary internal medicine.
2004 May; 18(3):350-3. doi:
10.1892/0891-6640(2004)18<350:psaatf>2.0.co;2. [PMID: 15188823] - Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of human volume of distribution values for neutral and basic drugs. 2. Extended data set and leave-class-out statistics.
Journal of medicinal chemistry.
2004 Feb; 47(5):1242-50. doi:
10.1021/jm030408h. [PMID: 14971904] - David N Bailey, John R Briggs. The effect of parenteral nutrition fluids on the binding of therapeutic drugs to human serum in vitro.
Therapeutic drug monitoring.
2004 Feb; 26(1):31-4. doi:
10.1097/00007691-200402000-00007. [PMID: 14749546] - René Severijnen, Nazila Bayat, Hans Bakker, Jules Tolboom, Ger Bongaerts. Enteral drug absorption in patients with short small bowel : a review.
Clinical pharmacokinetics.
2004; 43(14):951-62. doi:
10.2165/00003088-200443140-00001. [PMID: 15530127] - Maria Koufaki, Theodora Calogeropoulou, Eleni Rekka, Michael Chryselis, Panagiota Papazafiri, Catherine Gaitanaki, Alexandros Makriyannis. Bifunctional agents for reperfusion arrhythmias: novel hybrid vitamin E/class I antiarrhythmics.
Bioorganic & medicinal chemistry.
2003 Nov; 11(23):5209-19. doi:
10.1016/j.bmc.2003.08.010. [PMID: 14604685] - John M Ridley, James T Milnes, Andrew V Benest, Joe D Masters, Harry J Witchel, Jules C Hancox. Characterisation of recombinant HERG K+ channel blockade by the Class Ia antiarrhythmic drug procainamide.
Biochemical and biophysical research communications.
2003 Jun; 306(2):388-93. doi:
10.1016/s0006-291x(03)00980-x. [PMID: 12804575] - Shinji Fukui, Hiroshi Katoh, Nobusuke Tsuzuki, Shoichiro Ishihara, Naoki Otani, Hidetoshi Ooigawa, Terushige Toyooka, Akira Ohnuki, Takahito Miyazawa, Hiroshi Nawashiro, Katsuji Shima. Multivariate analysis of risk factors for QT prolongation following subarachnoid hemorrhage.
Critical care (London, England).
2003 Jun; 7(3):R7-R12. doi:
10.1186/cc2160. [PMID: 12793884] - Sandra R Knowles, Lori E Shapiro, Neil H Shear. Reactive metabolites and adverse drug reactions: clinical considerations.
Clinical reviews in allergy & immunology.
2003 Jun; 24(3):229-38. doi:
10.1385/criai:24:3:229. [PMID: 12721394] - Ludmiła Weglarz, Aneta Koceva-Chyła, Krzysztof Gwoździński, Zofia Dzierzewicz, Zofia Jóźwiak. Evaluation of hydralazine and procainamide effects on fibroblast membrane fluidity.
Biochimie.
2003 May; 85(5):549-56. doi:
10.1016/s0300-9084(03)00033-6. [PMID: 12763314] - K Bachmann, J Byers, R Ghosh. Prediction of in vivo hepatic clearance from in vitro data using cryopreserved human hepatocytes.
Xenobiotica; the fate of foreign compounds in biological systems.
2003 May; 33(5):475-83. doi:
10.1080/0049825031000076177. [PMID: 12746104] - François Hélie, Alain Vinet, René Cardinal. Spatiotemporal dynamics of reentrant ventricular tachycardias in canine myocardial infarction: pharmacological modulation.
Canadian journal of physiology and pharmacology.
2003 May; 81(5):413-22. doi:
10.1139/y03-040. [PMID: 12774847] - Dallas Bednarczyk, Sean Ekins, James H Wikel, Stephen H Wright. Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1.
Molecular pharmacology.
2003 Mar; 63(3):489-98. doi:
10.1124/mol.63.3.489. [PMID: 12606755] - Norbert Iost, László Virág, András Varró, Julius Gy Papp. Comparison of the effect of class IA antiarrhythmic drugs on transmembrane potassium currents in rabbit ventricular myocytes.
Journal of cardiovascular pharmacology and therapeutics.
2003 Mar; 8(1):31-41. doi:
10.1177/107424840300800i106. [PMID: 12652328] - Maria O Vannozzi, Massimo Ottone, Maria A Mariggiò, Sergio Cafaggi, Brunella Parodi, Michele Cilli, Edward Lindup, Maurizio Viale. Pharmacokinetic and pharmacodynamic analysis of platinum after combined treatment of cisplatin and procainamide hydrochloride in mice bearing P388 leukemia.
Anticancer research.
2003 Mar; 23(2B):1509-16. doi:
NULL. [PMID: 12820417] - Ralf Stahlmann, Hartmut Lode. Fluoroquinolones in the elderly: safety considerations.
Drugs & aging.
2003; 20(4):289-302. doi:
10.2165/00002512-200320040-00005. [PMID: 12641485] - Kerry B Goralski, Ganlu Lou, Matthew T Prowse, Valentin Gorboulev, Christopher Volk, Hermann Koepsell, Daniel S Sitar. The cation transporters rOCT1 and rOCT2 interact with bicarbonate but play only a minor role for amantadine uptake into rat renal proximal tubules.
The Journal of pharmacology and experimental therapeutics.
2002 Dec; 303(3):959-68. doi:
10.1124/jpet.102.038885. [PMID: 12438515] - Fei Li, Zhaojun Han. Purification and characterization of acetylcholinesterase from cotton aphid (Aphis gossypii Glover).
Archives of insect biochemistry and physiology.
2002 Sep; 51(1):37-45. doi:
10.1002/arch.10048. [PMID: 12210959] - Toshihiro Kitahashi, Itaru Furuta. Quantification of pilsicainide in serum by capillary electrophoresis.
Journal of pharmaceutical and biomedical analysis.
2002 Jul; 29(4):625-9. doi:
10.1016/s0731-7085(02)00077-8. [PMID: 12093491] - Yumiko Urakami, Maiko Akazawa, Hideyuki Saito, Masahiro Okuda, Ken-Ichi Inui. cDNA cloning, functional characterization, and tissue distribution of an alternatively spliced variant of organic cation transporter hOCT2 predominantly expressed in the human kidney.
Journal of the American Society of Nephrology : JASN.
2002 Jul; 13(7):1703-10. doi:
10.1097/01.asn.0000019413.78751.46. [PMID: 12089365] - Franco Lombardo, R Scott Obach, Marina Y Shalaeva, Feng Gao. Prediction of volume of distribution values in humans for neutral and basic drugs using physicochemical measurements and plasma protein binding data.
Journal of medicinal chemistry.
2002 Jun; 45(13):2867-76. doi:
10.1021/jm0200409. [PMID: 12061889] - Michael R Ujhelyi, Kelly Z Hadsall, David E Euler, Rahul Mehra. Intrapericardial therapeutics: a pharmacodynamic and pharmacokinetic comparison between pericardial and intravenous procainamide delivery.
Journal of cardiovascular electrophysiology.
2002 Jun; 13(6):605-11. doi:
10.1046/j.1540-8167.2002.00605.x. [PMID: 12108506]
