Fenpyroximate (BioDeep_00000001344)

   

natural product


代谢物信息卡片


Pesticide4_Fenpyroximate_C24H27N3O4_tert-Butyl 4-[({[(1E)-(1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylidene]amino}oxy)methyl]benzoate

化学式: C24H27N3O4 (421.2001)
中文名称: 唑螨酯, (Z)-唑螨酯
谱图信息: 最多检出来源 Viridiplantae(plant) 20.83%

分子结构信息

SMILES: CC1=NN(C(=C1C=NOCC2=CC=C(C=C2)C(=O)OC(C)(C)C)OC3=CC=CC=C3)C
InChI: InChI=1S/C24H27N3O4/c1-17-21(22(27(5)26-17)30-20-9-7-6-8-10-20)15-25-29-16-18-11-13-19(14-12-18)23(28)31-24(2,3)4/h6-15H,16H2,1-5H3

描述信息

CONFIDENCE standard compound; INTERNAL_ID 254; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10501; ORIGINAL_PRECURSOR_SCAN_NO 10500
CONFIDENCE standard compound; INTERNAL_ID 254; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10529; ORIGINAL_PRECURSOR_SCAN_NO 10528
CONFIDENCE standard compound; INTERNAL_ID 254; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10568; ORIGINAL_PRECURSOR_SCAN_NO 10566
CONFIDENCE standard compound; INTERNAL_ID 254; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10573; ORIGINAL_PRECURSOR_SCAN_NO 10568
CONFIDENCE standard compound; INTERNAL_ID 254; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10546; ORIGINAL_PRECURSOR_SCAN_NO 10545
CONFIDENCE standard compound; INTERNAL_ID 254; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 10595; ORIGINAL_PRECURSOR_SCAN_NO 10594

同义名列表

4 个代谢物同义名

Fenpyroximate; Pesticide4_Fenpyroximate_C24H27N3O4_tert-Butyl 4-[({[(1E)-(1,3-dimethyl-5-phenoxy-1H-pyrazol-4-yl)methylidene]amino}oxy)methyl]benzoate; Fenpyroximate (Z,E); Fenpyroximate



数据库引用编号

22 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ANXA5, BCL2, CASP3, CASP9, CAT, CRYZ, HPGDS, PARK7, SLC9A1, SNCA, SRY
Peripheral membrane protein 6 ACHE, ANXA5, CYP1B1, HSD17B6, NDUFA7, NDUFS7
Endoplasmic reticulum membrane 3 BCL2, CYP1B1, HMOX1
Nucleus 8 ACHE, BCL2, CASP3, CASP9, HMOX1, PARK7, SNCA, SRY
cytosol 11 ANXA5, BCL2, CASP3, CASP9, CAT, CRYZ, GSS, HMOX1, HPGDS, PARK7, SNCA
nucleoplasm 6 CASP3, HMOX1, HPGDS, PARK7, SLC9A1, SRY
Cell membrane 3 ACHE, PARK7, SLC9A1
Lipid-anchor 1 PARK7
Cytoplasmic side 1 HMOX1
lamellipodium 1 SLC9A1
Cell projection, axon 1 SNCA
Early endosome membrane 1 HSD17B6
Multi-pass membrane protein 1 SLC9A1
Synapse 2 ACHE, SNCA
cell cortex 1 SNCA
cell surface 2 ACHE, SLC9A1
glutamatergic synapse 1 CASP3
Golgi apparatus 1 ACHE
growth cone 1 SNCA
mitochondrial inner membrane 2 NDUFA7, NDUFS7
neuromuscular junction 1 ACHE
neuronal cell body 3 CASP3, NDUFS7, SNCA
postsynapse 1 SNCA
sarcolemma 1 ANXA5
synaptic vesicle 1 PARK7
Lysosome 1 SNCA
plasma membrane 4 ACHE, PARK7, SLC9A1, SNCA
synaptic vesicle membrane 1 SNCA
Membrane 9 ACHE, ANXA5, BCL2, CAT, CYP1B1, HMOX1, PARK7, SLC9A1, SNCA
apical plasma membrane 1 SLC9A1
axon 2 PARK7, SNCA
basolateral plasma membrane 1 SLC9A1
extracellular exosome 6 ANXA5, CAT, CRYZ, GSS, PARK7, SLC9A1
Lumenal side 1 HSD17B6
endoplasmic reticulum 4 BCL2, HMOX1, HSD17B6, PARK7
extracellular space 3 ACHE, HMOX1, SNCA
perinuclear region of cytoplasm 5 ACHE, HMOX1, PARK7, SLC9A1, SNCA
adherens junction 1 PARK7
intercalated disc 1 SLC9A1
mitochondrion 10 BCL2, CASP9, CAT, CRYZ, CYP1B1, NDUFA7, NDUFS7, PARK7, SLC9A1, SNCA
protein-containing complex 4 BCL2, CASP9, CAT, SNCA
intracellular membrane-bounded organelle 4 CAT, CYP1B1, HPGDS, HSD17B6
Microsome membrane 2 CYP1B1, HSD17B6
postsynaptic density 1 CASP3
Secreted 2 ACHE, SNCA
extracellular region 4 ACHE, ANXA5, CAT, SNCA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, HMOX1
mitochondrial matrix 3 CAT, NDUFS7, PARK7
Extracellular side 1 ACHE
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 ANXA5
actin cytoskeleton 1 SNCA
T-tubule 1 SLC9A1
Mitochondrion inner membrane 2 NDUFA7, NDUFS7
Matrix side 2 NDUFA7, NDUFS7
Membrane raft 2 PARK7, SLC9A1
pore complex 1 BCL2
focal adhesion 3 ANXA5, CAT, SLC9A1
Peroxisome 1 CAT
basement membrane 1 ACHE
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
PML body 1 PARK7
mitochondrial intermembrane space 1 PARK7
collagen-containing extracellular matrix 1 ANXA5
nuclear speck 1 SRY
Zymogen granule membrane 1 ANXA5
chromatin 2 PARK7, SRY
supramolecular fiber 1 SNCA
Basolateral cell membrane 1 SLC9A1
Lipid-anchor, GPI-anchor 1 ACHE
Nucleus speckle 1 SRY
cell body 1 PARK7
side of membrane 1 ACHE
myelin sheath 1 BCL2
synaptic membrane 1 NDUFS7
respiratory chain complex I 2 NDUFA7, NDUFS7
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 1 CAT
axon terminus 1 SNCA
Single-pass type IV membrane protein 1 HMOX1
apoptosome 1 CASP9
vesicle membrane 1 ANXA5
synaptic cleft 1 ACHE
death-inducing signaling complex 1 CASP3
catalase complex 1 CAT
inclusion body 1 SNCA
endothelial microparticle 1 ANXA5
BAD-BCL-2 complex 1 BCL2
cation-transporting ATPase complex 1 SLC9A1
[Isoform H]: Cell membrane 1 ACHE
caspase complex 1 CASP9


文献列表

  • Imen Ayed-Boussema, Karima Rjiba, Asma M'nassri, Hiba Hamdi, Salwa Abid. Subchronic exposure to fenpyroximate causes multiorgan toxicity in Wistar rats by disrupting lipid profile, inducing oxidative stress and DNA damage. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2024 Feb; ?(?):1-10. doi: 10.1080/1354750x.2024.2313663. [PMID: 38299991]
  • Mousa Ahmadpour, Weifeng Wang, Mohammad Hosein Sinkakarimi, Mohsen Ahmadpour, Seyed Hamid Hosseini. Joint toxicity of cadmium and fenpyroximate on two earthworms: Interspecific differences, subcellular partitioning and biomarker responses. Chemosphere. 2023 Jun; 337(?):139329. doi: 10.1016/j.chemosphere.2023.139329. [PMID: 37364643]
  • Imen Ayed-Boussema, Karima Rjiba, Hiba Hamdi, Asma M'nassri, Awatef Azzebi, Moncef Mokni, Salwa Abid. Evaluation of hepatotoxicity and nephrotoxicity induced by fenpyroximate in subchronic-orally exposed Wistar rats. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 2022 Nov; 27(7):648-658. doi: 10.1080/1354750x.2022.2096928. [PMID: 35775504]
  • Imen Ayed-Boussema, Hiba Hamdi, Hanen Chaabani, Asma M'nassri, Moncef Mokni, Salwa Abid. Fenpyroximate induced cytotoxicity and genotoxicity in Wistar rat brain and in human neuroblastoma (SH-SY5Y) cells: Involvement of oxidative stress and apoptosis. Neurotoxicology. 2022 07; 91(?):177-187. doi: 10.1016/j.neuro.2022.05.009. [PMID: 35580743]
  • Rassol Bahreini, Medhat Nasr, Cassandra Docherty, Samantha Muirhead, Olivia de Herdt, David Feindel. Miticidal activity of fenazaquin and fenpyroximate against Varroa destructor, an ectoparasite of Apis mellifera. Pest management science. 2022 Apr; 78(4):1686-1697. doi: 10.1002/ps.6788. [PMID: 34994089]
  • Razieh Yaghoobi, Jahangir Khajehali, Elaheh Shafiei Alavijeh, Ralf Nauen, Wannes Dermauw, Thomas Van Leeuwen. Fenpyroximate resistance in Iranian populations of the European red mite Panonychus ulmi (Acari: Tetranychidae). Experimental & applied acarology. 2021 Jan; 83(1):69-79. doi: 10.1007/s10493-020-00569-0. [PMID: 33165750]
  • Rassol Bahreini, Medhat Nasr, Cassandra Docherty, Olivia de Herdt, Samantha Muirhead, David Feindel. Evaluation of potential miticide toxicity to Varroa destructor and honey bees, Apis mellifera, under laboratory conditions. Scientific reports. 2020 12; 10(1):21529. doi: 10.1038/s41598-020-78561-2. [PMID: 33299084]
  • Somayyeh Ghasemzadeh, Jawwad A Qureshi. Demographic analysis of fenpyroximate and thiacloprid exposed predatory mite Amblyseius swirskii (Acari: Phytoseiidae). PloS one. 2018; 13(11):e0206030. doi: 10.1371/journal.pone.0206030. [PMID: 30439960]
  • Rika Ozawa, Hiroki Endo, Mei Iijima, Koichi Sugimoto, Junji Takabayashi, Tetsuo Gotoh, Gen-Ichiro Arimura. Intraspecific variation among Tetranychid mites for ability to detoxify and to induce plant defenses. Scientific reports. 2017 02; 7(?):43200. doi: 10.1038/srep43200. [PMID: 28240222]
  • Nesli Doğan, Zehra Yazıcı, Turgay Şişman, Hakan Aşkin. Acute toxic effects of fenpyroximate acaricide on Guppy (Poecilia reticulata Peters, 1859). Toxicology and industrial health. 2013 Sep; 29(8):716-21. doi: 10.1177/0748233712442736. [PMID: 22508399]
  • Vanessa Graillot, Florence Tomasetig, Jean-Pierre Cravedi, Marc Audebert. Evidence of the in vitro genotoxicity of methyl-pyrazole pesticides in human cells. Mutation research. 2012 Oct; 748(1-2):8-16. doi: 10.1016/j.mrgentox.2012.05.014. [PMID: 22743356]
  • Moosa Saber. Acute and population level toxicity of imidacloprid and fenpyroximate on an important egg parasitoid, Trichogramma cacoeciae (Hymenoptera: Trichogrammatidae). Ecotoxicology (London, England). 2011 Aug; 20(6):1476-84. doi: 10.1007/s10646-011-0704-3. [PMID: 21647819]
  • Ming-Long Yuan, Dan-Dan Wei, Bao-Jun Wang, Wei Dou, Jin-Jun Wang. The complete mitochondrial genome of the citrus red mite Panonychus citri (Acari: Tetranychidae): high genome rearrangement and extremely truncated tRNAs. BMC genomics. 2010 Oct; 11(?):597. doi: 10.1186/1471-2164-11-597. [PMID: 20969792]
  • Na Na, Huarong Guo, Shicui Zhang, Zhaojie Li, Licheng Yin. In vitro and in vivo acute toxicity of fenpyroximate to flounder Paralichthys olivaceus and its gill cell line FG. Aquatic toxicology (Amsterdam, Netherlands). 2009 Apr; 92(2):76-85. doi: 10.1016/j.aquatox.2008.12.006. [PMID: 19185358]
  • Andrea Slaninova, Miriam Smutna, Helena Modra, Zdenka Svobodova. A review: oxidative stress in fish induced by pesticides. Neuro endocrinology letters. 2009; 30 Suppl 1(?):2-12. doi: . [PMID: 20027135]
  • Hong Dai, Yong-Qiang Li, Ding Du, Xue Qin, Xin Zhang, Hai-Bo Yu, Jian-Xin Fang. Synthesis and biological activities of novel pyrazole oxime derivatives containing a 2-chloro-5-thiazolyl moiety. Journal of agricultural and food chemistry. 2008 Nov; 56(22):10805-10. doi: 10.1021/jf802429x. [PMID: 18959421]
  • Eunho Suh, Sang-Hyun Koh, Joon-Ho Lee, Key-Il Shin, Kijong Cho. Evaluation of resistance pattern to fenpyroximate and pyridaben in Tetranychus urticae collected from greenhouses and apple orchards using lethal concentration-slope relationship. Experimental & applied acarology. 2006; 38(2-3):151-65. doi: 10.1007/s10493-006-0009-z. [PMID: 16596349]
  • T Satoh, H Miyoshi, K Sakamoto, H Iwamura. Comparison of the inhibitory action of synthetic capsaicin analogues with various NADH-ubiquinone oxidoreductases. Biochimica et biophysica acta. 1996 Jan; 1273(1):21-30. doi: 10.1016/0005-2728(95)00131-x. [PMID: 8573592]