Hypotaurine (BioDeep_00000002849)

 

Secondary id: BioDeep_00000399865

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


2-aminoethane-1-sulfinic acid

化学式: C2H7NO2S (109.0197)
中文名称: 亚牛磺酸
谱图信息: 最多检出来源 Homo sapiens(blood) 35.37%

Reviewed

Last reviewed on 2024-07-15.

Cite this Page

Hypotaurine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/hypotaurine (retrieved 2024-12-27) (BioDeep RN: BioDeep_00000002849). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(CS(=O)O)N
InChI: InChI=1S/C2H7NO2S/c3-1-2-6(4)5/h1-3H2,(H,4,5)

描述信息

Hypotaurine belongs to the class of organic compounds known as sulfinic acids. Sulfinic acids are compounds containing a sulfinic acid functional group, with the general structure RS(=O)OH (R = organyl, not H). Hypotaurine exists in all living species, ranging from bacteria to humans. Within humans, hypotaurine participates in a number of enzymatic reactions. In particular, hypotaurine can be biosynthesized from cysteamine; which is catalyzed by the enzyme 2-aminoethanethiol dioxygenase. In addition, hypotaurine can be biosynthesized from 3-sulfinoalanine through its interaction with the enzyme cysteine sulfinic acid decarboxylase. In humans, hypotaurine is involved in taurine and hypotaurine metabolism.
[Spectral] Hypotaurine (exact mass = 109.01975) and Cytosine (exact mass = 111.04326) were not completely separated on HPLC under the present analytical conditions as described in AC$XXX. Additionally some of the peaks in this data contains dimers and other unidentified ions.
Hypotaurine is a product of enzyme cysteamine dioxygenase [EC 1.13.11.19] in taurine and hypotaurine metabolism pathway (KEGG). It may function as an antioxidant and a protective agent under physiological conditions (PMID 14992269). [HMDB]
Hypotaurine (2-aminoethanesulfinic acid), an intermediate in taurine biosynthesis from cysteine in astrocytes, is an endogenous inhibitory amino acid of the glycine receptor. Antioxidant[1].

同义名列表

14 个代谢物同义名

2-aminoethane-1-sulfinic acid; 2-Aminoethanesulphinic acid; 2-Amino-ethanesulfinic acid; 2-Aminoethanesulfinic acid; 2-Aminoethylsulfinic acid; 2-Amino-ethanesulfinate; 2-Aminoethanesulphinate; 2-Aminoethanesulfinate; Cystaminesulfinic acid; 2-Aminoethylsulfinate; Cystaminesulfinate; hypotaurine; Hypotaurine; Hypotaurine



数据库引用编号

42 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

20 个相关的代谢反应过程信息。

Reactome(12)

BioCyc(0)

WikiPathways(2)

Plant Reactome(0)

INOH(1)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(5)

PharmGKB(0)

20 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AKT1, ALB, CAT, CBS, CSAD, EZR, HPGDS
Peripheral membrane protein 1 EZR
Nucleus 5 AKT1, ALB, BHMT, CBS, GABPA
cytosol 11 ADO, AKT1, ALB, BHMT, CAT, CBS, CDO1, EZR, GPT, GSR, HPGDS
dendrite 1 SLC6A6
centrosome 1 ALB
nucleoplasm 3 AKT1, GABPA, HPGDS
Cell membrane 4 AKT1, GLRA2, SLC6A6, TNF
Cytoplasmic side 1 EZR
lamellipodium 1 AKT1
ruffle membrane 1 EZR
Multi-pass membrane protein 3 GLRA2, RHO, SLC6A6
Synapse 1 GLRA2
cell cortex 2 AKT1, EZR
cell surface 1 TNF
glutamatergic synapse 1 AKT1
Golgi apparatus 2 ALB, RHO
Golgi membrane 2 INS, RHO
neuronal cell body 2 SLC6A6, TNF
postsynapse 1 AKT1
Cytoplasm, cytosol 1 BHMT
endosome 1 EZR
plasma membrane 6 AKT1, EZR, GLRA2, RHO, SLC6A6, TNF
Membrane 6 AKT1, CAT, EZR, GLRA2, RHO, SLC6A6
apical plasma membrane 2 EZR, SLC6A6
basolateral plasma membrane 2 EZR, SLC6A6
brush border 1 EZR
extracellular exosome 6 ALB, BHMT, CAT, EZR, GPT, GSR
endoplasmic reticulum 1 ALB
extracellular space 6 ALB, CXCL8, EZR, IL17A, INS, TNF
perinuclear region of cytoplasm 1 EZR
adherens junction 1 EZR
mitochondrion 3 ADO, CAT, GSR
protein-containing complex 4 AKT1, ALB, CAT, EZR
intracellular membrane-bounded organelle 3 CAT, GLRA2, HPGDS
filopodium 1 EZR
Secreted 4 ALB, CXCL8, IL17A, INS
extracellular region 6 ALB, CAT, CXCL8, IL17A, INS, TNF
mitochondrial matrix 2 CAT, GSR
anchoring junction 1 ALB
ciliary membrane 1 RHO
photoreceptor inner segment 1 RHO
photoreceptor outer segment 1 RHO
external side of plasma membrane 3 GSR, IL17A, TNF
actin cytoskeleton 1 EZR
microtubule cytoskeleton 1 AKT1
apical part of cell 1 EZR
cell-cell junction 2 AKT1, RHO
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 2 AKT1, EZR
postsynaptic membrane 1 SLC6A6
Apical cell membrane 1 EZR
Cell projection, ruffle membrane 1 EZR
Membrane raft 1 TNF
Cytoplasm, cytoskeleton 1 EZR
focal adhesion 2 CAT, EZR
spindle 1 AKT1
GABA-ergic synapse 2 GLRA2, SLC6A6
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
Postsynaptic cell membrane 1 GLRA2
ruffle 1 EZR
neuron projection 1 GLRA2
ciliary basal body 3 AKT1, ALB, EZR
chromatin 1 GABPA
cell projection 3 EZR, GLRA2, SLC6A6
phagocytic cup 1 TNF
cell periphery 1 EZR
cytoskeleton 1 EZR
centriole 1 ALB
Cell projection, cilium, photoreceptor outer segment 1 RHO
plasma membrane protein complex 1 SLC6A6
spindle pole 1 ALB
Cytoplasm, cell cortex 1 EZR
actin filament 1 EZR
blood microparticle 1 ALB
sperm midpiece 1 RHO
transmembrane transporter complex 1 GLRA2
Cell projection, microvillus membrane 1 EZR
microvillus membrane 2 EZR, SLC6A6
fibrillar center 1 EZR
endosome lumen 1 INS
microvillus 1 EZR
chloride channel complex 1 GLRA2
Cell projection, microvillus 1 EZR
Golgi-associated vesicle membrane 1 RHO
plasma membrane raft 1 EZR
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 ALB, INS
platelet alpha granule lumen 1 ALB
Photoreceptor inner segment membrane 1 RHO
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 EZR
uropod 1 EZR
postsynaptic specialization membrane 1 GLRA2
photoreceptor outer segment membrane 1 RHO
sperm head plasma membrane 1 RHO
photoreceptor disc membrane 1 RHO
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 EZR
catalase complex 1 CAT
glycinergic synapse 1 GLRA2
rod photoreceptor outer segment 1 RHO
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

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