3beta-hydroxy-5-cholestenoic acid (BioDeep_00001869641)
Main id: BioDeep_00000011647
代谢物信息卡片
化学式: C27H44O3 (416.329)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(CCCC(C)C(=O)O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)O)C)C
InChI: InChI=1S/C27H44O3/c1-17(6-5-7-18(2)25(29)30)22-10-11-23-21-9-8-19-16-20(28)12-14-26(19,3)24(21)13-15-27(22,23)4/h8,17-18,20-24,28H,5-7,9-16H2,1-4H3,(H,29,30)/t17-,18?,20+,21+,22-,23+,24+,26+,27-/m1/s1
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Yunlu He, Yanbo Luo, Huan Chen, Jian Chen, Yaning Fu, Hongwei Hou, Qingyuan Hu. Profiling of carboxyl-containing metabolites in smokers and non-smokers by stable isotope labeling combined with LC-MS/MS.
Analytical biochemistry.
2019 03; 569(?):1-9. doi:
10.1016/j.ab.2018.12.006
. [PMID: 30543805] - Joo In Jung, Ashleigh R Price, Thomas B Ladd, Yong Ran, Hyo-Jin Park, Carolina Ceballos-Diaz, Lisa A Smithson, Günther Hochhaus, Yufei Tang, Rajender Akula, Saritha Ba, Edward H Koo, Gideon Shapiro, Kevin M Felsenstein, Todd E Golde. Cholestenoic acid, an endogenous cholesterol metabolite, is a potent γ-secretase modulator.
Molecular neurodegeneration.
2015 Jul; 10(?):29. doi:
10.1186/s13024-015-0021-z
. [PMID: 26169917] - William J Griffiths, Martin Hornshaw, Gary Woffendin, Sharon F Baker, Andrew Lockhart, Sibylle Heidelberger, Magnus Gustafsson, Jan Sjövall, Yuqin Wang. Discovering oxysterols in plasma: a window on the metabolome.
Journal of proteome research.
2008 Aug; 7(8):3602-12. doi:
10.1021/pr8001639
. [PMID: 18605750] - Akira Honda, Tadashi Yoshida, Guorong Xu, Yasushi Matsuzaki, Sugano Fukushima, Naomi Tanaka, Mikio Doy, Sarah Shefer, Gerald Salen. Significance of plasma 7alpha-hydroxy-4-cholesten-3-one and 27-hydroxycholesterol concentrations as markers for hepatic bile acid synthesis in cholesterol-fed rabbits.
Metabolism: clinical and experimental.
2004 Jan; 53(1):42-8. doi:
10.1016/j.metabol.2003.07.018
. [PMID: 14681840] - Steve Meaney, Amir Babiker, Dieter Lütjohann, Ulf Diczfalusy, Magnus Axelson, Ingemar Björkhem. On the origin of the cholestenoic acids in human circulation.
Steroids.
2003 Sep; 68(7-8):595-601. doi:
10.1016/s0039-128x(03)00081-3
. [PMID: 12957664] - Magnus Hansson, Ewa Ellis, Mary C Hunt, Gerd Schmitz, Amir Babiker. Marked induction of sterol 27-hydroxylase activity and mRNA levels during differentiation of human cultured monocytes into macrophages.
Biochimica et biophysica acta.
2003 Feb; 1593(2-3):283-9. doi:
10.1016/s0167-4889(02)00398-1
. [PMID: 12581873] - C Song, S Liao. Cholestenoic acid is a naturally occurring ligand for liver X receptor alpha.
Endocrinology.
2000 Nov; 141(11):4180-4. doi:
10.1210/endo.141.11.7772
. [PMID: 11089551] - A Babiker, U Diczfalusy. Transport of side-chain oxidized oxysterols in the human circulation.
Biochimica et biophysica acta.
1998 Jun; 1392(2-3):333-9. doi:
10.1016/s0005-2760(98)00047-2
. [PMID: 9630709] - A B Reiss, K O Martin, D E Rojer, S Iyer, E A Grossi, A C Galloway, N B Javitt. Sterol 27-hydroxylase: expression in human arterial endothelium.
Journal of lipid research.
1997 Jun; 38(6):1254-60. doi:
"
. [PMID: 9215552] - M Axelson, B Mörk, A Aly, O Wisén, J Sjövall. Concentrations of cholestenoic acids in plasma from patients with liver disease.
Journal of lipid research.
1989 Dec; 30(12):1877-82. doi:
. [PMID: 2621414]
- M Axelson, B Mörk, A Aly, G Walldius, J Sjövall. Concentrations of cholestenoic acids in plasma from patients with reduced intestinal reabsorption of bile acids.
Journal of lipid research.
1989 Dec; 30(12):1883-7. doi:
. [PMID: 2621415]
- M Axelson, B Mörk, J Sjövall. Occurrence of 3 beta-hydroxy-5-cholestenoic acid, 3 beta,7 alpha-dihydroxy-5-cholestenoic acid, and 7 alpha-hydroxy-3-oxo-4-cholestenoic acid as normal constituents in human blood.
Journal of lipid research.
1988 May; 29(5):629-41. doi:
10.1016/s0022-2275(20)38509-6
. [PMID: 3411238] - G Janssen, G Parmentier. A further study of the bile acids in infants with coprostanic acidemia.
Steroids.
1981 Jan; 37(1):81-9. doi:
10.1016/0039-128x(81)90010-6
. [PMID: 6784283] - . .
.
. doi:
. [PMID: 8078928]