Scymnol (BioDeep_00000011076)

   

natural product


代谢物信息卡片


(24R)-5beta-cholestane-3alpha,7alpha,12alpha,24,26,27-hexol

化学式: C27H48O6 (468.3450708)
中文名称:
谱图信息: 最多检出来源 Macaca mulatta(otcml) 0.53%

分子结构信息

SMILES: C1[C@@]2(C)[C@]([H])(C[C@@H](O)[C@]3([H])[C@]2([H])C[C@H](O)[C@@]2(C)[C@@]3([H])CC[C@]2([H])[C@H](C)CC[C@@H](O)C(CO)CO)C[C@H](O)C1
InChI: InChI=1S/C27H48O6/c1-15(4-7-22(31)16(13-28)14-29)19-5-6-20-25-21(12-24(33)27(19,20)3)26(2)9-8-18(30)10-17(26)11-23(25)32/h15-25,28-33H,4-14H2,1-3H3/t15-,17+,18-,19-,20+,21+,22-,23-,24+,25+,26+,27-/m1/s1

描述信息

同义名列表

7 个代谢物同义名

(24R)-5beta-cholestane-3alpha,7alpha,12alpha,24,26,27-hexol; 5beta-Cholestane-3alpha,7alpha,12alpha,24,26,27-hexol; 5beta-scymnol; ST 27:0;O6; Scymnol; SCHEMBL16226693; Scymnol



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Christopher Halkias, William G Darby, Bryce N Feltis, Peter McIntyre, Theodore A Macrides, Paul F A Wright. Marine Bile Natural Products as Agonists of the TGR5 Receptor. Journal of natural products. 2021 05; 84(5):1507-1514. doi: 10.1021/acs.jnatprod.0c01327. [PMID: 33904732]
  • Angela Lucas Slitt, Lee Naylor, J Hoivik, Jose E Manautou, Theo Macrides, Steven D Cohen. The shark bile salt 5 beta-scymnol abates acetaminophen toxicity, but not covalent binding. Toxicology. 2004 Oct; 203(1-3):109-21. doi: 10.1016/j.tox.2004.06.002. [PMID: 15363587]
  • N Ballatori, J F Rebbeor, G C Connolly, D J Seward, B E Lenth, J H Henson, P Sundaram, J L Boyer. Bile salt excretion in skate liver is mediated by a functional analog of Bsep/Spgp, the bile salt export pump. American journal of physiology. Gastrointestinal and liver physiology. 2000 Jan; 278(1):G57-63. doi: 10.1152/ajpgi.2000.278.1.g57. [PMID: 10644562]
  • H Ishida, H Nakayasu, H Nukaya, K Tsuji. Study of the pharmacological effect of the bile salt, sodium scymnol sulfate, from Rhizoprionodon acutus. III. Protective effect of scymnol against vascular endothelial cell damage in a rat peripheral arterial occlusion model. Biological & pharmaceutical bulletin. 1999 Aug; 22(8):822-7. doi: 10.1248/bpb.22.822. [PMID: 10480320]
  • H Ishida, H Nakayasu, K Tsuji. Study of the pharmacological effect of the bile salt, sodium scymnol sulfate, from Rhizoprionodon acutus. IV. Effects of naturally occurring bile alcohols, bile acids and their conjugates on lesion development and vascular endothelial cell injury in a rat peripheral arterial occlusion model. Biological & pharmaceutical bulletin. 1999 Aug; 22(8):828-35. doi: 10.1248/bpb.22.828. [PMID: 10480321]
  • T A Macrides, A Shihata, N Kalafatis, P F Wright. A comparison of the hydroxyl radical scavenging properties of the shark bile steroid 5 beta-scymnol and plant pycnogenols. Biochemistry and molecular biology international. 1997 Sep; 42(6):1249-60. doi: 10.1080/15216549700203721. [PMID: 9305543]
  • T A Macrides, L M Naylor, N Kalafatis, A Shihata, P F Wright. Hepatoprotective effects of the shark bile salt 5beta-scymnol on acetaminophen-induced liver damage in mice. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1996 Sep; 33(1):31-7. doi: 10.1006/faat.1996.0140. [PMID: 8812214]