Hygromycin B (BioDeep_00000014716)

 

Secondary id: BioDeep_00000004740, BioDeep_00001028379, BioDeep_00001868486, BioDeep_00001874510

human metabolite Chemicals and Drugs natural product Volatile Flavor Compounds


代谢物信息卡片


(3R,3aS,4S,4S,5R,6R,6R,7S,7aS)-4-[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2-oxane]-3,4,5,7-tetrol

化学式: C20H37N3O13 (527.2326272)
中文名称: 潮霉素B溶液
谱图信息: 最多检出来源 Macaca mulatta(otcml) 10.53%

分子结构信息

SMILES: CNC1CC(C(C(C1O)OC2C3C(C(C(O2)CO)O)OC4(O3)C(C(C(C(O4)C(CO)N)O)O)O)O)N
InChI: InChI=1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6+,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20?/m1/s1

描述信息

Hygromycin B is a fda approved antibiotic food additive for swine and poultry Hygromycin B is an antibiotic produced by the bacterium Streptomyces hygroscopicus. It is an aminoglycoside that kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis. In the laboratory it is used for the selection and maintenance of prokaryotic and eukaryotic cells that contain the hygromycin resistance gene. The resistance gene is a kinase that inactivates hygromycin B through phosphorylation. Since the discovery of hygromycin-resistance genes, hygromycin B has become a standard selection antibiotic in gene transfer experiments in many prokaryotic and eukaryotic cells
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
FDA approved antibiotic food additive for swine and poultry
Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells.

同义名列表

14 个代谢物同义名

(3R,3aS,4S,4S,5R,6R,6R,7S,7aS)-4-[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2-oxane]-3,4,5,7-tetrol; 4-{[3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy}-6-(1-amino-2-hydroxyethyl)-6-(hydroxymethyl)-tetrahydro-3aH-spiro[[1,3]dioxolo[4,5-c]pyran-2,2-oxane]-3,4,5,7-tetrol; Antibiotic a-396-II; b, Hygromycin; Antihelmycin; Hygrovectine; Hygromix 2.4; Hygromycin B; Hydromycin b; Hyanthelmix; Hygrovetine; Hygromix-8; Destomysin; Hygromycin B



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

24 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • M Reza Roushan, Chuchi Chen, Parisa Ahmadi, Valerie C A Ward. Agrobacterium tumefaciens-Mediated Genetic Engineering of Green Microalgae, Chlorella vulgaris. Journal of visualized experiments : JoVE. 2023 Oct; ?(200):. doi: 10.3791/65382. [PMID: 37955374]
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  • Mohammad Hossein Mirzaee, Masoumeh Emadpour. Advances in the Transformation of Cyclamen persicum Mill. Through Direct Regeneration Based on an Optimized Kanamycin Selection Scheme. Molecular biotechnology. 2023 May; ?(?):. doi: 10.1007/s12033-023-00758-3. [PMID: 37133706]
  • Xiaoqian Ding, Tianjie Yuan, Weiwei Chen, Xiachang Wang, Yiwen Chu, Xiao Liu, Yang Hu, Lihong Hu. Hygromycin A derivatives isolated from Streptomyces sp. PC-22 in the rhizosphere soil of Pulsatilla chinensis. The Journal of antibiotics. 2022 03; 75(3):176-180. doi: 10.1038/s41429-022-00506-w. [PMID: 35064242]
  • Nadja Leimer, Xiaoqian Wu, Yu Imai, Madeleine Morrissette, Norman Pitt, Quentin Favre-Godal, Akira Iinishi, Samta Jain, Mariaelena Caboni, Inga V Leus, Vincent Bonifay, Samantha Niles, Rachel Bargabos, Meghan Ghiglieri, Rachel Corsetti, Megan Krumpoch, Gabriel Fox, Sangkeun Son, Dorota Klepacki, Yury S Polikanov, Cecily A Freliech, Julie E McCarthy, Diane G Edmondson, Steven J Norris, Anthony D'Onofrio, Linden T Hu, Helen I Zgurskaya, Kim Lewis. A selective antibiotic for Lyme disease. Cell. 2021 10; 184(21):5405-5418.e16. doi: 10.1016/j.cell.2021.09.011. [PMID: 34619078]
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  • Olga Zimmermannova, Kristina Felcmanova, Lenka Sacka, Anne-Sophie Colinet, Pierre Morsomme, Hana Sychrova. K+-specific importers Trk1 and Trk2 play different roles in Ca2+ homeostasis and signalling in Saccharomyces cerevisiae cells. FEMS yeast research. 2021 04; 21(3):. doi: 10.1093/femsyr/foab015. [PMID: 33640956]
  • Raffaello Castoria, Cecilia Miccoli, Giuseppe Barone, Davide Palmieri, Filippo De Curtis, Giuseppe Lima, Joseph Heitman, Giuseppe Ianiri. Molecular Tools for the Yeast Papiliotrema terrestris LS28 and Identification of Yap1 as a Transcription Factor Involved in Biocontrol Activity. Applied and environmental microbiology. 2021 03; 87(7):. doi: 10.1128/aem.02910-20. [PMID: 33452020]
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  • Jaber Dehghani, Khosro Adibkia, Ali Movafeghi, Abolfazl Barzegari, Mohammad M Pourseif, Hadi Maleki Kakelar, Asal Golchin, Yadollah Omidi. Stable transformation of Spirulina (Arthrospira) platensis: a promising microalga for production of edible vaccines. Applied microbiology and biotechnology. 2018 Nov; 102(21):9267-9278. doi: 10.1007/s00253-018-9296-7. [PMID: 30159589]
  • Shouyun Lv, Xin Chen, Chunye Mou, Shenghong Dai, Yinbing Bian, Heng Kang. Agrobacterium-mediated transformation of the ascomycete mushroom Morchella importuna using polyubiquitin and glyceraldehyde-3-phosphate dehydrogenase promoter-based binary vectors. World journal of microbiology & biotechnology. 2018 Sep; 34(10):148. doi: 10.1007/s11274-018-2529-1. [PMID: 30218324]
  • Jianyu Liu, Chunyan Song, Qiaozhen Li, Zhen Xu, Dan Zhang, Meiyan Zhang, Qi Tan, Xiaodong Shang. A colonized millet grain method for Agrobacterium-mediated transformation of the button mushroom Agaricus bisporus. Journal of microbiological methods. 2018 09; 152(?):148-153. doi: 10.1016/j.mimet.2018.07.018. [PMID: 30071256]
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  • Jiaying Sun, Ruidi Xu, Shuqin Xiao, Yuanyuan Lu, Qifeng Zhang, Chunsheng Xue. Agrobacterium tumefaciens-mediated transformation as an efficient tool for insertional mutagenesis of Kabatiella zeae. Journal of microbiological methods. 2018 06; 149(?):96-100. doi: 10.1016/j.mimet.2018.05.004. [PMID: 29730323]
  • Glaucia B Cabral, Vera T C Carneiro, Ana Cristina M M Gomes, Ana Luiza Lacerda, Adriana P Martinelli, Diva M A Dusi. Genetic transformation of Brachiaria brizantha cv. Marandu by biolistics. Anais da Academia Brasileira de Ciencias. 2018 Apr; 90(2):1789-1797. doi: 10.1590/0001-3765201820170842. [PMID: 29898118]
  • Tao Xuan Vu, Tho Tien Ngo, Linh Thi Dam Mai, Tri-Thuc Bui, Diep Hong Le, Ha Thi Viet Bui, Huy Quang Nguyen, Binh Xuan Ngo, Van-Tuan Tran. A highly efficient Agrobacterium tumefaciens-mediated transformation system for the postharvest pathogen Penicillium digitatum using DsRed and GFP to visualize citrus host colonization. Journal of microbiological methods. 2018 01; 144(?):134-144. doi: 10.1016/j.mimet.2017.11.019. [PMID: 29175534]
  • Yueping Zhang, Huaxiang Qu, Ping Zhao, Yongping Tang, Jingsong Zhou, Shaochun Luo, Yuling Yin, Guangyu Chen. Generation and Screening of T-DNA Insertion Mutants Mediated by Agrobacterium tumefaciens in the Garden Asparagus Stem Blight Pathogen Phomopsis asparagi. Current microbiology. 2017 Nov; 74(11):1270-1277. doi: 10.1007/s00284-017-1312-0. [PMID: 28730458]
  • Y S Nai, M R Lee, S Kim, S J Lee, J C Kim, Y T Yang, J S Kim. Relationship between expression level of hygromycin B-resistant gene and Agrobacterium tumefaciens-mediated transformation efficiency in Beauveria bassiana JEF-007. Journal of applied microbiology. 2017 Sep; 123(3):724-731. doi: 10.1111/jam.13529. [PMID: 28667709]
  • Kim Christopher Cohrs, Joachim Burbank, Julia Schumacher. A new transformant selection system for the gray mold fungus Botrytis cinerea based on the expression of fenhexamid-insensitive ERG27 variants. Fungal genetics and biology : FG & B. 2017 03; 100(?):42-51. doi: 10.1016/j.fgb.2017.02.001. [PMID: 28188884]
  • Yuanyuan Lu, Shuqin Xiao, Fen Wang, Jiaying Sun, Likun Zhao, Libin Yan, Chunsheng Xue. Agrobacterium tumefaciens-mediated transformation as an efficient tool for insertional mutagenesis of Cercospora zeae-maydis. Journal of microbiological methods. 2017 02; 133(?):8-13. doi: 10.1016/j.mimet.2016.12.010. [PMID: 27965011]
  • Mebeaselassie Andargie, Chao Yang, Jianxiong Li. Generation of β-glucuronidase reporter-tagged strain to monitor Ustilaginoidea virens infection in rice. Journal of microbiological methods. 2016 12; 131(?):148-155. doi: 10.1016/j.mimet.2016.10.014. [PMID: 27789314]
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