muscimol (BioDeep_00001867707)

Main id: BioDeep_00000003468

 

natural product


代谢物信息卡片


muscimol

化学式: C4H6N2O2 (114.0429)
中文名称: 蝇蕈醇
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C(ONC1=O)CN
InChI: InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)

描述信息

A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018755 - GABA Agonists
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins

同义名列表

3 个代谢物同义名

muscimol; Muscimol; Muscimol



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

19 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 BDNF, CA1, CA3, POMC, TH
Peripheral membrane protein 1 ACHE
Endosome membrane 1 CLCN5
Endoplasmic reticulum membrane 1 GABBR1
Nucleus 3 ACHE, FOS, TH
cytosol 7 AVP, CA1, CA3, CLCN5, FOS, PRKCQ, TH
dendrite 4 AVP, BDNF, HTR1A, TH
mitochondrial membrane 1 GABBR1
nucleoplasm 1 FOS
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 6 ACHE, AGTR1, CLCN5, GABBR1, GRID1, HTR1A
Cell projection, axon 1 TH
Multi-pass membrane protein 6 AGTR1, CLCN5, GABBR1, GRID1, HTR1A, UCP1
Golgi apparatus membrane 1 CLCN5
Synapse 4 ACHE, HCRT, HTR1A, TAC1
cell surface 1 ACHE
dendritic shaft 1 GABBR1
glutamatergic synapse 2 GABBR1, GRID1
Golgi apparatus 3 ACHE, CLCN5, NPY
Golgi membrane 2 CLCN5, INS
lysosomal membrane 1 CLCN5
mitochondrial inner membrane 1 UCP1
neuromuscular junction 1 ACHE
neuronal cell body 2 GABBR1, TAC1
postsynapse 1 HCRT
presynaptic membrane 1 GABBR1
smooth endoplasmic reticulum 1 TH
synaptic vesicle 5 BDNF, CLCN5, GABBR1, HCRT, TH
plasma membrane 7 ACHE, AGTR1, CLCN5, GABBR1, GRID1, HTR1A, PRKCQ
terminal bouton 1 TH
Membrane 5 ACHE, AGTR1, BDNF, CLCN5, GABBR1
axon 3 BDNF, TAC1, TH
extracellular exosome 2 CA1, GRID1
endoplasmic reticulum 1 FOS
extracellular space 8 ACHE, AVP, BDNF, GABBR1, INS, NPY, POMC, TAC1
perinuclear region of cytoplasm 4 ACHE, BDNF, HCRT, TH
Schaffer collateral - CA1 synapse 1 GABBR1
mitochondrion 3 ABAT, TH, UCP1
Secreted 6 ACHE, AVP, BDNF, INS, NPY, POMC
extracellular region 8 ACHE, AVP, BDNF, HCRT, INS, NPY, POMC, TAC1
cytoplasmic side of plasma membrane 1 TH
mitochondrial matrix 1 ABAT
Extracellular side 1 ACHE
centriolar satellite 1 PRKCQ
dendritic spine 1 GABBR1
neuronal dense core vesicle lumen 1 HCRT
perikaryon 1 TH
cytoplasmic vesicle 2 HCRT, TH
Melanosome membrane 1 TH
Early endosome 1 CLCN5
apical part of cell 1 CLCN5
postsynaptic membrane 2 GABBR1, GRID1
Cytoplasm, perinuclear region 1 TH
Mitochondrion inner membrane 1 UCP1
axolemma 1 GABBR1
G protein-coupled GABA receptor complex 1 GABBR1
GABA-ergic synapse 3 GABBR1, GRID1, NPY
basement membrane 1 ACHE
secretory granule 2 AVP, POMC
Postsynaptic cell membrane 2 GABBR1, GRID1
neuron projection 1 TH
chromatin 1 FOS
Lipid-anchor, GPI-anchor 1 ACHE
endosome lumen 1 INS
Cell projection, dendrite 2 GABBR1, HTR1A
side of membrane 1 ACHE
secretory granule lumen 2 INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 BDNF, INS
nuclear matrix 1 FOS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
postsynaptic density membrane 1 GRID1
immunological synapse 1 PRKCQ
neuronal dense core vesicle 2 AVP, NPY
aggresome 1 PRKCQ
clathrin-coated endocytic vesicle membrane 1 AVP
synaptic cleft 1 ACHE
protein-DNA complex 1 FOS
Rough endoplasmic reticulum 1 HCRT
G protein-coupled receptor heterodimeric complex 1 GABBR1
transcription factor AP-1 complex 1 FOS
Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle 1 NPY
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle 1 TH
[Isoform H]: Cell membrane 1 ACHE
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
4-aminobutyrate transaminase complex 1 ABAT
[Isoform 1E]: Secreted 1 GABBR1


文献列表

  • Alexander Dushkov, Zuzana Vosáhlová, Alexander Tzintzarov, Květa Kalíková, Tomáš Křížek, Iva Ugrinova. Analysis of the Ibotenic Acid, Muscimol, and Ergosterol Content of an Amanita Muscaria Hydroalcoholic Extract with an Evaluation of Its Cytotoxic Effect against a Panel of Lung Cell Lines In Vitro. Molecules (Basel, Switzerland). 2023 Sep; 28(19):. doi: 10.3390/molecules28196824. [PMID: 37836667]
  • Yu-Ting Su, Jie Liu, Dan-Ni Yang, Qing Cai, Zhu L Yang, Zuo-Hong Chen. Determination of ibotenic acid and muscimol in species of the genus Amanita section Amanita from China. Toxicon : official journal of the International Society on Toxinology. 2023 Aug; ?(?):107257. doi: 10.1016/j.toxicon.2023.107257. [PMID: 37611670]
  • Ya-Hui Li, Dur-Zong Hsu, Chuan-Teng Liu, Victor Raj Mohan Chandrasekaran, Ming-Yie Liu. The protective effect of muscimol against systemic inflammatory response in endotoxemic mice is independent of GABAergic and cholinergic receptors. Canadian journal of physiology and pharmacology. 2022 Jul; 100(7):665-678. doi: 10.1139/cjpp-2021-0682. [PMID: 35856422]
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  • Anna Poliwoda, Katarzyna Zielińska, Piotr P Wieczorek. Direct Analysis of Psilocin and Muscimol in Urine Samples Using Single Drop Microextraction Technique In-Line with Capillary Electrophoresis. Molecules (Basel, Switzerland). 2020 Mar; 25(7):. doi: 10.3390/molecules25071566. [PMID: 32235328]
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