Latrunculin A (BioDeep_00000011473)
代谢物信息卡片
(4R)-4-[(1R,4E,8Z,10E,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one
化学式: C22H31NO5S (421.19228360000005)
中文名称: 红海海绵素A
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=CC(=O)OC2CC(CCC(C)C=CC=CCC1)OC(O)(C1CSC(O)=N1)C2
InChI: InChI=1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1
描述信息
A bicyclic macrolide natural product consisting of a 16-membered bicyclic lactone attached to the rare 2-thiazolidinone moiety. It is obtained from the Red Sea sponge Latrunculia magnifica and from the Fiji Islands sponge Cacospongia mycofijiensis. Latrunculin A inhibits actin polymerisation, microfilament organsation and microfilament-mediated processes.
同义名列表
5 个代谢物同义名
Latrunculin A; (4R)-4-[(1R,4E,8Z,10E,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-1,3-thiazolidin-2-one; (4R)-[(1R,4Z,8E,10Z,12S,15R,17R)-17-hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl]-2-thiazolidinone; MS000025472; NSC 613011
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:69136
- KEGG: C16901
- PubChem: 445420
- PubChem: 6437378
- PubChem: 3891
- Metlin: METLIN64706
- DrugBank: DB02621
- ChEMBL: CHEMBL404116
- CAS: 76343-93-6
- PMhub: MS000025472
- MetaboLights: MTBLC69136
- PubChem: 135626075
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
20 个相关的物种来源信息
- 1162744 Cacospongia mycofijiensis:
- 344322 Negombata magnifica:
- 296243 Lasioseius: 10.1021/JO00250A053
- 436463 Hyattella: 10.1021/JO00250A053
- 262607 Chromodoris lochi:
- 121495 Thorectidae: 10.1021/NP50082A019
- 1162744 Cacospongia mycofijiensis:
- 508129 Chromodoris elisabethina: 10.1007/BF01952094
- 1174603 Chromodoris hamiltoni: 10.1016/0040-4020(95)00440-J
- 1162778 Dactylospongia: 10.1002/1099-0690(200102)2001:4<775::AID-EJOC775>3.0.CO;2-Z
- 1162744 Cacospongia mycofijiensis:
- 344322 Negombata magnifica:
- 296243 Lasioseius: 10.1021/JO00250A053
- 436463 Hyattella: 10.1021/JO00250A053
- 262607 Chromodoris lochi:
- 121495 Thorectidae: 10.1021/NP50082A019
- 1162744 Cacospongia mycofijiensis:
- 508129 Chromodoris elisabethina: 10.1007/BF01952094
- 1174603 Chromodoris hamiltoni: 10.1016/0040-4020(95)00440-J
- 1162778 Dactylospongia: 10.1002/1099-0690(200102)2001:4<775::AID-EJOC775>3.0.CO;2-Z
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Francisco Correa, Cristina Enríquez-Cortina, Alejandro Silva-Palacios, Nadia Román-Anguiano, Aurora Gil-Hernández, Marcos Ostolga-Chavarría, Elizabeth Soria-Castro, Sharik Hernández-Rizo, Paola de Los Heros, María Chávez-Canales, Cecilia Zazueta. Actin-Cytoskeleton Drives Caveolae Signaling to Mitochondria during Postconditioning.
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Thrombosis and haemostasis.
2008 Jan; 99(1):86-95. doi:
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The Journal of biological chemistry.
2007 Nov; 282(48):35361-72. doi:
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The Journal of cell biology.
2007 Oct; 179(2):341-56. doi:
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The Journal of biological chemistry.
2007 Jun; 282(22):16295-307. doi:
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American journal of physiology. Cell physiology.
2007 May; 292(5):C1690-700. doi:
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Cell and tissue research.
2007 May; 328(2):391-400. doi:
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Plant & cell physiology.
2007 Apr; 48(4):585-97. doi:
10.1093/pcp/pcm030. [PMID: 17327257] - Libin Liu, Mark P Jedrychowski, Steven P Gygi, Paul F Pilch. Role of insulin-dependent cortical fodrin/spectrin remodeling in glucose transporter 4 translocation in rat adipocytes.
Molecular biology of the cell.
2006 Oct; 17(10):4249-56. doi:
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Journal of muscle research and cell motility.
2006; 27(1):53-67. doi:
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Kidney international.
2005 Dec; 68(6):2473-83. doi:
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Protoplasma.
2005 Dec; 227(1):25-36. doi:
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Protoplasma.
2005 Oct; 226(1-2):81-8. doi:
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Molecular biology of the cell.
2005 Sep; 16(9):3919-36. doi:
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Current biology : CB.
2005 Jul; 15(14):1331-6. doi:
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Journal of cell science.
2005 Jul; 118(Pt 13):2837-48. doi:
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Developmental cell.
2005 Jul; 9(1):87-98. doi:
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Molecular biology of the cell.
2005 Jun; 16(6):2746-58. doi:
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Protoplasma.
2005 Apr; 225(1-2):23-32. doi:
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The Journal of cell biology.
2005 Jan; 168(3):477-88. doi:
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Cell structure and function.
2005; 30(2):81-91. doi:
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Experimental cell research.
2004 Dec; 301(2):331-7. doi:
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Journal of cell science.
2004 Dec; 117(Pt 25):6031-41. doi:
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Biophysical journal.
2004 Nov; 87(5):3493-503. doi:
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The Journal of biological chemistry.
2004 Jul; 279(28):29231-5. doi:
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Bioscience reports.
2004 Jun; 24(3):203-14. doi:
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Eukaryotic cell.
2004 Jun; 3(3):675-84. doi:
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Nephron. Experimental nephrology.
2004; 97(2):e49-61. doi:
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American journal of physiology. Renal physiology.
2003 May; 284(5):F930-7. doi:
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Oncogene.
2003 Apr; 22(14):2097-109. doi:
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Journal of neurochemistry.
2003 Apr; 85(2):329-37. doi:
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Molecular biology of the cell.
2003 Mar; 14(3):1149-57. doi:
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Parasitology.
2003 Mar; 126(Pt 3):235-40. doi:
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The Biochemical journal.
2003 Feb; 370(Pt 1):255-63. doi:
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The Plant cell.
2003 Jan; 15(1):285-92. doi:
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Annals of biomedical engineering.
2002 Nov; 30(10):1273-80. doi:
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The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.
2002 Oct; 50(10):1313-24. doi:
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The Journal of biological chemistry.
2002 Sep; 277(39):36443-8. doi:
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Clinical physiology and functional imaging.
2002 Sep; 22(5):312-9. doi:
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The Journal of cell biology.
2002 Jun; 157(6):1071-81. doi:
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