Chelidonic acid (BioDeep_00000001105)
Secondary id: BioDeep_00000017725, BioDeep_00000860598
human metabolite PANOMIX_OTCML-2023 blood metabolite natural product
代谢物信息卡片
化学式: C7H4O6 (184.0008)
中文名称: 白屈菜酸
谱图信息:
最多检出来源 Homo sapiens(otcml) 37.41%
分子结构信息
SMILES: c1(cc(=O)cc(o1)C(=O)O)C(=O)O
InChI: InChI=1S/C7H4O6/c8-3-1-4(6(9)10)13-5(2-3)7(11)12/h1-2H,(H,9,10)(H,11,12)
描述信息
Chelidonic acid, also known as 4-oxo-4h-pyran-2,6-dicarboxylic acid or chelidonate, belongs to pyranones and derivatives class of compounds. Those are compounds containing a pyran ring which bears a ketone. Chelidonic acid is soluble (in water) and a moderately acidic compound (based on its pKa). Chelidonic acid can be found in corn, which makes chelidonic acid a potential biomarker for the consumption of this food product. Chelidonic acid is a heterocyclic organic acid with a pyran skeleton .
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1[1]. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM[2].
Chelidonic acid is a component of Chelidonium majus L., used as an antimicrobial. Chelidonic acid also shows anti-inflammatory activity. Chelidonic acid has potential to inhibit IL-6 production by blocking NF-κB and caspase-1[1]. Chelidonic acid is a glutamate decarboxylase inhibitor, with a Ki of 1.2 μM[2].
同义名列表
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:3586
- KEGG: C08476
- PubChem: 7431
- HMDB: HMDB0249899
- Metlin: METLIN67007
- Wikipedia: Chelidonic acid
- KNApSAcK: C00001304
- foodb: FDB007656
- chemspider: 7153
- CAS: 99-32-1
- PMhub: MS000015123
- PubChem: 10669
- PDB-CCD: HLD
- NIKKAJI: J4.968I
- RefMet: Chelidonic acid
- medchemexpress: HY-W041489
- KNApSAcK: 3586
- LOTUS: LTS0084071
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
34 个相关的物种来源信息
- 4668 - Amaryllidaceae: LTS0084071
- 71250 - Chelidonium: LTS0084071
- 71251 - Chelidonium majus:
- 71251 - Chelidonium majus: 10.1002/ARDP.19202580209
- 71251 - Chelidonium majus: 10.1002/JLCR.2590110404
- 71251 - Chelidonium majus: LTS0084071
- 71251 - Chelidonium majus L.: -
- 1622166 - Chelidonium majus subsp. majus: 10.1016/J.PHYMED.2014.07.012
- 1622166 - Chelidonium majus subsp. majus: LTS0084071
- 2759 - Eukaryota: LTS0084071
- 9606 - Homo sapiens: -
- 54834 - Leucojum: LTS0084071
- 54835 - Leucojum aestivum: 10.1016/S0031-9422(00)00496-9
- 54835 - Leucojum aestivum: LTS0084071
- 4447 - Liliopsida: LTS0084071
- 3398 - Magnoliopsida: LTS0084071
- 3465 - Papaveraceae: LTS0084071
- 33090 - Plants: -
- 4479 - Poaceae: LTS0084071
- 4557 - Sorghum: LTS0084071
- 4558 - Sorghum bicolor: LTS0084071
- 35493 - Streptophyta: LTS0084071
- 56863 - Stylophorum: LTS0084071
- 56864 - Stylophorum diphyllum: 10.1002/CBER.19020350103
- 56864 - Stylophorum diphyllum: LTS0084071
- 58023 - Tracheophyta: LTS0084071
- 4564 - Triticum: LTS0084071
- 4571 - Triticum turgidum: LTS0084071
- 4567 - Triticum turgidum subsp. durum: 10.1071/BI9650437
- 4567 - Triticum turgidum subsp. durum: LTS0084071
- 33090 - Viridiplantae: LTS0084071
- 4575 - Zea: LTS0084071
- 4577 - Zea mays: 10.1071/BI9650437
- 4577 - Zea mays: LTS0084071
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Shraddha I Khairnar, Yogesh A Kulkarni, S Murugesan, Kavita Singh. Effects of Acute and Repeated Dose Toxicity Profiling of Chelidonic Acid in Rats: in Silico and in Vivo Evidence.
Chemistry & biodiversity.
2023 Dec; 20(12):e202301241. doi:
10.1002/cbdv.202301241. [PMID: 37983725] - Elena Avdeeva, Elvira Shults, Tatyana Rybalova, Yaroslav Reshetov, Ekaterina Porokhova, Irina Sukhodolo, Larisa Litvinova, Valeria Shupletsova, Olga Khaziakhmatova, Igor Khlusov, Artem Guryev, Mikhail Belousov. Chelidonic Acid and Its Derivatives from Saussurea Controversa: Isolation, Structural Elucidation and Influence on the Osteogenic Differentiation of Multipotent Mesenchymal Stromal Cells In Vitro.
Biomolecules.
2019 05; 9(5):. doi:
10.3390/biom9050189. [PMID: 31100934] - Dhirendra Kumar Singh, Kavita Gulati, Arunabha Ray. Effects of chelidonic acid, a secondary plant metabolite, on mast cell degranulation and adaptive immunity in rats.
International immunopharmacology.
2016 Nov; 40(?):229-234. doi:
10.1016/j.intimp.2016.08.009. [PMID: 27620504] - Dae-Seung Kim, Su-Jin Kim, Min-Cheol Kim, Yong-Deok Jeon, Jae-young Um, Seung-Heon Hong. The therapeutic effect of chelidonic acid on ulcerative colitis.
Biological & pharmaceutical bulletin.
2012; 35(5):666-71. doi:
10.1248/bpb.35.666. [PMID: 22687399] - Shen Z-W, U Fisinger, A Poulev, W Eisenreich, I Werner, E Pleiner, A Bacher, M H Zenk. Tracer studies with 13C-labeled carbohydrates in cultured plant cells. Retrobiosynthetic analysis of chelidonic acid biosynthesis.
Phytochemistry.
2001 May; 57(1):33-42. doi:
10.1016/s0031-9422(00)00496-9. [PMID: 11336258] - E RAMSTAD. [Occurrence and distribution of chelidonic acid in various plant families].
Pharmaceutica acta Helvetiae.
1953 Mar; 28(2-3):45-57. doi:
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