Buspirone (BioDeep_00000001444)

 

Secondary id: BioDeep_00000398420

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


8-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione

化学式: C21H31N5O2 (385.2478)
中文名称: 丁螺环酮
谱图信息: 最多检出来源 Homo sapiens(blood) 58.96%

Reviewed

Last reviewed on 2024-09-14.

Cite this Page

Buspirone. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/buspirone (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001444). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1CCC2(C1)CC(=O)N(C(=O)C2)CCCCN3CCN(CC3)C4=NC=CC=N4
InChI: InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2

描述信息

Buspirone is only found in individuals that have used or taken this drug. It is an anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the benzodiazepines, but it has an efficacy comparable to diazepam. [PubChem]Buspirone binds to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus, thus inhibiting the firing rate of 5-HT-containing neurons in the dorsal raphe. Buspirone also binds at dopamine type 2 (DA2) receptors, blocking presynaptic dopamine receptors. Buspirone increases firing in the locus ceruleus, an area of brain where norepinephrine cell bodies are found in high concentration. The net result of buspirone actions is that serotonergic activity is suppressed while noradrenergic and dopaminergic cell firing is enhanced.
CONFIDENCE standard compound; INTERNAL_ID 520; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6951; ORIGINAL_PRECURSOR_SCAN_NO 6950
CONFIDENCE standard compound; INTERNAL_ID 520; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6947; ORIGINAL_PRECURSOR_SCAN_NO 6945
CONFIDENCE standard compound; INTERNAL_ID 520; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6914; ORIGINAL_PRECURSOR_SCAN_NO 6912
CONFIDENCE standard compound; INTERNAL_ID 520; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6879; ORIGINAL_PRECURSOR_SCAN_NO 6877
CONFIDENCE standard compound; INTERNAL_ID 520; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6955; ORIGINAL_PRECURSOR_SCAN_NO 6953
CONFIDENCE standard compound; INTERNAL_ID 520; DATASET 20200303_ENTACT_RP_MIX506; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 6922; ORIGINAL_PRECURSOR_SCAN_NO 6920
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014151 - Anti-Anxiety Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05B - Anxiolytics > N05BE - Azaspirodecanedione derivatives
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D017366 - Serotonin Receptor Agonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
C78272 - Agent Affecting Nervous System > C28197 - Antianxiety Agent
Buspirone is an orally active 5-HT1A receptor agonist, and a dopamine D2 autoreceptorsant antagonist. Buspirone is an anxiolytic agent, and can be used for the generalized anxiety disorder research[1].

同义名列表

46 个代谢物同义名

8-{4-[4-(pyrimidin-2-yl)piperazin-1-yl]butyl}-8-azaspiro[4.5]decane-7,9-dione; 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione; N-(4-(4-(2-Pyrimidinyl)-1-piperazinyl)butyl)-1-cyclopentanediacetamide; Bristol-myers squibb brand OF buspirone hydrochloride; Bristol myers squibb brand OF buspirone hydrochloride; Linson pharma brand OF buspirone hydrochloride; Bristol-myers brand OF buspirone hydrochloride; Pharmascience brand OF buspirone hydrochloride; Bristol myers brand OF buspirone hydrochloride; Ratiopharm brand OF buspirone hydrochloride; Armstrong brand OF buspirone hydrochloride; Novopharm brand OF buspirone hydrochloride; Nu pharm brand OF buspirone hydrochloride; Nu-pharm brand OF buspirone hydrochloride; Hormosan brand OF buspirone hydrochloride; Apotex brand OF buspirone hydrochloride; Hexal brand OF buspirone hydrochloride; Eisai brand OF buspirone hydrochloride; UPSA brand OF buspirone hydrochloride; Genpharm brand OF buspirone; Hydrochloride, buspirone; Buspirone hydrochloride; Ratio-buspirone; Ratio buspirone; Novo buspirone; Novo-buspirone; Gen-buspirone; Apo-buspirone; Apo buspirone; Lin-buspirone; PMS Buspirone; PMS-Buspirone; Gen buspirone; Lin buspirone; Nu buspirone; Nu-buspirone; Buspironum; buspirone; Buspirona; Neurosine; Bespar; Buspar; Anxut; Busp; Buspirone; Buspirone



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 BDNF, CA1, CA3, CYP3A4, POMC
Peripheral membrane protein 1 CYP1B1
Endosome membrane 1 SLC6A4
Endoplasmic reticulum membrane 3 CYP1B1, CYP3A4, DRD1
Nucleus 2 DRD1, FOS
cytosol 3 CA1, CA3, FOS
dendrite 6 BDNF, DRD2, HTR1A, HTR1B, HTR2A, HTR2C
nucleoplasm 1 FOS
RNA polymerase II transcription regulator complex 1 FOS
Cell membrane 10 DRD1, DRD2, DRD3, HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, SLC6A4, TNF
Cleavage furrow 1 HTR3A
Cell projection, axon 1 HTR2A
Multi-pass membrane protein 9 DRD1, DRD2, DRD3, HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, SLC6A4
Golgi apparatus membrane 1 DRD2
Synapse 7 CRH, DRD2, DRD3, HTR1A, HTR2C, HTR3A, SLC6A4
cell surface 1 TNF
dendritic shaft 1 HTR2A
glutamatergic synapse 3 DRD1, DRD2, HTR2A
Golgi membrane 2 DRD2, INS
neuronal cell body 2 HTR2A, TNF
postsynapse 1 HTR3A
presynaptic membrane 5 DRD1, DRD2, HTR1B, HTR2A, SLC6A4
synaptic vesicle 1 BDNF
Presynapse 2 HTR2A, SLC6A4
acrosomal vesicle 1 DRD2
plasma membrane 10 DRD1, DRD2, DRD3, HTR1A, HTR1B, HTR2A, HTR2C, HTR3A, SLC6A4, TNF
synaptic vesicle membrane 1 DRD2
Membrane 6 BDNF, CYP1B1, CYP3A4, DRD3, HTR3A, SLC6A4
axon 3 BDNF, DRD2, HTR2A
caveola 1 HTR2A
extracellular exosome 1 CA1
endoplasmic reticulum 2 FOS, HTR1B
extracellular space 6 BDNF, CRH, IL6, INS, POMC, TNF
perinuclear region of cytoplasm 1 BDNF
mitochondrion 1 CYP1B1
intracellular membrane-bounded organelle 2 CYP1B1, CYP3A4
Microsome membrane 2 CYP1B1, CYP3A4
Secreted 5 BDNF, CRH, IL6, INS, POMC
extracellular region 6 BDNF, CRH, IL6, INS, POMC, TNF
ciliary membrane 2 DRD1, DRD2
external side of plasma membrane 1 TNF
varicosity 1 CRH
dendritic spine 2 DRD1, DRD2
neuronal dense core vesicle lumen 1 CRH
perikaryon 2 CRH, DRD2
cytoplasmic vesicle 1 HTR2A
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
postsynaptic membrane 5 DRD1, DRD2, HTR2A, HTR3A, SLC6A4
Membrane raft 2 SLC6A4, TNF
Cell junction, focal adhesion 1 SLC6A4
focal adhesion 1 SLC6A4
GABA-ergic synapse 2 DRD1, DRD2
Cell projection, dendritic spine 1 DRD1
secretory granule 1 POMC
lateral plasma membrane 1 DRD2
Postsynaptic cell membrane 1 HTR3A
Cell projection, neuron projection 1 SLC6A4
neuron projection 2 HTR3A, SLC6A4
cilium 2 DRD1, DRD2
chromatin 1 FOS
phagocytic cup 1 TNF
non-motile cilium 2 DRD1, DRD2
serotonin-activated cation-selective channel complex 1 HTR3A
transmembrane transporter complex 1 HTR3A
sperm flagellum 1 DRD2
Endomembrane system 1 SLC6A4
endosome lumen 1 INS
Membrane, caveola 1 HTR2A
cell body fiber 1 HTR2A
Cell projection, dendrite 3 DRD1, HTR1A, HTR2A
secretory granule lumen 2 INS, POMC
Golgi lumen 1 INS
endoplasmic reticulum lumen 3 BDNF, IL6, INS
nuclear matrix 1 FOS
axon terminus 1 DRD2
endocytic vesicle 1 DRD2
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neurofilament 1 HTR2A
calyx of Held 1 HTR1B
protein-DNA complex 1 FOS
dopaminergic synapse 1 DRD2
Cell projection, cilium membrane 1 DRD1
transcription factor AP-1 complex 1 FOS
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
interleukin-6 receptor complex 1 IL6
G protein-coupled receptor complex 2 DRD1, DRD2
[Neurotrophic factor BDNF precursor form]: Secreted 1 BDNF
G protein-coupled serotonin receptor complex 3 HTR1B, HTR2A, HTR2C
serotonergic synapse 2 HTR1B, SLC6A4
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Darshak Shah, Mit Joshi, Jigna Shah, Bhoomika M Patel. Beneficial effects of buspirone in endothelin-1 induced stroke cachexia in rats. Molecular and cellular biochemistry. 2023 Jan; ?(?):. doi: 10.1007/s11010-022-04653-4. [PMID: 36609633]
  • Bo-Wen Zhang, Ni-Hong Pang, Ren-Ai Xu, Gao-Er Qu, Cong-Rong Tang. Inhibition of Axitinib on Buspirone Metabolism in vitro and in vivo. Drug design, development and therapy. 2022; 16(?):2031-2042. doi: 10.2147/dddt.s359451. [PMID: 35795848]
  • Andrew B Hawkey, Julia Hoeng, Manuel C Peitsch, Edward D Levin, Kyoko Koshibu. Subchronic effects of plant alkaloids on anxiety-like behavior in zebrafish. Pharmacology, biochemistry, and behavior. 2021 08; 207(?):173223. doi: 10.1016/j.pbb.2021.173223. [PMID: 34197843]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Eun Jung Bae, Won Gun Choi, Haushabhau S Pagire, Suvarna H Pagire, Saravanan Parameswaran, Jun-Ho Choi, Jihyeon Yoon, Won-Il Choi, Ji Hun Lee, Jin Sook Song, Myung Ae Bae, Mijin Kim, Jae-Han Jeon, In-Kyu Lee, Hail Kim, Jin Hee Ahn. Peripheral Selective Oxadiazolylphenyl Alanine Derivatives as Tryptophan Hydroxylase 1 Inhibitors for Obesity and Fatty Liver Disease. Journal of medicinal chemistry. 2021 01; 64(2):1037-1053. doi: 10.1021/acs.jmedchem.0c01560. [PMID: 33417443]
  • Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue. Archives of toxicology. 2020 12; 94(12):4037-4041. doi: 10.1007/s00204-020-02869-1. [PMID: 32808185]
  • Scott Maresh, Joel Prowting, Sarah Vaughan, Elizabeth Kruppe, Bander Alsabri, Hossein Yarandi, M Safwan Badr, Abdulghani Sankari. Buspirone decreases susceptibility to hypocapnic central sleep apnea in chronic SCI patients. Journal of applied physiology (Bethesda, Md. : 1985). 2020 10; 129(4):675-682. doi: 10.1152/japplphysiol.00435.2020. [PMID: 32816639]
  • I P Butkevich, V A Mikhailenko. Effects of Stress Exposure during Adolescent Period on Inflammatory Pain Response, Psychoemotional Behavior, and Action of Antidepressants in Prenatally Stressed Adult Male Rats. Bulletin of experimental biology and medicine. 2020 Jul; 169(3):306-309. doi: 10.1007/s10517-020-04875-w. [PMID: 32748140]
  • Minhee Kim, Inseon Hwang, Haushabhau S Pagire, Suvarna H Pagire, Wonsuk Choi, Won Gun Choi, Jihyeon Yoon, Won Mi Lee, Jin Sook Song, Eun Kyung Yoo, Seung Mi Lee, Mi-Jin Kim, Myung Ae Bae, Dooseop Kim, Heejong Lee, Eun-Young Lee, Jae-Han Jeon, In-Kyu Lee, Hail Kim, Jin Hee Ahn. Design, Synthesis, and Biological Evaluation of New Peripheral 5HT2A Antagonists for Nonalcoholic Fatty Liver Disease. Journal of medicinal chemistry. 2020 04; 63(8):4171-4182. doi: 10.1021/acs.jmedchem.0c00002. [PMID: 32285676]
  • Jakub Staroń, Rafał Kurczab, Dawid Warszycki, Grzegorz Satała, Martyna Krawczyk, Ryszard Bugno, Tomasz Lenda, Piotr Popik, Adam S Hogendorf, Agata Hogendorf, Krzysztof Dubiel, Mikołaj Matłoka, Rafał Moszczyński-Pętkowski, Jerzy Pieczykolan, Maciej Wieczorek, Paweł Zajdel, Andrzej J Bojarski. Virtual screening-driven discovery of dual 5-HT6/5-HT2A receptor ligands with pro-cognitive properties. European journal of medicinal chemistry. 2020 Jan; 185(?):111857. doi: 10.1016/j.ejmech.2019.111857. [PMID: 31734022]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Wenya Hu, Mi Jia, Siyan He, Huiru Xie, Xuehua Jiang, Ling Wang. Simultaneous determination of tandospirone and its active metabolite, 1-[2-pyrimidyl]-piperazine in rat plasma by LC-MS/MS and its application to a pharmacokinetic study. Biomedical chromatography : BMC. 2019 Jul; 33(7):e4525. doi: 10.1002/bmc.4525. [PMID: 30822365]
  • Nausheen Alam, Nousheen Wasi, Sadaf Naeem, Sadia Suri Kashif, Tuba Siddiqui, Lubna Bashir, Shazia Naz, Rahila Ikram. Methylphenidate increases the urinary excretion of vanillylmandelic acid in rats that is attenuated by buspirone co-administration. Pakistan journal of pharmaceutical sciences. 2019 Mar; 32(2 (Supplementary)):895-898. doi: . [PMID: 31103989]
  • Ahmad Salimi, Mosleh Razian, Jalal Pourahmad. Analysis of Toxicity Effects of Buspirone, Cetirizine and Olanzapine on Human Blood Lymphocytes: in Vitro Model. Current clinical pharmacology. 2018; 13(2):120-127. doi: 10.2174/1574884713666180516112920. [PMID: 29766823]
  • Katarzyna Kucwaj-Brysz, Dawid Warszycki, Sabina Podlewska, Jagna Witek, Karolina Witek, Andrea González Izquierdo, Grzegorz Satała, María I Loza, Annamaria Lubelska, Gniewomir Latacz, Andrzej J Bojarski, Marián Castro, Katarzyna Kieć-Kononowicz, Jadwiga Handzlik. Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation. European journal of medicinal chemistry. 2016 Apr; 112(?):258-269. doi: 10.1016/j.ejmech.2016.02.024. [PMID: 26900658]
  • Ki Taek Kim, Jae-Young Lee, Ju-Hwan Park, Min Hwan Kim, Ji-Su Kim, Hyeon-Jong Shin, Naewon Kang, Hyun-Jong Cho, In-Soo Yoon, Dae-Duk Kim. Development of HPLC Method for the Determination of Buspirone in Rat Plasma Using Fluorescence Detection and Its Application to a Pharmacokinetic Study. Chemical & pharmaceutical bulletin. 2016; 64(11):1582-1588. doi: 10.1248/cpb.c16-00405. [PMID: 27803469]
  • Bernard Le Foll, Doris Payer, Patricia Di Ciano, Mihail Guranda, Shinichiro Nakajima, Junchao Tong, Esmaeil Mansouri, Alan A Wilson, Sylvain Houle, Jeff H Meyer, Ariel Graff-Guerrero, Isabelle Boileau. Occupancy of Dopamine D3 and D2 Receptors by Buspirone: A [11C]-(+)-PHNO PET Study in Humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2016 Jan; 41(2):529-37. doi: 10.1038/npp.2015.177. [PMID: 26089182]
  • Aimee L McRae-Clark, Nathaniel L Baker, Kevin M Gray, Therese K Killeen, Amanda M Wagner, Kathleen T Brady, C Lindsay DeVane, Jessica Norton. Buspirone treatment of cannabis dependence: A randomized, placebo-controlled trial. Drug and alcohol dependence. 2015 Nov; 156(?):29-37. doi: 10.1016/j.drugalcdep.2015.08.013. [PMID: 26386827]
  • Aimee L McRae-Clark, Nathaniel L Baker, Susan C Sonne, C Lindsay DeVane, Amanda Wagner, Jessica Norton. Concordance of Direct and Indirect Measures of Medication Adherence in A Treatment Trial for Cannabis Dependence. Journal of substance abuse treatment. 2015 Oct; 57(?):70-4. doi: 10.1016/j.jsat.2015.05.002. [PMID: 26028133]
  • Sang-Bum Kim, Hyun-Jong Cho, Yeong Shik Kim, Dae-Duk Kim, In-Soo Yoon. Modulation of Cytochrome P450 Activity by 18β-Glycyrrhetic Acid and its Consequence on Buspirone Pharmacokinetics in Rats. Phytotherapy research : PTR. 2015 Aug; 29(8):1188-94. doi: 10.1002/ptr.5365. [PMID: 26010440]
  • Jinjun Wu, Zaixing Cheng, Shugui He, Jian Shi, Shuqiang Liu, Guiyu Zhang, Lijun Zhu, Liang Liu, Zhongqiu Liu, Na Lin, Linlin Lu. Pinelliae rhizoma, a toxic chinese herb, can significantly inhibit CYP3A activity in rats. Molecules (Basel, Switzerland). 2015 Jan; 20(1):792-806. doi: 10.3390/molecules20010792. [PMID: 25574821]
  • Haider A J Al Lawati, Afsal Mohammed Kadavilpparampu, FakhrEldin O Suliman. Combination of capillary micellar liquid chromatography with on-chip microfluidic chemiluminescence detection for direct analysis of buspirone in human plasma. Talanta. 2014 Sep; 127(?):230-8. doi: 10.1016/j.talanta.2014.03.052. [PMID: 24913881]
  • Anil Kumar, Gurleen Kaur, Puneet Rinwa. Buspirone along with melatonin attenuates oxidative damage and anxiety-like behavior in a mouse model of immobilization stress. Chinese journal of natural medicines. 2014 Aug; 12(8):582-9. doi: 10.1016/s1875-5364(14)60089-3. [PMID: 25156283]
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  • Sang-Bum Kim, In-Soo Yoon, Kyu-Sang Kim, Sung-Jun Cho, Yeong Shik Kim, Hyun-Jong Cho, Suk-Jae Chung, Saeho Chong, Dae-Duk Kim. In vitro and in vivo evaluation of the effect of puerarin on hepatic cytochrome p450-mediated drug metabolism. Planta medica. 2014 May; 80(7):561-7. doi: 10.1055/s-0034-1368350. [PMID: 24710899]
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  • Simona Bertoni, Valentina Arcaro, Valentina Vivo, Alberto Rapalli, Massimiliano Tognolini, Anna Maria Cantoni, Francesca Saccani, Lisa Flammini, Giuseppe Domenichini, Vigilio Ballabeni, Elisabetta Barocelli. Suppression of inflammatory events associated to intestinal ischemia-reperfusion by 5-HT1A blockade in mice. Pharmacological research. 2014 Mar; 81(?):17-25. doi: 10.1016/j.phrs.2014.02.002. [PMID: 24548822]
  • Hamza Bshara, Rihab Osman, Samar Mansour, Abd El-Hameed A El-Shamy. Chitosan and cyclodextrin in intranasal microemulsion for improved brain buspirone hydrochloride pharmacokinetics in rats. Carbohydrate polymers. 2014 Jan; 99(?):297-305. doi: 10.1016/j.carbpol.2013.08.027. [PMID: 24274510]
  • Lijun Zhu, Linlin Lu, Enshuang Guo, Jinjun Wu, Ying Wang, Ming Hu, Zhongqiu Liu. The influences of aconitine, an active/toxic alkaloid from aconitum, on the oral pharmacokinetics of CYP3A probe drug buspirone in rats. Drug metabolism letters. 2014; 8(2):135-44. doi: 10.2174/1872312808666140505162139. [PMID: 25434398]
  • Daphna Laifenfeld, Luping Qiu, Rachel Swiss, Jennifer Park, Michael Macoritto, Yvonne Will, Husam S Younis, Michael Lawton. Utilization of causal reasoning of hepatic gene expression in rats to identify molecular pathways of idiosyncratic drug-induced liver injury. Toxicological sciences : an official journal of the Society of Toxicology. 2014 Jan; 137(1):234-48. doi: 10.1093/toxsci/kft232. [PMID: 24136188]
  • Nathalie Rioux, Edith Bellavance, Serge Bourg, Michel Garneau, Maria D Ribadeneira, Jianmin Duan. Assessment of CYP3A-mediated drug-drug interaction potential for victim drugs using an in vivo rat model. Biopharmaceutics & drug disposition. 2013 Oct; 34(7):396-401. doi: 10.1002/bdd.1855. [PMID: 23873286]
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