Muscimol (BioDeep_00000003468)

 

Secondary id: BioDeep_00001867707

human metabolite blood metabolite Volatile Flavor Compounds natural product


代谢物信息卡片


5-(Aminomethyl)-3(2H)-isoxazolone

化学式: C4H6N2O2 (114.04292559999999)
中文名称: 蝇蕈醇
谱图信息: 最多检出来源 Homo sapiens(blood) 66.67%

分子结构信息

SMILES: C1=C(ONC1=O)CN
InChI: InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)

描述信息

D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018755 - GABA Agonists
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins
KEIO_ID M115

同义名列表

7 个代谢物同义名

5-(Aminomethyl)-3(2H)-isoxazolone; 5-(aminomethyl)-1,2-oxazol-3-ol; Pantherine; muscimol; Agarin; Muscimol; Muscimol



数据库引用编号

23 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Alexander Dushkov, Zuzana Vosáhlová, Alexander Tzintzarov, Květa Kalíková, Tomáš Křížek, Iva Ugrinova. Analysis of the Ibotenic Acid, Muscimol, and Ergosterol Content of an Amanita Muscaria Hydroalcoholic Extract with an Evaluation of Its Cytotoxic Effect against a Panel of Lung Cell Lines In Vitro. Molecules (Basel, Switzerland). 2023 Sep; 28(19):. doi: 10.3390/molecules28196824. [PMID: 37836667]
  • Yu-Ting Su, Jie Liu, Dan-Ni Yang, Qing Cai, Zhu L Yang, Zuo-Hong Chen. Determination of ibotenic acid and muscimol in species of the genus Amanita section Amanita from China. Toxicon : official journal of the International Society on Toxinology. 2023 Aug; ?(?):107257. doi: 10.1016/j.toxicon.2023.107257. [PMID: 37611670]
  • Ya-Hui Li, Dur-Zong Hsu, Chuan-Teng Liu, Victor Raj Mohan Chandrasekaran, Ming-Yie Liu. The protective effect of muscimol against systemic inflammatory response in endotoxemic mice is independent of GABAergic and cholinergic receptors. Canadian journal of physiology and pharmacology. 2022 Jul; 100(7):665-678. doi: 10.1139/cjpp-2021-0682. [PMID: 35856422]
  • Laura C Ornelas, Kalynn Van Voorhies, Joyce Besheer. The role of the nucleus reuniens in regulating contextual conditioning with the predator odor TMT in female rats. Psychopharmacology. 2021 Dec; 238(12):3411-3421. doi: 10.1007/s00213-021-05957-x. [PMID: 34390359]
  • Zhimin Song, Sujith Swarna, Joseph R Manns. Prioritization of social information by the basolateral amygdala in rats. Neurobiology of learning and memory. 2021 10; 184(?):107489. doi: 10.1016/j.nlm.2021.107489. [PMID: 34271138]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Xiao-Min Xu, Jing-Shun Zhang, Bai-Fen Huang, Jian-Long Han, Qing Chen. Determination of ibotenic acid and muscimol in plasma by liquid chromatography-triple quadrupole mass spectrometry with bimolecular dansylation. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Jun; 1146(?):122128. doi: 10.1016/j.jchromb.2020.122128. [PMID: 32361630]
  • Anna Poliwoda, Katarzyna Zielińska, Piotr P Wieczorek. Direct Analysis of Psilocin and Muscimol in Urine Samples Using Single Drop Microextraction Technique In-Line with Capillary Electrophoresis. Molecules (Basel, Switzerland). 2020 Mar; 25(7):. doi: 10.3390/molecules25071566. [PMID: 32235328]
  • Cheryl A Frye, Vincent F Lembo, Alicia A Walf. Progesterone's Effects on Cognitive Performance of Male Mice Are Independent of Progestin Receptors but Relate to Increases in GABAA Activity in the Hippocampus and Cortex. Frontiers in endocrinology. 2020; 11(?):552805. doi: 10.3389/fendo.2020.552805. [PMID: 33505354]
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  • Somandla Ncube, Anna Poliwoda, Hlanganani Tutu, Piotr Wieczorek, Luke Chimuka. Multivariate optimization of the hollow fibre liquid phase microextraction of muscimol in human urine samples. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2016 Oct; 1033-1034(?):372-381. doi: 10.1016/j.jchromb.2016.09.008. [PMID: 27631575]
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  • Pavlína Ginterová, Barbora Sokolová, Peter Ondra, Joanna Znaleziona, Jan Petr, Juraj Ševčík, Vítězslav Maier. Determination of mushroom toxins ibotenic acid, muscimol and muscarine by capillary electrophoresis coupled with electrospray tandem mass spectrometry. Talanta. 2014 Jul; 125(?):242-7. doi: 10.1016/j.talanta.2014.03.019. [PMID: 24840440]
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