Hypotaurine (BioDeep_00000002849)

 

Secondary id: BioDeep_00000399865

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019 Volatile Flavor Compounds


代谢物信息卡片


2-aminoethane-1-sulfinic acid

化学式: C2H7NO2S (109.0197482)
中文名称: 亚牛磺酸
谱图信息: 最多检出来源 Homo sapiens(blood) 0.35%

Reviewed

Last reviewed on 2024-07-15.

Cite this Page

Hypotaurine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/hypotaurine (retrieved 2024-11-24) (BioDeep RN: BioDeep_00000002849). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(CS(=O)O)N
InChI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)

描述信息

Hypotaurine belongs to the class of organic compounds known as sulfinic acids. Sulfinic acids are compounds containing a sulfinic acid functional group, with the general structure RS(=O)OH (R = organyl, not H). Hypotaurine exists in all living species, ranging from bacteria to humans. Within humans, hypotaurine participates in a number of enzymatic reactions. In particular, hypotaurine can be biosynthesized from cysteamine; which is catalyzed by the enzyme 2-aminoethanethiol dioxygenase. In addition, hypotaurine can be biosynthesized from 3-sulfinoalanine through its interaction with the enzyme cysteine sulfinic acid decarboxylase. In humans, hypotaurine is involved in taurine and hypotaurine metabolism.
[Spectral] Hypotaurine (exact mass = 109.01975) and Cytosine (exact mass = 111.04326) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions.
Hypotaurine is a product of enzyme cysteamine dioxygenase [EC 1.13.11.19] in taurine and hypotaurine metabolism pathway (KEGG). It may function as an antioxidant and a protective agent under physiological conditions (PMID 14992269). [HMDB]
Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor. Antioxidant[1].

同义名列表

14 个代谢物同义名

2-aminoethane-1-sulfinic acid; 2-Aminoethanesulphinic acid; 2-Amino-ethanesulfinic acid; 2-Aminoethanesulfinic acid; 2-Aminoethylsulfinic acid; 2-Amino-ethanesulfinate; 2-Aminoethanesulphinate; 2-Aminoethanesulfinate; Cystaminesulfinic acid; 2-Aminoethylsulfinate; Cystaminesulfinate; hypotaurine; Hypotaurine; Hypotaurine



数据库引用编号

42 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

20 个相关的代谢反应过程信息。

Reactome(12)

BioCyc(0)

WikiPathways(2)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(5)

PharmGKB(0)

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Cheng-Lu Yu, Fang Lu, Dong-Hua Yu, Xiao-Min Xu, Peng Xu, Shu-Min Liu. [Mechanism of acteoside in prevention and treatment of gouty arthritis based on liver metabolomics]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2024 Jan; 49(1):224-231. doi: 10.19540/j.cnki.cjcmm.20230808.402. [PMID: 38403355]
  • Mengxing Yin, Dezhi Zhou, Fu Jia, Xiaosan Su, Xiufang Li, Ruifen Sun, Junmin Li. Metabolomics analysis of the potential mechanism of Yi-Guan-Jian decoction to reverse bone loss in glucocorticoid-induced osteoporosis. Journal of orthopaedic surgery and research. 2023 Jun; 18(1):409. doi: 10.1186/s13018-023-03778-6. [PMID: 37277810]
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  • Katsuhiko Tsuchida, Natsuki Sakiyama. Blue light-induced lipid oxidation and the antioxidant property of hypotaurine: evaluation via measuring ultraweak photon emission. Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology. 2023 Feb; 22(2):345-356. doi: 10.1007/s43630-022-00319-8. [PMID: 36271182]
  • Yangyang Wang, Yanping Sun, Bingyou Yang, Qiuhong Wang, Haixue Kuang. Integrate metabolomics strategy and target prediction to reveal the ameliorate effect of four typical 'cold' property herbs on hyperthyroidism rats. Journal of ethnopharmacology. 2023 Jan; 301(?):115772. doi: 10.1016/j.jep.2022.115772. [PMID: 36202164]
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  • Sunil Veeravalli, Ian R Phillips, Rafael T Freire, Dorsa Varshavi, Jeremy R Everett, Elizabeth A Shephard. Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine. Drug metabolism and disposition: the biological fate of chemicals. 2020 05; 48(5):378-385. doi: 10.1124/dmd.119.089995. [PMID: 32156684]
  • Yan Xu, Tianyu Zhao, Haowei Ren, Yindan Xie, Jingjing An, Jiaqi Shang, Dina Tabys, Ning Liu. Urinary Metabolic Profiling via LC-MS/MS Reveals Impact of Bovine Lactoferrin on Bone Formation in Growing SD Rats. Nutrients. 2020 Apr; 12(4):. doi: 10.3390/nu12041116. [PMID: 32316396]
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  • Tomohiro Nishimura, Kei Higuchi, Yuko Yoshida, Yuki Sugita-Fujisawa, Kazuaki Kojima, Maiko Sugimoto, Marie Santo, Masatoshi Tomi, Emi Nakashima. Hypotaurine Is a Substrate of GABA Transporter Family Members GAT2/Slc6a13 and TAUT/Slc6a6. Biological & pharmaceutical bulletin. 2018; 41(10):1523-1529. doi: 10.1248/bpb.b18-00168. [PMID: 30270321]
  • Hongming Guo, Heng Zhou, Jing Zhang, Wenxue Guan, Sheng Xu, Wenbiao Shen, Guohua Xu, Yanjie Xie, Christine Helen Foyer. l-cysteine desulfhydrase-related H2 S production is involved in OsSE5-promoted ammonium tolerance in roots of Oryza sativa. Plant, cell & environment. 2017 Sep; 40(9):1777-1790. doi: 10.1111/pce.12982. [PMID: 28474399]
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  • Sa Rang Lim, Sun-Hee Hyun, Seul Gi Lee, Jin-Young Kim, So-Hyun Kim, Sang-Jin Park, Kyoung-Sik Moon, Donggeun Sul, Dong Hyun Kim, Hyung-Kyoon Choi. Potential urinary biomarkers of nephrotoxicity in cyclophosphamide-treated rats investigated by NMR-based metabolic profiling. Journal of biochemical and molecular toxicology. 2017 Mar; 31(3):. doi: 10.1002/jbt.21871. [PMID: 27870266]
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  • Renyi Peng, Zhiyuan Bian, Lina Zhou, Wei Cheng, Na Hai, Changquan Yang, Tao Yang, Xinyu Wang, Chongying Wang. Hydrogen sulfide enhances nitric oxide-induced tolerance of hypoxia in maize (Zea mays L.). Plant cell reports. 2016 Nov; 35(11):2325-2340. doi: 10.1007/s00299-016-2037-4. [PMID: 27516180]
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  • Hui Chan Kwak, Young-Mi Kim, Soo Jin Oh, Sang Kyum Kim. Sulfur amino acid metabolism in Zucker diabetic fatty rats. Biochemical pharmacology. 2015 Aug; 96(3):256-66. doi: 10.1016/j.bcp.2015.05.014. [PMID: 26047850]
  • T Nishimura, M Duereh, Y Sugita, Y Yoshida, K Higuchi, M Tomi, E Nakashima. Protective effect of hypotaurine against oxidative stress-induced cytotoxicity in rat placental trophoblasts. Placenta. 2015 Jun; 36(6):693-8. doi: 10.1016/j.placenta.2015.02.014. [PMID: 25801460]
  • Tao Fang, Zeyu Cao, Jiale Li, Wenbiao Shen, Liqin Huang. Auxin-induced hydrogen sulfide generation is involved in lateral root formation in tomato. Plant physiology and biochemistry : PPB. 2014 Mar; 76(?):44-51. doi: 10.1016/j.plaphy.2013.12.024. [PMID: 24463534]
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