Phillyrin (BioDeep_00000000149)

 

Secondary id: BioDeep_00000231287, BioDeep_00000233123, BioDeep_00001103624

natural product PANOMIX_OTCML-2023


代谢物信息卡片


(2S,3R,4S,5S,6R)-2-[4-[(3R,3aR,6S,6aR)-3-(3,4-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-2-methoxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol

化学式: C27H34O11 (534.2101)
中文名称: 连翘苷
谱图信息: 最多检出来源 Viridiplantae(plant) 38.35%

分子结构信息

SMILES: COC(C=C1[C@@H]2[C@](CO[C@H]3C4=CC(OC)=C(OC)C=C4)([H])[C@]3([H])CO2)=C(C=C1)O[C@@H]([C@@H]([C@@H](O)[C@@H]5O)O)O[C@@H]5CO
InChI: InChI=1S/C27H34O11/c1-32-17-6-4-13(8-19(17)33-2)25-15-11-36-26(16(15)12-35-25)14-5-7-18(20(9-14)34-3)37-27-24(31)23(30)22(29)21(10-28)38-27/h4-9,15-16,21-31H,10-12H2,1-3H3

描述信息

Forsythin is a lignan and a glycoside.
Phillyrin is a natural product found in Forsythia suspensa, Phillyrea latifolia, and other organisms with data available.
Annotation level-1
2-[4-[3-(3,4-Dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-2-methoxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol is a natural product found in Pteris semipinnata with data available.
Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat CYP1A2 and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities[1]. Phillyrin has anti-influenza A virus activities[2].
Phillyrin is isolated from Forsythia suspensa Vahl (Oleaceae), has antibacterial and anti-inflammatory activities. Phillyrin has potential inductive effects on rat CYP1A2 and CYP2D1 activities, without affecting CYP2C11 and CYP3A1/2 activities[1]. Phillyrin has anti-influenza A virus activities[2].

同义名列表

17 个代谢物同义名

(2S,3R,4S,5S,6R)-2-[4-[(3R,3aR,6S,6aR)-3-(3,4-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-2-methoxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triol; beta-D-Glucopyranoside, 4-(4-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo(3,4-c)furan-1-yl)-2-methoxyphenyl, (1S-(1alpha,3aalpha,4beta,6aalpha))-; 4-(4-(3,4-dimethoxyphenyl)tetrahydro-1H,3H-furo(3,4-c)furan-1-yl)-2-methoxyphenyl, (1S-(1alpha,3aalpha,4beta,6aalpha))-beta-D-glucopyranoside; 4-((1S,3AR,4R,6AR))-4-(4-(3,4-DIMETHOXYPHENYL)TETRAHYDRO-1H,3H-FURO(3,4-C)FURAN-1-YL)-2-METHOXYPHENYL-.BETA.-D-GLUCOPYRANOSIDE; .BETA.-D-GLUCOPYRANOSIDE, 4-((1S,3AR,4R,6AR)-4-(3,4-DIMETHOXYPHENYL)TETRAHYDRO-1H,3H-FURO(3,4-C)FURAN-1-YL)-2-METHOXYPHENYL; Phillyrin, >=98\\% (HPLC); PHILLYROSIDE, (+)-; UNII-VE9P4964MG; PHILLYRIN [MI]; VE9P4964MG; Phillyrin; Forsythin; phyllyrin; 2-[4-[3-(3,4-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-2-methoxy-phenoxy]-6-(hydroxymethyl)tetrahydropyran-3,4,5-triol; (+)-Pinoresinol monomethyl ether 4-O-beta-D-glucoside; (+)-Pinoresinol monomethyl ether O-β-D-glucoside; Forsythin



数据库引用编号

44 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

53 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 AIMP2, BCL2, KEAP1, MAPK8, MTOR, MYD88, PIK3CA, PPARG, PTGS2, TP53
Peripheral membrane protein 3 GORASP1, MTOR, PTGS2
Endosome membrane 1 MYD88
Endoplasmic reticulum membrane 4 BCL2, HMOX1, MTOR, PTGS2
Nucleus 10 AIMP2, BCL2, GABPA, HMOX1, KEAP1, MAPK8, MTOR, MYD88, PPARG, TP53
cytosol 12 AIMP2, BCL2, HMOX1, KEAP1, MAPK8, MTOR, MYD88, PIK3CA, PPARG, RPE, SLC2A4, TP53
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
trans-Golgi network 1 SLC2A4
centrosome 1 TP53
nucleoplasm 7 GABPA, HMOX1, KEAP1, MAPK8, MTOR, PPARG, TP53
RNA polymerase II transcription regulator complex 1 PPARG
Cell membrane 2 SLC2A4, TNF
Cytoplasmic side 3 GORASP1, HMOX1, MTOR
lamellipodium 1 PIK3CA
Multi-pass membrane protein 1 SLC2A4
Golgi apparatus membrane 2 GORASP1, MTOR
Synapse 1 MAPK8
cell surface 2 MYD88, TNF
Golgi apparatus 1 GORASP1
Golgi membrane 3 GORASP1, INS, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 1 TNF
sarcolemma 1 SLC2A4
Cytoplasm, cytosol 1 AIMP2
Lysosome 1 MTOR
Presynapse 1 SLC2A4
plasma membrane 4 MYD88, PIK3CA, SLC2A4, TNF
Membrane 6 AIMP2, BCL2, HMOX1, MTOR, SLC2A4, TP53
axon 1 MAPK8
caveola 1 PTGS2
extracellular exosome 3 MMP9, RPE, SLC2A4
Lysosome membrane 1 MTOR
endoplasmic reticulum 5 BCL2, HMOX1, KEAP1, PTGS2, TP53
extracellular space 6 CCL2, HMOX1, IL6, INS, MMP9, TNF
perinuclear region of cytoplasm 4 HMOX1, PIK3CA, PPARG, SLC2A4
intercalated disc 1 PIK3CA
mitochondrion 2 BCL2, TP53
protein-containing complex 4 BCL2, MYD88, PTGS2, TP53
intracellular membrane-bounded organelle 1 PPARG
Microsome membrane 2 MTOR, PTGS2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Secreted 3 CCL2, IL6, INS
extracellular region 5 CCL2, IL6, INS, MMP9, TNF
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
Mitochondrion matrix 1 TP53
mitochondrial matrix 1 TP53
transcription regulator complex 1 TP53
centriolar satellite 1 KEAP1
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 TP53
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 SLC2A4, TNF
Secreted, extracellular space, extracellular matrix 1 MMP9
multivesicular body 1 SLC2A4
T-tubule 1 SLC2A4
nucleolus 1 TP53
midbody 1 KEAP1
clathrin-coated pit 1 SLC2A4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 1 SLC2A4
Membrane raft 2 SLC2A4, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 TP53
cis-Golgi network 1 GORASP1
sarcoplasmic reticulum 1 SLC2A4
Nucleus, PML body 2 MTOR, TP53
PML body 2 MTOR, TP53
collagen-containing extracellular matrix 1 MMP9
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 PPARG
neuron projection 1 PTGS2
chromatin 3 GABPA, PPARG, TP53
phagocytic cup 1 TNF
actin filament 1 KEAP1
site of double-strand break 1 TP53
Cul3-RING ubiquitin ligase complex 1 KEAP1
nuclear envelope 1 MTOR
Endomembrane system 2 MTOR, SLC2A4
endosome lumen 1 INS
Cytoplasmic vesicle membrane 1 SLC2A4
germ cell nucleus 1 TP53
replication fork 1 TP53
myelin sheath 1 BCL2
clathrin-coated vesicle 1 SLC2A4
trans-Golgi network transport vesicle 1 SLC2A4
ficolin-1-rich granule lumen 1 MMP9
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 IL6, INS, PTGS2
nuclear matrix 1 TP53
transcription repressor complex 1 TP53
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
tertiary granule lumen 1 MMP9
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 GORASP1, INS
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
vesicle membrane 1 SLC2A4
[Isoform 1]: Nucleus 1 TP53
extrinsic component of cytoplasmic side of plasma membrane 1 MYD88
basal dendrite 1 MAPK8
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
Cytoplasmic vesicle, phagosome 1 MTOR
extrinsic component of plasma membrane 1 MYD88
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
inclusion body 1 KEAP1
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
insulin-responsive compartment 1 SLC2A4
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Hong-Yan Guo, Xiaoting Li, Xiao-Tong Sang, Zhe-Shan Quan, Qing-Kun Shen. Design and synthesis of forsythin derivatives as anti-inflammatory agents for acute lung injury. European journal of medicinal chemistry. 2024 Mar; 267(?):116223. doi: 10.1016/j.ejmech.2024.116223. [PMID: 38342013]
  • Shanyu Zhang, Fengzhi Sun, Jinlu Zhu, Jianhong Qi, Wenjing Wang, Ziming Liu, Wenqian Li, Chuanguo Liu, Xuehuan Liu, Nonghan Wang, Xinyu Song, Dan Zhang, Dongmei Qi, Xiaolong Wang. Phillyrin ameliorates influenza a virus-induced pulmonary inflammation by antagonizing CXCR2 and inhibiting NLRP3 inflammasome activation. Virology journal. 2023 Nov; 20(1):262. doi: 10.1186/s12985-023-02219-4. [PMID: 37957672]
  • Jing Li, Qiao Qin, Sheng-Hua Zha, Qing-Sheng Zhao, Hang Li, Lu-Peng Liu, Shou-Bu Hou, Bing Zhao. Green Extraction of Forsythoside A, Phillyrin and Phillygenol from Forsythia suspensa Leaves Using a β-Cyclodextrin-Assisted Method. Molecules (Basel, Switzerland). 2022 Oct; 27(20):. doi: 10.3390/molecules27207055. [PMID: 36296648]
  • Wang Jun Yuan, Su Ping Zhang, Zhi Yin He, Yan Xia He, She Qi He, Li Jun Liu, Xin Sun, Qin Li. Comparative transcriptome analyses identify genes involved into the biosynthesis of forsythin and forsythoside A in Forsythia suspensa. Functional & integrative genomics. 2022 10; 22(5):731-741. doi: 10.1007/s10142-022-00887-z. [PMID: 35870023]
  • Chenyu Zhou, Mengya Lu, Jialei Cheng, Emelda Rosseleena Rohani, Hamizah Shahirah Hamezah, Rongchun Han, Xiaohui Tong. Review on the Pharmacological Properties of Phillyrin. Molecules (Basel, Switzerland). 2022 Jun; 27(12):. doi: 10.3390/molecules27123670. [PMID: 35744798]
  • Tianyang Wang, Xuejiao Wen, Ziwen Zhang, Minjuan Xie, Jie Zhou. Phillyrin ameliorates diabetic nephropathy through the PI3K/Akt/GSK-3β signalling pathway in streptozotocin-induced diabetic mice. Human & experimental toxicology. 2021 Dec; 40(12_suppl):S487-S496. doi: 10.1177/09603271211051598. [PMID: 34649470]
  • Xin Guo, Pingping Cao, Xiongfeng Lian, Meng Hu, Jingyi Zhao, Wenjing Shen, Haili Wang, Hailong Yu, Yingzhu Chen. The neuroprotective effect of phillyrin in intracerebral hemorrhagic mice is produced by activation of the Nrf2 signaling pathway. European journal of pharmacology. 2021 Oct; 909(?):174439. doi: 10.1016/j.ejphar.2021.174439. [PMID: 34425100]
  • Lu-Lu Pan, Tao Chen, Min Hui, Shuo Wang, Li Fu, Cui-Yun Li, Hong Zhang, Yan-Hua Ding, Yong Yang, Da-Fang Zhong. Simultaneous determination of forsythin and its major metabolites in human plasma via liquid chromatography-tandem mass spectrometry. Journal of pharmaceutical and biomedical analysis. 2021 May; 198(?):113992. doi: 10.1016/j.jpba.2021.113992. [PMID: 33676168]
  • Sansei Nishibe, Kumiko Mitsui-Saitoh, Junichi Sakai, Takahiko Fujikawa. The Biological Effects of Forsythia Leaves Containing the Cyclic AMP Phosphodiesterase 4 Inhibitor Phillyrin. Molecules (Basel, Switzerland). 2021 Apr; 26(8):. doi: 10.3390/molecules26082362. [PMID: 33921630]
  • Zibin Lu, Huihui Cao, Dongyi Liu, Yuanru Zheng, Chunyang Tian, Shanhong Liu, Jingyu Quan, Lingzhu Shi, Junshan Liu, Linzhong Yu. Optimal combination of anti-inflammatory components from Chinese medicinal formula Liang-Ge-San. Journal of ethnopharmacology. 2021 Apr; 269(?):113747. doi: 10.1016/j.jep.2020.113747. [PMID: 33359185]
  • Lu-Lu Pan, Yong Yang, Min Hui, Shuo Wang, Cui-Yun Li, Hong Zhang, Yan-Hua Ding, Li Fu, Xing-Xing Diao, Da-Fang Zhong. Sulfation predominates the pharmacokinetics, metabolism, and excretion of forsythin in humans: major enzymes and transporters identified. Acta pharmacologica Sinica. 2021 Feb; 42(2):311-322. doi: 10.1038/s41401-020-0481-8. [PMID: 32860005]
  • Qinhai Ma, Runfeng Li, Weiqi Pan, Wenbo Huang, Bin Liu, Yuqi Xie, Zhoulang Wang, Chufang Li, Haiming Jiang, Jicheng Huang, Yongxia Shi, Jun Dai, Kui Zheng, Xiaobo Li, Min Hui, Li Fu, Zifeng Yang. Phillyrin (KD-1) exerts anti-viral and anti-inflammatory activities against novel coronavirus (SARS-CoV-2) and human coronavirus 229E (HCoV-229E) by suppressing the nuclear factor kappa B (NF-κB) signaling pathway. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Nov; 78(?):153296. doi: 10.1016/j.phymed.2020.153296. [PMID: 32890913]
  • Dong Zhang, Boyang Qi, Dongxiao Li, Jiali Feng, Xiao Huang, Xiaohong Ma, Lina Huang, Xiaozhi Wang, Xiangyong Liu. Phillyrin Relieves Lipopolysaccharide-Induced AKI by Protecting Against Glycocalyx Damage and Inhibiting Inflammatory Responses. Inflammation. 2020 Apr; 43(2):540-551. doi: 10.1007/s10753-019-01136-5. [PMID: 31832909]
  • Qian Jiang, Jun Chen, Xiaobing Long, Xiaolong Yao, Xin Zou, Yiping Yang, Guangying Huang, Huaqiu Zhang. Phillyrin protects mice from traumatic brain injury by inhibiting the inflammation of microglia via PPARγ signaling pathway. International immunopharmacology. 2020 Feb; 79(?):106083. doi: 10.1016/j.intimp.2019.106083. [PMID: 31923823]
  • Xiaoqing Xu, Fatma S A Saadeldeen, Lanting Xu, Yingying Zhao, Jinfeng Wei, Hui-Min David Wang, Zhenhua Liu, Wenyi Kang. The Mechanism of Phillyrin from the Leaves of Forsythia suspensa for Improving Insulin Resistance. BioMed research international. 2019; 2019(?):3176483. doi: 10.1155/2019/3176483. [PMID: 31355254]
  • Xinsheng Fang, Shubo Gu, Zongyuan Jin, Mingqian Hao, Zhenzhen Yin, Jianhua Wang. Optimization of Ultrasonic-Assisted Simultaneous Extraction of Three Active Compounds from the Fruits of Forsythia suspensa and Comparison with Conventional Extraction Methods. Molecules (Basel, Switzerland). 2018 Aug; 23(9):. doi: 10.3390/molecules23092115. [PMID: 30142873]
  • Hong-Bo Xiao, Guo-Guang Sui, Xiang-Yang Lu. Phillyrin lowers body weight in obese mice via the modulation of PPAR/-ANGPTL 4 pathway. Obesity research & clinical practice. 2018 Jan; 12(Suppl 2):71-79. doi: 10.1016/j.orcp.2017.02.002. [PMID: 28320596]
  • Liling Yang, Xiangjun Zhou, Weijuan Huang, Qin Fang, Jianlan Hu, Linzhong Yu, Ning Ma, Wenqing Zhang. Protective Effect of Phillyrin on Lethal LPS-Induced Neutrophil Inflammation in Zebrafish. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 2017; 43(5):2074-2087. doi: 10.1159/000484192. [PMID: 29059681]
  • Xin-Yan Qu, Qing-Jun Li, Hui-Min Zhang, Xiao-Juan Zhang, Peng-Hui Shi, Xiu-Juan Zhang, Jing Yang, Zhe Zhou, Sheng-Qi Wang. Protective effects of phillyrin against influenza A virus in vivo. Archives of pharmacal research. 2016 Jul; 39(7):998-1005. doi: 10.1007/s12272-016-0775-z. [PMID: 27323762]
  • Hairong Wang, Xiaoxu Zhang, Peipei Jia, Yanfen Zhang, Siwen Tang, Hongtao Wang, Song Li, Xinluan Yu, Yingfei Li, Lantong Zhang. Metabolic profile of phillyrin in rats obtained by UPLC-Q-TOF-MS. Biomedical chromatography : BMC. 2016 Jun; 30(6):913-22. doi: 10.1002/bmc.3629. [PMID: 26425840]
  • Lei Zhang, Haiyu Zhao, Yang Liu, Honghuan Dong, Beiran Lv, Min Fang, Huihui Zhao. Metabolic routes along digestive system of licorice: multicomponent sequential metabolism method in rat. Biomedical chromatography : BMC. 2016 Jun; 30(6):902-12. doi: 10.1002/bmc.3626. [PMID: 26418123]
  • Wei-ze Li, Ning Zhao, Ze Liang, Han-fang Kang, Jin-jie Li. [Effects of Forsythia suspensa Volatile Oil Loaded Nanomicellar on Transdermal and Transmucosal Drug Delivery of Phillyrin in Vitro]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 2016 Jan; 39(1):134-7. doi: ". [PMID: 30080015]
  • Yun Luo, Guo-Wei Zhao, Xin-Li Liang, Jing Zhang, Xiao-Fei Zhang, Qin Zheng, Ming Yang, Zheng-Gen Liao. [Changes of specific chromatograms and contents of five components in Yinqiao powder decoctions during decocting process]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2016 Jan; 41(1):60-64. doi: 10.4268/cjcmm20160112. [PMID: 28845641]
  • Jinping Jia, Fusheng Zhang, Zhenyu Li, Xuemei Qin, Liwei Zhang. Comparison of Fruits of Forsythia suspensa at Two Different Maturation Stages by NMR-Based Metabolomics. Molecules (Basel, Switzerland). 2015 May; 20(6):10065-81. doi: 10.3390/molecules200610065. [PMID: 26035103]
  • Chang Li, Zhi-Hong Yao, Zi-Fei Qin, Jin-Bo Zhang, Rui-Yuan Cao, Yi Dai, Xin-Sheng Yao. Isolation and identification of phase I metabolites of phillyrin in rats. Fitoterapia. 2014 Sep; 97(?):92-7. doi: 10.1016/j.fitote.2014.05.011. [PMID: 24879901]
  • Poren Kong, Linlin Zhang, Yuyu Guo, Yingli Lu, Dongping Lin. Phillyrin, a natural lignan, attenuates tumor necrosis factor α-mediated insulin resistance and lipolytic acceleration in 3T3-L1 adipocytes. Planta medica. 2014 Jul; 80(11):880-6. doi: 10.1055/s-0034-1368614. [PMID: 24995500]
  • Wei-ting Zhong, Yi-chun Wu, Xian-xing Xie, Xuan Zhou, Miao-miao Wei, Lanan-Wassy Soromou, Xin-xin Ci, Da-cheng Wang. Phillyrin attenuates LPS-induced pulmonary inflammation via suppression of MAPK and NF-κB activation in acute lung injury mice. Fitoterapia. 2013 Oct; 90(?):132-9. doi: 10.1016/j.fitote.2013.06.003. [PMID: 23751215]
  • Xinsheng Fang, Yingzi Wang, Jianhua Wang, Jin Zhang, Xin Wang. Microwave-assisted extraction followed by RP-HPLC for the simultaneous extraction and determination of forsythiaside A, rutin, and phillyrin in the fruits of Forsythia suspensa. Journal of separation science. 2013 Aug; 36(16):2672-9. doi: 10.1002/jssc.201300317. [PMID: 23913652]
  • Minh Truong Do, Hyung Gyun Kim, Jae Ho Choi, Tilak Khanal, Bong Hwan Park, Thu Phuong Tran, Yong Pil Hwang, Minkyun Na, Hye Gwang Jeong. Phillyrin attenuates high glucose-induced lipid accumulation in human HepG2 hepatocytes through the activation of LKB1/AMP-activated protein kinase-dependent signalling. Food chemistry. 2013 Jan; 136(2):415-25. doi: 10.1016/j.foodchem.2012.09.012. [PMID: 23122079]
  • Bing He, Shi-Yan Yang, Yan Zhang. [A new method of calibration and positioning in quantitative analysis of multicomponents by single marker]. Yao xue xue bao = Acta pharmaceutica Sinica. 2012 Dec; 47(12):1653-9. doi: . [PMID: 23460972]
  • Qingmiao Zhang, Xiying Wei, Jiawen Wang. Phillyrin produced by Colletotrichum gloeosporioides, an endophytic fungus isolated from Forsythia suspensa. Fitoterapia. 2012 Dec; 83(8):1500-5. doi: 10.1016/j.fitote.2012.08.017. [PMID: 22960349]
  • Jing Ye, Xiaowei Song, Zhihong Liu, Xu Zhao, Lulu Geng, Kaishun Bi, Xiaohui Chen. Development of an LC-MS method for determination of three active constituents of Shuang-huang-lian injection in rat plasma and its application to the drug interaction study of Shuang-huang-lian freeze-dried powder combined with levofloxacin injection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2012 Jun; 898(?):130-5. doi: 10.1016/j.jchromb.2012.04.036. [PMID: 22608805]
  • Chiara Beatrice Vicentini, Lorenzo Altieri, Stefano Manfredini. In search of Cinchona substitutes in nineteenth-century Italy. Pharmacy in history. 2012; 54(1):33-6. doi: ". [PMID: 24620481]
  • Jiqing Bai, Xiaoping Wang, Linlin Cao, Ning Zhang, Zhao Zhang. [Effect of habitat processing method on phillyrin and forsythiaside A of Forsythiae Fructus]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2011 Dec; 36(23):3258-61. doi: . [PMID: 22393731]
  • Do-Gyeong Lee, Sang-Min Lee, Myun-Ho Bang, Hee-Jung Park, Tae-Hoon Lee, Yun-Hee Kim, Ji-Young Kim, Nam-In Baek. Lignans from the flowers of Osmanthus fragrans var. aurantiacus and their inhibition effect on NO production. Archives of pharmacal research. 2011 Dec; 34(12):2029-35. doi: 10.1007/s12272-011-1204-y. [PMID: 22210027]
  • Zong-Hua Song, Yan-Hong Wang, Zhong-Zhi Qian, Troy J Smillie, Ikhlas A Khan. Quantitative determination of 10 phenylpropanoid and lignan compounds in Lancea tibetica by high-performance liquid chromatography with UV detection. Planta medica. 2011 Sep; 77(13):1562-6. doi: 10.1055/s-0030-1270833. [PMID: 21347996]
  • Yun-xia Li, Cheng Peng, Liang-hong Ye, Ruo-Qi Zhang, Xue-hua Jiang. Investigation on the absorption of phillyrin and forsythiaside in rat digestive tract. European journal of drug metabolism and pharmacokinetics. 2011 Jun; 36(2):79-85. doi: 10.1007/s13318-011-0031-3. [PMID: 21547451]
  • Laurent Boyer, Béatrice Baghdikian, Sok-Siya Bun, Khalil Taoubi, Ana Diaz-Lanza, Riad Elias, Evelyne Ollivier. Chionanthus virginicus L.: phytochemical analysis and quality control of herbal drug and herbal preparations. Natural product communications. 2011 Jun; 6(6):753-8. doi: . [PMID: 21815404]
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