Gomisin D (BioDeep_00000011908)

 

Secondary id: BioDeep_00000230808

PANOMIX_OTCML-2023 Volatile Flavor Compounds


代谢物信息卡片


(11S,12R,15S,24S,25S)-12,25-Dihydroxy-18,19,20-trimethoxy-11,12,24,25-tetramethyl-4,6,9,14-tetraoxapentacyclo[13.7.3.03,7.08,22.016,21]pentacosa-1,3(7),8(22),16,18,20-hexaen-13-one

化学式: C28H34O10 (530.2151864)
中文名称: 戈米辛D, 戈米辛 D
谱图信息: 最多检出来源 unclassified Codonopsis(otcml) 0.65%

分子结构信息

SMILES: CC1CC2=CC3=C(C4=C2C5=C(C(=C(C=C5C(C1(C)O)OC(=O)C(C(CO4)C)(C)O)OC)OC)OC)OCO3
InChI: InChI=1S/C28H34O10/c1-13-8-15-9-18-22(37-12-36-18)24-19(15)20-16(10-17(32-5)21(33-6)23(20)34-7)25(27(13,3)30)38-26(29)28(4,31)14(2)11-35-24/h9-10,13-14,25,30-31H,8,11-12H2,1-7H3

描述信息

Gomisin D is a natural product found in Schisandra chinensis with data available.
Gomisin D, a lignan compound isolated from Fructus Schisandra, is a potential antidiabetic and anti-Alzheimer’s agent. Gomisin D inhibits UDP-Glucuronosyltransferases activity and scavenges ABTS(+) radicals. Gomisin D is used as a quality marker of Shengmai San and shenqi Jiangtang Granule[1].
Gomisin D, a lignan compound isolated from Fructus Schisandra, is a potential antidiabetic and anti-Alzheimer’s agent. Gomisin D inhibits UDP-Glucuronosyltransferases activity and scavenges ABTS(+) radicals. Gomisin D is used as a quality marker of Shengmai San and shenqi Jiangtang Granule[1].

同义名列表

7 个代谢物同义名

CID 75130910; Gomisin D; (11S,12R,15S,24S,25S)-12,25-Dihydroxy-18,19,20-trimethoxy-11,12,24,25-tetramethyl-4,6,9,14-tetraoxapentacyclo[13.7.3.03,7.08,22.016,21]pentacosa-1,3(7),8(22),16,18,20-hexaen-13-one; 5,13-(Epoxybutanoxy)benzo(3,4)cycloocta(1,2-f)(1,3)benzodioxol-18-one, 5,6,7,8-tetrahydro-6,17-dihydroxy-1,2,3-trimethoxy-6,7,16,17-tetramethyl-, stereoisomer; 7,19-Dihydroxy-12,13,14-trimethoxy-6,7,18,19-tetramethyl-6,7-dihydro-2H,10H-10,15-propano-1,3,4,9-tetraoxabenzo[3,4]cycloundeca[1,2-e]inden-8(5H)-one; CID 5317799; Gomisin D



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Joong Suk Jeon, He Mi Kang, Sun Young Park, Young-Whan Choi. Comparative study of the photo‑protective and anti‑melanogenic properties of gomisin D, J and O. Molecular medicine reports. 2022 Jan; 25(1):. doi: 10.3892/mmr.2021.12524. [PMID: 34751410]
  • Xiaoyong Zheng, Feng Feng, Xiunan Jiang, Jieying Qiu, Xiaojun Cai, Zheng Xiang. A Rapid UPLC-MS Method for Quantification of Gomisin D in Rat Plasma and Its Application to a Pharmacokinetic and Bioavailability Study. Molecules (Basel, Switzerland). 2019 Apr; 24(7):. doi: 10.3390/molecules24071403. [PMID: 30974748]
  • Ai-Hua Zhang, Jing-Bo Yu, Hui Sun, Ling Kong, Xiang-Qian Wang, Qing-Yu Zhang, Xi-Jun Wang. Identifying quality-markers from Shengmai San protects against transgenic mouse model of Alzheimer's disease using chinmedomics approach. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2018 Jun; 45(?):84-92. doi: 10.1016/j.phymed.2018.04.004. [PMID: 29685366]
  • Jin-Hui Song, Li Cui, Li-Bin An, Wen-Tao Li, Zhong-Ze Fang, Yan-Yan Zhang, Pei-Pei Dong, Xue Wu, Li-Xuan Wang, Frank J Gonzalez, Xiao-Yu Sun, De-Wei Zhao. Inhibition of UDP-Glucuronosyltransferases (UGTs) Activity by constituents of Schisandra chinensis. Phytotherapy research : PTR. 2015 Oct; 29(10):1658-64. doi: 10.1002/ptr.5395. [PMID: 26084208]
  • Xue-Mei Gao, Rui-Rui Wang, De-Yun Niu, Chun-Yang Meng, Liu-Meng Yang, Yong-Tang Zheng, Guang-Yu Yang, Qiu-Fen Hu, Han-Dong Sun, Wei-Lie Xiao. Bioactive dibenzocyclooctadiene lignans from the stems of Schisandra neglecta. Journal of natural products. 2013 Jun; 76(6):1052-7. doi: 10.1021/np400070x. [PMID: 23738539]
  • Y Ikeya, H Taguchi, I Yosioka, Y Iitaka, H Kobayashi. The constituents of Schizandra chinensis Baill. II. The structure of a new lignan, gomisin D. Chemical & pharmaceutical bulletin. 1979 Jun; 27(6):1395-401. doi: 10.1248/cpb.27.1395. [PMID: 544052]