Caffeine (BioDeep_00000000141)

 

Secondary id: BioDeep_00000229638, BioDeep_00000397991, BioDeep_00000862758

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Chemicals and Drugs BioNovoGene_Lab2019


代谢物信息卡片


1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione

化学式: C8H10N4O2 (194.0804)
中文名称: 咖啡因
谱图信息: 最多检出来源 Homo sapiens(plant) 14.69%

Reviewed

Last reviewed on 2024-06-29.

Cite this Page

Caffeine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/caffeine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000000141). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: Cn(c2)c(C(=O)1)c(n2)N(C)C(=O)N(C)1
InChI: InChI=1/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H3

描述信息

Caffeine is a methyl xanthine alkaloid that is also classified as a purine. Formally, caffeine belongs to the class of organic compounds known as xanthines. These are purine derivatives with a ketone group conjugated at carbons 2 and 6 of the purine moiety. Caffeine is chemically related to the adenine and guanine bases of deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). It is found in the seeds, nuts, or leaves of a number of plants native to Africa, East Asia and South America and helps to protect them against predator insects and to prevent germination of nearby seeds. The most well-known source of caffeine is the coffee bean. Caffeine is the most widely consumed psychostimulant drug in the world. 85\\\% of American adults consumed some form of caffeine daily, consuming 164 mg on average. Caffeine is mostly is consumed in the form of coffee. Caffeine is a central nervous system stimulant that reduces fatigue and drowsiness. At normal doses, caffeine has variable effects on learning and memory, but it generally improves reaction time, wakefulness, concentration, and motor coordination. Caffeine is a proven ergogenic aid in humans. Caffeine improves athletic performance in aerobic (especially endurance sports) and anaerobic conditions. Moderate doses of caffeine (around 5 mg/kg) can improve sprint performance, cycling and running time trial performance, endurance and cycling power output (PMID: 32551869). At intake levels associated with coffee consumption, caffeine appears to exert most of its biological effects through the antagonism of the A1 and A2A subtypes of the adenosine receptor. Adenosine is an endogenous neuromodulator with mostly inhibitory effects, and adenosine antagonism by caffeine results in effects that are generally stimulatory. Some physiological effects associated with caffeine administration include central nervous system stimulation, acute elevation of blood pressure, increased metabolic rate, and diuresis. A number of in vitro and in vivo studies have demonstrated that caffeine modulates both innate and adaptive immune responses. For instance, studies indicate that caffeine and its major metabolite paraxanthine suppress neutrophil and monocyte chemotaxis, and also suppress production of the pro-inflammatory cytokine tumor necrosis factor (TNF) alpha from human blood. Caffeine has also been reported to suppress human lymphocyte function as indicated by reduced T-cell proliferation and impaired production of Th1 (interleukin [IL]-2 and interferon [IFN]-gamma), Th2 (IL-4, IL-5) and Th3 (IL-10) cytokines. Studies also indicate that caffeine suppresses antibody production. The evidence suggests that at least some of the immunomodulatory actions of caffeine are mediated via inhibition of cyclic adenosine monophosphate (cAMP)-phosphodiesterase (PDE), and consequential increase in intracellular cAMP concentrations. Overall, these studies indicate that caffeine, like other members of the methylxanthine family, is largely anti-inflammatory in nature, and based on the pharmacokinetics of caffeine, many of its immunomodulatory effects occur at concentrations that are relevant to normal human consumption. (PMID: 16540173). Caffeine is rapidly and almost completely absorbed in the stomach and small intestine and distributed to all tissues, including the brain. Caffeine metabolism occurs primarily in the liver, where the activity of the cytochrome P450 isoform CYP1A2 accounts for almost 95\\\% of the primary metabolism of caffeine. CYP1A2-catalyzed 3-demethylation of caffeine results in the formation of 1,7-dimethylxanthine (paraxanthine). Paraxanthine may be demethylated by CYP1A2 to form 1-methylxanthine, which may be oxidized to 1-methyluric acid by xanthine oxidase. Paraxanthine may also be hydroxylated by CYP2A6 to form 1,7-dimethyluric acid, or acetylated by N-acetyltransferase 2 (NAT2) to form 5-acetylamino-6-formylamino-3-methyluracil, an unstable compound that may be deformylated nonenzymatically to form ...
Caffeine appears as odorless white powder or white glistening needles, usually melted together. Bitter taste. Solutions in water are neutral to litmus. Odorless. (NTP, 1992)
Caffeine is a trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee. It has a role as a central nervous system stimulant, an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor, an adenosine receptor antagonist, an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor, a ryanodine receptor agonist, a fungal metabolite, an adenosine A2A receptor antagonist, a psychotropic drug, a diuretic, a food additive, an adjuvant, a plant metabolite, an environmental contaminant, a xenobiotic, a human blood serum metabolite, a mouse metabolite, a geroprotector and a mutagen. It is a purine alkaloid and a trimethylxanthine.
Caffeine is a drug of the methylxanthine class used for a variety of purposes, including certain respiratory conditions of the premature newborn, pain relief, and to combat drowsiness. Caffeine is similar in chemical structure to [Theophylline] and [Theobromine]. It can be sourced from coffee beans, but also occurs naturally in various teas and cacao beans, which are different than coffee beans. Caffeine is also used in a variety of cosmetic products and can be administered topically, orally, by inhalation, or by injection. The caffeine citrate injection, used for apnea of the premature newborn, was initially approved by the FDA in 1999. According to an article from 2017, more than 15 million babies are born prematurely worldwide. This correlates to about 1 in 10 births. Premature birth can lead to apnea and bronchopulmonary dysplasia, a condition that interferes with lung development and may eventually cause asthma or early onset emphysema in those born prematurely. Caffeine is beneficial in preventing and treating apnea and bronchopulmonary dysplasia in newborns, improving the quality of life of premature infants.
Caffeine is a Central Nervous System Stimulant and Methylxanthine. The physiologic effect of caffeine is by means of Central Nervous System Stimulation.
Caffeine is xanthine alkaloid that occurs naturally in seeds, leaves and fruit of several plants and trees that acts as a natural pesticide. Caffeine is a major component of coffee, tea and chocolate and in humans acts as a central nervous system (CNS) stimulant. Consumption of caffeine, even in high doses, has not been associated with elevations in serum enzyme elevations or instances of clinically apparent liver injury.
Caffeine is a natural product found in Mus musculus, Herrania cuatrecasana, and other organisms with data available.
Caffeine is a methylxanthine alkaloid found in the seeds, nuts, or leaves of a number of plants native to South America and East Asia that is structurally related to adenosine and acts primarily as an adenosine receptor antagonist with psychotropic and anti-inflammatory activities. Upon ingestion, caffeine binds to adenosine receptors in the central nervous system (CNS), which inhibits adenosine binding. This inhibits the adenosine-mediated downregulation of CNS activity; thus, stimulating the activity of the medullary, vagal, vasomotor, and respiratory centers in the brain. This agent also promotes neurotransmitter release that further stimulates the CNS. The anti-inflammatory effects of caffeine are due the nonselective competitive inhibition of phosphodiesterases (PDEs). Inhibition of PDEs raises the intracellular concentration of cyclic AMP (cAMP), activates protein kinase A, and inhibits leukotriene synthesis, which leads to reduced inflammation and innate immunity.
Caffeine is the most widely consumed psychostimulant drug in the world that mostly is consumed in the form of coffee. Whether caffeine and/or coffee consumption contribute to the development of cardiovascular disease (CVD), the single leading cause of death in the US, is uncle...
Component of coffee beans (Coffea arabica), many other Coffea subspecies, chocolate (Theobroma cacao), tea (Camellia thea), kolanut (Cola acuminata) and several other Cola subspecies and several other plants. It is used in many cola-type beverages as a flavour enhancer. Caffeine is found in many foods, some of which are black cabbage, canola, jerusalem artichoke, and yellow bell pepper.
A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.

[Raw Data] CBA01_Caffeine_pos_50eV.txt
[Raw Data] CBA01_Caffeine_pos_20eV.txt
[Raw Data] CBA01_Caffeine_pos_40eV.txt
[Raw Data] CBA01_Caffeine_pos_10eV.txt
[Raw Data] CBA01_Caffeine_pos_30eV.txt

Caffeine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=58-08-2 (retrieved 2024-06-29) (CAS RN: 58-08-2). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

同义名列表

309 个代谢物同义名

Caffeine Melting Point Standard, Pharmaceutical Secondary Standard; Certified Reference Material; Caffeine melting point standard, United States Pharmacopeia (USP) Reference Standard; Caffeine for system suitability, European Pharmacopoeia (EP) Reference Standard; Caffeine, Pharmaceutical Secondary Standard; Certified Reference Material; InChI=1/C8H10N4O2/c1-10-4-9-6-5(10)7(13)12(3)8(14)11(6)2/h4H,1-3H; Caffeine, United States Pharmacopeia (USP) Reference Standard; Caffeine, European Pharmacopoeia (EP) Reference Standard; Caffeine, British Pharmacopoeia (BP) Reference Standard; 3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion (coffein); 1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione; Caffeine, meets USP testing specifications, anhydrous; Caffeine, certified reference material, TraceCERT(R); 1,3,7-trimethyl-2,6-dioxo-1,2,3,6-tetrahydropurine; 1,3,7-Trimethyl-3,7-dihydro-1H-purine-2,6-dione #; THEOPHYLLINE MONOHYDRATE IMPURITY A [EP IMPURITY]; 1H-Purine-2,6-dione, 3,7-dihydro-1,3,7-trimethyl-; Caffeine, anhydrous, tested according to Ph.Eur.; 1,3,7-Trimethyl-3,7-dihydro-1H-purine-2,6-dione; 3,7-Dihydro-1,3,7-trimethyl-1H-purine-2,6-dione; 1,3,7-trimethyl-1,3,7-trihydropurine-2,6-dione; 3,7-Dihydro-1,3,7-trimethyl-1H-purin-2,6-dion; 5-26-13-00558 (Beilstein Handbook Reference); Caffeine, purum, anhydrous, >=99.0\\% (HPLC); 1,3,7-trimethyl-3,7-dihydropurine-2,6-dione; 3,7-dihydro-1,3,7-trimethyl-1H-purine (9CI); 1,3,7-trimethyl-1H-purine-2,6(3H,7H)-dione; 1H-Purine-2, 3,7-dihydro-1,3,7-trimethyl-; component of A.S.A. Compound (Salt/Mix); DIMENHYDRINATE IMPURITY C (EP IMPURITY); PENTOXIFYLLINE IMPURITY F [EP IMPURITY]; CAFFEINE COMPONENT OF ORPHENGESIC FORTE; DIMENHYDRINATE IMPURITY C [EP IMPURITY]; PENTOXIFYLLINE IMPURITY F (EP IMPURITY); component of P-A-C Compound (Salt/Mix); Bristol-myers squibb brand OF caffeine; CAFFEINE COMPONENT OF INVAGESIC FORTE; THEOPHYLLINE IMPURITY A [EP IMPURITY]; THEOPHYLLINE IMPURITY A (EP IMPURITY); Monomethyl derivative of Theophylline; 3,7-dihydro-1,3,7-trimethyl-1H-purine; Caffeine, SAJ special grade, >=98.5\\%; Bayer Select Headache Pain (Salt/Mix); CAFFEINE COMPONENT OF DARVON COMPOUND; Carolina Cannabis Uplifting Chewables; CAFFEINE COMPONENT OF MEDIGESIC PLUS; ORPHENGESIC FORTE COMPONENT CAFFEINE; 07E4FB58-FD79-4175-8E3D-05BF96954522; Valumeds Maximum Strength Stay Awake; Propoxyphene Compound 65 (Salt/Mix); CAFFEINE COMPONENT OF SYNALGOS-DC-A; NoDoz Alertness AidMaximum Strength; 3,3,7-trimethyl-1H-purine-2,6-dione; caffeine (1,3,7-trimethylxanthine); Topcare Stay AwakeMaximum Strength; DARVON COMPOUND COMPONENT CAFFEINE; Caffeine, anhydrous, 99\\%, FCC, FG; INVAGESIC FORTE COMPONENT CAFFEINE; NoDoz Caplets and Chewable Tablets; CAFFEINE COMPONENT OF ORPHENGESIC; MEDIGESIC PLUS COMPONENT CAFFEINE; Caffeine 10 microg/mL in Methanol; GlaxoSmithKline brand OF caffeine; CAFFEINE COMPONENT OF SYNALGOS-DC; component of Percodan (Salt/Mix); Caffeine, powder, ReagentPlus(R); SYNALGOS-DC-A COMPONENT CAFFEINE; CAFFEINE COMPONENT OF LANORINAL; 1,3,7-Trimethylpurine-2,6-dione; Berlin-chemie brand OF caffeine; Republic drug brand OF caffeine; Caffeine melting point standard; 1,3,7-Trimethyl-2,6-dioxopurine; CAFFEINE COMPONENT OF INVAGESIC; ORPHENGESIC COMPONENT CAFFEINE; CAFFEINE COMPONENT OF CAFERGOT; Caffeine 1.0 mg/ml in Methanol; Pierre fabre brand OF caffeine; CAFFEINE COMPONENT OF DHC PLUS; component of Dilone (Salt/Mix); CAFFEINE COMPONENT OF MIGERGOT; WLN: T56 BN DN FNVNVJ B1 F1 H1; CAFFEINE COMPONENT OF WIGRAINE; CAFFEINE COMPONENT OF EXCEDRIN; CAFFEINE COMPONENT OF FIORICET; CAFFEINE COMPONENT OF NORGESIC; CAFFEINE COMPONENT OF FIORINAL; SYNALGOS-DC COMPONENT CAFFEINE; CAFFEINE COMPONENT OF ANOQUAN; 1,7-Trimethyl-2,6-dioxopurine; Thompson brand 1 OF caffeine; Merck dura brand OF caffeine; Caffeine tablet, film-coated; INVAGESIC COMPONENT CAFFEINE; LANORINAL COMPONENT CAFFEINE; CAFFEINE COMPONENT OF FEMCET; Thompson brand 2 OF caffeine; Caffeine, 1mg/ml in methanol; MIGERGOT COMPONENT CAFFEINE; CAFERGOT COMPONENT CAFFEINE; Methylxanthine theophylline; DHC PLUS COMPONENT CAFFEINE; WIGRAINE COMPONENT CAFFEINE; CAFFEINE COMPONENT OF ESGIC; FIORINAL COMPONENT CAFFEINE; CAFFEINE COMPONENT OF TRIAD; CAFFEINE ANHYDROUS [WHO-IP]; EXCEDRIN COMPONENT CAFFEINE; A.S.A. and Codeine Compound; NORGESIC COMPONENT CAFFEINE; FIORICET COMPONENT CAFFEINE; Jet Alert Regular Strength; ANOQUAN COMPONENT CAFFEINE; Passauer brand OF caffeine; Stay AwakeMaximum Strength; Anhydrous caffeine (JP17); FEMCET COMPONENT CAFFEINE; DIMENHYDRINATE IMPURITY C; TREZIX COMPONENT CAFFEINE; Anhydrous caffeine (JP15); Xanthine, 1,3,7-trimethyl; Jet Alert Double Strength; 5-26-13-00558 (Beilstein); Alertness Aid Stay Awake; Propoxyphene Compound 65; COFFEINUM [WHO-IP LATIN]; CAFFEINE [USP MONOGRAPH]; TRIAD COMPONENT CAFFEINE; CAFFEINE (USP MONOGRAPH); ANHYDROUS CAFFEINE [JAN]; ESGIC COMPONENT CAFFEINE; Anhydrous caffeine (TN); P-A-C Analgesic Tablets; 1 3 7-Trimethylxanthine; 1,3,7-Trimethylxanthine; Anacin Maximum Strength; CAFFEINE (EP MONOGRAPH); CAFFEINE [EP MONOGRAPH]; CAFFEINE(3-METHYL-13C); CAFFEINE [ORANGE BOOK]; Seid brand OF caffeine; Theobromine, 1-methyl-; Xanthine,3,7-trimethyl; 1,3,7-Trimethylxantine; Caffeine (USP:BAN:JAN); 1 3 7-trimetilksantina; Theophylline, 7-methyl; Caffeine [USP:BAN:JAN]; AwakeMaximum Strength; Diurex Water PillsXPL; 7-methyl Theophylline; 1,7-Trimethylxanthine; Sohmed Alertness Aid; 7-Methyltheophylline; 1-methyl-Theobromine; Monohydrate Caffeine; Caffeine, synthetic; 1-methyltheobromine; Cafergot (Salt/Mix); Caffeine, anhydrous; NoDoz Alertness Aid; Diurex Water Pills; Topcare Stay Awake; Caffeine (natural); Caffeine [BAN:JAN]; Caffeina [Italian]; CAFFEINE ANHYDROUS; Methyltheophylline; Anhydrous caffeine; careone stay awake; Methyltheobromide; CAFFEINE [WHO-IP]; CAFFEINE [WHO-DD]; CAFFEINE [USP-RS]; Caffeine, BioXtra; CAFFEINE (USP-RS); Methyltheobromine; trimetilksantina; Percoffedrinol N; NoSnoozeCircle K; CAFFEINUM [HPUS]; Spectrum2_001261; Spectrum3_000321; Caffeine hydrous; CAFFEINE (MART.); Coffeinum Purrum; CAFFEINE [VANDF]; Spectrum5_000423; CAFFEINE [MART.]; Sprayable Energy; Coffein [German]; Spectrum4_001782; Koffein [German]; Theophylline Me; CAFFEINE [HSDB]; UNII-3G6A5W338E; CAFFEINE [INCI]; CAFFEINE [IARC]; Uplift Chewable; CAFFEINE [FHFI]; CAFFEINE (IARC); NCIOpen2_008255; metilteobromina; CAFFEINE [FCC]; SK-65 Compound; DiurexUltimate; Kofein [Czech]; Probes2_000128; Allertness Aid; Theobromine Me; SK 65 Compound; Probes1_000150; Caffeine (USP); CAFFEINE (II); Alertness Aid; CAFFEINE [II]; DivK1c_000730; CAFFEINE [MI]; Lopac0_000228; MEGxp0_001350; KBio2_001781; Tox21_300010; PDSP2_001000; KBio2_004349; ACon1_000085; KBio2_006917; PDSP1_001235; Tox21_201685; KBio3_001141; PDSP1_001016; Tox21_500228; Propoxyphene; Percutaféine; KBio1_000730; PDSP2_001219; Coffeinum N; Bio1_000962; Conrx Alert; Respia (TN); IDI1_000730; CAFFEINE-D3; CAS-58-08-2; Bio1_000473; DiurexUltra; Bio1_001451; Eldiatric C; 3G6A5W338E; Stay Awake; Caffedrine; Lanorinal; Quick Pep; Alert Aid; AI3-20154; Quick-Pep; Alert-pep; C8H10N4O2; Caffeinum; Coffeinum; Guaranine; caffenium; Durvitan; Hycomine; Tri-Aqua; Refreshn; QuickPep; Synalgos; Coffeine; NoSnooze; Caffeina; Caffeine; HSDB 36; cafeine; Vivarin; Cafeina; Mateina; Caffein; Cafecon; Cafamil; Coffein; Caffine; Phensal; Kafeina; Koffein; Cafipel; Dexitac; Organex; DHCplus; Nix Nap; Anacin; No-Doz; Nodaca; Theine; Respia; Tirend; No Doz; Kofein; Miudol; teina; Thein; Awake; 1l5q; 1l7x; Stim; 1gfz; 3g6m; 2a3b; CFF; Caffeine,Anhydrous; Caffeine; Caffeine



数据库引用编号

44 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(6)

BioCyc(5)

PlantCyc(0)

代谢反应

72 个相关的代谢反应过程信息。

Reactome(51)

BioCyc(7)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(9)

COVID-19 Disease Map(0)

PathBank(4)

  • Caffeine Metabolism: Oxygen + Paraxanthine + Water ⟶ 1,7-Dimethyluric acid + Hydrogen peroxide
  • Caffeine Metabolism: Oxygen + Paraxanthine + Water ⟶ 1,7-Dimethyluric acid + Hydrogen peroxide
  • Caffeine Metabolism: Oxygen + Paraxanthine + Water ⟶ 1,7-Dimethyluric acid + Hydrogen peroxide
  • Caffeine Metabolism: Oxygen + Paraxanthine + Water ⟶ 1,7-Dimethyluric acid + Hydrogen peroxide

PharmGKB(0)

337 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ABCB1, CHEK1, CYP1A1, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4, PRKX, RYR1
Peripheral membrane protein 1 CYP1A1
Endoplasmic reticulum membrane 6 CYP1A1, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
Nucleus 3 CHEK1, PLCZ1, PRKX
cytosol 2 CHEK1, PLCZ1
dendrite 1 SLC8A1
centrosome 1 CHEK1
nucleoplasm 5 CD2, CHEK1, PLCZ1, PRKX, SLC8A1
Cell membrane 4 ABCB1, ADRB3, CD2, SLC8A1
Multi-pass membrane protein 7 ABCB1, ADRB3, CACNA1I, RYR1, RYR2, SLC8A1, UCP1
Synapse 1 SLC8A1
cell cortex 1 RYR1
cell junction 1 SLC8A1
cell surface 2 ABCB1, CD2
Golgi apparatus 1 CD2
mitochondrial inner membrane 2 CYP1A1, UCP1
neuronal cell body 1 SLC8A1
postsynapse 1 SLC8A1
sarcolemma 3 RYR1, RYR2, SLC8A1
smooth endoplasmic reticulum 2 RYR1, RYR2
plasma membrane 12 ABCB1, ADRB3, CACNA1I, CD2, CYP2C19, CYP2C9, GCG, KNG1, REN, RYR1, RYR2, SLC8A1
Membrane 9 ABCB1, CACNA1I, CYP2A6, CYP2D6, CYP3A4, REN, RYR1, RYR2, SLC8A1
apical plasma membrane 1 ABCB1
axon 1 SLC8A1
extracellular exosome 3 ABCB1, KNG1, RYR1
endoplasmic reticulum 1 CYP2D6
extracellular space 4 CHEK1, GCG, KNG1, REN
perinuclear region of cytoplasm 1 PLCZ1
intercalated disc 1 SLC8A1
mitochondrion 3 CYP1A1, CYP2D6, UCP1
protein-containing complex 3 CD2, CHEK1, RYR2
intracellular membrane-bounded organelle 7 CHEK1, CYP1A1, CYP2A6, CYP2C19, CYP2C9, CYP2D6, CYP3A4
Microsome membrane 4 CYP1A1, CYP2C9, CYP2D6, CYP3A4
postsynaptic density 1 SLC8A1
pronucleus 1 PLCZ1
Single-pass type I membrane protein 1 CD2
Secreted 2 GCG, REN
extracellular region 4 CD2, GCG, KNG1, REN
cytoplasmic side of plasma membrane 1 CD2
Single-pass membrane protein 1 CYP2D6
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CHEK1
external side of plasma membrane 1 CD2
T-tubule 1 SLC8A1
Z disc 3 RYR1, RYR2, SLC8A1
nucleolus 1 PLCZ1
apical part of cell 1 REN
cell-cell junction 1 CD2
Apical cell membrane 1 ABCB1
Cytoplasm, perinuclear region 1 PLCZ1
Mitochondrion inner membrane 2 CYP1A1, UCP1
sarcoplasmic reticulum 2 RYR1, RYR2
collagen-containing extracellular matrix 1 KNG1
receptor complex 1 ADRB3
chromatin 1 CHEK1
cell periphery 1 SLC8A1
Chromosome 1 CHEK1
Secreted, extracellular space 1 KNG1
blood microparticle 1 KNG1
organelle membrane 1 RYR1
I band 1 RYR1
replication fork 1 CHEK1
secretory granule lumen 1 GCG
endoplasmic reticulum lumen 2 GCG, KNG1
platelet alpha granule lumen 1 KNG1
axon terminus 1 SLC8A1
voltage-gated calcium channel complex 1 CACNA1I
Sarcoplasmic reticulum membrane 2 RYR1, RYR2
condensed nuclear chromosome 1 CHEK1
calcium channel complex 2 RYR1, RYR2
junctional sarcoplasmic reticulum membrane 2 RYR1, RYR2
cytoplasmic microtubule 1 CYP2A6
external side of apical plasma membrane 1 ABCB1
terminal cisterna 1 RYR1
[Glucagon-like peptide 1]: Secreted 1 GCG
sperm head 1 PLCZ1
ryanodine receptor complex 1 RYR1


文献列表

  • Ana M León-Inga, Sebastián Velásquez, Mónica Quintero, Nelson Taborda, Mónica P Cala. Effects of ultrafiltration membrane processing on the metabolic and sensory profiles of coffee extracts. Food chemistry. 2024 Sep; 451(?):139396. doi: 10.1016/j.foodchem.2024.139396. [PMID: 38670027]
  • Lin Chen, Jingyi Wang, Yijun Yang, Huajie Wang, Anan Xu, Junhui Ma, Yuefei Wang, Ping Xu. Identifying the temporal contributors and their interactions during dynamic formation of black tea cream. Food chemistry. 2024 Aug; 448(?):139138. doi: 10.1016/j.foodchem.2024.139138. [PMID: 38569407]
  • Lu Lu, Lu Wang, Ruyi Liu, Yingbin Zhang, Xinqiang Zheng, Jianliang Lu, Xinchao Wang, Jianhui Ye. An efficient artificial intelligence algorithm for predicting the sensory quality of green and black teas based on the key chemical indices. Food chemistry. 2024 May; 441(?):138341. doi: 10.1016/j.foodchem.2023.138341. [PMID: 38176147]
  • Riccardo Lorrai, Dario Cavaterra, Sara Giammaria, Diego Sbardella, Grazia Raffaella Tundo, Alessandra Boccaccini. Eye Diseases: When the Solution Comes from Plant Alkaloids. Planta medica. 2024 May; 90(6):426-439. doi: 10.1055/a-2283-2350. [PMID: 38452806]
  • Zihao Qiu, Jinmei Liao, Jiahao Chen, Ansheng Li, Minyao Lin, Hongmei Liu, Wei Huang, Binmei Sun, Jing Liu, Shaoqun Liu, Peng Zheng. Comprehensive analysis of fresh tea (Camellia sinensis cv. Lingtou Dancong) leaf quality under different nitrogen fertilization regimes. Food chemistry. 2024 May; 439(?):138127. doi: 10.1016/j.foodchem.2023.138127. [PMID: 38064834]
  • Nouran A I Tawfik, Zienab A El-Bakary, Khaleid F Abd El-Wakeil. Determination of caffeine in treated wastewater discharged in the Nile River with emphasis on the effect of zinc and physicochemical factors. Environmental science and pollution research international. 2024 Apr; 31(19):28124-28138. doi: 10.1007/s11356-024-32918-6. [PMID: 38530524]
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  • Lidiia Samarina, Jaroslava Fedorina, Daria Kuzmina, Lyudmila Malyukova, Karina Manakhova, Tatyana Kovalenko, Alexandra Matskiv, Enhua Xia, Wei Tong, Zhaoliang Zhang, Alexey Ryndin, Yuriy L Orlov, Elena K Khlestkina. Analysis of Functional Single-Nucleotide Polymorphisms (SNPs) and Leaf Quality in Tea Collection under Nitrogen-Deficient Conditions. International journal of molecular sciences. 2023 Sep; 24(19):. doi: 10.3390/ijms241914538. [PMID: 37833988]
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  • Roberto Tira, Giovanna Viola, Carlo Giorgio Barracchia, Francesca Parolini, Francesca Munari, Stefano Capaldi, Michael Assfalg, Mariapina D'Onofrio. Espresso Coffee Mitigates the Aggregation and Condensation of Alzheimer's Associated Tau Protein. Journal of agricultural and food chemistry. 2023 Aug; 71(30):11429-11441. doi: 10.1021/acs.jafc.3c01072. [PMID: 37466260]
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  • David Fernando Dos Santos, Vandressa Alves, Edlaine Costa, André Martins, Alexia Flavia França Vieira, Gustavo Henrique Fidelis Dos Santos, Cátia Tavares Dos Passos Francisco, Vânia Zanella Pinto. Yerba Mate (Ilex paraguariensis) Processing and Extraction: Retention of Bioactive Compounds. Plant foods for human nutrition (Dordrecht, Netherlands). 2023 Jul; ?(?):. doi: 10.1007/s11130-023-01082-6. [PMID: 37466823]
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  • Haley A Abernathy, Ross M Boyce, Michael H Reiskind. Exploring the effects of caffeine on Aedes albopictus (Diptera: Culicidae) survival and fecundity. Journal of medical entomology. 2023 07; 60(4):837-841. doi: 10.1093/jme/tjad047. [PMID: 37085153]
  • Haysem M Alhassen, Fiona J Dyer, Ross M Thompson. The photolytic breakdown of caffeine and paracetamol residues in surface water. Water environment research : a research publication of the Water Environment Federation. 2023 Jul; ?(?):e10909. doi: 10.1002/wer.10909. [PMID: 37429828]
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  • Lu Zhang, Jiahui Yin, Jinling Li, Haiyang Sun, Yuanxiang Liu, Jiguo Yang. Association between dietary caffeine intake and severe headache or migraine in US adults. Scientific reports. 2023 Jun; 13(1):10220. doi: 10.1038/s41598-023-36325-8. [PMID: 37353507]
  • Idalia Casas-Hinojosa, Leobardo Manuel Gómez-Oliván, Veronica Margarita Gutierrez-Noya, Sandra Gracía-Medina, Karina Elisa Rosales-Pérez, José Manuel Orozco-Hernández, Gustavo Axel Elizalde-Velázquez, Marcela Galar-Martínez, Octavio Dublán-García, María Dolores Hernández-Navarro, Hariz Islas-Flores. Integrative approach to elucidate the embryological effects of caffeine in Cyprinus carpio: Bioconcentration and alteration of oxidative stress-related gene expression patterns. The Science of the total environment. 2023 Jun; 894(?):165016. doi: 10.1016/j.scitotenv.2023.165016. [PMID: 37348709]
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  • Javier Gallardo-Ignacio, Anislada Santibáñez, Octavio Oropeza-Mariano, Ricardo Salazar, Rosa Mariana Montiel-Ruiz, Sandra Cabrera-Hilerio, Manasés Gonzáles-Cortazar, Francisco Cruz-Sosa, Pilar Nicasio-Torres. Chemical and Biological Characterization of Green and Processed Coffee Beans from Coffea arabica Varieties. Molecules (Basel, Switzerland). 2023 Jun; 28(12):. doi: 10.3390/molecules28124685. [PMID: 37375240]
  • Marco Carnevale Miino, Tomáš Macsek, Taťána Halešová, Tomáš Chorazy, Petr Hlavínek. Pharmaceutical and narcotics monitoring in Brno wastewater system and estimation of seasonal effect on the abuse of illicit drugs by a wastewater-based epidemiology approach. The Science of the total environment. 2023 May; ?(?):164386. doi: 10.1016/j.scitotenv.2023.164386. [PMID: 37263433]
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  • Philippa A Jackson, Charlotte Kenney, Joanne Forster, Ellen F Smith, Rian Elcoate, Bethany Spittlehouse, Jodee Johnson, David O Kennedy. Acute Cognitive Performance and Mood Effects of Coffeeberry Extract: A Randomized, Double Blind, Placebo-Controlled Crossover Study in Healthy Humans. Nutrients. 2023 May; 15(11):. doi: 10.3390/nu15112418. [PMID: 37299382]
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  • Miroslav Gancar, Elena Kurin, Zuzana Bednarikova, Jozef Marek, Pavel Mucaji, Milan Nagy, Zuzana Gazova. Green tea leaf constituents inhibit the formation of lysozyme amyloid aggregates: An effect of mutual interactions. International journal of biological macromolecules. 2023 May; 242(Pt 2):124856. doi: 10.1016/j.ijbiomac.2023.124856. [PMID: 37178892]
  • Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products. ACS pharmacology & translational science. 2023 May; 6(5):683-701. doi: 10.1021/acsptsci.2c00194. [PMID: 37200814]
  • Yejin Ahn, Hee Hwan Lee, Byung-Hak Kim, Sang Jae Park, Young Suk Kim, Hyung Joo Suh, Kyungae Jo. Heukharang lettuce (Lactuca sativa L.) leaf extract displays sleep-promoting effects through GABAA receptor. Journal of ethnopharmacology. 2023 May; ?(?):116602. doi: 10.1016/j.jep.2023.116602. [PMID: 37149068]
  • Ruihong Dong, Mengting Zhu, You Long, Qiang Yu, Chang Li, Jianhua Xie, Yousheng Huang, Yi Chen. Exploring correlations between green coffee bean components and thermal contaminants in roasted coffee beans. Food research international (Ottawa, Ont.). 2023 05; 167(?):112700. doi: 10.1016/j.foodres.2023.112700. [PMID: 37087268]
  • Oliver J Perkin, Yung-Chih Chen, Drusus A Johnson, Joel E Thomas, Greg Atkinson, James A Betts, Javier T Gonzalez. Postprandial metabolic responses to high-fat feeding in healthy adults following ingestion of oolong tea-derived polymerized polyphenols: a randomized, double-blinded, placebo-controlled crossover study. The American journal of clinical nutrition. 2023 Apr; ?(?):. doi: 10.1016/j.ajcnut.2023.04.020. [PMID: 37080462]
  • Xiaozeng Mi, Chun Yang, Dahe Qiao, Mengsha Tang, Yan Guo, Sihui Liang, Yan Li, Zhengwu Chen, Juan Chen. De novo full length transcriptome analysis of a naturally caffeine-free tea plant reveals specificity in secondary metabolic regulation. Scientific reports. 2023 04; 13(1):6015. doi: 10.1038/s41598-023-32435-5. [PMID: 37045909]
  • Minghui Hu, Muxuan Han, Hao Zhang, Zifa Li, Kaiyong Xu, Huaixing Kang, Jiancheng Zong, Feng Zhao, Yuanxiang Liu, Wei Liu. Curcumin (CUMINUP60®) mitigates exercise fatigue through regulating PI3K/Akt/AMPK/mTOR pathway in mice. Aging. 2023 Mar; 15(6):2308-2320. doi: 10.18632/aging.204614. [PMID: 36988546]
  • Yan Cheng, Fumin Xue, Yu Yang. Hot Water Extraction of Antioxidants from Tea Leaves-Optimization of Brewing Conditions for Preparing Antioxidant-Rich Tea Drinks. Molecules (Basel, Switzerland). 2023 Mar; 28(7):. doi: 10.3390/molecules28073030. [PMID: 37049793]
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  • Jing-Jing Zhang, Qi-Jie Xu, Claudia Schmidt, Mohamed A Abu El Maaty, Jinglin Song, Chunqiu Yu, Jun Zhou, Kang Han, Hao Sun, Angela Casini, Ingo Ott, Stefan Wölfl. Elucidating the Multimodal Anticancer Mechanism of an Organometallic Terpyridine Platinum(II) N-Heterocyclic Carbene Complex against Triple-Negative Breast Cancer In Vitro and In Vivo. Journal of medicinal chemistry. 2023 03; 66(6):3995-4008. doi: 10.1021/acs.jmedchem.2c01925. [PMID: 36898000]
  • Heider Carreño, Elena E Stashenko, Patricia Escobar. Essential Oils Distilled from Colombian Aromatic Plants and Their Constituents as Penetration Enhancers for Transdermal Drug Delivery. Molecules (Basel, Switzerland). 2023 Mar; 28(6):. doi: 10.3390/molecules28062872. [PMID: 36985843]
  • Thirakorn Mokkawes, Samuel P de Visser. Caffeine biodegradation by cytochrome P450 1A2. What determines the product distributions?. Chemistry (Weinheim an der Bergstrasse, Germany). 2023 Mar; ?(?):e202203875. doi: 10.1002/chem.202203875. [PMID: 36929809]
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