Morphine-3-glucuronide (BioDeep_00000001381)

 

Secondary id: BioDeep_00001874417

human metabolite Endogenous blood metabolite natural product


代谢物信息卡片


(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-{[(1S,5R,13R,14S,17R)-14-hydroxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10,15-tetraen-10-yl]oxy}oxane-2-carboxylic acid

化学式: C23H27NO9 (461.1686)
中文名称: 吗啡-3-Β-D-葡糖苷酸
谱图信息: 最多检出来源 Viridiplantae(plant) 24.72%

分子结构信息

SMILES: CN1CCC23C4C1CC5=C2C(=C(C=C5)OC6C(C(C(C(O6)C(=O)O)O)O)O)OC3C(C=C4)O
InChI: InChI=1S/C23H27NO9/c1-24-7-6-23-10-3-4-12(25)20(23)32-18-13(5-2-9(14(18)23)8-11(10)24)31-22-17(28)15(26)16(27)19(33-22)21(29)30/h2-5,10-12,15-17,19-20,22,25-28H,6-8H2,1H3,(H,29,30)/t10-,11+,12-,15-,16-,17+,19-,20-,22+,23-/m0/s1

描述信息

Morphine-3-glucuronide belongs to the family of Morphinans. These are polycyclic compounds with a four-ring skeleton with three condensed six-member rings forming a partially hydrogenated phenanthrene moiety, one of which is aromatic while the two others are alicyclic.
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants

同义名列表

8 个代谢物同义名

(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-{[(1S,5R,13R,14S,17R)-14-hydroxy-4-methyl-12-oxa-4-azapentacyclo[9.6.1.0¹,¹³.0⁵,¹⁷.0⁷,¹⁸]octadeca-7(18),8,10,15-tetraen-10-yl]oxy}oxane-2-carboxylic acid; Morphine-3-glucuronide (stereo-aspecific); Morphine 3-glucuronide(minor); Morphine-3beta-D-glucuronide; Morphine 3-glucuronide; Morphine-3-glucuronide; m-3-g hydrate; Morphine-3-glucuronide



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

4 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(1)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(2)

PharmGKB(1)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ABCB1, ALB, CYP2D6, CYP3A4, TLR4
Peripheral membrane protein 1 CYP1B1
Endosome membrane 2 LY96, TLR4
Endoplasmic reticulum membrane 6 CYP1B1, CYP2D6, CYP3A4, UGT1A1, UGT1A6, UGT2B7
Nucleus 2 ALB, FOS
cytosol 2 ALB, FOS
dendrite 2 OPRM1, PDYN
centrosome 1 ALB
nucleoplasm 1 FOS
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 4 ABCB1, OPRD1, OPRM1, TLR4
Cell projection, axon 1 OPRM1
Multi-pass membrane protein 6 ABCB1, ABCC2, ABCC3, OPRD1, OPRM1, SLC45A2
Golgi apparatus membrane 1 B3GAT2
Synapse 3 OPRM1, PDYN, TAC1
cell surface 3 ABCB1, ABCC2, TLR4
Golgi apparatus 2 ALB, OPRM1
Golgi membrane 1 B3GAT2
neuronal cell body 2 PDYN, TAC1
presynaptic membrane 1 OPRD1
endosome 1 OPRM1
plasma membrane 9 ABCB1, ABCC2, ABCC3, LY96, OPRD1, OPRM1, PDYN, TLR4, UGT1A1
synaptic vesicle membrane 1 OPRD1
Membrane 14 ABCB1, ABCC2, ABCC3, B3GAT2, CYP1B1, CYP2D6, CYP3A4, OPRD1, OPRM1, SLC45A2, TLR4, UGT1A1, UGT1A6, UGT2B7
apical plasma membrane 2 ABCB1, ABCC2
axon 2 OPRM1, TAC1
basolateral plasma membrane 1 ABCC3
extracellular exosome 2 ABCB1, ALB
endoplasmic reticulum 6 ALB, CYP2D6, FOS, OPRM1, UGT1A1, UGT1A6
extracellular space 3 ALB, IL6, TAC1
perinuclear region of cytoplasm 2 TLR4, UGT1A1
intercellular canaliculus 1 ABCC2
mitochondrion 2 CYP1B1, CYP2D6
protein-containing complex 1 ALB
intracellular membrane-bounded organelle 4 CYP1B1, CYP2D6, CYP3A4, UGT1A6
Microsome membrane 3 CYP1B1, CYP2D6, CYP3A4
Single-pass type I membrane protein 1 TLR4
Secreted 4 ALB, IL6, LY96, PDYN
extracellular region 5 ALB, IL6, LY96, PDYN, TAC1
Single-pass membrane protein 4 CYP2D6, UGT1A1, UGT1A6, UGT2B7
hippocampal mossy fiber to CA3 synapse 1 PDYN
anchoring junction 1 ALB
external side of plasma membrane 1 TLR4
perikaryon 1 OPRM1
Melanosome membrane 1 SLC45A2
Early endosome 1 TLR4
Single-pass type II membrane protein 1 B3GAT2
Apical cell membrane 2 ABCB1, ABCC2
Cytoplasm, perinuclear region 1 UGT1A1
Cell projection, ruffle 1 TLR4
ruffle 1 TLR4
receptor complex 2 LY96, TLR4
neuron projection 2 OPRD1, OPRM1
ciliary basal body 1 ALB
chromatin 1 FOS
phagocytic cup 1 TLR4
centriole 1 ALB
Secreted, extracellular space 1 LY96
spindle pole 1 ALB
blood microparticle 1 ALB
Basolateral cell membrane 1 ABCC3
Cell projection, dendrite 1 OPRM1
basal plasma membrane 1 ABCC3
lipopolysaccharide receptor complex 2 LY96, TLR4
endoplasmic reticulum lumen 2 ALB, IL6
nuclear matrix 1 FOS
platelet alpha granule lumen 1 ALB
axon terminus 2 OPRD1, PDYN
postsynaptic density membrane 1 OPRD1
neuronal dense core vesicle 2 OPRD1, PDYN
Basal cell membrane 1 ABCC3
protein-DNA complex 1 FOS
external side of apical plasma membrane 1 ABCB1
dendrite membrane 1 OPRD1
transcription factor AP-1 complex 1 FOS
interleukin-6 receptor complex 1 IL6
endoplasmic reticulum chaperone complex 1 UGT1A1
cytochrome complex 1 UGT1A1
[Isoform 12]: Cytoplasm 1 OPRM1
spine apparatus 1 OPRD1
ciliary transition fiber 1 ALB


文献列表

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  • Kaiyuan Wang, Jian Wang, Ting Liu, Wenwen Yu, Nan Dong, Chen Zhang, Wenbin Xia, Feng Wei, Lili Yang, Xiubao Ren. Morphine-3-glucuronide upregulates PD-L1 expression via TLR4 and promotes the immune escape of non-small cell lung cancer. Cancer biology & medicine. 2021 02; 18(1):155-171. doi: 10.20892/j.issn.2095-3941.2020.0442. [PMID: 33628591]
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