L-Kynurenine (BioDeep_00000001372)
Secondary id: BioDeep_00000229698, BioDeep_00000398725, BioDeep_00000405334
natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019
代谢物信息卡片
(AlphaS)-alpha,2-diamino-3-hydroxy-gamma-oxo-benzenebutanoic acid
化学式: C10H12N2O3 (208.0848)
中文名称: 犬尿素, 犬尿氨酸, L-犬尿氨酸水合物
谱图信息:
最多检出来源 Homo sapiens(blood) 14.05%
Reviewed
Last reviewed on 2024-07-01.
Cite this Page
L-Kynurenine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/l-kynurenine (retrieved
2024-12-22) (BioDeep RN: BioDeep_00000001372). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C1=CC=C(C(=C1)C(=O)CC(C(=O)O)N)N
InChI: InChI=1S/C10H12N2O3/c11-7-4-2-1-3-6(7)9(13)5-8(12)10(14)15/h1-4,8H,5,11-12H2,(H,14,15)/t8-/m0/s1
描述信息
Kynurenine is a metabolite of the amino acid tryptophan used in the production of niacin. L-Kynurenine is a central compound of the tryptophan metabolism pathway since it can change into the neuroprotective agent kynurenic acid or to the neurotoxic agent quinolinic acid. The break-up of these endogenous compounds balance can be observable in many disorders such as stroke, epilepsy, multiple sclerosis, and amyotrophic lateral sclerosis. It can also occur in neurodegenerative disorders such as Parkinsons disease, Huntingtons, and Alzheimers disease; and in mental disorders such as schizophrenia and depression.
Kynurenine is a metabolite of the amino acid tryptophan used in the production of niacin.
[Raw Data] CBA10_Kynurenine_pos_10eV_1-2_01_666.txt
[Raw Data] CBA10_Kynurenine_pos_30eV_1-2_01_668.txt
[Raw Data] CBA10_Kynurenine_pos_40eV_1-2_01_669.txt
[Raw Data] CBA10_Kynurenine_pos_20eV_1-2_01_667.txt
[Raw Data] CBA10_Kynurenine_pos_50eV_1-2_01_670.txt
L-Kynurenine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=2922-83-0 (retrieved 2024-07-01) (CAS RN: 2922-83-0). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid is an endogenous metabolite.
L-Kynurenine is a metabolite of the amino acid L-tryptophan. L-Kynurenine is an aryl hydrocarbon receptor agonist.
同义名列表
23 个代谢物同义名
(AlphaS)-alpha,2-diamino-3-hydroxy-gamma-oxo-benzenebutanoic acid; (AlphaS)-alpha,2-diamino-3-hydroxy-gamma-oxo-benzenebutanoate; (S)-alpha,2-Diamino-3-hydroxy-gamma-oxo-benzenebutanoic acid; (S)-alpha,2-Diamino-3-hydroxy-gamma-oxo-benzenebutanoate; (2S)-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid; alpha,2-Diamino-gamma-oxo-benzenebutanoic acid; (2S)-2-Amino-4-(2-aminophenyl)-4-oxobutanoate; alpha,2-Diamino-gamma-oxo-benzenebutanoate; 3-(3-Hydroxyanthraniloyl)-L-alanine; 3-Anthraniloyl-L-alanine; 3-Anthraniloyl-alanine; 3-Hydroxy-L-kynurenine; DL-Kynureninefree base; 3-Anthraniloylalanine; DL-Kynurenine; L-Kynurenine; Quinurenine; Kynurenine; Kynurenin; Kynurenine; 2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid; L-Kynurenine; L-kynurenine
数据库引用编号
42 个数据库交叉引用编号
- ChEBI: CHEBI:16946
- KEGG: C00328
- PubChem: 161166
- PubChem: 846
- HMDB: HMDB0000684
- Metlin: METLIN72
- DrugBank: DB02070
- ChEMBL: CHEMBL498416
- Wikipedia: Kynurenine
- MetaCyc: CPD-14736
- KNApSAcK: C00007604
- foodb: FDB022181
- chemspider: 141580
- CAS: 2922-83-0
- MoNA: PS006601
- MoNA: KO003270
- MoNA: FIO00640
- MoNA: FIO00642
- MoNA: KO009020
- MoNA: FIO00641
- MoNA: KO009019
- MoNA: KO009016
- MoNA: KO009017
- MoNA: FIO00639
- MoNA: FIO00638
- MoNA: KO003269
- MoNA: KO003271
- MoNA: KO009018
- MoNA: KO003268
- MoNA: KO003267
- PMhub: MS000000407
- PDB-CCD: KYN
- 3DMET: B01218
- NIKKAJI: J208.656E
- NIKKAJI: J5.688J
- medchemexpress: HY-W014504
- medchemexpress: HY-104026
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-137
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-889
- PubChem: 3622
- KNApSAcK: 16946
- LOTUS: LTS0100823
分类词条
相关代谢途径
Reactome(4)
BioCyc(4)
PlantCyc(0)
代谢反应
86 个相关的代谢反应过程信息。
Reactome(68)
- Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
CARN + SAM ⟶ Anserine + SAH - Tryptophan catabolism:
L-KYN + PYR ⟶ AP-DOBu + L-Ala - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
CARN + SAM ⟶ Anserine + SAH - Tryptophan catabolism:
L-KYN + PYR ⟶ AP-DOBu + L-Ala - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
ATP + L-His + b-Ala ⟶ ADP + CARN + Pi - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Metabolism:
CAR + propionyl CoA ⟶ CoA-SH + Propionylcarnitine - Amino acid and derivative metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Amino acid and derivative metabolism:
GAA + SAM ⟶ CRET + H+ + SAH - Tryptophan catabolism:
L-KYN + PYR ⟶ AP-DOBu + L-Ala - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Metabolism:
ATP + PROP-CoA + carbon dioxide ⟶ ADP + MEMA-CoA + Pi - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Metabolism:
3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA + CoA-SH ⟶ choloyl-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA - Tryptophan catabolism:
L-Trp + Oxygen ⟶ NFK - Metabolism:
1-3-oxo-THA-CoA + CoA-SH ⟶ DHA-CoA + propionyl CoA - Amino acid and derivative metabolism:
2MACA-CoA + CoA ⟶ Ac-CoA + PROP-CoA
BioCyc(8)
- tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde:
H+ + O2 + trp ⟶ N-formylkynurenine - tryptophan degradation I (via anthranilate):
H+ + O2 + trp ⟶ N-formylkynurenine - tryptophan degradation I (via anthranilate):
N-formylkynurenine + H2O ⟶ H+ + formate + kynurenine - tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde:
N-formylkynurenine + H2O ⟶ H+ + formate + kynurenine - NAD biosynthesis II (from tryptophan):
N-formylkynurenine + H2O ⟶ H+ + formate + kynurenine - tryptophan degradation via kynurenine:
N-formylkynurenine + H2O ⟶ formate + kynurenine - NAD biosynthesis (from tryptophan):
N-formylkynurenine + H2O ⟶ formate + kynurenine - NAD biosynthesis II (from tryptophan):
H+ + O2 + trp ⟶ N-formylkynurenine
WikiPathways(2)
- Kynurenine pathway and links to cell senescence:
N-Formylkynurenine ⟶ Kynurenine - Malignant pleural mesothelioma:
Tryptophan ⟶ Kynurenine
Plant Reactome(0)
INOH(1)
- Tryptophan degradation ( Tryptophan degradation ):
L-Tryptophan + O2 ⟶ N-Formyl-L-kynurenine
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(7)
- Tryptophan Metabolism:
L-Tryptophan + Oxygen ⟶ N'-Formylkynurenine - Tryptophan Metabolism:
N'-Formylkynurenine + Water ⟶ Formic acid + Hydrogen Ion + L-Kynurenine - Tryptophan Metabolism:
L-Tryptophan + Oxygen ⟶ N'-Formylkynurenine - Tryptophan Metabolism:
L-Tryptophan + Oxygen ⟶ N'-Formylkynurenine - Tryptophan Metabolism:
L-Tryptophan + Oxygen ⟶ N'-Formylkynurenine - Tryptophan Metabolism:
L-Tryptophan + Oxygen ⟶ N'-Formylkynurenine - NAD Metabolism:
N'-Formylkynurenine + Water ⟶ Formic acid + Hydrogen Ion + L-Kynurenine
PharmGKB(0)
24 个相关的物种来源信息
- 6656 - Arthropoda: LTS0100823
- 7089 - Bombycidae: LTS0100823
- 7090 - Bombyx: LTS0100823
- 7091 - Bombyx mori: 10.1515/BCHM2.1967.348.1.979
- 7091 - Bombyx mori: LTS0100823
- 6658 - Branchiopoda: LTS0100823
- 7711 - Chordata: LTS0100823
- 6668 - Daphnia: LTS0100823
- 6669 - Daphnia pulex: 10.1038/SREP25125
- 6669 - Daphnia pulex: LTS0100823
- 77658 - Daphniidae: LTS0100823
- 2759 - Eukaryota: LTS0100823
- 9604 - Hominidae: LTS0100823
- 9605 - Homo: LTS0100823
- 9606 - Homo sapiens: -
- 9606 - Homo sapiens: 10.1038/NBT.2488
- 9606 - Homo sapiens: LTS0100823
- 50557 - Insecta: LTS0100823
- 40674 - Mammalia: LTS0100823
- 33208 - Metazoa: LTS0100823
- 10066 - Muridae: LTS0100823
- 10088 - Mus: LTS0100823
- 10090 - Mus musculus: LTS0100823
- 10090 - Mus musculus: NA
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shanchun Ge, Lei Wang, Chang Jin, Haifeng Xie, Guoping Zheng, Zhengguo Cui, Chaofeng Zhang. Unveiling the neuroprotection effects of Volvalerenic acid A: Mitochondrial fusion induction via IDO1-mediated Stat3-Opa1 signaling pathway.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jul; 129(?):155555. doi:
10.1016/j.phymed.2024.155555. [PMID: 38579641] - Er Jin, Zhidong Yin, Xiuxiu Zheng, Chenhong Yan, Kai Xu, Fouejio Yemele Eunice, Yue Gao. Potential of Targeting TDO2 as the Lung Adenocarcinoma Treatment.
Journal of proteome research.
2024 Apr; 23(4):1341-1350. doi:
10.1021/acs.jproteome.3c00746. [PMID: 38421152] - Aurélie Hanin, Céline Chollet, Sophie Demeret, Lucas Di Meglio, Florence Castelli, Vincent Navarro. Metabolomic changes in adults with status epilepticus: A human case-control study.
Epilepsia.
2024 Apr; 65(4):929-943. doi:
10.1111/epi.17899. [PMID: 38339978] - Fan Ye, Meng-Chen Dong, Chen-Xi Xu, Ning Jiang, Qi Chang, Xin-Min Liu, Rui-Le Pan. Effects of different chronic restraint stress periods on anxiety- and depression-like behaviors and tryptophan-kynurenine metabolism along the brain-gut axis in C57BL/6N mice.
European journal of pharmacology.
2024 Feb; 965(?):176301. doi:
10.1016/j.ejphar.2023.176301. [PMID: 38145646] - Yolanda Pérez-Pérez, María Teresa Solís, Alfonso Albacete, Pilar S Testillano. Opposite Auxin Dynamics Determine the Gametophytic and Embryogenic Fates of the Microspore.
International journal of molecular sciences.
2023 Jul; 24(13):. doi:
10.3390/ijms241311177. [PMID: 37446349] - Hans-Christian Heitkamp. [Paracrine and endocrine functions of muscles].
MMW Fortschritte der Medizin.
2023 07; 165(Suppl 4):13-19. doi:
10.1007/s15006-023-2493-z. [PMID: 37415033] - Spencer R Rosario, Bowen Dong, Yali Zhang, Hua-Hsin Hsiao, Emily Isenhart, Jianmin Wang, Erin M Siegel, Arta M Monjazeb, Dwight H Owen, Prasenjit Dey, Fred K Tabung, Daniel J Spakowicz, William J Murphy, Stephen Edge, Sai Yendamuri, Sami Ibrahimi, Jill M Kolesar, Patsy H McDonald, Deepak Vadehra, Michelle Churchman, Song Liu, Pawel Kalinski, Sarbajit Mukherjee. Metabolic Dysregulation Explains the Diverse Impacts of Obesity in Males and Females with Gastrointestinal Cancers.
International journal of molecular sciences.
2023 Jun; 24(13):. doi:
10.3390/ijms241310847. [PMID: 37446025] - Erika Dorochow, Nico Kraus, Nicolas Chenaux-Repond, Sandra Pierre, Anja Kolbinger, Gerd Geisslinger, Cristina Ortiz, Christoph Welsch, Jonel Trebicka, Robert Gurke, Lisa Hahnefeld, Sabine Klein, Klaus Scholich. Differential Lipidomics, Metabolomics and Immunological Analysis of Alcoholic and Non-Alcoholic Steatohepatitis in Mice.
International journal of molecular sciences.
2023 Jun; 24(12):. doi:
10.3390/ijms241210351. [PMID: 37373497] - Handong Xu, Can Hu, Yi Wang, Yunfu Shi, Li Yuan, Jingli Xu, Yanqiang Zhang, Jiahui Chen, Qin Wei, Jiangjiang Qin, Zhiyuan Xu, Xiangdong Cheng. Glutathione peroxidase 2 knockdown suppresses gastric cancer progression and metastasis via regulation of kynurenine metabolism.
Oncogene.
2023 May; ?(?):. doi:
10.1038/s41388-023-02708-4. [PMID: 37138031] - Mykola Zdioruk, Jorge-Luis Jimenez-Macias, Michal Oskar Nowicki, Katherine E Manz, Kurt D Pennell, Marilin S Koch, Tomer Finkelberg, Bin Wu, Paul Boucher, Yuji Takeda, Weiyi Li, Raziye Piranlioglu, Alexander L Ling, E Antonio Chiocca, Sean E Lawler. PPRX-1701, a nanoparticle formulation of 6'-bromoindirubin acetoxime, improves delivery and shows efficacy in preclinical GBM models.
Cell reports. Medicine.
2023 Apr; ?(?):101019. doi:
10.1016/j.xcrm.2023.101019. [PMID: 37060903] - Xin Liu, Liwen Wang, Tsokyi Choera, Xin Fang, Gang Wang, Wenhua Chen, Yin-Won Lee, Sherif Ramzy Mohamed, Dawood H Dawood, Jianrong Shi, Jianhong Xu, Nancy P Keller. Paralogous FgIDO genes with differential roles in tryptophan catabolism, fungal development and virulence in Fusarium graminearum.
Microbiological research.
2023 Apr; 272(?):127382. doi:
10.1016/j.micres.2023.127382. [PMID: 37030080] - Ping Lin, Dan Li, Yun Shi, Qingtian Li, Xiaokui Guo, Ke Dong, Qing Chen, Xiaoyan Lou, Zhenhua Li, Ping Li, Weifeng Jin, Shuzi Chen, Yang Sun, Jing Sun, Xunjia Cheng. Dysbiosis of the Gut Microbiota and Kynurenine (Kyn) Pathway Activity as Potential Biomarkers in Patients with Major Depressive Disorder.
Nutrients.
2023 Apr; 15(7):. doi:
10.3390/nu15071752. [PMID: 37049591] - Lu Yan, Chu-Han Liu, Li Xu, Yi-Yun Qian, Ping-Ping Song, Min Wei, Bao-Lin Liu. Alpha-Asarone modulates kynurenine disposal in muscle and mediates resilience to stress-induced depression via PGC-1α induction.
CNS neuroscience & therapeutics.
2023 Mar; 29(3):941-956. doi:
10.1111/cns.14030. [PMID: 36575869] - Arya Afrooghe, Mohammadreza Babaei, Maryam Shayan, Elham Ahmadi, Razieh Mohammad Jafari, Ahmad-Reza Dehpour. Therapeutic potential of bromhexine for acute itch in mice: Involvement of TMPRSS2 and kynurenine pathway.
International immunopharmacology.
2023 Feb; 117(?):109919. doi:
10.1016/j.intimp.2023.109919. [PMID: 36842232] - Savera Aggarwal, Vipin Yadav, Rakhi Maiwall, Archana Rastogi, Viniyendra Pamecha, Onkar Bedi, Jaswinder Singh Maras, Nirupma Trehanpati, Gayatri Ramakrishna. Metabolomic analysis shows dysregulation in amino acid and NAD+ metabolism in palmitate treated hepatocytes and plasma of non-alcoholic fatty liver disease spectrum.
Biochemical and biophysical research communications.
2023 Feb; 643(?):129-138. doi:
10.1016/j.bbrc.2022.12.078. [PMID: 36603530] - Chen-Chen Li, Fan Ye, Chen-Xi Xu, Ning Jiang, Qi Chang, Xin-Min Liu, Rui-Le Pan. Tryptophan-kynurenine metabolic characterization in the gut and brain of depressive-like rats induced by chronic restraint stress.
Journal of affective disorders.
2023 Feb; 328(?):273-286. doi:
10.1016/j.jad.2023.02.008. [PMID: 36746244] - Hélène Ruffieux, Aimee L Hanson, Samantha Lodge, Nathan G Lawler, Luke Whiley, Nicola Gray, Tui H Nolan, Laura Bergamaschi, Federica Mescia, Lorinda Turner, Aloka de Sa, Victoria S Pelly, Prasanti Kotagiri, Nathalie Kingston, John R Bradley, Elaine Holmes, Julien Wist, Jeremy K Nicholson, Paul A Lyons, Kenneth G C Smith, Sylvia Richardson, Glenn R Bantug, Christoph Hess. A patient-centric modeling framework captures recovery from SARS-CoV-2 infection.
Nature immunology.
2023 02; 24(2):349-358. doi:
10.1038/s41590-022-01380-2. [PMID: 36717723] - Zhenzhen Duan, Lei Shi, Zhen Ning Tony He, Chunxiang Kuang, Tianxiong Han, Qing Yang. The Protective Effect of IDO1 Inhibition in Aβ-Treated Neurons and APP/PS1 Mice.
American journal of Alzheimer's disease and other dementias.
2023 Jan; 38(?):15333175231214861. doi:
10.1177/15333175231214861. [PMID: 37944012] - Rouhollah Haghshenas, Younes Aftabi, Saied Doaei, Maryam Gholamalizadeh. Synergistic effect of endurance training and nettle leaf extract on the IDO1-KYN-AHR pathway homeostasis and inhibiting of liver toxicity in rats with STZ-induced diabetes.
Frontiers in endocrinology.
2023; 14(?):1071424. doi:
10.3389/fendo.2023.1071424. [PMID: 37305057] - Ewa Rodziewicz-Flis, Ulana Juhas, Jakub Antoni Kortas, Joanna Jaworska, Ilona Bidzan-Bluma, Anna Babińska, Katarzyna Micielska, Małgorzata Żychowska, Giovanni Lombardi, Jędrzej Antosiewicz, Ewa Ziemann. Nordic Walking training in BungyPump form improves cognitive functions and physical performance and induces changes in amino acids and kynurenine profiles in older adults.
Frontiers in endocrinology.
2023; 14(?):1151184. doi:
10.3389/fendo.2023.1151184. [PMID: 37766686] - Cristina Razquin, Miguel Ruiz-Canela, Estefania Toledo, Clary B Clish, Marta Guasch-Ferré, Jesús F García-Gavilán, Clemens Wittenbecher, Angel Alonso-Gómez, Montse Fitó, Liming Liang, Dolores Corella, Enrique Gómez-Gracia, Ramon Estruch, Miquel Fiol, Jose M Santos-Lozano, Luis Serra-Majem, Emilio Ros, Fernando Aros, Jordi Salas-Salvadó, Frank B Hu, Miguel A Martínez-González. Circulating Amino Acids and Risk of Peripheral Artery Disease in the PREDIMED Trial.
International journal of molecular sciences.
2022 Dec; 24(1):. doi:
10.3390/ijms24010270. [PMID: 36613713] - Jinxue Wei, Zijian Zhang, Yue Du, Xiao Yang, Liansheng Zhao, Peiyan Ni, Rongjun Ni, Meng Gong, Xiaohong Ma. A combination of neuroimaging and plasma metabolomic analysis suggests inflammation is associated with white matter structural connectivity in major depressive disorder.
Journal of affective disorders.
2022 12; 318(?):7-15. doi:
10.1016/j.jad.2022.08.108. [PMID: 36057287] - Bowen Xu, Peng Zhang, Xiaolong Tang, Shiguan Wang, Jing Shen, Yuanwen Zheng, Chao Gao, Ping Mi, Cuijuan Zhang, Hui Qu, Shiyang Li, Detian Yuan. Metabolic Rewiring of Kynurenine Pathway during Hepatic Ischemia-Reperfusion Injury Exacerbates Liver Damage by Impairing NAD Homeostasis.
Advanced science (Weinheim, Baden-Wurttemberg, Germany).
2022 12; 9(35):e2204697. doi:
10.1002/advs.202204697. [PMID: 36310151] - Yanmei Chen, Jiahui Zhang, Yueying Yang, Ke Xiang, Hua Li, Dejuan Sun, Lixia Chen. Kynurenine-3-monooxygenase (KMO): From its biological functions to therapeutic effect in diseases progression.
Journal of cellular physiology.
2022 12; 237(12):4339-4355. doi:
10.1002/jcp.30876. [PMID: 36088660] - Max Schuller, Monika Oberhuber, Barbara Prietl, Elmar Zügner, Eva-Maria Prugger, Christoph Magnes, Alexander H Kirsch, Sabine Schmaldienst, Thomas Pieber, Marianne Brodmann, Alexander R Rosenkranz, Philipp Eller, Kathrin Eller. Alterations in the Kynurenine-Tryptophan Pathway and Lipid Dysregulation Are Preserved Features of COVID-19 in Hemodialysis.
International journal of molecular sciences.
2022 Nov; 23(22):. doi:
10.3390/ijms232214089. [PMID: 36430566] - Yun Seok Kim, Bongsub Ko, Da Jung Kim, Jihoon Tak, Chang Yeob Han, Joo-Youn Cho, Won Kim, Sang Geon Kim. Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.
Nature communications.
2022 10; 13(1):6080. doi:
10.1038/s41467-022-33749-0. [PMID: 36241614] - Mohammed Ghiboub, Susanne Penny, Charlotte M Verburgt, Rotem Sigall Boneh, Eytan Wine, Alejandro Cohen, Katherine A Dunn, Devanand M Pinto, Marc A Benninga, Wouter J de Jonge, Arie Levine, Johan E Van Limbergen. Metabolome Changes With Diet-Induced Remission in Pediatric Crohn's Disease.
Gastroenterology.
2022 10; 163(4):922-936.e15. doi:
10.1053/j.gastro.2022.05.050. [PMID: 35679949] - Cong Lu, Zhen Wei, Yongquan Wang, Shuying Li, Litao Tong, Xinmin Liu, Bei Fan, Fengzhong Wang. Soy isoflavones alleviate lipopolysaccharide-induced depressive-like behavior by suppressing neuroinflammation, mediating tryptophan metabolism and promoting synaptic plasticity.
Food & function.
2022 Sep; 13(18):9513-9522. doi:
10.1039/d2fo01437h. [PMID: 35993820] - Xiaoli Gong, Rui Chang, Ju Zou, Sijie Tan, Zeyi Huang. The role and mechanism of tryptophan - kynurenine metabolic pathway in depression.
Reviews in the neurosciences.
2022 Sep; ?(?):. doi:
10.1515/revneuro-2022-0047. [PMID: 36054612] - Petra Majerova, Dominika Olesova, Greta Golisova, Martina Buralova, Alena Michalicova, Jozef Vegh, Juraj Piestansky, Mangesh Bhide, Jozef Hanes, Andrej Kovac. Analog of kynurenic acid decreases tau pathology by modulating astrogliosis in rat model for tauopathy.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Aug; 152(?):113257. doi:
10.1016/j.biopha.2022.113257. [PMID: 35714514] - Melike Kucukkarapinar, Aysegul Yay-Pence, Yesim Yildiz, Merve Buyukkoruk, Gizem Yaz-Aydin, Tuba S Deveci-Bulut, Ozlem Gulbahar, Esin Senol, Selcuk Candansayar. Psychological outcomes of COVID-19 survivors at sixth months after diagnose: the role of kynurenine pathway metabolites in depression, anxiety, and stress.
Journal of neural transmission (Vienna, Austria : 1996).
2022 08; 129(8):1077-1089. doi:
10.1007/s00702-022-02525-1. [PMID: 35796878] - Ahmed Farouk, Rasha A Hamed, Saeid Elsawy, Nashwa F Abd El Hafez, Farag M Moftah, Muammar A Y Nassar, Fify Alfy Gabra, Tahia H Saleem. Measuring the Systemic Inflammatory Response to On- and Off-Pump Coronary Artery Bypass Graft (CABG) Surgeries Using the Tryptophan/Kynurenine Pathway.
Journal of investigative surgery : the official journal of the Academy of Surgical Research.
2022 Aug; 35(8):1621-1625. doi:
10.1080/08941939.2022.2084188. [PMID: 35694760] - Oskar Olsson, Sten Skogmar, Fregenet Tesfaye, Daba Mulleta, Marianne Jansson, Per Björkman. Kynurenine/tryptophan ratio for detection of active tuberculosis in adults with HIV prior to antiretroviral therapy.
AIDS (London, England).
2022 07; 36(9):1245-1253. doi:
10.1097/qad.0000000000003235. [PMID: 35703207] - Leticia Gil de Biedma-Elduayen, Pablo Giménez-Gómez, Nuria Morales-Puerto, Rebeca Vidal, Carlos Núñez-de la Calle, María Dolores Gutiérrez-López, Esther O'Shea, María Isabel Colado. Influx of kynurenine into the brain is involved in the reduction of ethanol consumption induced by Ro 61-8048 after chronic intermittent ethanol in mice.
British journal of pharmacology.
2022 07; 179(14):3711-3726. doi:
10.1111/bph.15825. [PMID: 35189673] - Bartosz Osuch, Karolina Kołosowska, Natalia Chmielewska, Danuta Turzyńska, Alicja Sobolewska, Janusz Szyndler, Piotr Maciejak. Increased Hippocampal Afterdischarge Threshold in Ketogenic Diet is Accompanied by Enhanced Kynurenine Pathway Activity.
Neurochemical research.
2022 Jul; 47(7):2109-2122. doi:
10.1007/s11064-022-03605-0. [PMID: 35522366] - Teng Huang, Jia Song, Jia Gao, Jia Cheng, Hao Xie, Lu Zhang, Yu-Han Wang, Zhichao Gao, Yi Wang, Xiaohui Wang, Jinhan He, Shiwei Liu, Qilin Yu, Shu Zhang, Fei Xiong, Qing Zhou, Cong-Yi Wang. Adipocyte-derived kynurenine promotes obesity and insulin resistance by activating the AhR/STAT3/IL-6 signaling.
Nature communications.
2022 06; 13(1):3489. doi:
10.1038/s41467-022-31126-5. [PMID: 35715443] - Joseph P Dewulf, Manon Martin, Sandrine Marie, Fabie Oguz, Leila Belkhir, Julien De Greef, Jean Cyr Yombi, Xavier Wittebole, Pierre-François Laterre, Michel Jadoul, Laurent Gatto, Guido T Bommer, Johann Morelle. Urine metabolomics links dysregulation of the tryptophan-kynurenine pathway to inflammation and severity of COVID-19.
Scientific reports.
2022 Jun; 12(1):9959. doi:
10.1038/s41598-022-14292-w. [PMID: 35705608] - Liu Ouyang, Changjiang Yu, Zhiyong Xie, Xiaoyan Su, Zengmei Xu, Ping Song, Jian Li, Hui Huang, Ye Ding, Ming-Hui Zou. Indoleamine 2,3-Dioxygenase 1 Deletion-Mediated Kynurenine Insufficiency in Vascular Smooth Muscle Cells Exacerbates Arterial Calcification.
Circulation.
2022 06; 145(24):1784-1798. doi:
10.1161/circulationaha.121.057868. [PMID: 35582948] - Mi Mi Ko, Jeeyoun Jung, Jung-Eun Lee, Seon Mi Shin, Hyun-Kyung Sung, Ho-Yeon Go, Soobin Jang. Metabolomic analysis of Gyejibongnyeong-Hwan for shoulder pain: A randomized, wait-list controlled pilot trial.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2022 Jun; 104(?):154248. doi:
10.1016/j.phymed.2022.154248. [PMID: 35716471] - Huan Wang, Jian Li, Zheng Wang, Yanfeng Tian, Chunlei Li, Feng Jin, Jia Li, Lanfeng Wang. Perivascular brown adipocytes-derived kynurenic acid relaxes blood vessel via endothelium PI3K-Akt-eNOS pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Jun; 150(?):113040. doi:
10.1016/j.biopha.2022.113040. [PMID: 35658210] - Duygu Eryavuz Onmaz, Dilek Tezcan, Sedat Abusoglu, Abdullah Sivrikaya, Menekse Kuzu, Fatma Humeyra Yerlikaya, Sema Yilmaz, Ali Unlu. Elevated serum levels of kynurenine pathway metabolites in patients with Behçet disease.
Amino acids.
2022 Jun; 54(6):877-887. doi:
10.1007/s00726-022-03170-4. [PMID: 35604497] - Patrick M Honore, Sebastien Redant, Pharan Djimafo, Thierry Preseau, Bogdan Vasile Cismas, Keitiane Kaefer, Leonel Barreto Gutierrez, Sami Anane, Rachid Attou, Andrea Gallerani, David De Bels. Letter to the Editor: 'Activation of the kynurenine pathway predicts mortality and neurological outcome in cardiac arrest patients: A validation study'.
Journal of critical care.
2022 06; 69(?):154005. doi:
10.1016/j.jcrc.2022.154005. [PMID: 35176637] - M Gelpi, B Vestad, S C Raju, S Hyll Hansen, J Høgh, Ø Midttun, P M Ueland, T Ueland, T Benfield, Klaus F Kofoed, J R Hov, M Trøseid, S Dam Nielsen. Association of the Kynurenine Pathway of Tryptophan Metabolism With Human Immunodeficiency Virus-Related Gut Microbiota Alterations and Visceral Adipose Tissue Accumulation.
The Journal of infectious diseases.
2022 06; 225(11):1948-1954. doi:
10.1093/infdis/jiac018. [PMID: 35089326] - Qibin Qi, Jun Li, Bing Yu, Jee-Young Moon, Jin C Chai, Jordi Merino, Jie Hu, Miguel Ruiz-Canela, Casey Rebholz, Zheng Wang, Mykhaylo Usyk, Guo-Chong Chen, Bianca C Porneala, Wenshuang Wang, Ngoc Quynh Nguyen, Elena V Feofanova, Megan L Grove, Thomas J Wang, Robert E Gerszten, Josée Dupuis, Jordi Salas-Salvadó, Wei Bao, David L Perkins, Martha L Daviglus, Bharat Thyagarajan, Jianwen Cai, Tao Wang, JoAnn E Manson, Miguel A Martínez-González, Elizabeth Selvin, Kathryn M Rexrode, Clary B Clish, Frank B Hu, James B Meigs, Rob Knight, Robert D Burk, Eric Boerwinkle, Robert C Kaplan. Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies.
Gut.
2022 06; 71(6):1095-1105. doi:
10.1136/gutjnl-2021-324053. [PMID: 34127525] - Karen Mei-Ling Tan, Mya-Thway Tint, Narasimhan Kothandaraman, Fabian Yap, Keith M Godfrey, Yung Seng Lee, Kok Hian Tan, Peter D Gluckman, Yap-Seng Chong, Mary F F Chong, Johan G Eriksson, David Cameron-Smith. Association of plasma kynurenine pathway metabolite concentrations with metabolic health risk in prepubertal Asian children.
International journal of obesity (2005).
2022 06; 46(6):1128-1137. doi:
10.1038/s41366-022-01085-4. [PMID: 35173282] - Maiqueli Eduarda Dama Mingoti, Amanda Gollo Bertollo, Júlia Leão Batista Simões, Gabriel Rossi Francisco, Margarete Dulce Bagatini, Zuleide Maria Ignácio. COVID-19, Oxidative Stress, and Neuroinflammation in the Depression Route.
Journal of molecular neuroscience : MN.
2022 Jun; 72(6):1166-1181. doi:
10.1007/s12031-022-02004-y. [PMID: 35322375] - Maria Giovanna Scarale, Mario Mastroianno, Cornelia Prehn, Massimiliano Copetti, Lucia Salvemini, Jerzy Adamski, Salvatore De Cosmo, Vincenzo Trischitta, Claudia Menzaghi. Circulating Metabolites Associate With and Improve the Prediction of All-Cause Mortality in Type 2 Diabetes.
Diabetes.
2022 06; 71(6):1363-1370. doi:
10.2337/db22-0095. [PMID: 35358315] - Anna Krupa, Mikolaj M Krupa, Krystyna Pawlak. Indoleamine 2,3 Dioxygenase 1-The Potential Link between the Innate Immunity and the Ischemia-Reperfusion-Induced Acute Kidney Injury?.
International journal of molecular sciences.
2022 May; 23(11):. doi:
10.3390/ijms23116176. [PMID: 35682852] - Tarek Bekfani, Mohamed Bekhite, Sophie Neugebauer, Steffen Derlien, Ali Hamadanchi, Jenny Nisser, Marion S Hilse, Daniela Haase, Tom Kretzschmar, Mei-Fang Wu, Michael Lichtenauer, Michael Kiehntopf, Stephan von Haehling, Peter Schlattmann, Gabriele Lehmann, Marcus Franz, Sven Möbius-Winkler, Christian Schulze. Metabolomic Profiling in Patients with Heart Failure and Exercise Intolerance: Kynurenine as a Potential Biomarker.
Cells.
2022 05; 11(10):. doi:
10.3390/cells11101674. [PMID: 35626711] - Yunqing Duan, Junfang Liu, Fuxiang Wang, Zhiqing Duan. Increasing the bioactivity of kynurenine by ultraviolet irradiation via resonance energy transfer in vitro.
Analytical biochemistry.
2022 05; 645(?):114605. doi:
10.1016/j.ab.2022.114605. [PMID: 35181297] - Aastha Arora, Gustavo Luis Tripodi, Ilona Kareinen, Martin Berg, Maria Josefa Forteza, Anton Gisterå, Silke Griepke, Felipe Beccaria Casagrande, Joilson O Martins, Dulcineia Saes Parra Abdalla, Jennifer Cole, Claudia Monaco, Daniel F J Ketelhuth. Genetic Deficiency of Indoleamine 2,3-dioxygenase Aggravates Vascular but Not Liver Disease in a Nonalcoholic Steatohepatitis and Atherosclerosis Comorbidity Model.
International journal of molecular sciences.
2022 May; 23(9):. doi:
10.3390/ijms23095203. [PMID: 35563591] - Kamlesh Patel, Marcos Fernandez-Villamarin, Craig Ward, Janet M Lord, Peter Tino, Paula M Mendes. Establishing a quantitative fluorescence assay for the rapid detection of kynurenine in urine.
The Analyst.
2022 May; 147(9):1931-1936. doi:
10.1039/d2an00107a. [PMID: 35388832] - Alperen Emre Akgün, Yalın Tolga Yaylalı, Mücahit Seçme, Yavuz Dodurga, Hande Şenol. Kynurenine-PARP-1 Link Mediated by MicroRNA 210 May Be Dysregulated in Pulmonary Hypertension.
Anatolian journal of cardiology.
2022 05; 26(5):388-393. doi:
10.5152/anatoljcardiol.2021.861. [PMID: 35552175] - Ebru Nur Ay, Şeyda Demirkol, Mehmet Tolgahan Hakan, Cem Horozoğlu, Soykan Arıkan, Mehmet Baki Doğan, Filiz Akyüz, Ceylan Özsoy Hepokur, İlhan Yaylım. Investigation of possible associations between tryptophan/kynurenine status and FOXP3 expression in colorectal cancer.
Scandinavian journal of clinical and laboratory investigation.
2022 05; 82(3):185-191. doi:
10.1080/00365513.2022.2040050. [PMID: 35452343] - Medha Priyadarshini, Guadalupe Navarro, Derek J Reiman, Anukriti Sharma, Kai Xu, Kristen Lednovich, Christopher R Manzella, Md Wasim Khan, Mariana Salas Garcia, Sarah Allard, Barton Wicksteed, George E Chlipala, Barbara Szynal, Beatriz Penalver Bernabe, Pauline M Maki, Ravinder K Gill, Gary H Perdew, Jack Gilbert, Yang Dai, Brian T Layden. Gestational Insulin Resistance Is Mediated by the Gut Microbiome-Indoleamine 2,3-Dioxygenase Axis.
Gastroenterology.
2022 05; 162(6):1675-1689.e11. doi:
10.1053/j.gastro.2022.01.008. [PMID: 35032499] - Elisa Pose, Elsa Solà, Juan J Lozano, Adrià Juanola, Julia Sidorova, Giacomo Zaccherini, Koos de Wit, Frank Uschner, Marta Tonon, Konstantin Kazankov, Cesar Jiménez, Daniela Campion, Laura Napoleone, Ann T Ma, Marta Carol, Manuel Morales-Ruiz, Carlo Alessandria, Ulrich Beuers, Paolo Caraceni, Claire Francoz, François Durand, Rajeshwar P Mookerjee, Jonel Trebicka, Victor Vargas, Salvatore Piano, Hugh Watson, Juan G Abraldes, Patrick S Kamath, Mark M Davis, Pere Ginès. Treatment With Simvastatin and Rifaximin Restores the Plasma Metabolomic Profile in Patients With Decompensated Cirrhosis.
Hepatology communications.
2022 05; 6(5):1100-1112. doi:
10.1002/hep4.1881. [PMID: 34964311] - Juncai Pu, Yiyun Liu, Siwen Gui, Lu Tian, Yue Yu, Dongfang Wang, Xiaogang Zhong, Weiyi Chen, Xiaopeng Chen, Yue Chen, Xiang Chen, Xue Gong, Lanxiang Liu, Wenxia Li, Haiyang Wang, Peng Xie. Effects of pharmacological treatment on metabolomic alterations in animal models of depression.
Translational psychiatry.
2022 04; 12(1):175. doi:
10.1038/s41398-022-01947-5. [PMID: 35487889] - Md Amran Gazi, Md Abdullah Siddique, Md Ashraful Alam, Farzana Hossaini, Md Mehedi Hasan, Shah Mohammad Fahim, Barbie Zaman Wahid, Md Mamun Kabir, Subhasish Das, Mustafa Mahfuz, Tahmeed Ahmed. Plasma Kynurenine to Tryptophan Ratio Is Not Associated with Undernutrition in Adults but Reduced after Nutrition Intervention: Results from a Community-Based Study in Bangladesh.
Nutrients.
2022 Apr; 14(9):. doi:
10.3390/nu14091708. [PMID: 35565678] - Ethar A Mudhish, Abu Bakar Siddique, Hassan Y Ebrahim, Khaldoun S Abdelwahed, Judy Ann King, Khalid A El Sayed. The Tobacco β-Cembrenediol: A Prostate Cancer Recurrence Suppressor Lead and Prospective Scaffold via Modulation of Indoleamine 2,3-Dioxygenase and Tryptophan Dioxygenase.
Nutrients.
2022 Apr; 14(7):. doi:
10.3390/nu14071505. [PMID: 35406118] - Inês Delgado, Sofia Cussotto, Andrea Anesi, Sandra Dexpert, Agnès Aubert, Bruno Aouizerate, Cédric Beau, Damien Forestier, Patrick Ledaguenel, Eric Magne, Fulvio Mattivi, Lucile Capuron. Association between the indole pathway of tryptophan metabolism and subclinical depressive symptoms in obesity: a preliminary study.
International journal of obesity (2005).
2022 04; 46(4):885-888. doi:
10.1038/s41366-021-01049-0. [PMID: 35001078] - Ying-Jie Zhao, Chi Zhou, Ying-Ying Wei, Hui-Hui Li, Wei Lei, Derek S Boeldt, Kai Wang, Jing Zheng. Differential Distribution of Tryptophan-Metabolites in Fetal and Maternal Circulations During Normotensive and Preeclamptic Pregnancies.
Reproductive sciences (Thousand Oaks, Calif.).
2022 04; 29(4):1278-1286. doi:
10.1007/s43032-021-00759-0. [PMID: 34622427] - Jumin Huang, Di Liu, Yuwei Wang, Liang Liu, Jian Li, Jing Yuan, Zhihong Jiang, Zebo Jiang, Wl Wendy Hsiao, Haizhou Liu, Imran Khan, Ying Xie, Jianlin Wu, Yajia Xie, Yizhong Zhang, Yu Fu, Junyi Liao, Wenjun Wang, Huanling Lai, Axi Shi, Jun Cai, Lianxiang Luo, Runze Li, Xiaojun Yao, Xingxing Fan, Qibiao Wu, Zhongqiu Liu, Peiyu Yan, Jingguang Lu, Mingrong Yang, Lin Wang, Yabing Cao, Hong Wei, Elaine Lai-Han Leung. Ginseng polysaccharides alter the gut microbiota and kynurenine/tryptophan ratio, potentiating the antitumour effect of antiprogrammed cell death 1/programmed cell death ligand 1 (anti-PD-1/PD-L1) immunotherapy.
Gut.
2022 04; 71(4):734-745. doi:
10.1136/gutjnl-2020-321031. [PMID: 34006584] - Marta Galán-Díez, Florence Borot, Abdullah Mahmood Ali, Junfei Zhao, Eva Gil-Iturbe, Xiaochuan Shan, Na Luo, Yongfeng Liu, Xi-Ping Huang, Brygida Bisikirska, Rossella Labella, Irwin Kurland, Bryan L Roth, Matthias Quick, Siddhartha Mukherjee, Raul Rabadán, Martin Carroll, Azra Raza, Stavroula Kousteni. Subversion of Serotonin Receptor Signaling in Osteoblasts by Kynurenine Drives Acute Myeloid Leukemia.
Cancer discovery.
2022 04; 12(4):1106-1127. doi:
10.1158/2159-8290.cd-21-0692. [PMID: 35046097] - Fabiana Russo, Francesco Tolomeo, Maria Angela Vandelli, Giuseppe Biagini, Roberta Paris, Flavia Fulvio, Aldo Laganà, Anna Laura Capriotti, Luigi Carbone, Giuseppe Gigli, Giuseppe Cannazza, Cinzia Citti. Kynurenine and kynurenic acid: Two human neuromodulators found in Cannabis sativa L.
Journal of pharmaceutical and biomedical analysis.
2022 Mar; 211(?):114636. doi:
10.1016/j.jpba.2022.114636. [PMID: 35124451] - Alex Gomez-Gomez, Paula Aguilera, Klaus Langohr, Gregori Casals, Cristina Pavon, Josep Marcos, Jordi To-Figueras, Oscar J Pozo. Evaluation of Metabolic Changes in Acute Intermittent Porphyria Patients by Targeted Metabolomics.
International journal of molecular sciences.
2022 Mar; 23(6):. doi:
10.3390/ijms23063219. [PMID: 35328641] - Druszczynska Magdalena, Seweryn Michal, Sieczkowska Marta, Kowalewska-Pietrzak Magdalena, Pankowska Anna, Godkowicz Magdalena, Szewczyk Rafał. Targeted metabolomics analysis of serum and Mycobacterium tuberculosis antigen-stimulated blood cultures of pediatric patients with active and latent tuberculosis.
Scientific reports.
2022 03; 12(1):4131. doi:
10.1038/s41598-022-08201-4. [PMID: 35260782] - Murat Cihan, Özlem Doğan, Ceyhan Ceran Serdar, Arzu Altunçekiç Yıldırım, Celali Kurt, Muhittin A Serdar. Kynurenine pathway in Coronavirus disease (COVID-19): Potential role in prognosis.
Journal of clinical laboratory analysis.
2022 Mar; 36(3):e24257. doi:
10.1002/jcla.24257. [PMID: 35092710] - Maija Saraste, Markus Matilainen, Cecilia Rajda, Zsolt Galla, Marcus Sucksdorff, László Vécsei, Laura Airas. Association between microglial activation and serum kynurenine pathway metabolites in multiple sclerosis patients.
Multiple sclerosis and related disorders.
2022 Mar; 59(?):103667. doi:
10.1016/j.msard.2022.103667. [PMID: 35151985] - Aleksandr V Zhuravlev, Boris F Shchegolev, Gennadii A Zakharov, Polina N Ivanova, Ekaterina A Nikitina, Elena V Savvateeva-Popova. 3-Hydroxykynurenine as a Potential Ligand for Hsp70 Proteins and Its Effects on Drosophila Memory After Heat Shock.
Molecular neurobiology.
2022 Mar; 59(3):1862-1871. doi:
10.1007/s12035-021-02704-3. [PMID: 35029786] - Lihui Guo, Bernadette Schurink, Eva Roos, Esther J Nossent, Jan Willem Duitman, Alexander Pj Vlaar, Paul van der Valk, Frédéric M Vaz, Syun-Ru Yeh, Zachary Geeraerts, Annemiek Dijkhuis, Lonneke van Vught, Marianna Bugiani, René Lutter. Indoleamine 2,3-dioxygenase (IDO)-1 and IDO-2 activity and severe course of COVID-19.
The Journal of pathology.
2022 03; 256(3):256-261. doi:
10.1002/path.5842. [PMID: 34859884] - Mariola Bochniarz, Roman Dąbrowski, Tomasz Kocki, Przemysław Błaszczyk, Marek Szczubiał, Piotr Brodzki, Leszek Krakowski, Waldemar A Turski. Content of tryptophan and kynurenines in serum and milk of dairy cows with mastitis caused by Streptococcus spp.
Reproduction in domestic animals = Zuchthygiene.
2022 Mar; 57(3):277-283. doi:
10.1111/rda.14050. [PMID: 34826180] - Elisabeth R Paul, Lilly Schwieler, Sophie Erhardt, Sandra Boda, Ada Trepci, Robin Kämpe, Anna Asratian, Lovisa Holm, Adam Yngve, Robert Dantzer, Markus Heilig, J Paul Hamilton, Martin Samuelsson. Peripheral and central kynurenine pathway abnormalities in major depression.
Brain, behavior, and immunity.
2022 03; 101(?):136-145. doi:
10.1016/j.bbi.2022.01.002. [PMID: 34999196] - Tiziana Guarnieri. Hypothesis: Emerging Roles for Aryl Hydrocarbon Receptor in Orchestrating CoV-2-Related Inflammation.
Cells.
2022 02; 11(4):. doi:
10.3390/cells11040648. [PMID: 35203299] - Mary Kimmel, Wanting Jin, Kai Xia, Kun Lun, Andrea Azcarate-Peril, Anna Plantinga, Michael Wu, Shirin Ataei, Hannah Rackers, Ian Carroll, Samantha Meltzer-Brody, Emma Fransson, Rebecca Knickmeyer. Metabolite trajectories across the perinatal period and mental health: A preliminary study of tryptophan-related metabolites, bile acids and microbial composition.
Behavioural brain research.
2022 02; 418(?):113635. doi:
10.1016/j.bbr.2021.113635. [PMID: 34755640] - Smita Ghare, Richa Singhal, Vaughn Bryant, Sabina Gautam, Chanakya Charan Tirumala, Praneet Kumar Srisailam, Andrea Reyes-Vega, Dushan Ghooray, Craig J McClain, Kristi Hoffman, Joseph Petrosino, Kendall Bryant, Varan Govind, Ronald Cohen, Robert L Cook, Shirish Barve. Age-Associated Gut Dysbiosis, Marked by Loss of Butyrogenic Potential, Correlates With Altered Plasma Tryptophan Metabolites in Older People Living With HIV.
Journal of acquired immune deficiency syndromes (1999).
2022 02; 89(Suppl 1):S56-S64. doi:
10.1097/qai.0000000000002866. [PMID: 35015746] - Stefano Comai, Elisa Melloni, Cristina Lorenzi, Irene Bollettini, Benedetta Vai, Raffaella Zanardi, Cristina Colombo, Flavia Valtorta, Francesco Benedetti, Sara Poletti. Selective association of cytokine levels and kynurenine/tryptophan ratio with alterations in white matter microstructure in bipolar but not in unipolar depression.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology.
2022 02; 55(?):96-109. doi:
10.1016/j.euroneuro.2021.11.003. [PMID: 34847455] - Chunlong Mu, Anamika Choudhary, Shyamchand Mayengbam, Karlene T Barrett, Jong M Rho, Jane Shearer, Morris H Scantlebury. Seizure modulation by the gut microbiota and tryptophan-kynurenine metabolism in an animal model of infantile spasms.
EBioMedicine.
2022 Feb; 76(?):103833. doi:
10.1016/j.ebiom.2022.103833. [PMID: 35090836] - Arshad Ghaffari-Nasab, Reza Badalzadeh, Gisou Mohaddes, Gonja Javani, Abbas Ebrahimi-Kalan, Mohammad Reza Alipour. Young Plasma Induces Antidepressant-Like Effects in Aged Rats Subjected to Chronic Mild Stress by Suppressing Indoleamine 2,3-Dioxygenase Enzyme and Kynurenine Pathway in the Prefrontal Cortex.
Neurochemical research.
2022 Feb; 47(2):358-371. doi:
10.1007/s11064-021-03440-9. [PMID: 34626305] - Marzieh Rostaminejad, Abdolmohamad Rostami, Abbas Behzad-Behbahani, Gholam Reza Rafiei Dehbidi, Tahereh Kalantari. The effect of 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase gene overexpression in the kynurenine pathway on the expression levels of indoleamine 2,3-dioxygenase 1 and interferon-γ in inflammatory conditions: an in vitro study.
Molecular biology reports.
2022 Feb; 49(2):1103-1111. doi:
10.1007/s11033-021-06935-4. [PMID: 34775574] - Izabela Zakrocka, Wojciech Załuska. Kynurenine pathway in kidney diseases.
Pharmacological reports : PR.
2022 Feb; 74(1):27-39. doi:
10.1007/s43440-021-00329-w. [PMID: 34617264] - Amit Jain, Massimo Lamperti, D John Doyle. COVID-19, perioperative neurocognitive disorder and SARS-CoV-2-induced dysregulation of the renin-angiotensin system and kynurenine metabolism. Comment on Br J Anaesth 2021; 127: e113-e115.
British journal of anaesthesia.
2022 02; 128(2):e46-e49. doi:
10.1016/j.bja.2021.10.031. [PMID: 34865826] - Qiong Sha, Zach Madaj, Sarah Keaton, Martha L Escobar Galvis, LeAnn Smart, Stanislaw Krzyzanowski, Asgerally T Fazleabas, Richard Leach, Teodor T Postolache, Eric D Achtyes, Lena Brundin. Cytokines and tryptophan metabolites can predict depressive symptoms in pregnancy.
Translational psychiatry.
2022 01; 12(1):35. doi:
10.1038/s41398-022-01801-8. [PMID: 35078975] - Simon Michaelis, Sieglinde Zelzer, Wolfgang J Schnedl, Andreas Baranyi, Andreas Meinitzer, Dietmar Enko. Assessment of tryptophan and kynurenine as prognostic markers in patients with SARS-CoV-2.
Clinica chimica acta; international journal of clinical chemistry.
2022 Jan; 525(?):29-33. doi:
10.1016/j.cca.2021.12.005. [PMID: 34902346] - Julia Lischka, Andrea Schanzer, Margot Baumgartner, Charlotte de Gier, Susanne Greber-Platzer, Maximilian Zeyda. Tryptophan Metabolism Is Associated with BMI and Adipose Tissue Mass and Linked to Metabolic Disease in Pediatric Obesity.
Nutrients.
2022 Jan; 14(2):. doi:
10.3390/nu14020286. [PMID: 35057467] - Kai Tai Derek Yeung, Nicholas Penney, Luke Whiley, Hutan Ashrafian, Matthew R Lewis, Sanjay Purkayastha, Ara Darzi, Elaine Holmes. The impact of bariatric surgery on serum tryptophan-kynurenine pathway metabolites.
Scientific reports.
2022 01; 12(1):294. doi:
10.1038/s41598-021-03833-4. [PMID: 34996930] - Nkiruka V Arinze, Wenqing Yin, Saran Lotfollahzadeh, Marc Arthur Napoleon, Sean Richards, Joshua A Walker, Mostafa Belghasem, Jonathan D Ravid, Mohamed Hassan Kamel, Stephen A Whelan, Norman Lee, Jeffrey J Siracuse, Stephan Anderson, Alik Farber, David Sherr, Jean Francis, Naomi M Hamburg, Nader Rahimi, Vipul C Chitalia. Tryptophan metabolites suppress the Wnt pathway and promote adverse limb events in chronic kidney disease.
The Journal of clinical investigation.
2022 01; 132(1):. doi:
10.1172/jci142260. [PMID: 34752422] - Emina Sudar-Milovanovic, Zoran Gluvic, Milan Obradovic, Bozidarka Zaric, Esma R Isenovic. Tryptophan Metabolism in Atherosclerosis and Diabetes.
Current medicinal chemistry.
2022; 29(1):99-113. doi:
10.2174/0929867328666210714153649. [PMID: 34269660] - Annet Vulto, Martijn van Faassen, Michiel N Kerstens, André P van Beek. Susceptibility to Adrenal Crisis Is Associated With Differences in Cortisol Excretion in Patients With Secondary Adrenal Insufficiency.
Frontiers in endocrinology.
2022; 13(?):849188. doi:
10.3389/fendo.2022.849188. [PMID: 35518935] - Yuqing Liang, Shan Xie, Yanyun He, Manru Xu, Xi Qiao, Yue Zhu, Wenbin Wu. Kynurenine Pathway Metabolites as Biomarkers in Alzheimer's Disease.
Disease markers.
2022; 2022(?):9484217. doi:
10.1155/2022/9484217. [PMID: 35096208] - Jéssica Araujo da Paixão de Oliveira, Mariana Martins de Athaide, Atta Ur Rahman, Mayara Garcia de Mattos Barbosa, Marcia Maria Jardim, Milton Ozório Moraes, Roberta Olmo Pinheiro. Kynurenines in the Pathogenesis of Peripheral Neuropathy During Leprosy and COVID-19.
Frontiers in cellular and infection microbiology.
2022; 12(?):815738. doi:
10.3389/fcimb.2022.815738. [PMID: 35281455] - Mary I Butler, Caitriona Long-Smith, Gerard M Moloney, Sabrina Morkl, Siobhain M O'Mahony, John F Cryan, Gerard Clarke, Timothy G Dinan. The immune-kynurenine pathway in social anxiety disorder.
Brain, behavior, and immunity.
2022 01; 99(?):317-326. doi:
10.1016/j.bbi.2021.10.020. [PMID: 34758380] - William O Jonsson, Jonathan Ponette, Oscar Horwath, Tomas Rydenstam, Karin Söderlund, Björn Ekblom, Michele Azzolini, Jorge L Ruas, Eva Blomstrand. Changes in plasma concentration of kynurenine following intake of branched-chain amino acids are not caused by alterations in muscle kynurenine metabolism.
American journal of physiology. Cell physiology.
2022 01; 322(1):C49-C62. doi:
10.1152/ajpcell.00285.2021. [PMID: 34817270] - Penghao Sun, Mengli Wang, Zhuoni Li, Jingjing Wei, Feng Liu, Wei Zheng, Xiaoyan Zhu, Xuejun Chai, Shanting Zhao. Eucommiae cortex polysaccharides mitigate obesogenic diet-induced cognitive and social dysfunction via modulation of gut microbiota and tryptophan metabolism.
Theranostics.
2022; 12(8):3637-3655. doi:
10.7150/thno.72756. [PMID: 35664075] - Siyu Wang, Liangshan Mu, Chunmei Zhang, Xiaoyu Long, Yurong Zhang, Rong Li, Yue Zhao, Jie Qiao. Abnormal Activation of Tryptophan-Kynurenine Pathway in Women With Polycystic Ovary Syndrome.
Frontiers in endocrinology.
2022; 13(?):877807. doi:
10.3389/fendo.2022.877807. [PMID: 35721725] - Kaat Hebbrecht, Manuel Morrens, Erik J Giltay, Alexander L N van Nuijs, Bernard Sabbe, Seline van den Ameele. The Role of Kynurenines in Cognitive Dysfunction in Bipolar Disorder.
Neuropsychobiology.
2022; 81(3):184-191. doi:
10.1159/000520152. [PMID: 34883494] - Laura Ansone, Monta Briviba, Ivars Silamikelis, Anna Terentjeva, Ingus Perkons, Liga Birzniece, Vita Rovite, Baiba Rozentale, Ludmila Viksna, Oksana Kolesova, Kristaps Klavins, Janis Klovins. Amino Acid Metabolism is Significantly Altered at the Time of Admission in Hospital for Severe COVID-19 Patients: Findings from Longitudinal Targeted Metabolomics Analysis.
Microbiology spectrum.
2021 12; 9(3):e0033821. doi:
10.1128/spectrum.00338-21. [PMID: 34878333] - Jacopo Lucchetti, Francesca Fumagalli, Davide Olivari, Roberta Affatato, Claudia Fracasso, Daria De Giorgio, Carlo Perego, Francesca Motta, Alice Passoni, Lidia Staszewsky, Deborah Novelli, Aurora Magliocca, Silvio Garattini, Roberto Latini, Giuseppe Ristagno, Marco Gobbi. Brain Kynurenine Pathway and Functional Outcome of Rats Resuscitated From Cardiac Arrest.
Journal of the American Heart Association.
2021 12; 10(23):e021071. doi:
10.1161/jaha.121.021071. [PMID: 34816736] - Rami Bou Khalil, Rhéa El Khoury. δEPCD: the electrophysiologic coefficient of depressiveness.
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.
2021 Dec; 26(8):752-759. doi:
10.1080/1354750x.2021.1995497. [PMID: 34664533] - Juncai Pu, Yiyun Liu, Siwen Gui, Lu Tian, Yue Yu, Xuemian Song, Xiaogang Zhong, Xiaopeng Chen, Weiyi Chen, Peng Zheng, Hanping Zhang, Xue Gong, Lanxiang Liu, Jing Wu, Haiyang Wang, Peng Xie. Metabolomic changes in animal models of depression: a systematic analysis.
Molecular psychiatry.
2021 12; 26(12):7328-7336. doi:
10.1038/s41380-021-01269-w. [PMID: 34471249]
