Panthenol (BioDeep_00000001402)
Main id: BioDeep_00000398596
Secondary id: BioDeep_00001867650
human metabolite PANOMIX_OTCML-2023 Endogenous
代谢物信息卡片
D(+)-alpha,gamma-Dihydroxy-N-(3-hydroxypropyl)-beta,beta-dimethylbutyramide
化学式: C9H19NO4 (205.1314014)
中文名称: DL-泛醇, D-泛醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(CO)C(C(=O)NCCCO)O
InChI: InChI=1S/C9H19NO4/c1-9(2,6-12)7(13)8(14)10-4-3-5-11/h7,11-13H,3-6H2,1-2H3,(H,10,14)
描述信息
In cosmetics, panthenol (also called pantothenol) is a humectant, emollient, and moisturizer. It binds to hair follicles readily and is a frequent component of shampoos and hair conditioners (in concentrations of 0.1-1\\\%). It coats the hair and seals its surface, lubricating follicles and making strands appear shiny. Panthenol (specifically D-panthenol or dexpanthenol) is the alcohol analog of pantothenic acid (vitamin B5), and is thus the provitamin of B5. In organisms, it is quickly oxidized into pantothenate. Panthenol is a viscous transparent liquid at room temperature, but salts of pantothenic acid (for example sodium pantothenate) are powders (typically white). It is very soluble in water, alcohol, and propylene glycol, soluble in ether and chloroform, and only slightly soluble in glycerin.
D - Dermatologicals > D03 - Preparations for treatment of wounds and ulcers > D03A - Cicatrizants
A - Alimentary tract and metabolism > A11 - Vitamins
S - Sensory organs > S01 - Ophthalmologicals
Dietary supplement
D-Panthenol is the biologically-active alcohol of pantothenic acid, which leads to an elevation in the amount of coenzyme A in the cell.
同义名列表
79 个代谢物同义名
D(+)-alpha,gamma-Dihydroxy-N-(3-hydroxypropyl)-beta,beta-dimethylbutyramide; D-(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide; D(+)-α,γ-Dihydroxy-N-(3-hydroxypropyl)-β,β-dimethylbutyramide; (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide; D(+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide; (R)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide; (+)-2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutyramide; 2,4-Dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide; Roche consumer health brand OF dexpanthenol; CT-Arzneimittel brand OF dexpanthenol; Roche nicholas brand OF dexpanthenol; Lichtenstein brand OF dexpanthenol; Cassella-med brand OF dexpanthenol; Ratiopharm brand OF dexpanthenol; Dermapharm brand OF dexpanthenol; Jenapharm brand OF dexpanthenol; NasenSpray ratiopharm panthenol; Azupharma brand OF dexpanthenol; Novartis brand OF dexpanthenol; Heumann brand OF dexpanthenol; Bioglan brand OF dexpanthenol; Merckle brand OF dexpanthenol; Artesan brand OF dexpanthenol; Savage brand OF dexpanthenol; Winzer brand OF dexpanthenol; Febena brand OF dexpanthenol; Merck brand OF dexpanthenol; Jones brand OF dexpanthenol; Roche brand OF dexpanthenol; Braun brand OF dexpanthenol; Mann brand OF dexpanthenol; LAW brand OF dexpanthenol; D(+)-Pantothenyl alcohol; Wund- und heilsalbe law; N-Pantoyl-propanolamine; Panthenol lichtenstein; DL-Pantothenyl alcohol; D-Pantothenyl alcohol; Panthenol-ratiopharm; Otriven dexpanthenol; Dexpanthenol heumann; Pantothenyl alcohol; Panthenol jenapharm; Panthenol von CT; D-p-a Injection; Panthenol braun; D(+)-Panthenol; (+)-Panthenol; Panthenol law; D-Pantothenol; Provitamin b; DL-Panthenol; Dexpanthenol; Repa-ophtal; Siozwo sana; Pantothenol; Panthogenat; D-Panthenol; Bepanthene; Pan rhinol; Corneregel; Pan-ophtal; Panthoderm; Bepanthen; Thenalton; Rhinoclir; Marolderm; Panthenol; Bepantol; Zentinic; Motilyn; Synapan; Nasicur; Panadon; Pantol; Urupan; Ucee D; Cozyme; Ilopan
数据库引用编号
25 个数据库交叉引用编号
- ChEBI: CHEBI:27373
- KEGG: C05944
- KEGGdrug: D00193
- KEGGdrug: D70909
- PubChem: 131204
- PubChem: 4678
- HMDB: HMDB0004231
- Metlin: METLIN3978
- DrugBank: DB09357
- ChEMBL: CHEMBL1200979
- ChEMBL: CHEMBL1371937
- Wikipedia: Dexpanthenol
- MetaCyc: PANTOTHENOL
- foodb: FDB008430
- chemspider: 115991
- CAS: 62507-76-0
- CAS: 16485-10-2
- CAS: 1113-70-8
- CAS: 81-13-0
- PMhub: MS000000449
- PubChem: 8228
- LipidMAPS: LMFA08020198
- 3DMET: B00882
- NIKKAJI: J4.605A
- medchemexpress: HY-B1391
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mahsa Bagheri, Michelle Werres, Paul C Fuchs, Harun Seyhan, Rolf Lefering, Gerrit Grieb, Jennifer Lynn Schiefer. Which Moisturizer to Use in Scar Therapy after Burn Injuries? A Subjective and Objective Skin and Scar Evaluation after Topical Treatment with Dexpanthenol, Aloe Vera, and Plant Oil.
Medicina (Kaunas, Lithuania).
2023 Oct; 59(10):. doi:
10.3390/medicina59101874. [PMID: 37893592] - Bárbara Torrecillas-Baena, Marta Camacho-Cardenosa, María Dolores Carmona-Luque, Gabriel Dorado, Miriam Berenguer-Pérez, José Manuel Quesada-Gómez, María Ángeles Gálvez-Moreno, Antonio Casado-Díaz. Comparative Study of the Efficacy of EHO-85, a Hydrogel Containing Olive Tree (Olea europaea) Leaf Extract, in Skin Wound Healing.
International journal of molecular sciences.
2023 Aug; 24(17):. doi:
10.3390/ijms241713328. [PMID: 37686133] - Dmitry S Semenovich, Egor Y Plotnikov, Elena P Lukiyenko, Alexander A Astrowski, Nina P Kanunnikova. Protective Effect of D-Panthenol in Rhabdomyolysis-Induced Acute Kidney Injury.
International journal of molecular sciences.
2022 Oct; 23(20):. doi:
10.3390/ijms232012273. [PMID: 36293129] - Azibe Yildiz, Tugba Demiralp, Nigar Vardi, Gul Otlu, Elif Taslidere, Hilal Cirik, Elif Gurel. Protective effects of dexpanthenol in carbon tetrachloride-induced myocardial toxicity in rats.
Tissue & cell.
2022 Aug; 77(?):101824. doi:
10.1016/j.tice.2022.101824. [PMID: 35653907] - Xi Zhao, Siquan Zhang, Hongyi Shao. Dexpanthenol attenuates inflammatory damage and apoptosis in kidney and liver tissues of septic mice.
Bioengineered.
2022 05; 13(5):11625-11635. doi:
10.1080/21655979.2022.2070585. [PMID: 35510377] - Xianru Xia, Xiandong Li, Fei Xie, Guolin Yuan, Dongliang Cheng, Chunyan Peng. Non-targeted metabonomic analysis of plasma in patients with atherosclerosis by liquid chromatography-mass spectrometry.
Annals of translational medicine.
2022 Feb; 10(3):133. doi:
10.21037/atm-22-118. [PMID: 35284547] - Neslihan Pınar, Meyli Topaloğlu, İlke Evrim Seçinti, Esra Büyük, Mahir Kaplan. Protective effect of dexpanthenol on cisplatin induced nephrotoxicity in rats.
Biotechnic & histochemistry : official publication of the Biological Stain Commission.
2022 Jan; 97(1):39-43. doi:
10.1080/10520295.2021.1890215. [PMID: 33632031] - Arif Aydın, Mehmet Giray Sönmez, Gökhan Ecer, Fahriye Kılınç, Rahim Kocabaş, Adeviye Elçi Atılgan, Pembe Oltulu, Mehmet Balasar. The effect of intratesticular dexpanthenol on experimentally-induced testicular ischaemia/reperfusion injury.
Journal of pediatric urology.
2021 08; 17(4):440.e1-440.e7. doi:
10.1016/j.jpurol.2021.03.031. [PMID: 33883095] - Sara Jiménez-Jiménez, Georgiana Amariei, Karina Boltes, María Ángeles García, María Luisa Marina. Enantiomeric separation of panthenol by Capillary Electrophoresis. Analysis of commercial formulations and toxicity evaluation on non-target organisms.
Journal of chromatography. A.
2021 Feb; 1639(?):461919. doi:
10.1016/j.chroma.2021.461919. [PMID: 33535114] - Anis Irawan Anwar, Anni Adriani, Sri Rimayani, Asvira Anis Anwar, Arifin Seweng, Rina Munirah, We Sagara Dewi, Ivan Kurniadi. The Effectiveness of Galactomyces Ferment Filtrate, Dexpanthenol, and Centella Asiatica Combination Serum in the Treatment of Post-Acne Hyperpigmentation in Subjects with Skin of Color.
Skinmed.
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European review for medical and pharmacological sciences.
2021 01; 25(2):1016-1023. doi:
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2019 Dec; 41(6):534-547. doi:
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The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology.
2019 Sep; 30(9):826-834. doi:
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International urology and nephrology.
2019 Aug; 51(8):1387-1394. doi:
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Balkan medical journal.
2019 02; 36(2):88-95. doi:
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Biotechnic & histochemistry : official publication of the Biological Stain Commission.
2019 Feb; 94(2):84-91. doi:
10.1080/10520295.2018.1508746. [PMID: 30317873] - Caroline M I Lopes, Liriane Baratella-Evêncio, Ivone A DE Souza, Erwelly B DE Oliveira, Jéssica G A Sá, Marllon A N Santana, Pedro P Marcelino Neto, Eduarda S DE Santana, Luzia A DA Silva, Jeymesson R C Vieira. Evaluation of cytotoxicity and wound healing activity of Avicennia schaueriana in cream.
Anais da Academia Brasileira de Ciencias.
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Transplantation proceedings.
2018 Dec; 50(10):3135-3143. doi:
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Scientific reports.
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 May; 89(?):1409-1414. doi:
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The Journal of dermatological treatment.
2017 Mar; 28(2):173-180. doi:
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Reproductive sciences (Thousand Oaks, Calif.).
2017 02; 24(2):285-290. doi:
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International journal of nanomedicine.
2017; 12(?):4869-4878. doi:
10.2147/ijn.s140835. [PMID: 28744121] - Huseyin Sen, Suleyman Deniz, A Erturk Yedekci, Gokhan Inangil, Tuba Muftuoglu, Aptullah Haholu, Sezai Ozkan. Effects of dexpanthenol and N-acetylcysteine pretreatment in rats before renal ischemia/reperfusion injury.
Renal failure.
2014 Nov; 36(10):1570-4. doi:
10.3109/0886022x.2014.949768. [PMID: 25156619] - Ahmet Pişkin, Berrin Zuhal Altunkaynak, Gamze Tümentemur, Süleyman Kaplan, Ozgür Bülent Yazıcı, Murat Hökelek. The beneficial effects of Momordica charantia (bitter gourd) on wound healing of rabbit skin.
The Journal of dermatological treatment.
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Vestnik oftalmologii.
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Bratislavske lekarske listy.
2014; 115(4):190-6. doi:
10.4149/bll_2014_040. [PMID: 24797592] - Pei Wang, Yun Zhao, Hua-bing Qi, Dong Yi, Feng-jun Wang, Shi-liang Wang, Xi Peng. [Effects of panthenol-glutamine on intestine of rats with burn injury and its dose-effect relationship].
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Archives of pharmacal research.
2012 Nov; 35(11):1999-2006. doi:
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Urology.
2012 May; 79(5):1023-6. doi:
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Kidney & blood pressure research.
2012; 36(1):220-30. doi:
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BMC complementary and alternative medicine.
2011 Dec; 11(?):122. doi:
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Pharmacognosy research.
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Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft.
2010 Jun; 107(6):529-32, 534. doi:
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2009 Sep; 88(9):587-91. doi:
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Kinderkrankenschwester : Organ der Sektion Kinderkrankenpflege.
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Hellenic journal of nuclear medicine.
2009 Jan; 12(1):55-8. doi:
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British journal of cancer.
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European journal of pediatrics.
2007 Sep; 166(9):943-8. doi:
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Journal of ethnopharmacology.
2007 Apr; 111(1):33-9. doi:
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Pediatric surgery international.
2007 Feb; 23(2):177-81. doi:
10.1007/s00383-006-1781-x. [PMID: 16983563] - Hugh Roberts, Jason Williams, Bruce Tate. Allergic contact dermatitis to panthenol and cocamidopropyl PG dimonium chloride phosphate in a facial hydrating lotion.
Contact dermatitis.
2006 Dec; 55(6):369-70. doi:
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Journal of the Medical Association of Thailand = Chotmaihet thangphaet.
2006 Oct; 89(10):1654-8. doi:
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Planta medica.
2006 Mar; 72(4):289-94. doi:
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