Glutethimide (BioDeep_00000001473)
Secondary id: BioDeep_00001867881
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
3-ethyl-3-phenylpiperidine-2,6-dione
化学式: C13H15NO2 (217.1103)
中文名称: 格鲁米特, 谷硫胺
谱图信息:
最多检出来源 Homo sapiens(plant) 12.44%
分子结构信息
SMILES: CCC1(c2ccccc2)CCC(=O)NC1=O
InChI: InChI=1S/C13H15NO2/c1-2-13(10-6-4-3-5-7-10)9-8-11(15)14-12(13)16/h3-7H,2,8-9H2,1H3,(H,14,15,16)
描述信息
Glutethimide is only found in individuals that have used or taken this drug. It is a hypnotic and sedative. Its use has been largely superseded by other drugs. [PubChem]Glutethimide seems to be a GABA agonist which helps induced sedation. It also induces CYP 2D6. When taken with codeine, it enables the body to convert higher amounts of the codeine (higher than the average 5 - 10\\%) to morphine. The general sedative effect also adds to the power of the combination.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
N - Nervous system > N05 - Psycholeptics > N05C - Hypnotics and sedatives > N05CE - Piperidinedione derivatives
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic
同义名列表
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:5439
- KEGG: C07489
- KEGGdrug: D00532
- PubChem: 3487
- HMDB: HMDB0015505
- Metlin: METLIN66661
- DrugBank: DB01437
- ChEMBL: CHEMBL1102
- Wikipedia: Glutethimide
- MeSH: Glutethimide
- chemspider: 3367
- CAS: 77-21-4
- PMhub: MS000000592
- PubChem: 9692
- NIKKAJI: J1.475C
- KNApSAcK: 5439
- ChEBI: CHEBI:251300
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
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- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
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Clinical chemistry.
1974 Feb; 20(2):272-4. doi:
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Journal of chemical education.
1974 Feb; 51(2):133-5. doi:
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Clinical chemistry.
1974 Feb; 20(2):309-11. doi:
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Clinica chimica acta; international journal of clinical chemistry.
1974 Jan; 50(1):19-30. doi:
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Clinical science and molecular medicine.
1974 Jan; 46(1):1-17. doi:
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Steroids and lipids research.
1974; 5(1):10-22. doi:
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Journal of the Royal College of Physicians of London.
1974 Jan; 8(2):163-74. doi:
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Journal of chromatography.
1973 Dec; 87(2):379-86. doi:
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1973 Dec; 4(4):357-82. doi:
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Clinical chemistry.
1973 Oct; 19(10):1158-61. doi:
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The American journal of medical technology.
1973 Sep; 39(9):338-44. doi:
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Archiv fur Toxikologie.
1973 Aug; 31(1):81-7. doi:
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Clinical pharmacology and therapeutics.
1973 Jul; 14(4):552-60. doi:
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The American journal of medical technology.
1973 Jun; 39(6):237-43. doi:
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British medical journal.
1973 Mar; 1(5854):643-5. doi:
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Canadian Medical Association journal.
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