Chemical Formula: C8H12N2O2
Chemical Formula C8H12N2O2
Found 123 metabolite its formula value is C8H12N2O2
Pyridoxamine
Pyridoxamine is one form of vitamin B6. Chemically it is based on a pyridine ring structure, with hydroxyl, methyl, aminomethyl, and hydroxymethyl substituents. It differs from pyridoxine by the substituent at the 4-position. The hydroxyl at position 3 and aminomethyl group at position 4 of its ring endow pyridoxamine with a variety of chemical properties, including the scavenging of free radical species and carbonyl species formed in sugar and lipid degradation and chelation of metal ions that catalyze Amadori reactions. Pyridoxamine, also known as PM, belongs to the class of organic compounds known as pyridoxamine 5-phosphates. These are heterocyclic aromatic compounds containing a pyridoxamine that carries a phosphate group at the 5-position. Within humans, pyridoxamine participates in a number of enzymatic reactions. In particular, pyridoxamine can be converted into pyridoxal; which is mediated by the enzyme pyridoxine-5-phosphate oxidase. In addition, pyridoxamine can be converted into pyridoxamine 5-phosphate; which is catalyzed by the enzyme pyridoxal kinase. Pyridoxamine also inhibits the formation of advanced lipoxidation endproducts during lipid peroxidation reactions by reaction with dicarbonyl intermediates. In humans, pyridoxamine is involved in vitamin B6 metabolism. Outside of the human body, pyridoxamine has been detected, but not quantified in several different foods, such as nutmegs, sparkleberries, fennels, turmerics, and swiss chards. Pyridoxamine inhibits the Maillard reaction and can block the formation of advanced glycation endproducts, which are associated with medical complications of diabetes. Pyridoxamine is hypothesized to trap intermediates in the formation of Amadori products released from glycated proteins, possibly preventing the breakdown of glycated proteins by disrupting the catalysis of this process through disruptive interactions with the metal ions crucial to the redox reaction. One research study found that pyridoxamine specifically reacts with the carbonyl group in Amadori products, but inhibition of post-Amadori reactions (that can lead to advanced glycation endproducts) is due in much greater part to the metal chelation effects of pyridoxamine. The 4-aminomethyl form of vitamin B6. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate. -- Pubchem; Pyridoxamine is one of the compounds that can be called vitamin B6, along with Pyridoxal and Pyridoxine. -- Wikipedia [HMDB]. Pyridoxamine is found in many foods, some of which are cucumber, fox grape, millet, and teff. Acquisition and generation of the data is financially supported in part by CREST/JST. D018977 - Micronutrients > D014815 - Vitamins KEIO_ID P116 Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions.
Cyclo(deltaAla-L-Val)
A 2,5-diketopiperazine where the substituents are methylidene and (S)-isopropyl at positions 3 and 6 respectively.
Hexamethylene diisocyanate
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D003432 - Cross-Linking Reagents D004785 - Environmental Pollutants > D000393 - Air Pollutants
L,L-Cyclo(prolylalanyl)
Isolated from cocoa. L,L-Cyclo(prolylalanyl) is found in cocoa and cocoa products.
1,2,3,4-Tetrahydropyrrolo<2,3-c>-5H-azepine-1,5-diol|1,2,3,4-Tetrahydropyrrolo[2,3-c]-5H-azepine-1,5-diol
(E)-N-[(E)-2-butenoyl]-2-butenoylhydrazide|N,N-Dicrotonoyl-hydrazin|N,N-dicrotonoyl-hydrazine
pyridoxamine
A monohydroxypyridine that is pyridine substituted by a hydroxy group at position 3, an aminomethyl group at position 4, a hydroxymethyl group at position 5 and a methyl group at position 2. The 4-aminomethyl form of vitamin B6, it is used (in the form of the hydrochloride salt) for treatment of diabetic nephropathy. D018977 - Micronutrients > D014815 - Vitamins Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions.
Pyridoxylamine
Pyridoxylamine is an advanced glycation end production (AGEs) and lipoxidation end products (ALEs) inhibitor, to protect against diabetes-induced retinal vascular lesions.
1H-Imidazole-4-carboxylicacid,2-ethyl-5-methyl-,methylester(9CI)
1H-Imidazole-4-carboxylicacid,2,5-dimethyl-,ethylester(9CI)
1H-Imidazole-2-carboxylicacid,1-methyl-,1-methylethylester(9CI)
1H-Imidazole-4-carboxylicacid,5-(1,1-dimethylethyl)-(9CI)
Pyrrolo[1,2-c]pyrimidine-1,4-dione, hexahydro-2-methyl- (9CI)
1H-Imidazole-4-carboxylicacid,1-propyl-,methylester(9CI)
1H-Imidazole-1-aceticacid,α-methyl-,ethylester,(alphaS)-(9CI)
3-Isopropyl-1-methyl-1H-pyrazole-5-carboxylic acid
Spiro[1-azabicyclo[2.2.1]heptane-3,5-oxazolidin]-2-one (9CI)
1H-Imidazole-4-carboxylicacid,1-(1,1-dimethylethyl)-(9CI)
1H-Imidazole-4-carboxylicacid,2-ethyl-,ethylester(9CI)
1H-Imidazole-4-carboxylicacid,1,1-dimethylethylester(9CI)
1H-Imidazole-2-methanol,1-ethenyl-alpha-ethoxy-(9CI)
Propanamide, N-methyl-N-(5-methyl-4-isoxazolyl)- (9CI)
Pyrrolo[1,2-a]pyrazine-1,4-dione, hexahydro-2-methyl-, (S)- (9CI)
1H-Pyrrole-2-carboxylicacid,3-amino-4-methyl-,ethylester(9CI)
1H-Imidazole-4-carboxylic acid,2-(1,1-dimethylethyl)- (9CI)
1-ETHYL-3,5-DIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
1H-1,4-Diazepine-2-carboxylicacid,2,3-dihydro-5,7-dimethyl-(9CI)
1H-Pyrazole-3-carboxylicacid,5-propyl-,methylester(9CI)
4-Isoxazolecarboxamide,5-methyl-N-(1-methylethyl)-(9CI)
1-ISOPROPYL-3-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID
2(1H)-Pyrimidinone, 1-(2-hydroxyethyl)-4,6-dimethyl-
D057847 - Lipid Regulating Agents > D000960 - Hypolipidemic Agents D020011 - Protective Agents > D016587 - Antimutagenic Agents D009676 - Noxae > D000963 - Antimetabolites D007155 - Immunologic Factors
2,4(1H,3H)-Pyrimidinedione, 5-(1,1-dimethylethyl)-
Hexamethylene diisocyanate
D019995 - Laboratory Chemicals > D007202 - Indicators and Reagents > D003432 - Cross-Linking Reagents D004785 - Environmental Pollutants > D000393 - Air Pollutants