Hygromycin B (BioDeep_00000014716)

 

Secondary id: BioDeep_00000004740, BioDeep_00001028379, BioDeep_00001868486, BioDeep_00001874510

human metabolite Chemicals and Drugs natural product


代谢物信息卡片


(3R,3aS,4S,4S,5R,6R,6R,7S,7aS)-4-[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2-oxane]-3,4,5,7-tetrol

化学式: C20H37N3O13 (527.2326)
中文名称: 潮霉素B溶液
谱图信息: 最多检出来源 Homo sapiens(otcml) 31.08%

分子结构信息

SMILES: CNC1CC(C(C(C1O)OC2C3C(C(C(O2)CO)O)OC4(O3)C(C(C(C(O4)C(CO)N)O)O)O)O)N
InChI: InChI=1S/C20H37N3O13/c1-23-7-2-5(21)9(26)15(10(7)27)33-19-17-16(11(28)8(4-25)32-19)35-20(36-17)18(31)13(30)12(29)14(34-20)6(22)3-24/h5-19,23-31H,2-4,21-22H2,1H3/t5-,6+,7+,8-,9+,10-,11+,12-,13+,14-,15-,16+,17+,18-,19+,20?/m1/s1

描述信息

Hygromycin B is a fda approved antibiotic food additive for swine and poultry Hygromycin B is an antibiotic produced by the bacterium Streptomyces hygroscopicus. It is an aminoglycoside that kills bacteria, fungi and higher eukaryotic cells by inhibiting protein synthesis. In the laboratory it is used for the selection and maintenance of prokaryotic and eukaryotic cells that contain the hygromycin resistance gene. The resistance gene is a kinase that inactivates hygromycin B through phosphorylation. Since the discovery of hygromycin-resistance genes, hygromycin B has become a standard selection antibiotic in gene transfer experiments in many prokaryotic and eukaryotic cells
D000890 - Anti-Infective Agents > D000977 - Antiparasitic Agents > D000871 - Anthelmintics
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents
FDA approved antibiotic food additive for swine and poultry
Hygromycin B is an aminoglycoside antibiotic active against prokaryotic and eukaryotic cells.

同义名列表

14 个代谢物同义名

(3R,3aS,4S,4S,5R,6R,6R,7S,7aS)-4-[(1R,2S,3R,5S,6R)-3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy-6-[(1S)-1-amino-2-hydroxyethyl]-6-(hydroxymethyl)spiro[4,6,7,7a-tetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-2,2-oxane]-3,4,5,7-tetrol; 4-{[3-amino-2,6-dihydroxy-5-(methylamino)cyclohexyl]oxy}-6-(1-amino-2-hydroxyethyl)-6-(hydroxymethyl)-tetrahydro-3aH-spiro[[1,3]dioxolo[4,5-c]pyran-2,2-oxane]-3,4,5,7-tetrol; Antibiotic a-396-II; b, Hygromycin; Antihelmycin; Hygrovectine; Hygromix 2.4; Hygromycin B; Hydromycin b; Hyanthelmix; Hygrovetine; Hygromix-8; Destomysin; Hygromycin B



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

24 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 ADAM8, ARL1, GAPDH, GPD1, NLRP7, NR4A1, RUNX2, SLC9A1
Golgi apparatus, trans-Golgi network membrane 1 ARL1
Peripheral membrane protein 2 ARL1, GBA1
Endoplasmic reticulum membrane 1 CD4
Nucleus 4 GAPDH, NR4A1, RUNX2, TRERF1
cytosol 7 ARL1, GAPDH, GPD1, NR4A1, RUNX2, TRERF1, VPS54
trans-Golgi network 3 ARL1, GBA1, VPS54
nucleoplasm 6 ATP2B1, NR4A1, RUNX2, SLC9A1, TRERF1, VPS54
Cell membrane 3 ATP2B1, CD4, SLC9A1
Lipid-anchor 1 ARL1
Cytoplasmic side 1 ARL1
lamellipodium 1 SLC9A1
Multi-pass membrane protein 2 ATP2B1, SLC9A1
Golgi apparatus membrane 1 ARL1
Synapse 2 ATP2B1, VPS54
cell surface 2 ADAM8, SLC9A1
glutamatergic synapse 1 ATP2B1
Golgi apparatus 3 ARL1, GBA1, VPS54
Golgi membrane 1 ARL1
lysosomal membrane 1 GBA1
presynaptic membrane 1 ATP2B1
Cytoplasm, cytosol 2 GAPDH, NR4A1
Lysosome 1 GBA1
Presynapse 1 NR4A1
plasma membrane 6 ADAM8, ATP2B1, CD4, GAPDH, IFNLR1, SLC9A1
synaptic vesicle membrane 1 ATP2B1
Membrane 7 ADAM8, ARL1, ATP2B1, GAPDH, IFNLR1, SLC9A1, VPS54
apical plasma membrane 1 SLC9A1
basolateral plasma membrane 2 ATP2B1, SLC9A1
extracellular exosome 7 ATP2B1, GAPDH, GBA1, GPD1, LYZ, SLC9A1, SPINK1
Lysosome membrane 1 GBA1
Lumenal side 1 GBA1
endoplasmic reticulum 1 GBA1
extracellular space 2 IL2, LYZ
lysosomal lumen 1 GBA1
perinuclear region of cytoplasm 3 GAPDH, SLC9A1, VPS54
intercalated disc 1 SLC9A1
mitochondrion 3 NR4A1, SLC9A1, VPS54
intracellular membrane-bounded organelle 2 ATP2B1, GAPDH
Single-pass type I membrane protein 3 ADAM8, CD4, IFNLR1
Secreted 2 IL2, SPINK1
extracellular region 2 IL2, LYZ
transcription regulator complex 3 NR4A1, RUNX2, TRERF1
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane 1 ATP2B1
nuclear membrane 2 GAPDH, NR4A1
external side of plasma membrane 1 CD4
T-tubule 1 SLC9A1
microtubule cytoskeleton 1 GAPDH
Early endosome 1 CD4
vesicle 1 GAPDH
Cytoplasm, perinuclear region 1 GAPDH
Membrane raft 2 CD4, SLC9A1
Cytoplasm, cytoskeleton 1 GAPDH
focal adhesion 1 SLC9A1
lateral plasma membrane 1 ATP2B1
chromatin 2 NR4A1, RUNX2
cell projection 1 ATP2B1
cytoskeleton 1 GAPDH
podosome 1 ADAM8
Golgi apparatus, trans-Golgi network 1 VPS54
Basolateral cell membrane 2 ATP2B1, SLC9A1
fibrillar center 1 TRERF1
Lipid droplet 1 GAPDH
specific granule membrane 1 ADAM8
tertiary granule membrane 1 ADAM8
Presynaptic cell membrane 1 ATP2B1
specific granule 1 ADAM8
tertiary granule 1 ADAM8
trans-Golgi network membrane 2 ARL1, VPS54
endoplasmic reticulum lumen 1 CD4
specific granule lumen 1 LYZ
tertiary granule lumen 1 LYZ
histone deacetylase complex 1 TRERF1
azurophil granule lumen 1 LYZ
immunological synapse 1 ATP2B1
clathrin-coated endocytic vesicle membrane 1 CD4
ribonucleoprotein complex 1 GAPDH
ficolin-1-rich granule membrane 1 ADAM8
GAIT complex 1 GAPDH
T cell receptor complex 1 CD4
alpha9-beta1 integrin-ADAM8 complex 1 ADAM8
photoreceptor ribbon synapse 1 ATP2B1
phagolysosome 1 ADAM8
cation-transporting ATPase complex 1 SLC9A1
dense core granule membrane 1 ADAM8
interleukin-28 receptor complex 1 IFNLR1
GARP complex 1 VPS54


文献列表

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  • Mohammad Hossein Mirzaee, Masoumeh Emadpour. Advances in the Transformation of Cyclamen persicum Mill. Through Direct Regeneration Based on an Optimized Kanamycin Selection Scheme. Molecular biotechnology. 2023 May; ?(?):. doi: 10.1007/s12033-023-00758-3. [PMID: 37133706]
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