Neriifolin (BioDeep_00000001048)

PANOMIX_OTCML-2023 Chemicals and Drugs Toxin

代谢物信息卡片

化学式: C30H46O8 (534.3192516)
中文名称: 黄夹次甙乙
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 15.34%

Reviewed

Last reviewed on 2024-09-27.

Cite this Page

Neriifolin. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/neriifolin (retrieved 2024-11-06) (BioDeep RN: BioDeep_00000001048). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1[C@@H](C[C@@H]2[C@](C1)([C@@H]1[C@@H](CC2)[C@@]2([C@](CC1)([C@H](CC2)C1=CC(=O)OC1)C)O)C)O[C@@H]1[C@@H]([C@H]([C@H]([C@@H](O1)C)O)OC)O
InChI: InChI=1S/C30H46O8/c1-16-24(32)26(35-4)25(33)27(37-16)38-19-7-10-28(2)18(14-19)5-6-22-21(28)8-11-29(3)20(9-12-30(22,29)34)17-13-23(31)36-15-17/h13,16,18-22,24-27,32-34H,5-12,14-15H2,1-4H3/t16-,18+,19-,20+,21-,22+,24-,25+,26-,27+,28-,29+,30-/m0/s1

描述信息

Neriifolin is a cardenolide glycoside that is digitoxigenin in which the hydroxy goup at position 3 has been converted to its (6-deoxy-3-O-methyl-alpha-L-glucopyranoside derivative. Found in the seeds of Cerbera odollamand in Thevetia ahouia and Thevitia neriifolia. It has a role as a cardiotonic drug, a toxin and a neuroprotective agent. It is functionally related to a digitoxigenin.
Neriifolin is a natural product found in Cerbera manghas, Cerbera odollam, and other organisms with data available.
A cardenolide glycoside that is digitoxigenin in which the hydroxy goup at position 3 has been converted to its (6-deoxy-3-O-methyl-alpha-L-glucopyranoside derivative. Found in the seeds of Cerbera odollamand in Thevetia ahouia and Thevitia neriifolia.
D020011 - Protective Agents > D002316 - Cardiotonic Agents > D002301 - Cardiac Glycosides
[Raw Data] CB071_Neriifolin_pos_40eV_CB000031.txt
[Raw Data] CB071_Neriifolin_pos_10eV_CB000031.txt
[Raw Data] CB071_Neriifolin_pos_20eV_CB000031.txt
[Raw Data] CB071_Neriifolin_pos_50eV_CB000031.txt
[Raw Data] CB071_Neriifolin_pos_30eV_CB000031.txt
Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[1][2.
Neriifolin, a CNS-penetrating cardiac glycoside, is an inhibitor of the Na+, K+-ATPase. Neriifolin can target beclin 1, inhibits the formation of LC3-associated phagosomes and ameliorates experimental autoimmune encephalomyelitis (EAE) development. Neriifolin induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells[1][2.

同义名列表

19 个代谢物同义名

3-[(3S,5R,8R,9S,10S,13R,14S,17R)-3-[(2R,3S,4R,5S,6S)-3,5-dihydroxy-4-methoxy-6-methyloxan-2-yl]oxy-14-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,15,16,17-tetradecahydrocyclopenta[a]phenanthren-17-yl]-2H-furan-5-one; CARD-20(22)-ENOLIDE, 3-((6-DEOXY-3-O-METHYL-.ALPHA.-L-GLUCOPYRANOSYL)OXY)-14-HYDROXY-, (3.BETA.,5.BETA.)-; 5-beta-Card-20(22)-enolide, 3-beta-((6-deoxy-3-O-methyl-beta-L-glucopyranosyl)oxy)-14-hydroxy-; (5beta)-3beta-((6-Deoxy-3-O-methyl-alpha-L-glucopyranosyl)oxy)-14-hydroxycard-20(22)-enolide; 3beta-(6-deoxy-3-O-methyl-alpha-L-glucopyranosyloxy)-14-hydroxy-5beta-card-20(22)-enolide; (3beta,5beta)-3-[(6-Deoxy-3-O-methyl-alpha-L-glucopyranosyl)oxy]card-20(22)-enolide; neriifolin, beta-D-glucopyranosyl cpd (3beta,5beta)-isomer; 4-18-00-01486 (Beilstein Handbook Reference); Digitoxigenin 3-(alpha-L-thevetoside); Digitoxigenin + thevetose [German]; neriifolin, (3beta,5alpha)-isomer; Digitoxigenin + thevetose; 17.BETA.-NERIIFOLIN; 17beta-Neriifolin; UNII-5RD2ADS9WV; NERIIFOLIN [MI]; Neriifolin; 5RD2ADS9WV; Odoroside H

数据库引用编号

20 个数据库交叉引用编号

ChEBI: CHEBI:7522
KEGG: C08876
PubChem: 441867
Metlin: METLIN43898
ChEMBL: CHEMBL501533
LipidMAPS: LMST01120021
MeSH: neriifolin
ChemIDplus: 0000466079
KNApSAcK: C00003632
CAS: 466-07-9
MoNA: FIO00215
MoNA: FIO00219
MoNA: FIO00218
MoNA: FIO00217
MoNA: FIO00216
medchemexpress: HY-N8441
PMhub: MS000001825
MetaboLights: MTBLC7522
3DMET: B02484
NIKKAJI: J12.074J

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

10 个相关的物种来源信息

141544 - Cerbera: 10.1016/J.PHYTOCHEM.2003.10.019
141545 - Cerbera manghas:
141546 - Cerbera odollam: 10.1016/J.PHYTOCHEM.2003.10.019
141546 - Cerbera odollam: 10.1248/CPB.52.1023
392618 - Cunila: 10.1007/S00299-018-2303-8
63479 - Nerium oleander: 10.1016/J.TOXICON.2010.03.026
33090 - Plants: -
141618 - Thevetia ahouai:
930818 - Thevetia neriifolia:
52862 - Thevetia peruviana:

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Muhammad Irfan Waris, Yanyuan Lei, Guojun Qi, Ziying Guan, Abdul Rashied, Jie Chen, Lihua Lyu. The temporal-spatial expression and functional analysis of three gustatory receptor genes in Solenopsis invicta using sweet and bitter compounds. Insect science. 2024 Apr; 31(2):448-468. doi: 10.1111/1744-7917.13301. [PMID: 38010036]
Cécile Ficko, Pierre-Louis Conan. [Malaria in 2022: clinical and therapeutic aspects]. Medecine tropicale et sante internationale. 2023 06; 3(2):. doi: 10.48327/mtsi.v3i2.2023.378. [PMID: 37525671]
Louis H Miller, Jesus Rojas-Jaimes, Leanne M Low, Gilberto Corbellini. What Historical Records Teach Us about the Discovery of Quinine. The American journal of tropical medicine and hygiene. 2023 01; 108(1):7-11. doi: 10.4269/ajtmh.22-0404. [PMID: 36410328]
Shohei Takase, Young Sook Yun, Fuki Moriya, Saaya Sekine, Satoshi Yotsumoto, Katsunori Miyake, Tadahiro Yahagi, Akihiro Ito, Hideshi Inoue. 17β-neriifolin from unripe fruits of Cerbera manghas suppressed cell proliferation via the inhibition of HOXA9-dependent transcription and the induction of apoptosis in the human AML cell line THP-1. Journal of natural medicines. 2023 Jan; 77(1):180-187. doi: 10.1007/s11418-022-01659-6. [PMID: 36266527]
Ning Wen, Ping-Shun Song, Lin Ni, Juan Chen. Tannic acid-aminopropyltriethoxysilane co-deposition modified polymer membrane for α-glucosidase immobilization. Journal of chromatography. A. 2022 Nov; 1683(?):463550. doi: 10.1016/j.chroma.2022.463550. [PMID: 36219969]
Parker Elijah Joshua, Junaidu Yahaya, Daniel Emmanuel Ekpo, Joyce Oloaigbe Ogidigo, Arome Solomon Odiba, Rita Onyekachukwu Asomadu, Samson Ayodeji Oka, Olasupo Stephen Adeniyi. Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats. BMC immunology. 2022 10; 23(1):50. doi: 10.1186/s12865-022-00519-y. [PMID: 36261807]
M G Semedo, A L Pereira, J R Pita. Cinchona bark and quinine in the Portuguese official pharmacopoeias (1794-2001). Die Pharmazie. 2022 09; 77(7):278-285. doi: 10.1691/ph.2022.2034. [PMID: 36199186]
Ryuta Asaumi, Ken-Ichi Nunoya, Yoshiyuki Yamaura, Kunal S Taskar, Yuichi Sugiyama. Robust physiologically based pharmacokinetic model of rifampicin for predicting drug-drug interactions via P-glycoprotein induction and inhibition in the intestine, liver, and kidney. CPT: pharmacometrics & systems pharmacology. 2022 07; 11(7):919-933. doi: 10.1002/psp4.12807. [PMID: 35570332]
Rajinder Bhardwaj, Julie L Collins, Joseph Stringfellow, Jennifer Madonia, Matt S Anderson, Jeri-Anne Finley, David A Stock, Vladimir Coric, Robert Croop, Richard Bertz. P-Glycoprotein and Breast Cancer Resistance Protein Transporter Inhibition by Cyclosporine and Quinidine on the Pharmacokinetics of Oral Rimegepant in Healthy Subjects. Clinical pharmacology in drug development. 2022 07; 11(7):889-897. doi: 10.1002/cpdd.1088. [PMID: 35304977]
Peyman Rezaie, Vida Bitarafan, Braden D Rose, Kylie Lange, Jens F Rehfeld, Michael Horowitz, Christine Feinle-Bisset. Quinine Effects on Gut and Pancreatic Hormones and Antropyloroduodenal Pressures in Humans-Role of Delivery Site and Sex. The Journal of clinical endocrinology and metabolism. 2022 06; 107(7):e2870-e2881. doi: 10.1210/clinem/dgac182. [PMID: 35325161]
Nourhan M Abd El-Aziz, Ibrahim Khalifa, Amira M G Darwish, Ahmed N Badr, Huda Aljumayi, El-Sayed Hafez, Mohamed G Shehata. Docking Analysis of Some Bioactive Compounds from Traditional Plants against SARS-CoV-2 Target Proteins. Molecules (Basel, Switzerland). 2022 Apr; 27(9):. doi: 10.3390/molecules27092662. [PMID: 35566014]
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Anna Svedberg, Svante Vikingsson, Anders Vikström, Niels Hornstra, Magnus Kentson, Eva Branden, Hirsh Koyi, Bengt Bergman, Henrik Gréen. Erlotinib treatment induces cytochrome P450 3A activity in non-small cell lung cancer patients. British journal of clinical pharmacology. 2019 08; 85(8):1704-1709. doi: 10.1111/bcp.13953. [PMID: 30945322]
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Jay W Mason, David G Strauss, Martino Vaglio, Fabio Badilini. Correction of the QRS duration for heart rate. Journal of electrocardiology. 2019 May; 54(?):1-4. doi: 10.1016/j.jelectrocard.2019.02.005. [PMID: 30782546]
Kai Wu, Yi Yao, Fang Chen, Mingxing Xu, Guangquan Lu, Tingting Jiang, Ziyu Liu, Weixing Du, Fang Li, Rugui Li, Huabing Tan, Jian Li. Analysis of Plasmodium falciparum Na+/H+ exchanger (pfnhe1) polymorphisms among imported African malaria parasites isolated in Wuhan, Central China. BMC infectious diseases. 2019 Apr; 19(1):354. doi: 10.1186/s12879-019-3921-7. [PMID: 31035938]
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Shoji Maehara, Andria Agusta, Yoshimi Tokunaga, Hirotaka Shibuya, Toshiyuki Hata. Endophyte composition and Cinchona alkaloid production abilities of Cinchona ledgeriana cultivated in Japan. Journal of natural medicines. 2019 Mar; 73(2):431-438. doi: 10.1007/s11418-018-1273-z. [PMID: 30552602]
Jinrong Li, Christian H Lemon. Mouse Parabrachial Neurons Signal a Relationship between Bitter Taste and Nociceptive Stimuli. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2019 02; 39(9):1631-1648. doi: 10.1523/jneurosci.2000-18.2018. [PMID: 30606758]
Naohiro Imura, Masamichi Ae, Rin Hoshino, Masami Abe, Tatsuya Yamamuro, Keisuke Oyama, Yasuo Oyama. Membrane hyperpolarization and depolarization of rat thymocytes by azoxystrobin, a post harvest fungicide. Chemico-biological interactions. 2019 Feb; 300(?):35-39. doi: 10.1016/j.cbi.2019.01.006. [PMID: 30629953]
Shinsaku Yoshitomi, Yukitoshi Takahashi, Tokito Yamaguchi, Taikan Oboshi, Asako Horino, Hiroko Ikeda, Katsumi Imai, Tohru Okanishi, Mitsuko Nakashima, Hirotomo Saitsu, Naomichi Matsumoto, Jun Yoshimoto, Takako Fujita, Atsushi Ishii, Shinichi Hirose, Yushi Inoue. Quinidine therapy and therapeutic drug monitoring in four patients with KCNT1 mutations. Epileptic disorders : international epilepsy journal with videotape. 2019 Feb; 21(1):48-54. doi: 10.1684/epd.2019.1026. [PMID: 30782581]
Ana Leonor Pardo Campos Godoy, Natália Valadares de Moraes, Jhohann Richard de Lima Benzi, Vera Lucia Lanchote. Changes in tramadol enantioselective pharmacokinetics and metabolism in rats with experimental diabetes treated or not with insulin. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 2019 Feb; 128(?):97-102. doi: 10.1016/j.ejps.2018.11.032. [PMID: 30502451]
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Kenta Watanabe, Tadashi Tsubouchi, Toru Yamada, Eiichi Hinoi, Izuru Miyawaki. Telemetered common marmosets is useful for the assessment of electrocardiogram parameters changes induced by multiple cardiac ion channel inhibitors. The Journal of toxicological sciences. 2019; 44(7):441-457. doi: 10.2131/jts.44.441. [PMID: 31270301]
Ashish Dogra, Shipra Bhatt, Asmita Magotra, Anjna Sharma, Pankul Kotwal, Abhishek Gour, Priya Wazir, Gurdarshan Singh, Utpal Nandi. Intervention of curcumin on oral pharmacokinetics of daclatasvir in rat: A possible risk for long-term use. Phytotherapy research : PTR. 2018 Oct; 32(10):1967-1974. doi: 10.1002/ptr.6123. [PMID: 29806225]
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Hadi Molanaei, Abdul Rashid Qureshi, Olof Heimbürger, Bengt Lindholm, Ulf Diczfalusy, Björn Anderstam, Leif Bertilsson, Peter Stenvinkel. Inflammation down-regulates CYP3A4-catalysed drug metabolism in hemodialysis patients. BMC pharmacology & toxicology. 2018 06; 19(1):33. doi: 10.1186/s40360-018-0221-6. [PMID: 29941014]
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Kazuki Harada, Hidekazu Sakaguchi, Shoko Sada, Rika Ishida, Yuki Hayasaka, Takashi Tsuboi. Bitter tastant quinine modulates glucagon-like peptide-1 exocytosis from clonal GLUTag enteroendocrine L cells via actin reorganization. Biochemical and biophysical research communications. 2018 06; 500(3):723-730. doi: 10.1016/j.bbrc.2018.04.143. [PMID: 29684353]
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Sonia Goineau, Vincent Castagné. Electrophysiological characteristics and pharmacological sensitivity of two lines of human induced pluripotent stem cell derived cardiomyocytes coming from two different suppliers. Journal of pharmacological and toxicological methods. 2018 Mar; 90(?):58-66. doi: 10.1016/j.vascn.2017.12.003. [PMID: 29274391]
Sarah M Tindall, Cindy Vallières, Dev H Lakhani, Farida Islahudin, Kang-Nee Ting, Simon V Avery. Heterologous Expression of a Novel Drug Transporter from the Malaria Parasite Alters Resistance to Quinoline Antimalarials. Scientific reports. 2018 02; 8(1):2464. doi: 10.1038/s41598-018-20816-0. [PMID: 29410428]
David Aguilera-Alonso, Eva María López Medina, Teresa Del Rosal, Julián Villota Arrieta, Luis Escosa-García, Milagros García-Hortelano. Acalculous Cholecystitis in a Pediatric Patient With Plasmodium Falciparum Infection: A Case Report and Literature Review. The Pediatric infectious disease journal. 2018 02; 37(2):e43-e45. doi: 10.1097/inf.0000000000001734. [PMID: 28787387]
Graziela Scheuer Gomes, Tamara Ramos Maciel, Eduarda Martini Piegas, Luana Roberta Michels, Letícia Marques Colomé, Rodrigo José Freddo, Daiana Silva de Ávila, Andre Gundel, Sandra Elisa Haas. Optimization of Curcuma Oil/Quinine-Loaded Nanocapsules for Malaria Treatment. AAPS PharmSciTech. 2018 Feb; 19(2):551-564. doi: 10.1208/s12249-017-0854-6. [PMID: 28875471]
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Javier Franco-Pérez, Joaquín Manjarrez-Marmolejo, Cesar Rodríguez-Balderas, Nelly Castro, Paola Ballesteros-Zebadua. Quinine and carbenoxolone enhance the anticonvulsant activity of some classical antiepileptic drugs. Neurological research. 2018 Jan; 40(1):26-33. doi: 10.1080/01616412.2017.1384092. [PMID: 28988516]
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Caitlin McIntyre, Rory McQuillan, Chaim Bell, Marisa Battistella. Targeted Deprescribing in an Outpatient Hemodialysis Unit: A Quality Improvement Study to Decrease Polypharmacy. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2017 Nov; 70(5):611-618. doi: 10.1053/j.ajkd.2017.02.374. [PMID: 28416321]
Evaren E Page, Dustin J Little, Sara K Vesely, James N George. Quinine-Induced Thrombotic Microangiopathy: A Report of 19 Patients. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2017 Nov; 70(5):686-695. doi: 10.1053/j.ajkd.2017.05.023. [PMID: 28780041]
John I Glendinning, Joyce Tang, Ana Paula Morales Allende, Bruce P Bryant, Lisa Youngentob, Steven L Youngentob. Fetal alcohol exposure reduces responsiveness of taste nerves and trigeminal chemosensory neurons to ethanol and its flavor components. Journal of neurophysiology. 2017 08; 118(2):1198-1209. doi: 10.1152/jn.00108.2017. [PMID: 28490641]
Papa Alioune Ndour, Sébastien Larréché, Oussama Mouri, Nicolas Argy, Frédérick Gay, Camille Roussel, Stéphane Jauréguiberry, Claire Perillaud, Dominique Langui, Sylvestre Biligui, Nathalie Chartrel, Audrey Mérens, Eric Kendjo, Aniruddha Ghose, Md Mahtab Uddin Hassan, Md Amir Hossain, Hugh W F Kingston, Katherine Plewes, Arjen M Dondorp, Martin Danis, Sandrine Houzé, Serge Bonnefoy, Marc Thellier, Charles J Woodrow, Pierre A Buffet. Measuring the Plasmodium falciparum HRP2 protein in blood from artesunate-treated malaria patients predicts post-artesunate delayed hemolysis. Science translational medicine. 2017 07; 9(397):. doi: 10.1126/scitranslmed.aaf9377. [PMID: 28679662]
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Subramanyam J Tantry, Shankar D Markad, Vikas Shinde, Jyothi Bhat, Gayathri Balakrishnan, Amit K Gupta, Anisha Ambady, Anandkumar Raichurkar, Chaitanyakumar Kedari, Sreevalli Sharma, Naina V Mudugal, Ashwini Narayan, C N Naveen Kumar, Robert Nanduri, Sowmya Bharath, Jitendar Reddy, Vijender Panduga, K R Prabhakar, Karthikeyan Kandaswamy, Ramanatha Saralaya, Parvinder Kaur, Neela Dinesh, Supreeth Guptha, Kirsty Rich, David Murray, Helen Plant, Marian Preston, Helen Ashton, Darren Plant, Jarrod Walsh, Peter Alcock, Kathryn Naylor, Matthew Collier, James Whiteaker, Robert E McLaughlin, Meenakshi Mallya, Manoranjan Panda, Suresh Rudrapatna, Vasanthi Ramachandran, Radha Shandil, Vasan K Sambandamurthy, Khisi Mdluli, Christopher B Cooper, Harvey Rubin, Takahiro Yano, Pravin Iyer, Shridhar Narayanan, Stefan Kavanagh, Kakoli Mukherjee, V Balasubramanian, Vinayak P Hosagrahara, Suresh Solapure, Sudha Ravishankar, Shahul Hameed P. Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis. Journal of medicinal chemistry. 2017 02; 60(4):1379-1399. doi: 10.1021/acs.jmedchem.6b01358. [PMID: 28075132]
Margarete do Socorro Mendonça Gomes, José Luiz Fernandes Vieira, Álvaro Augusto Ribeiro D'Almeida Couto, Vanja Suely Calvosa D'Almeida Couto, Michelle Valéria Dias Ferreira Vieira, Francis Christian da Silva Pereira, Ricado Luiz Dantas Machado. Recurrence of Plasmodium falciparum after treatment with quinine and doxycycline in the Amazon basin. Tropical medicine & international health : TM & IH. 2017 02; 22(2):133-138. doi: 10.1111/tmi.12813. [PMID: 27862676]
G Gachelin, P Garner, E Ferroni, U Tröhler, I Chalmers. Evaluating Cinchona bark and quinine for treating and preventing malaria. Journal of the Royal Society of Medicine. 2017 Feb; 110(2):73-82. doi: 10.1177/0141076816688411. [PMID: 28169590]
Zhou Meng, Harma Ellens, Joe Bentz. Extrapolation of Elementary Rate Constants of P-glycoprotein-Mediated Transport from MDCKII-hMDR1-NKI to Caco-2 Cells. Drug metabolism and disposition: the biological fate of chemicals. 2017 02; 45(2):190-197. doi: 10.1124/dmd.116.072140. [PMID: 27856526]
Rao Mukkavilli, Gajanan Jadhav, Subrahmanyam Vangala. Evaluation of Drug Transport in MDCKII-Wild Type, MDCKII-MDR1, MDCKII-BCRP and Caco-2 Cell Lines. Current pharmaceutical biotechnology. 2017; 18(14):1151-1158. doi: 10.2174/1389201019666180308091855. [PMID: 29521222]
Atthanee Jeeyapant, Hugh W Kingston, Katherine Plewes, Richard J Maude, Josh Hanson, M Trent Herdman, Stije J Leopold, Thatsanun Ngernseng, Prakaykaew Charunwatthana, Nguyen Hoan Phu, Aniruddha Ghose, M Mahtab Uddin Hasan, Caterina I Fanello, Md Abul Faiz, Tran Tinh Hien, Nicholas P J Day, Nicholas J White, Arjen M Dondorp. Defining Surrogate Endpoints for Clinical Trials in Severe Falciparum Malaria. PloS one. 2017; 12(1):e0169307. doi: 10.1371/journal.pone.0169307. [PMID: 28052109]
G Gachelin, P Garner, E Ferroni, U Tröhler, I Chalmers. Evaluating Cinchona bark and quinine for treating and preventing malaria. Journal of the Royal Society of Medicine. 2017 Jan; 110(1):31-40. doi: 10.1177/0141076816681421. [PMID: 28106483]
Ricardo P Garay, George T Grossberg. AVP-786 for the treatment of agitation in dementia of the Alzheimer's type. Expert opinion on investigational drugs. 2017 Jan; 26(1):121-132. doi: 10.1080/13543784.2017.1267726. [PMID: 27936965]
Valerie B Duffy, Shristi Rawal, Jeeha Park, Mark H Brand, Mastaneh Sharafi, Bradley W Bolling. Characterizing and improving the sensory and hedonic responses to polyphenol-rich aronia berry juice. Appetite. 2016 12; 107(?):116-125. doi: 10.1016/j.appet.2016.07.026. [PMID: 27457970]
Miki Fukao, Eri Kondo, Hiroki Nishino, Ryutaro Hattori, Asuka Horie, Yukiya Hashimoto. Presence of an H+/Quinidine Antiport System in Madin-Darby Canine Kidney Cells. European journal of drug metabolism and pharmacokinetics. 2016 Dec; 41(6):819-824. doi: 10.1007/s13318-015-0314-1. [PMID: 26628429]
Fabrice Bruneel, Florence Tubach, Jean-Paul Mira, Sandrine Houze, Sebastien Gibot, Marie-Genevieve Huisse, Bruno Megarbane, Christophe Choquet, Philippe Corne, Eric Peytel, Daniel Villers, Christophe Camus, Olivier Bouchaud, Eric Caumes, Pierre-Marie Girard, Fabrice Simon, Antoine Kalloumeh, Carine Roy, Remy Durand, Jacques Le Bras, Sophie Matheron, Michel Wolff. Imported falciparum malaria in adults: host- and parasite-related factors associated with severity. The French prospective multicenter PALUREA cohort study. Intensive care medicine. 2016 Oct; 42(10):1588-1596. doi: 10.1007/s00134-016-4356-x. [PMID: 27169586]
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Charles P Taylor, Stephen F Traynelis, Joao Siffert, Laura E Pope, Rae R Matsumoto. Pharmacology of dextromethorphan: Relevance to dextromethorphan/quinidine (Nuedexta®) clinical use. Pharmacology & therapeutics. 2016 08; 164(?):170-82. doi: 10.1016/j.pharmthera.2016.04.010. [PMID: 27139517]