Scymnol (BioDeep_00000011076)

   

natural product


代谢物信息卡片


(24R)-5beta-cholestane-3alpha,7alpha,12alpha,24,26,27-hexol

化学式: C27H48O6 (468.3451)
中文名称:
谱图信息: 最多检出来源 Homo sapiens(otcml) 8.48%

分子结构信息

SMILES: C1[C@@]2(C)[C@]([H])(C[C@@H](O)[C@]3([H])[C@]2([H])C[C@H](O)[C@@]2(C)[C@@]3([H])CC[C@]2([H])[C@H](C)CC[C@@H](O)C(CO)CO)C[C@H](O)C1
InChI: InChI=1S/C27H48O6/c1-15(4-7-22(31)16(13-28)14-29)19-5-6-20-25-21(12-24(33)27(19,20)3)26(2)9-8-18(30)10-17(26)11-23(25)32/h15-25,28-33H,4-14H2,1-3H3/t15-,17+,18-,19-,20+,21+,22-,23-,24+,25+,26+,27-/m1/s1

描述信息

同义名列表

7 个代谢物同义名

(24R)-5beta-cholestane-3alpha,7alpha,12alpha,24,26,27-hexol; 5beta-Cholestane-3alpha,7alpha,12alpha,24,26,27-hexol; 5beta-scymnol; ST 27:0;O6; Scymnol; SCHEMBL16226693; Scymnol



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 ABCB1, GPBAR1, MAPK14, MME
Peripheral membrane protein 1 SORD
Endoplasmic reticulum membrane 2 DHRS9, SLC51A
Mitochondrion membrane 1 SORD
Nucleus 2 MAPK14, NR1H4
cytosol 3 GPT, MAPK14, SORD
dendrite 1 MME
mitochondrial membrane 1 SORD
trans-Golgi network 1 MME
nucleoplasm 2 MAPK14, NR1H4
RNA polymerase II transcription regulator complex 1 NR1H4
Cell membrane 8 ABCB1, ABCB11, GPBAR1, MME, SLC10A1, SLC51A, SLC51B, TNF
Multi-pass membrane protein 6 ABCB1, ABCB11, ABCC3, GPBAR1, SLC10A1, SLC51A
Synapse 1 MME
cell surface 4 ABCB1, ABCB11, MME, TNF
glutamatergic synapse 1 MAPK14
Golgi membrane 1 ABCB11
neuronal cell body 2 MME, TNF
synaptic vesicle 1 MME
Presynapse 1 MME
endosome 1 ABCB11
plasma membrane 11 ABCB1, ABCB11, ABCC3, F2, GPBAR1, MME, SERPINC1, SLC10A1, SLC51A, SLC51B, TNF
Membrane 8 ABCB1, ABCB11, ABCC3, MME, SLC10A1, SLC51A, SLC51B, SORD
apical plasma membrane 2 ABCB1, ABCB11
axon 1 MME
basolateral plasma membrane 4 ABCC3, SLC10A1, SLC51A, SLC51B
brush border 1 MME
extracellular exosome 7 ABCB1, ABCB11, F2, GPT, MME, SERPINC1, SORD
extracellular space 4 F2, SERPINC1, SORD, TNF
intercellular canaliculus 1 ABCB11
mitochondrion 1 MAPK14
protein-containing complex 2 SLC51A, SLC51B
intracellular membrane-bounded organelle 1 DHRS9
Microsome membrane 1 DHRS9
Secreted 1 F2
extracellular region 4 F2, MAPK14, SERPINC1, TNF
Single-pass membrane protein 1 SLC51B
motile cilium 1 SORD
external side of plasma membrane 1 TNF
cytoplasmic vesicle 1 MME
Early endosome 1 MME
recycling endosome 2 ABCB11, TNF
Single-pass type II membrane protein 2 MME, TNF
Apical cell membrane 2 ABCB1, ABCB11
Membrane raft 2 MME, TNF
focal adhesion 1 MME
collagen-containing extracellular matrix 2 F2, SERPINC1
nuclear speck 1 MAPK14
receptor complex 2 GPBAR1, NR1H4
chromatin 1 NR1H4
phagocytic cup 1 TNF
[Isoform 3]: Nucleus 1 NR1H4
Secreted, extracellular space 1 SERPINC1
spindle pole 1 MAPK14
blood microparticle 2 F2, SERPINC1
Cell projection, cilium, flagellum 1 SORD
Basolateral cell membrane 1 ABCC3
Recycling endosome membrane 1 ABCB11
euchromatin 1 NR1H4
basal plasma membrane 1 ABCC3
ficolin-1-rich granule lumen 1 MAPK14
secretory granule lumen 1 MAPK14
secretory granule membrane 1 MME
Golgi lumen 1 F2
endoplasmic reticulum lumen 2 F2, SERPINC1
[Isoform 2]: Nucleus 1 NR1H4
[Isoform 1]: Nucleus 1 NR1H4
Basal cell membrane 1 ABCC3
external side of apical plasma membrane 1 ABCB1
[Isoform 4]: Nucleus 1 NR1H4
intracellular canaliculus 1 ABCB11
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
neuron projection terminus 1 MME
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Christopher Halkias, William G Darby, Bryce N Feltis, Peter McIntyre, Theodore A Macrides, Paul F A Wright. Marine Bile Natural Products as Agonists of the TGR5 Receptor. Journal of natural products. 2021 05; 84(5):1507-1514. doi: 10.1021/acs.jnatprod.0c01327. [PMID: 33904732]
  • Angela Lucas Slitt, Lee Naylor, J Hoivik, Jose E Manautou, Theo Macrides, Steven D Cohen. The shark bile salt 5 beta-scymnol abates acetaminophen toxicity, but not covalent binding. Toxicology. 2004 Oct; 203(1-3):109-21. doi: 10.1016/j.tox.2004.06.002. [PMID: 15363587]
  • N Ballatori, J F Rebbeor, G C Connolly, D J Seward, B E Lenth, J H Henson, P Sundaram, J L Boyer. Bile salt excretion in skate liver is mediated by a functional analog of Bsep/Spgp, the bile salt export pump. American journal of physiology. Gastrointestinal and liver physiology. 2000 Jan; 278(1):G57-63. doi: 10.1152/ajpgi.2000.278.1.g57. [PMID: 10644562]
  • H Ishida, H Nakayasu, H Nukaya, K Tsuji. Study of the pharmacological effect of the bile salt, sodium scymnol sulfate, from Rhizoprionodon acutus. III. Protective effect of scymnol against vascular endothelial cell damage in a rat peripheral arterial occlusion model. Biological & pharmaceutical bulletin. 1999 Aug; 22(8):822-7. doi: 10.1248/bpb.22.822. [PMID: 10480320]
  • H Ishida, H Nakayasu, K Tsuji. Study of the pharmacological effect of the bile salt, sodium scymnol sulfate, from Rhizoprionodon acutus. IV. Effects of naturally occurring bile alcohols, bile acids and their conjugates on lesion development and vascular endothelial cell injury in a rat peripheral arterial occlusion model. Biological & pharmaceutical bulletin. 1999 Aug; 22(8):828-35. doi: 10.1248/bpb.22.828. [PMID: 10480321]
  • T A Macrides, A Shihata, N Kalafatis, P F Wright. A comparison of the hydroxyl radical scavenging properties of the shark bile steroid 5 beta-scymnol and plant pycnogenols. Biochemistry and molecular biology international. 1997 Sep; 42(6):1249-60. doi: 10.1080/15216549700203721. [PMID: 9305543]
  • T A Macrides, L M Naylor, N Kalafatis, A Shihata, P F Wright. Hepatoprotective effects of the shark bile salt 5beta-scymnol on acetaminophen-induced liver damage in mice. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1996 Sep; 33(1):31-7. doi: 10.1006/faat.1996.0140. [PMID: 8812214]