muscimol (BioDeep_00001867707)
Main id: BioDeep_00000003468
代谢物信息卡片
muscimol
化学式: C4H6N2O2 (114.04292559999999)
中文名称: 蝇蕈醇
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=C(ONC1=O)CN
InChI: InChI=1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
描述信息
A member of the class of isoxazoles that is 1,2-oxazol-3(2H)-one substituted by an aminomethyl group at position 5. It has been isolated from mushrooms of the genus Amanita.
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018755 - GABA Agonists
D009676 - Noxae > D011042 - Poisons > D009183 - Mycotoxins
同义名列表
1 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:7035
- KEGG: C08311
- PubChem: 4266
- DrugBank: DB12458
- ChEMBL: CHEMBL273481
- MeSH: Muscimol
- CAS: 2763-96-4
- MetaboLights: MTBLC7035
- PubChem: 10509
- KNApSAcK: C00001423
- NIKKAJI: J7.909J
- RefMet: Muscimol
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Alexander Dushkov, Zuzana Vosáhlová, Alexander Tzintzarov, Květa Kalíková, Tomáš Křížek, Iva Ugrinova. Analysis of the Ibotenic Acid, Muscimol, and Ergosterol Content of an Amanita Muscaria Hydroalcoholic Extract with an Evaluation of Its Cytotoxic Effect against a Panel of Lung Cell Lines In Vitro.
Molecules (Basel, Switzerland).
2023 Sep; 28(19):. doi:
10.3390/molecules28196824. [PMID: 37836667] - Yu-Ting Su, Jie Liu, Dan-Ni Yang, Qing Cai, Zhu L Yang, Zuo-Hong Chen. Determination of ibotenic acid and muscimol in species of the genus Amanita section Amanita from China.
Toxicon : official journal of the International Society on Toxinology.
2023 Aug; ?(?):107257. doi:
10.1016/j.toxicon.2023.107257. [PMID: 37611670] - Ya-Hui Li, Dur-Zong Hsu, Chuan-Teng Liu, Victor Raj Mohan Chandrasekaran, Ming-Yie Liu. The protective effect of muscimol against systemic inflammatory response in endotoxemic mice is independent of GABAergic and cholinergic receptors.
Canadian journal of physiology and pharmacology.
2022 Jul; 100(7):665-678. doi:
10.1139/cjpp-2021-0682. [PMID: 35856422] - Laura C Ornelas, Kalynn Van Voorhies, Joyce Besheer. The role of the nucleus reuniens in regulating contextual conditioning with the predator odor TMT in female rats.
Psychopharmacology.
2021 Dec; 238(12):3411-3421. doi:
10.1007/s00213-021-05957-x. [PMID: 34390359] - Zhimin Song, Sujith Swarna, Joseph R Manns. Prioritization of social information by the basolateral amygdala in rats.
Neurobiology of learning and memory.
2021 10; 184(?):107489. doi:
10.1016/j.nlm.2021.107489. [PMID: 34271138] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Xiao-Min Xu, Jing-Shun Zhang, Bai-Fen Huang, Jian-Long Han, Qing Chen. Determination of ibotenic acid and muscimol in plasma by liquid chromatography-triple quadrupole mass spectrometry with bimolecular dansylation.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2020 Jun; 1146(?):122128. doi:
10.1016/j.jchromb.2020.122128. [PMID: 32361630] - Anna Poliwoda, Katarzyna Zielińska, Piotr P Wieczorek. Direct Analysis of Psilocin and Muscimol in Urine Samples Using Single Drop Microextraction Technique In-Line with Capillary Electrophoresis.
Molecules (Basel, Switzerland).
2020 Mar; 25(7):. doi:
10.3390/molecules25071566. [PMID: 32235328] - Cheryl A Frye, Vincent F Lembo, Alicia A Walf. Progesterone's Effects on Cognitive Performance of Male Mice Are Independent of Progestin Receptors but Relate to Increases in GABAA Activity in the Hippocampus and Cortex.
Frontiers in endocrinology.
2020; 11(?):552805. doi:
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The New phytologist.
2020 01; 225(2):671-678. doi:
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Pharmacological reports : PR.
2019 Aug; 71(4):636-643. doi:
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Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.
2019 May; 31(3):485-487. doi:
10.1177/1040638719842897. [PMID: 30957709] - Michael J Moss, Robert G Hendrickson. Toxicity of muscimol and ibotenic acid containing mushrooms reported to a regional poison control center from 2002-2016.
Clinical toxicology (Philadelphia, Pa.).
2019 02; 57(2):99-103. doi:
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Scientific reports.
2018 09; 8(1):13608. doi:
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Psychopharmacology.
2017 Aug; 234(16):2431-2441. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Oct; 1033-1034(?):372-381. doi:
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Behavioural brain research.
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Canadian journal of physiology and pharmacology.
2016 Jan; 94(1):18-27. doi:
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Scientific reports.
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Nature communications.
2015 Jul; 6(?):7879. doi:
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Neuron.
2015 May; 86(3):755-67. doi:
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Journal of ethnopharmacology.
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Behavioural brain research.
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10.1016/j.bbr.2014.11.020. [PMID: 25449843] - Megan E Bardgett, Amanda L Sharpe, Glenn M Toney. Activation of corticotropin-releasing factor receptors in the rostral ventrolateral medulla is required for glucose-induced sympathoexcitation.
American journal of physiology. Endocrinology and metabolism.
2014 Nov; 307(10):E944-53. doi:
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Magnetic resonance in chemistry : MRC.
2014 Nov; 52(11):711-4. doi:
10.1002/mrc.4104. [PMID: 25042675] - Pavlína Ginterová, Barbora Sokolová, Peter Ondra, Joanna Znaleziona, Jan Petr, Juraj Ševčík, Vítězslav Maier. Determination of mushroom toxins ibotenic acid, muscimol and muscarine by capillary electrophoresis coupled with electrospray tandem mass spectrometry.
Talanta.
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Physiology & behavior.
2014 Jun; 133(?):272-81. doi:
10.1016/j.physbeh.2014.04.040. [PMID: 24805978] - Robert Frithiof, Tao Xing, Michael J McKinley, Clive N May, Rohit Ramchandra. Intracarotid hypertonic sodium chloride differentially modulates sympathetic nerve activity to the heart and kidney.
American journal of physiology. Regulatory, integrative and comparative physiology.
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Neuroscience letters.
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Neuroscience letters.
2013 Oct; 555(?):42-6. doi:
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Bioorganic & medicinal chemistry.
2013 Sep; 21(17):4938-50. doi:
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Progress in neuro-psychopharmacology & biological psychiatry.
2013 Jul; 44(?):184-92. doi:
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Molecules (Basel, Switzerland).
2013 Jun; 18(7):7584-99. doi:
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Annals of transplantation.
2013 Jun; 18(?):299-313. doi:
10.12659/aot.883955. [PMID: 23792534] - Audrey Dagorn, Annelise Chapalain, Lily Mijouin, Mélanie Hillion, Cécile Duclairoir-Poc, Sylvie Chevalier, Laure Taupin, Nicole Orange, Marc G J Feuilloley. Effect of GABA, a bacterial metabolite, on Pseudomonas fluorescens surface properties and cytotoxicity.
International journal of molecular sciences.
2013 Jun; 14(6):12186-204. doi:
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The Journal of surgical research.
2013 Jun; 182(1):166-75. doi:
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Pharmaceutical biology.
2013 May; 51(5):581-8. doi:
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European journal of pharmacology.
2013 Apr; 706(1-3):17-24. doi:
10.1016/j.ejphar.2013.02.037. [PMID: 23499700] - Mohammad Hadi Gharedaghi, Mehrak Javadi-Paydar, Yashar Yousefzadeh-Fard, Mohammad Salehi-Sadaghiani, Pouya Javadian, Nahid Fakhraei, Seyed Mohammad Tavangar, Ahmad Reza Dehpour. Muscimol delays lipopolysaccharide-induced preterm delivery in mice: role of GABA(A) receptors and nitric oxide.
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians.
2013 Jan; 26(1):36-43. doi:
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The Journal of physiology.
2013 Jan; 591(1):93-107. doi:
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CNS neuroscience & therapeutics.
2012 Dec; 18(12):1030-2. doi:
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Autonomic neuroscience : basic & clinical.
2012 Nov; 171(1-2):41-8. doi:
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Neuroscience.
2012 Sep; 221(?):21-7. doi:
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Assay and drug development technologies.
2012 Aug; 10(4):325-35. doi:
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International journal of legal medicine.
2012 Jul; 126(4):519-24. doi:
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Biological psychiatry.
2012 Apr; 71(7):574-82. doi:
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Pharmacology, biochemistry, and behavior.
2012 Apr; 101(2):231-8. doi:
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Neurobiology of aging.
2012 Apr; 33(4):827.e1-9. doi:
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2012 Feb; 19(?):25. doi:
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2012 Feb; 37(2):221-9. doi:
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European journal of pharmacology.
2012 Jan; 674(2-3):265-74. doi:
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PloS one.
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Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):583479. doi:
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British journal of pharmacology.
2011 Dec; 164(7):1802-16. doi:
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Brain research.
2011 Sep; 1414(?):1-9. doi:
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The Journal of physiology.
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Toxins.
2011 03; 3(3):260-93. doi:
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Indian journal of experimental biology.
2011 Mar; 49(3):211-8. doi:
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Neuropharmacology.
2011 Feb; 60(2-3):513-9. doi:
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