Notoginsenoside R1 (BioDeep_00000000014)

 

Secondary id: BioDeep_00000376913, BioDeep_00000870654, BioDeep_00001867457

human metabolite PANOMIX_OTCML-2023 Endogenous natural product


代谢物信息卡片


2-{[2-(8-{[4,5-dihydroxy-6-(hydroxymethyl)-3-[(3,4,5-trihydroxyoxan-2-yl)oxy]oxan-2-yl]oxy}-5,16-dihydroxy-2,6,6,10,11-pentamethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl)-6-methylhept-5-en-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol

化学式: C47H80O18 (932.5344)
中文名称: 三七皂甙 R1, 三七皂苷 R1, 三七皂苷R1, 三七皂甙
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 77.03%

分子结构信息

SMILES: CC(=CCCC(C)(C1CCC2(C1C(CC3C2(CC(C4C3(CCC(C4(C)C)O)C)OC5C(C(C(C(O5)CO)O)O)OC6C(C(C(CO6)O)O)O)C)O)C)OC7C(C(C(C(O7)CO)O)O)O)C
InChI: InChI=1S/C47H80O18/c1-21(2)10-9-13-47(8,65-41-37(59)34(56)32(54)26(18-48)62-41)22-11-15-45(6)30(22)23(50)16-28-44(5)14-12-29(52)43(3,4)39(44)25(17-46(28,45)7)61-42-38(35(57)33(55)27(19-49)63-42)64-40-36(58)31(53)24(51)20-60-40/h10,22-42,48-59H,9,11-20H2,1-8H3

描述信息

Notoginsenoside R1 is a ginsenoside found in Panax notoginseng that is dammarane which is substituted by hydroxy groups at the 3beta, 6alpha, 12beta and 20 pro-S positions, in which the hydroxy groups at positions 6 and 20 have been converted to the corresponding beta-D-xylopyranosyl-(1->2)-beta-D-glucopyranoside and beta-D-glucopyranoside respectively, and in which a double bond has been introduced at the 24-25 position. It has a role as a plant metabolite, an antioxidant, a neuroprotective agent, an apoptosis inducer and a phytoestrogen. It is a beta-D-glucoside, a 12beta-hydroxy steroid, a 3beta-hydroxy steroid, a disaccharide derivative, a ginsenoside, a tetracyclic triterpenoid and a 3beta-hydroxy-4,4-dimethylsteroid. It derives from a hydride of a dammarane.
Notoginsenoside R1 is a natural product found in Panax ginseng, Panax notoginseng, and other organisms with data available.
See also: Panax notoginseng root (part of).
Notoginsenoside R1 is found in tea. Notoginsenoside R1 is a constituent of roots of Panax notoginseng (ginseng)
Constituent of roots of Panax notoginseng (ginseng). Notoginsenoside R1 is found in tea.
Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells[1][2][3].
Notoginsenoside R1 (Sanchinoside R1), a saponin, is isolated from P. notoginseng. Notoginsenoside R1 exhibits anti-oxidation, anti-inflammatory, anti-angiogenic, and anti-apoptosis activities. Notoginsenoside R1 provides cardioprotection against ischemia/reperfusion (I/R) injury. Notoginsenoside R1 also provides neuroprotection in H2O2-induced oxidative damage in PC12 cells[1][2][3].

同义名列表

24 个代谢物同义名

2-{[2-(8-{[4,5-dihydroxy-6-(hydroxymethyl)-3-[(3,4,5-trihydroxyoxan-2-yl)oxy]oxan-2-yl]oxy}-5,16-dihydroxy-2,6,6,10,11-pentamethyltetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadecan-14-yl)-6-methylhept-5-en-2-yl]oxy}-6-(hydroxymethyl)oxane-3,4,5-triol; .BETA.-D-GLUCOPYRANOSIDE, (3.BETA.,6.ALPHA.,12.BETA.)-20-(.BETA.-D-GLUCOPYRANOSYLOXY)-3,12-DIHYDROXYDAMMAR-24-EN-6-YL 2-O-.BETA.-D-XYLOPYRANOSYL-; beta-D-Glucopyranoside, (3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-beta-D-xylopyranosyl-; (3beta,6alpha,12beta)-20-(beta-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-beta-D-xylopyranosyl-beta-D-glucopyranoside; b-D-Glucopyranoside,(3b,6a,12b)-20-(b-D-glucopyranosyloxy)-3,12-dihydroxydammar-24-en-6-yl 2-O-b-D-xylopyranosyl-; NOTOGINSENOSIDE R1 (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG) [DSC]; NOTOGINSENOSIDE R1 (CONSTITUENT OF AMERICAN GINSENG, ASIAN GINSENG, AND TIENCHI GINSENG); Notoginsenoside R1, analytical standard; Sanchinoside R1; Notoginsenoside R1, >=98\\% (HPLC); O-Acetylseudolaric acid C; (-)-Pseudolaric acid B; (20S)-ginsenoside R1; notoginsenoside R 1; netoginsenoside R1; notoginsenoside-R1; Notoginsenoside R1; Sanqi glucoside R1; NotoginsenosideR1; Notoginsenoside; sanchinoside R1; ginsenoside R1; Sanqi glucoside R1; Notoginsenoside R1



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

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81 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 AKT1, BCL2, CASP3, CTNNB1, MAPK14, MAPK8, MTOR, PIK3CA, RUNX2, STAT3, TLR4, VEGFA
Peripheral membrane protein 2 GORASP1, MTOR
Endosome membrane 1 TLR4
Endoplasmic reticulum membrane 3 BCL2, HMOX1, MTOR
Nucleus 12 AKT1, BCL2, CASP3, CTNNB1, HMOX1, MAPK14, MAPK8, MPO, MTOR, RUNX2, STAT3, VEGFA
cytosol 11 AKT1, BCL2, CASP3, CTNNB1, HMOX1, MAPK14, MAPK8, MTOR, PIK3CA, RUNX2, STAT3
dendrite 1 MTOR
phagocytic vesicle 1 MTOR
centrosome 1 CTNNB1
nucleoplasm 10 AKT1, CASP3, CTNNB1, HMOX1, MAPK14, MAPK8, MPO, MTOR, RUNX2, STAT3
RNA polymerase II transcription regulator complex 1 STAT3
Cell membrane 5 AKT1, CTNNB1, ITGAM, TLR4, TNF
Cytoplasmic side 3 GORASP1, HMOX1, MTOR
lamellipodium 3 AKT1, CTNNB1, PIK3CA
Golgi apparatus membrane 2 GORASP1, MTOR
Synapse 2 CTNNB1, MAPK8
cell cortex 2 AKT1, CTNNB1
cell junction 1 CTNNB1
cell surface 4 ITGAM, TLR4, TNF, VEGFA
glutamatergic synapse 4 AKT1, CASP3, CTNNB1, MAPK14
Golgi apparatus 2 GORASP1, VEGFA
Golgi membrane 2 GORASP1, MTOR
lysosomal membrane 1 MTOR
neuronal cell body 2 CASP3, TNF
postsynapse 1 AKT1
presynaptic membrane 1 CTNNB1
Lysosome 2 MPO, MTOR
plasma membrane 7 AKT1, CTNNB1, ITGAM, PIK3CA, STAT3, TLR4, TNF
Membrane 8 AKT1, BCL2, CTNNB1, HMOX1, ITGAM, MTOR, TLR4, VEGFA
axon 2 CCK, MAPK8
basolateral plasma membrane 1 CTNNB1
extracellular exosome 4 BMP3, CTNNB1, ITGAM, MPO
Lysosome membrane 1 MTOR
endoplasmic reticulum 3 BCL2, HMOX1, VEGFA
extracellular space 8 BMP3, CCK, HMOX1, IL6, ITGAM, MPO, TNF, VEGFA
perinuclear region of cytoplasm 4 CTNNB1, HMOX1, PIK3CA, TLR4
Schaffer collateral - CA1 synapse 1 CTNNB1
adherens junction 2 CTNNB1, VEGFA
apicolateral plasma membrane 1 CTNNB1
bicellular tight junction 1 CTNNB1
intercalated disc 1 PIK3CA
mitochondrion 2 BCL2, MAPK14
protein-containing complex 3 AKT1, BCL2, CTNNB1
intracellular membrane-bounded organelle 1 MPO
Microsome membrane 1 MTOR
postsynaptic density 1 CASP3
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 2 ITGAM, TLR4
Secreted 4 BMP3, CCK, IL6, VEGFA
extracellular region 7 BMP3, CCK, IL6, MAPK14, MPO, TNF, VEGFA
Mitochondrion outer membrane 2 BCL2, MTOR
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 3 BCL2, HMOX1, MTOR
transcription regulator complex 3 CTNNB1, RUNX2, STAT3
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 3 ITGAM, TLR4, TNF
Secreted, extracellular space, extracellular matrix 1 VEGFA
Z disc 1 CTNNB1
beta-catenin destruction complex 1 CTNNB1
microtubule cytoskeleton 1 AKT1
Wnt signalosome 1 CTNNB1
Early endosome 1 TLR4
apical part of cell 1 CTNNB1
cell-cell junction 2 AKT1, CTNNB1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
postsynaptic membrane 1 CTNNB1
Membrane raft 2 ITGAM, TNF
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 CTNNB1
focal adhesion 1 CTNNB1
spindle 1 AKT1
cis-Golgi network 1 GORASP1
Cell junction, adherens junction 1 CTNNB1
flotillin complex 1 CTNNB1
extracellular matrix 1 VEGFA
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
secretory granule 2 MPO, VEGFA
fascia adherens 1 CTNNB1
lateral plasma membrane 1 CTNNB1
nuclear speck 1 MAPK14
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 1 TLR4
ciliary basal body 1 AKT1
chromatin 2 RUNX2, STAT3
phagocytic cup 2 TLR4, TNF
cell periphery 1 CTNNB1
Cytoplasm, cytoskeleton, cilium basal body 1 CTNNB1
spindle pole 2 CTNNB1, MAPK14
postsynaptic density, intracellular component 1 CTNNB1
microvillus membrane 1 CTNNB1
nuclear envelope 1 MTOR
Endomembrane system 2 CTNNB1, MTOR
specific granule membrane 1 ITGAM
tertiary granule membrane 1 ITGAM
euchromatin 1 CTNNB1
myelin sheath 1 BCL2
azurophil granule 1 MPO
lipopolysaccharide receptor complex 1 TLR4
plasma membrane raft 1 ITGAM
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
endoplasmic reticulum lumen 1 IL6
platelet alpha granule lumen 1 VEGFA
phosphatidylinositol 3-kinase complex 1 PIK3CA
phosphatidylinositol 3-kinase complex, class IA 1 PIK3CA
beta-catenin-TCF complex 1 CTNNB1
azurophil granule lumen 1 MPO
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 GORASP1
Golgi apparatus, cis-Golgi network membrane 1 GORASP1
Single-pass type IV membrane protein 1 HMOX1
presynaptic active zone cytoplasmic component 1 CTNNB1
phagocytic vesicle lumen 1 MPO
protein-DNA complex 1 CTNNB1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
Cytoplasmic vesicle, phagosome 1 MTOR
catenin complex 1 CTNNB1
integrin complex 1 ITGAM
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
integrin alphaM-beta2 complex 1 ITGAM
interleukin-6 receptor complex 1 IL6
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
beta-catenin-TCF7L2 complex 1 CTNNB1
beta-catenin-ICAT complex 1 CTNNB1
Scrib-APC-beta-catenin complex 1 CTNNB1
phosphatidylinositol 3-kinase complex, class IB 1 PIK3CA
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Shuxia Zhang, Qiuyan Chen, Meiqi Jin, Jiahui Ren, Xiao Sun, Zhixiu Zhang, Yun Luo, Xiaobo Sun. Notoginsenoside R1 alleviates cerebral ischemia/reperfusion injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway through microbiota-gut-brain axis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jun; 128(?):155530. doi: 10.1016/j.phymed.2024.155530. [PMID: 38493723]
  • Jingyue Yu, Jinyu Hu, Margaret Baldini, Huan Lei, Lei Li, Shanshan Luo, Jielian Wu, Xupin Liu, Dan Shan, Yanfei Xie, Haihong Fang, Jun Yu. Integrating network pharmacology and experimental models to identify notoginsenoside R1 ameliorates atherosclerosis by inhibiting macrophage NLRP3 inflammasome activation. Journal of natural medicines. 2024 Jun; 78(3):644-654. doi: 10.1007/s11418-023-01776-w. [PMID: 38409483]
  • Cheng Guo, Linying Lai, Boyu Ma, Qian Huang, Zhirong Wang. Notoginsenoside R1 targets PPAR-γ to inhibit hepatic stellate cell activation and ameliorates liver fibrosis. Experimental cell research. 2024 Apr; 437(1):113992. doi: 10.1016/j.yexcr.2024.113992. [PMID: 38492634]
  • Chunhou Li, Xican Li, Jingyuan Zeng, Rongxin Cai, Shaoman Chen, Ban Chen, Xiaojun Zhao. Detection of Adulterated Naodesheng Tablet (Naodesheng Pian) via In-Depth Chemical Analysis and Subsequent Reconstruction of Its Pharmacopoeia Q-Markers. Molecules (Basel, Switzerland). 2024 Mar; 29(6):. doi: 10.3390/molecules29061392. [PMID: 38543029]
  • Caixia Pei, Nan Jia, Yilan Wang, Sijing Zhao, Zherui Shen, Shihua Shi, Demei Huang, Yongcan Wu, Xiaomin Wang, Shuiqin Li, Yacong He, Zhenxing Wang. Notoginsenoside R1 protects against hypobaric hypoxia-induced high-altitude pulmonary edema by inhibiting apoptosis via ERK1/2-P90rsk-BAD ignaling pathway. European journal of pharmacology. 2023 Sep; 959(?):176065. doi: 10.1016/j.ejphar.2023.176065. [PMID: 37775017]
  • Anna Lichota, Monika Sienkiewicz. Evaluation of antioxidant activity of NG-R1 saponin against bacterial cells in induced oxidative stress - a preliminary study. Annals of agricultural and environmental medicine : AAEM. 2023 Mar; 30(1):83-89. doi: 10.26444/aaem/161339. [PMID: 36999860]
  • Junchen Liu, Yuehang Wu, Wenrui Ma, Hongyan Zhang, Xianyao Meng, Huirong Zhang, Miaomiao Guo, Xiao Ling, Li Li. Anti-Inflammatory Activity of Panax notoginseng Flower Saponins Quantified Using LC/MS/MS. Molecules (Basel, Switzerland). 2023 Mar; 28(5):. doi: 10.3390/molecules28052416. [PMID: 36903661]
  • Ting Zhu, Qi Wan. Pharmacological properties and mechanisms of Notoginsenoside R1 in ischemia-reperfusion injury. Chinese journal of traumatology = Zhonghua chuang shang za zhi. 2023 Jan; 26(1):20-26. doi: 10.1016/j.cjtee.2022.06.008. [PMID: 35922249]
  • Ye Li, Yan-Yan Zhang, Di Wu, Ke-Ming Qi, Wei Lu, Yi-Cong Wei. [Antidepressant effect and molecular mechanism of notoginsenoside R_1 based on network pharmacology and animal experiments]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2022 Oct; 47(20):5599-5609. doi: 10.19540/j.cnki.cjcmm.20220509.704. [PMID: 36471978]
  • Kangrui Hu, Changjian Li, Tengjie Yu, Huimin Guo, Hong Sun, Shuying Mao, Zhihao Zhou, Wei Jin, Keanqi Liu, Lin Xie, Guangji Wang, Yan Liang. Global analysis of qualitative and quantitative metabolism of Notoginsenoside R1 in rat liver-brain-gut axis based on LC-IT-TOF/MS combing mMDF strategy. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2022 Sep; 104(?):154261. doi: 10.1016/j.phymed.2022.154261. [PMID: 35793598]
  • Han Li, Jing Zhu, Yan-Wu Xu, Fang-Fang Mou, Xiao-Li Shan, Qiang-Li Wang, Bao-Nian Liu, Ke Ning, Jia-Jia Liu, Ya-Chao Wang, Jin-Xia Mi, Xiaohui Wei, Shui-Jin Shao, Guo-Hong Cui, Rong Lu, Hai-Dong Guo. Notoginsenoside R1-loaded mesoporous silica nanoparticles targeting the site of injury through inflammatory cells improves heart repair after myocardial infarction. Redox biology. 2022 08; 54(?):102384. doi: 10.1016/j.redox.2022.102384. [PMID: 35777198]
  • Bowen Liu, Tingting Zhao, Yiyang Li, Yan Han, Youhua Xu, Hua Yang, Shengpeng Wang, Yonghua Zhao, Ping Li, Yitao Wang. Notoginsenoside R1 ameliorates mitochondrial dysfunction to circumvent neuronal energy failure in acute phase of focal cerebral ischemia. Phytotherapy research : PTR. 2022 May; 36(5):2223-2235. doi: 10.1002/ptr.7450. [PMID: 35419891]
  • Xu Gong, Linlin Shan, Sisi Cao, Kaitao Li, Yanli Wu, Qing Zhang. Notoginsenoside R1, An Active Compound from Panax notoginseng, Inhibits Hepatic Stellate Cell Activation and Liver Fibrosis via MAPK Signaling Pathway. The American journal of Chinese medicine. 2022; 50(2):511-523. doi: 10.1142/s0192415x22500197. [PMID: 35114912]
  • Ruiqi Han, Wenjuan Zhang, Lina Zhang, Jinghua Zou, Yanran Yang, Hongkun Li, Jun Zhang. Notoginsenoside R1 Promotes Proliferation and Osteogenic Differentiation of hPDLSCs via Wnt/β-Catenin Signaling Pathway. Drug design, development and therapy. 2022; 16(?):4399-4409. doi: 10.2147/dddt.s387004. [PMID: 36583114]
  • Xiao-Qing Li, Tian-Yi Huang. Notoginsenoside R1 alleviates high glucose-induced inflammation and oxidative stress in HUVECs via upregulating miR-147a. The Kaohsiung journal of medical sciences. 2021 Dec; 37(12):1101-1112. doi: 10.1002/kjm2.12433. [PMID: 34369659]
  • Z Jin, C Gan, G Luo, G Hu, X Yang, Z Qian, S Yao. Notoginsenoside R1 protects hypoxia-reoxygenation deprivation-induced injury by upregulation of miR-132 in H9c2 cells. Human & experimental toxicology. 2021 Dec; 40(12_suppl):S29-S38. doi: 10.1177/09603271211025589. [PMID: 34212764]
  • Xumin Li, Haiyan Lin, Xiaorong Zhang, Richard T Jaspers, Qihao Yu, Yinghui Ji, Tim Forouzanfar, Dongyun Wang, Shengbin Huang, Gang Wu. Notoginsenoside R1 attenuates oxidative stress-induced osteoblast dysfunction through JNK signalling pathway. Journal of cellular and molecular medicine. 2021 12; 25(24):11278-11289. doi: 10.1111/jcmm.17054. [PMID: 34786818]
  • Xuanming Zhang, Liwen Han, Peihai Li, Shanshan Zhang, Mengqi Zhang, Xiaobin Li, Jie Chu, Lizhen Wang, Pengfei Tu, Yun Zhang, Kechun Liu. Region-Specific Biomarkers and Their Mechanisms in the Treatment of Lung Adenocarcinoma: A Study of Panax quinquefolius from Wendeng, China. Molecules (Basel, Switzerland). 2021 Nov; 26(22):. doi: 10.3390/molecules26226829. [PMID: 34833921]
  • Bowen Liu, Yiyang Li, Yan Han, Shengpeng Wang, Hua Yang, Yonghua Zhao, Ping Li, Yitao Wang. Notoginsenoside R1 intervenes degradation and redistribution of tight junctions to ameliorate blood-brain barrier permeability by Caveolin-1/MMP2/9 pathway after acute ischemic stroke. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2021 Sep; 90(?):153660. doi: 10.1016/j.phymed.2021.153660. [PMID: 34344565]
  • Ting Zhu, Wei-Jie Xie, Lei Wang, Xin-Biao Jin, Xiang-Bao Meng, Gui-Bo Sun, Xiao-Bo Sun. Notoginsenoside R1 activates the NAMPT-NAD+-SIRT1 cascade to promote postischemic angiogenesis by modulating Notch signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2021 Aug; 140(?):111693. doi: 10.1016/j.biopha.2021.111693. [PMID: 34029951]
  • Minan Lu, Kegong Xie, Xianzhe Lu, Lu Lu, Yu Shi, Yujin Tang. Notoginsenoside R1 counteracts mesenchymal stem cell-evoked oncogenesis and doxorubicin resistance in osteosarcoma cells by blocking IL-6 secretion-induced JAK2/STAT3 signaling. Investigational new drugs. 2021 04; 39(2):416-425. doi: 10.1007/s10637-020-01027-9. [PMID: 33128383]
  • Ting Cai, Wenquan Wu, Longhua Guo, Yongwu Xia, Xiaoxin Jiang, Limei Zhang, Feiding Peng, Pinghong Ming. Notoginsenoside R1 induces DNA damage via PHF6 protein to inhibit cervical carcinoma cell proliferation. Molecular medicine reports. 2021 04; 23(4):. doi: 10.3892/mmr.2021.11881. [PMID: 33537816]
  • Lei Wang, Hui Fu, Wenwen Wang, Yi Liu, Xumin Li, Jijing Yang, Lingli Li, Gang Wu, Yihuai Pan. Notoginsenoside R1 functionalized gelatin hydrogels to promote reparative dentinogenesis. Acta biomaterialia. 2021 03; 122(?):160-171. doi: 10.1016/j.actbio.2020.12.031. [PMID: 33348063]
  • Hai-Long Qin, Xue-Jun Wang, Bi-Xian Yang, Bin Du, Xue-Lin Yun. Notoginsenoside R1 attenuates breast cancer progression by targeting CCND2 and YBX3. Chinese medical journal. 2021 Jan; 134(5):546-554. doi: 10.1097/cm9.0000000000001328. [PMID: 33480613]
  • Qing Yuan, Jin-Xin Wang, Rui-Lin Li, Zhuang-Zhuang Jia, Shao-Xia Wang, Hong Guo, Li-Juan Chai, Li-Min Hu. Effects of salvianolate lyophilized injection combined with Xueshuantong injection in regulation of BBB function in a co-culture model of endothelial cells and pericytes. Brain research. 2021 01; 1751(?):147185. doi: 10.1016/j.brainres.2020.147185. [PMID: 33129805]
  • Jincheng Zhong, Weijin Lu, Jiayan Zhang, Maohua Huang, Wenyu Lyu, Geni Ye, Lijuan Deng, Minfeng Chen, Nan Yao, Yong Li, Guanping Liu, Yunfei Liang, Jingwen Fu, Dongmei Zhang, Wencai Ye. Notoginsenoside R1 activates the Ang2/Tie2 pathway to promote angiogenesis. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2020 Nov; 78(?):153302. doi: 10.1016/j.phymed.2020.153302. [PMID: 32823242]
  • Ting Zhu, Lei Wang, Fang Tian, Xin Zhao, Xiao-Ping Pu, Gui-Bo Sun, Xiao-Bo Sun. Anti-ischemia/reperfusion injury effects of notoginsenoside R1 on small molecule metabolism in rat brain after ischemic stroke as visualized by MALDI-MS imaging. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Sep; 129(?):110470. doi: 10.1016/j.biopha.2020.110470. [PMID: 32768957]
  • Fa Ren, Tianyu Feng, Tongjuan Niu, Yitian Yuan, Qi Liu, Jinhong Xiao, Gaoxiao Xu, Jianhong Hu. Notoginsenoside R1 protects boar sperm during liquid storage at 17°C. Reproduction in domestic animals = Zuchthygiene. 2020 Sep; 55(9):1072-1079. doi: 10.1111/rda.13745. [PMID: 32531853]
  • W Wang, L Huang, Y Hu, E R Thomas, X Li. Neuroprotective effects of notoginsenoside R1 by upregulating Trx-1 on acrylamide-induced neurotoxicity in PC12. Human & experimental toxicology. 2020 Jun; 39(6):797-807. doi: 10.1177/0960327120901586. [PMID: 31971015]
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