Chemical Formula: C10H11NO4
Chemical Formula C10H11NO4
Found 126 metabolite its formula value is C10H11NO4
Hydroxyphenylacetylglycine
Hydroxyphenylacetylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction:. acyl-CoA + glycine < -- > CoA + N-acylglycine. Hydroxyphenylacetylglycine is an endogenous human metabolite. It can be originated from the metabolism of tyramine, itself is a monoamine compound derived from the amino acid tyrosine. Hydroxyphenylacetylglycine can also be derived from the metabolism of 3,4-dihydroxyphenylalanine (L-DOPA). In the metabolism of tyrosine, this compound is involved in the reaction Hydroxyphenylacetyl-CoA + Glycine <=> Hydroxyphenylacetylglycine + CoA, catalyzed by acyltransferase enzymes (EC 2.3.1.-). Hydroxyphenylacetylglycine has been identified in human biofluids. (PMID: 14201174, 912020, 716472, 7096501, 7438429, 7438430). Hydroxyphenylacetylglycine is an acyl glycine. Acyl glycines are normally minor metabolites of fatty acids. However, the excretion of certain acyl glycines is increased in several inborn errors of metabolism. In certain cases the measurement of these metabolites in body fluids can be used to diagnose disorders associated with mitochondrial fatty acid beta-oxidation. Acyl glycines are produced through the action of glycine N-acyltransferase (EC 2.3.1.13) which is an enzyme that catalyzes the chemical reaction: Hydroxyphenylacetylglycine is an acyl glycine, and an endogenous human metabolite.
3-Carbamoyl-2-phenylpropionic acid
3-Carbamoyl-2-phenylpropionic acid is a metabolite of felbamate. Felbamate (marketed under the brand name Felbatol by MedPointe) is an anti-epileptic drug used in the treatment of epilepsy. It is used to treat partial seizures (with and without generalization) in adults and partial and generalized seizures associated with Lennox-Gastaut syndrome in children. However, an increased risk of potentially fatal aplastic anemia and/or liver failure limit the drugs usage to severe refractory epilepsy. (Wikipedia)
alpha-Methyl-4-carboxyphenylglycine
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists (RS)-MCPG (alpha-MCPG) is a competitive and selective group I/group II metabotropic glutamate receptor (mGluR) antagonist. (RS)-MCPG blocks theta-burst stimulation (TBS)-induced shifts in both juvenile and neonatal rat hippocampal neurons[1][2].
4-[(S)-Amino(carboxy)methyl]-3-methylbenzoic acid
(±)-LY367385 is the racemate of LY367385. LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a[1][2].
1-(2-furylmethyl)-5-oxopyrrolidine-3-carboxylic acid
1,2,3,4-TETRAHYDRO-6,7-DIHYDROXY-3-ISOQUINOLINECARBOXYLIC ACID
2-amino-3-(3-formyl-4-hydroxyphenyl)propanoic acid
Hydroxyphenylacetylglycine
Hydroxyphenylacetylglycine is an acyl glycine, and an endogenous human metabolite.
7-Amino-2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester
methyl 7-hydroxy-5-oxo-2,3-dihydro-1H-indolizine-8-carboxylate
7-methoxycarbonyl-6,7-dihydro-5H-pyrrolizine-1-carboxylic acid
N-Formyl-L-tyrosine
An N-formyl amino acid that is L-tyrosine in which one of the hydrogens of the amino group has been replaced by a formyl group.
(R)-3-AMINO-3-(BENZO[D][1,3]DIOXOL-5-YL)PROPANOIC ACID
(S)-4-Ethyl-4-hydroxy-1H-pyrano[3,4-c]pyridine-3,8(4H,7H)-dione
(S)-MCPG
D018377 - Neurotransmitter Agents > D018683 - Excitatory Amino Acid Agents > D018691 - Excitatory Amino Acid Antagonists
1,2-Benzenedicarboxylicacid, 4-amino-, 1,2-dimethyl ester
1H-Indene-2-carboxylic acid, 2-amino-2,3-dihydro-4,5-dihydroxy- (9CI)
methyl 7-amino-2,3-dihydro-1,4-benzodioxine-5-carboxylate
2,3-Pyridinedicarboxylic acid, 2-(1-Methylethyl) ester
METHYL 6-HYDROXY-5-OXO-1,2,3,5-TETRAHYDROINDOLIZINE-8-CARBOXYLATE
2-Amino-2-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acetic acid
2-Methylidene-3-oxo-4A,7,8,8A-tetrahydro-4H-1,4-benzoxazine-7-carboxylic acid
(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
(3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate
(3S)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
(3R)-7,8-dihydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
4-Hydroxyphenylacetylglycine
Phenylacetylglycine hydroxylated at the phenyl C-4 position. Hydroxyphenylacetylglycine is an acyl glycine, and an endogenous human metabolite.
(S)-alpha-methyl-4-carboxyphenylglycine
A non-proteinogenic alpha-amino acid that is alanine in which the alpha-hydrogen is replaced by a 4-carboxyphenyl group (the S-enantiomer). It is a non-selective group I/group II metabotropic glutamate receptor (mGluR) antagonist.