SOMAN (BioDeep_00001867969)
Main id: BioDeep_00000006512
代谢物信息卡片
SOMAN
化学式: C7H16FO2P (182.0872)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C(C)(C)C)OP(=O)(C)F
InChI: InChI=1S/C7H16FO2P/c1-6(7(2,3)4)10-11(5,8)9/h6H,1-5H3
描述信息
D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants > D003292 - Convulsants
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D002800 - Cholinesterase Inhibitors
D009676 - Noxae > D011042 - Poisons > D002619 - Chemical Warfare Agents
D004791 - Enzyme Inhibitors
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:9195
- KEGG: C07494
- PubChem: 7305
- ChEMBL: CHEMBL15910
- MeSH: Soman
- CAS: 96-64-0
- PubChem: 9697
- NIKKAJI: J4.722H
- KNApSAcK: 9195
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- RamaRao Golime, Naveen Singh, Ankush Rajput, Nagar Dp, Vinod K Lodhi. Chronic sub lethal nerve agent (Soman) exposure induced long-term neurobehavioral, histological, and biochemical alterations in rats.
Journal of chemical neuroanatomy.
2024 Jan; 136(?):102388. doi:
10.1016/j.jchemneu.2024.102388. [PMID: 38182038] - Qiao Lv, Hui-Lan Yu, Yang Yang, Fan-Hua Meng, Xian-Dong Dai, Pei-Yu Jiang, Chang-Cai Liu. Screening of monoclonal antibodies against specific phosphonylation sites and analysis of serum samples exposed to soman and VX using an indirect competitive enzyme-linked immunosorbent assay.
Analytical and bioanalytical chemistry.
2022 Mar; 414(8):2713-2724. doi:
10.1007/s00216-022-03914-x. [PMID: 35083511] - Ashima Saxena, Todd M Myers, Maurice L Sipos. Conjugates of human serum butyrylcholinesterase and nerve agents are behaviorally safe in rhesus macaques.
Chemico-biological interactions.
2021 Aug; 344(?):109499. doi:
10.1016/j.cbi.2021.109499. [PMID: 33961835] - Brenda M Marrero-Rosado, Michael F Stone, Marcio de Araujo Furtado, Caroline R Schultz, C Linn Cadieux, Lucille A Lumley. Novel Genetically Modified Mouse Model to Assess Soman-Induced Toxicity and Medical Countermeasure Efficacy: Human Acetylcholinesterase Knock-in Serum Carboxylesterase Knockout Mice.
International journal of molecular sciences.
2021 Feb; 22(4):. doi:
10.3390/ijms22041893. [PMID: 33672922] - Erica R Kundrick, Brenda M Marrero-Rosado, Marcio de Araujo Furtado, Michael Stone, Caroline R Schultz, Lucille A Lumley. Cannabidiol reduces soman-induced lethality and seizure severity in female plasma carboxylesterase knockout mice treated with midazolam.
Neurotoxicology.
2021 01; 82(?):130-136. doi:
10.1016/j.neuro.2020.12.002. [PMID: 33290784] - Erica Kundrick, Brenda Marrero-Rosado, Michael Stone, Caroline Schultz, Katie Walker, Robyn B Lee-Stubbs, Marcio de Araujo Furtado, Lucille A Lumley. Delayed midazolam dose effects against soman in male and female plasma carboxylesterase knockout mice.
Annals of the New York Academy of Sciences.
2020 11; 1479(1):94-107. doi:
10.1111/nyas.14311. [PMID: 32027397] - Brenda M Marrero-Rosado, Marcio de Araujo Furtado, Erica R Kundrick, Katie A Walker, Michael F Stone, Caroline R Schultz, Donna A Nguyen, Lucille A Lumley. Ketamine as adjunct to midazolam treatment following soman-induced status epilepticus reduces seizure severity, epileptogenesis, and brain pathology in plasma carboxylesterase knockout mice.
Epilepsy & behavior : E&B.
2020 10; 111(?):107229. doi:
10.1016/j.yebeh.2020.107229. [PMID: 32575012] - Katie M Rubin, Bruce A Goldberger, Timothy J Garrett. Detection of Chemical Weapon Nerve Agents in Bone by Liquid Chromatography-Mass Spectrometry.
Journal of analytical toxicology.
2020 May; 44(4):391-401. doi:
10.1093/jat/bkz118. [PMID: 32103269] - Douglas M Cerasoli, Stuart J Armstrong, Tony E Reeves, Sean M Hodgins, Shane A Kasten, Robyn B Lee-Stubbs, C Linn Cadieux, Tamara C Otto, Benedict R Capacio, David E Lenz. Butyrylcholinesterase, a stereospecific in vivo bioscavenger against nerve agent intoxication.
Biochemical pharmacology.
2020 01; 171(?):113670. doi:
10.1016/j.bcp.2019.113670. [PMID: 31628910] - Todd M Myers. Human plasma-derived butyrylcholinesterase is behaviorally safe and effective in cynomolgus macaques (Macaca fascicularis) challenged with soman.
Chemico-biological interactions.
2019 Aug; 308(?):170-178. doi:
10.1016/j.cbi.2019.05.021. [PMID: 31129133] - Feiyan Fu, Runli Gao, Ruihua Zhang, Pengcheng Zhao, Xiaogang Lu, Liqin Li, Hongmei Wang, Chengxin Pei. Verification of soman-related nerve agents via detection of phosphonylated adducts from rabbit albumin in vitro and in vivo.
Archives of toxicology.
2019 07; 93(7):1853-1863. doi:
10.1007/s00204-019-02485-8. [PMID: 31161358] - V N Babakov, E V Shreiner, O A Keltsieva, Y A Dubrovskii, V V Shilovskikh, I M Zorin, N G Sukhodolov, I G Zenkevich, E P Podolskaya, A A Selyutin. Application of lanthanum stearate monolayers as a metal-affinity sorbent for the selective sorption of soman adducts to human serum albumin.
Talanta.
2019 Apr; 195(?):728-731. doi:
10.1016/j.talanta.2018.11.103. [PMID: 30625608] - Li-Ping Liang, Jennifer N Pearson-Smith, Jie Huang, Brian J Day, Manisha Patel. Neuroprotective effects of a catalytic antioxidant in a rat nerve agent model.
Redox biology.
2019 01; 20(?):275-284. doi:
10.1016/j.redox.2018.10.010. [PMID: 30384261] - Teodora Król, Wojciech Trybus, Ewa Trybus, Anna Kopacz-Bednarska, Marek Kowalczyk, Marek Brytan, Małgorzata Paluch, Bożena Antkowiak, Marek Saracyn, Grzegorz Król, Magdalena Ciechanowska. Assessment of exogenous melatonin action on mouse liver cells after exposure to soman.
Environmental toxicology and pharmacology.
2018 Dec; 64(?):147-154. doi:
10.1016/j.etap.2018.10.007. [PMID: 30391876] - Brenda Marrero-Rosado, Marcio de Araujo Furtado, Caroline R Schultz, Michael Stone, Erica Kundrick, Katie Walker, Sean O'Brien, Fu Du, Lucille A Lumley. Soman-induced status epilepticus, epileptogenesis, and neuropathology in carboxylesterase knockout mice treated with midazolam.
Epilepsia.
2018 12; 59(12):2206-2218. doi:
10.1111/epi.14582. [PMID: 30368799] - Derese Getnet, Aarti Gautam, Raina Kumar, Allison Hoke, Amrita K Cheema, Franco Rossetti, Caroline R Schultz, Rasha Hammamieh, Lucille A Lumley, Marti Jett. Poisoning with Soman, an Organophosphorus Nerve Agent, Alters Fecal Bacterial Biota and Urine Metabolites: a Case for Novel Signatures for Asymptomatic Nerve Agent Exposure.
Applied and environmental microbiology.
2018 11; 84(21):. doi:
10.1128/aem.00978-18. [PMID: 30217846] - Emily N Dunn, Teresa M Ferrara-Bowens, Mark E Chachich, Cary L Honnold, Cristin C Rothwell, Heidi M Hoard-Fruchey, Catherine A Lesyna, Erik A Johnson, Douglas M Cerasoli, John H McDonough, C Linn Cadieux. Evaluating mice lacking serum carboxylesterase as a behavioral model for nerve agent intoxication.
Toxicology mechanisms and methods.
2018 Oct; 28(8):563-572. doi:
10.1080/15376516.2018.1476637. [PMID: 29768075] - M E Price, C L Whitmore, J E H Tattersall, A C Green, H Rice. Efficacy of the antinicotinic compound MB327 against soman poisoning - Importance of experimental end point.
Toxicology letters.
2018 Sep; 293(?):167-171. doi:
10.1016/j.toxlet.2017.11.006. [PMID: 29127032] - Harri Koskela, Boban Andjelkovic, Annette Pettersson, Marja-Leena Rapinoja, Marja-Leena Kuitunen, Paula Vanninen. pH-Dependent Piecewise Linear Correlation of 1H,31P Chemical Shifts: Application in NMR Identification of Nerve Agent Metabolites in Urine Samples.
Analytical chemistry.
2018 07; 90(14):8495-8500. doi:
10.1021/acs.analchem.8b01308. [PMID: 29888904] - Jin Young Lee, Changhwan Kim, Yong Han Lee. Simultaneous Time-concentration Analysis of Soman and VX Adducts to Butyrylcholinesterase and Albumin by LC-MS-MS.
Journal of analytical toxicology.
2018 Jun; 42(5):293-299. doi:
10.1093/jat/bkx066. [PMID: 29618078] - David E Lenz, Douglas Cerasoli, Donald M Maxwell. Radiolabelled soman binding to sera from Rats, Guinea Pigs and Monkeys.
Toxicology letters.
2018 Feb; 283(?):86-90. doi:
10.1016/j.toxlet.2017.11.016. [PMID: 29155040] - Maud Bonichon, Valentina Valbi, Audrey Combès, Charlotte Desoubries, Anne Bossée, Valérie Pichon. Online coupling of immunoextraction, digestion, and microliquid chromatography-tandem mass spectrometry for the analysis of sarin and soman-butyrylcholinesterase adducts in human plasma.
Analytical and bioanalytical chemistry.
2018 Jan; 410(3):1039-1051. doi:
10.1007/s00216-017-0640-z. [PMID: 28971225] - P Kumar, D Swami, D P Nagar, K P Singh, J Acharya, H N Karade, R Yadav. In vivo protection studies of bis-quaternary 2-(hydroxyimino)- N-(pyridin-3-yl) acetamide derivatives (HNK oximes) against tabun and soman poisoning in Swiss albino mice.
Human & experimental toxicology.
2017 Dec; 36(12):1270-1285. doi:
10.1177/0960327116685888. [PMID: 28078916] - Timur Baygildiev, Alexandra Zatirakha, Igor Rodin, Arkady Braun, Andrey Stavrianidi, Nadezhda Koryagina, Igor Rybalchenko, Oleg Shpigun. Rapid IC-MS/MS determination of methylphosphonic acid in urine of rats exposed to organophosphorus nerve agents.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Jul; 1058(?):32-39. doi:
10.1016/j.jchromb.2017.05.005. [PMID: 28531843] - Marloes J A Joosen, Stefanie M Vester, Jouk Hamelink, Steven D Klaassen, Roland M van den Berg. Increasing nerve agent treatment efficacy by P-glycoprotein inhibition.
Chemico-biological interactions.
2016 Nov; 259(Pt B):115-121. doi:
10.1016/j.cbi.2016.06.012. [PMID: 27287416] - Valentina Bušić, Maja Katalinić, Goran Šinko, Zrinka Kovarik, Dajana Gašo-Sokač. Pyridoxal oxime derivative potency to reactivate cholinesterases inhibited by organophosphorus compounds.
Toxicology letters.
2016 Nov; 262(?):114-122. doi:
10.1016/j.toxlet.2016.09.015. [PMID: 27693733] - Chang-Cai Liu, Gui-Lan Huang, Hai-Ling Xi, Shi-Lei Liu, Jing-Quan Liu, Hui-Lan Yu, Shi-Kun Zhou, Long-Hui Liang, Ling Yuan. Simultaneous quantification of soman and VX adducts to butyrylcholinesterase, their aged methylphosphonic acid adduct and butyrylcholinesterase in plasma using an off-column procainamide-gel separation method combined with UHPLC-MS/MS.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2016 Nov; 1036-1037(?):57-65. doi:
10.1016/j.jchromb.2016.09.044. [PMID: 27718463] - Amanda S Appel, John H McDonough, Joseph D McMonagle, Brian A Logue. Analysis of Nerve Agent Metabolites from Hair for Long-Term Verification of Nerve Agent Exposure.
Analytical chemistry.
2016 06; 88(12):6523-30. doi:
10.1021/acs.analchem.6b01274. [PMID: 27161086] - T M Baygildiev, I A Rodin, A N Stavrianidi, A V Braun, A T Lebedev, I V Rybalchenko, O A Shpigun. Hydrophilic interaction liquid chromatography-tandem mass spectrometry methylphosponic and alkyl methylphosphonic acids determination in environmental samples after pre-column derivatization with p-bromophenacyl bromide.
Journal of chromatography. A.
2016 Apr; 1442(?):19-25. doi:
10.1016/j.chroma.2016.03.001. [PMID: 26965649] - Matthew E Price, Cerys J Docx, Helen Rice, Sarah J Fairhall, Sarah J C Poole, Michael Bird, Luke Whiley, Daniel P Flint, A Christopher Green, Christopher M Timperley, John E H Tattersall. Pharmacokinetic profile and quantitation of protection against soman poisoning by the antinicotinic compound MB327 in the guinea-pig.
Toxicology letters.
2016 Feb; 244(?):154-160. doi:
10.1016/j.toxlet.2015.08.013. [PMID: 26325216] - Stephen D Kirby, Joseph Norris, Richard Sweeney, Brian J Bahnson, Douglas M Cerasoli. A rationally designed mutant of plasma platelet-activating factor acetylhydrolase hydrolyzes the organophosphorus nerve agent soman.
Biochimica et biophysica acta.
2015 Dec; 1854(12):1809-1815. doi:
10.1016/j.bbapap.2015.09.001. [PMID: 26343853] - Brian S Crow, Brooke G Pantazides, Jennifer Quiñones-González, Joshua W Garton, Melissa D Carter, Jonas W Perez, Caroline M Watson, Dennis J Tomcik, Michael D Crenshaw, Bobby N Brewer, James R Riches, Sarah J Stubbs, Robert W Read, Ronald A Evans, Jerry D Thomas, Thomas A Blake, Rudolph C Johnson. Simultaneous measurement of tabun, sarin, soman, cyclosarin, VR, VX, and VM adducts to tyrosine in blood products by isotope dilution UHPLC-MS/MS.
Analytical chemistry.
2014 Oct; 86(20):10397-405. doi:
10.1021/ac502886c. [PMID: 25286390] - D A Belinskaia, V I Shmurak, D S Prokof'eva, N V Goncharov. [Serum albumin: search for new sites with esterase activity according to molecular modeling data].
Bioorganicheskaia khimiia.
2014 Sep; 40(5):541-9. doi:
. [PMID: 25895349] - Ying Lin, Jia Chen, Long Yan, Lei Guo, Bidong Wu, Chunzheng Li, Jianlin Feng, Qin Liu, Jianwei Xie. Determination of nerve agent metabolites in human urine by isotope-dilution gas chromatography-tandem mass spectrometry after solid phase supported derivatization.
Analytical and bioanalytical chemistry.
2014 Aug; 406(21):5213-20. doi:
10.1007/s00216-014-7695-x. [PMID: 24633564] - Elizabeth I Hamelin, Nicholas D Schulze, Rebecca L Shaner, Rebecca M Coleman, Richard J Lawrence, Brian S Crow, E M Jakubowski, Rudolph C Johnson. Quantitation of five organophosphorus nerve agent metabolites in serum using hydrophilic interaction liquid chromatography and tandem mass spectrometry.
Analytical and bioanalytical chemistry.
2014 Aug; 406(21):5195-202. doi:
10.1007/s00216-014-7702-2. [PMID: 24633507] - S Graziani, D Christin, S Daulon, P Breton, N Perrier, L Taysse. Effects of repeated low-dose exposure of the nerve agent VX on monoamine levels in different brain structures in mice.
Neurochemical research.
2014 May; 39(5):911-21. doi:
10.1007/s11064-014-1286-2. [PMID: 24676701] - Golime RamaRao, Prachiti Afley, Jyothiranjan Acharya, Bijoy Krishna Bhattacharya. Efficacy of antidotes (midazolam, atropine and HI-6) on nerve agent induced molecular and neuropathological changes.
BMC neuroscience.
2014 Apr; 15(?):47. doi:
10.1186/1471-2202-15-47. [PMID: 24708580] - Timo Wille, Horst Thiermann, Franz Worek. In vitro kinetics of nerve agent degradation by fresh frozen plasma (FFP).
Archives of toxicology.
2014 Feb; 88(2):301-7. doi:
10.1007/s00204-013-1130-5. [PMID: 24057572] - Naama Hen, Tawfeeq Shekh-Ahmad, Boris Yagen, John H McDonough, Richard H Finnell, Bogdan Wlodarczyk, Meir Bialer. Stereoselective pharmacodynamic and pharmacokinetic analysis of sec-Butylpropylacetamide (SPD), a new CNS-active derivative of valproic acid with unique activity against status epilepticus.
Journal of medicinal chemistry.
2013 Aug; 56(16):6467-77. doi:
10.1021/jm4007565. [PMID: 23879329] - Elizabeth I Hamelin, William Bragg, Rebecca L Shaner, Leigh L Swaim, Rudolph C Johnson. Comparison of high-resolution and tandem mass spectrometry for the analysis of nerve agent metabolites in urine.
Rapid communications in mass spectrometry : RCM.
2013 Aug; 27(15):1697-704. doi:
10.1002/rcm.6621. [PMID: 23821563] - Robert VanDine, Uma Mahesh Babu, Peter Condon, Arlene Mendez, Robert Sambursky. A 10-minute point-of-care assay for detection of blood protein adducts resulting from low level exposure to organophosphate nerve agents.
Chemico-biological interactions.
2013 Mar; 203(1):108-12. doi:
10.1016/j.cbi.2012.11.011. [PMID: 23200942] - Wei Sun, Chunyuan Luo, Prasanthi Tipparaju, Bhupendra P Doctor, Ashima Saxena. Effect of polyethylene glycol conjugation on the circulatory stability of plasma-derived human butyrylcholinesterase in mice.
Chemico-biological interactions.
2013 Mar; 203(1):172-6. doi:
10.1016/j.cbi.2012.11.021. [PMID: 23220586] - Lakshmi Chandrasekaran, Tatyana Belinskaya, Ashima Saxena. In vitro characterization of organophosphorus compound hydrolysis by native and recombinant human prolidase.
Toxicology in vitro : an international journal published in association with BIBRA.
2013 Feb; 27(1):499-506. doi:
10.1016/j.tiv.2012.05.012. [PMID: 22677456] - Charlotte Desoubries, Florence Chapuis-Hugon, Anne Bossée, Valérie Pichon. Three-phase hollow fiber liquid-phase microextraction of organophosphorous nerve agent degradation products from complex samples.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2012 Jul; 900(?):48-58. doi:
10.1016/j.jchromb.2012.05.029. [PMID: 22705170] - Manojkumar Valiyaveettil, Yonas A Alamneh, Bhupendra P Doctor, Madhusoodana P Nambiar. Crossroads in the evaluation of paraoxonase 1 for protection against nerve agent and organophosphate toxicity.
Toxicology letters.
2012 Apr; 210(1):87-94. doi:
10.1016/j.toxlet.2012.01.013. [PMID: 22301377] - Yi Bao, Qin Liu, Jia Chen, Ying Lin, Bidong Wu, Jianwei Xie. Quantification of nerve agent adducts with albumin in rat plasma using liquid chromatography-isotope dilution tandem mass spectrometry.
Journal of chromatography. A.
2012 Mar; 1229(?):164-71. doi:
10.1016/j.chroma.2012.01.032. [PMID: 22305360] - Frank Zydel, J Richard Smith, Vincent S Pagnotti, Richard J Lawrence, Charles N McEwen, Benedict R Capacio. Rapid screening of chemical warfare nerve agent metabolites in urine by atmospheric solids analysis probe-mass spectroscopy (ASAP-MS).
Drug testing and analysis.
2012 Mar; 4(3-4):308-11. doi:
10.1002/dta.1331. [PMID: 22383148] - Ellen G Duysen, John R Cashman, Lawrence M Schopfer, Florian Nachon, Patrick Masson, Oksana Lockridge. Differential sensitivity of plasma carboxylesterase-null mice to parathion, chlorpyrifos and chlorpyrifos oxon, but not to diazinon, dichlorvos, diisopropylfluorophosphate, cresyl saligenin phosphate, cyclosarin thiocholine, tabun thiocholine, and carbofuran.
Chemico-biological interactions.
2012 Feb; 195(3):189-98. doi:
10.1016/j.cbi.2011.12.006. [PMID: 22209767] - Michael Costante, Lionel Biggemann, Yonas Alamneh, Iswarduth Soojhawon, Radley Short, Savita Nigam, Gregory Garcia, Bhupendra P Doctor, Manojkumar Valiyaveettil, Madhusoodana P Nambiar. Hydrolysis potential of recombinant human skin and kidney prolidase against diisopropylfluorophosphate and sarin by in vitro analysis.
Toxicology in vitro : an international journal published in association with BIBRA.
2012 Feb; 26(1):182-8. doi:
10.1016/j.tiv.2011.11.006. [PMID: 22120822] - Dimo Dimov, Kamen Kanev, Ivanka Dimova. Correlation between butyrylcholinesterase variants and sensitivity to soman toxicity.
Acta biochimica Polonica.
2012; 59(2):313-6. doi:
. [PMID: 22696303] - Helle R Andersen, Christine Wohlfahrt-Veje, Christine Dalgård, Lene Christiansen, Katharina M Main, Christine Nellemann, Katsuyuki Murata, Tina K Jensen, Niels E Skakkebæk, Philippe Grandjean. Paraoxonase 1 polymorphism and prenatal pesticide exposure associated with adverse cardiovascular risk profiles at school age.
PloS one.
2012; 7(5):e36830. doi:
10.1371/journal.pone.0036830. [PMID: 22615820] - H Steve White, Anitha B Alex, Amanda Pollock, Naama Hen, Tawfeeq Shekh-Ahmad, Karen S Wilcox, John H McDonough, James P Stables, Dan Kaufmann, Boris Yagen, Meir Bialer. A new derivative of valproic acid amide possesses a broad-spectrum antiseizure profile and unique activity against status epilepticus and organophosphate neuronal damage.
Epilepsia.
2012 Jan; 53(1):134-46. doi:
10.1111/j.1528-1167.2011.03338.x. [PMID: 22150444] - Jordi Camps, Anabel García-Heredia, Anna Rull, Carlos Alonso-Villaverde, Gerard Aragonès, Raúl Beltrán-Debón, Esther Rodríguez-Gallego, Jorge Joven. PPARs in Regulation of Paraoxonases: Control of Oxidative Stress and Inflammation Pathways.
PPAR research.
2012; 2012(?):616371. doi:
10.1155/2012/616371. [PMID: 22315585] - G RamaRao, B K Bhattacharya, Subodh Kumar, C K Waghmare. Gene expression and phosphoprotein profile of certain key neuronal signaling proteins following soman intoxication.
Toxicology.
2011 Dec; 290(2-3):195-202. doi:
10.1016/j.tox.2011.09.005. [PMID: 21971501] - Ming-Tsung Lee, Aleksey Vishnyakov, Gennady Yu Gor, Alexander V Neimark. Interactions of phosphororganic agents with water and components of polyelectrolyte membranes.
The journal of physical chemistry. B.
2011 Nov; 115(46):13617-23. doi:
10.1021/jp207469h. [PMID: 21988501] - Ellen G Duysen, Frank Koentgen, Gareth R Williams, Christopher M Timperley, Lawrence M Schopfer, Douglas M Cerasoli, Oksana Lockridge. Production of ES1 plasma carboxylesterase knockout mice for toxicity studies.
Chemical research in toxicology.
2011 Nov; 24(11):1891-8. doi:
10.1021/tx200237a. [PMID: 21875074] - Marloes J A Joosen, Marcel J van der Schans, Christian G M van Dijk, Willem C Kuijpers, Heleen M Wortelboer, Herman P M van Helden. Increasing oxime efficacy by blood-brain barrier modulation.
Toxicology letters.
2011 Sep; 206(1):67-71. doi:
10.1016/j.toxlet.2011.05.231. [PMID: 21600273] - Rory Cochran, Jaroslaw Kalisiak, Tuba Küçükkilinç, Zoran Radic, Edzna Garcia, Limin Zhang, Kwok-Yiu Ho, Gabriel Amitai, Zrinka Kovarik, Valery V Fokin, K Barry Sharpless, Palmer Taylor. Oxime-assisted acetylcholinesterase catalytic scavengers of organophosphates that resist aging.
The Journal of biological chemistry.
2011 Aug; 286(34):29718-24. doi:
10.1074/jbc.m111.264739. [PMID: 21730071] - Golime RamaRao, Chandrakant Waghmare, Arvind Kumar Gupta, Bijoy Krishna Bhattacharya. Soman-induced alterations of protein kinase C isozymes expression in five discrete areas of the rat brain.
Drug and chemical toxicology.
2011 Jul; 34(3):221-32. doi:
10.3109/01480545.2010.511647. [PMID: 21649475] - Miroslav Pohanka, Ladislav Novotny, Jana Zdarova-Karasova, Hana Bandouchova, Filip Zemek, Martina Hrabinova, Jan Misik, Kamil Kuca, Jiri Bajgar, Ondrej Zitka, Natalia Cernei, Rene Kizek, Jiri Pikula. Asoxime (HI-6) impact on dogs after one and tenfold therapeutic doses: assessment of adverse effects, distribution, and oxidative stress.
Environmental toxicology and pharmacology.
2011 Jul; 32(1):75-81. doi:
10.1016/j.etap.2011.03.014. [PMID: 21787733] - Kuntal Bhattacharyya, Sibaji Phaujdar, Rathindranath Sarkar, Omar S Mullick. Serum creatine phosphokinase: a probable marker of severity in organophosphorus poisoning.
Toxicology international.
2011 Jul; 18(2):117-23. doi:
10.4103/0971-6580.84263. [PMID: 21976816] - Golime RamaRao, J N Acharya, B K Bhattacharya. Changes of protein oxidation, calpain and cytoskeletal proteins (alpha tubulin and pNF-H) levels in rat brain after nerve agent poisoning.
Toxicology letters.
2011 Jun; 203(3):227-36. doi:
10.1016/j.toxlet.2011.03.020. [PMID: 21439362] - Sang-Yong Eom, Yun-Sik Kim, Chung-Jong Lee, Chul-Ho Lee, Yong-Dae Kim, Heon Kim. Effects of intronic and exonic polymorphisms of paraoxonase 1 (PON1) gene on serum PON1 activity in a Korean population.
Journal of Korean medical science.
2011 Jun; 26(6):720-5. doi:
10.3346/jkms.2011.26.6.720. [PMID: 21655055] - G Ramarao, Ck Waghmare, Nalini Srivastava, Bk Bhattacharya. Regional alterations of JNK3 and CaMKIIα subunit expression in the rat brain after soman poisoning.
Human & experimental toxicology.
2011 Jun; 30(6):448-59. doi:
10.1177/0960327110386814. [PMID: 21041242] - Manojkumar Valiyaveettil, Yonas Alamneh, Peter Rezk, Lionel Biggemann, Michael W Perkins, Alfred M Sciuto, Bhupendra P Doctor, Madhusoodana P Nambiar. Protective efficacy of catalytic bioscavenger, paraoxonase 1 against sarin and soman exposure in guinea pigs.
Biochemical pharmacology.
2011 Mar; 81(6):800-9. doi:
10.1016/j.bcp.2010.12.024. [PMID: 21219877] - Kian Loong Lim, Annie Tay, Vishna Devi Nadarajah, Nilesh Kumar Mitra. The effect of consequent exposure of stress and dermal application of low doses of chlorpyrifos on the expression of glial fibrillary acidic protein in the hippocampus of adult mice.
Journal of occupational medicine and toxicology (London, England).
2011 Mar; 6(1):4. doi:
10.1186/1745-6673-6-4. [PMID: 21385392] - Daquan Chen, Wanhui Liu, Yan Shen, Hongjie Mu, Yanchun Zhang, Rongcai Liang, Aiping Wang, Kaoxiang Sun, Fenghua Fu. Effects of a novel pH-sensitive liposome with cleavable esterase-catalyzed and pH-responsive double smart mPEG lipid derivative on ABC phenomenon.
International journal of nanomedicine.
2011; 6(?):2053-61. doi:
10.2147/ijn.s24344. [PMID: 21976980] - Ashima Saxena, Wei Sun, James M Fedorko, Irwin Koplovitz, Bhupendra P Doctor. Prophylaxis with human serum butyrylcholinesterase protects guinea pigs exposed to multiple lethal doses of soman or VX.
Biochemical pharmacology.
2011 Jan; 81(1):164-9. doi:
10.1016/j.bcp.2010.09.007. [PMID: 20846507] - Matthew W Peterson, Steven Z Fairchild, Tamara C Otto, Mojdeh Mohtashemi, Douglas M Cerasoli, Wenling E Chang. VX hydrolysis by human serum paraoxonase 1: a comparison of experimental and computational results.
PloS one.
2011; 6(5):e20335. doi:
10.1371/journal.pone.0020335. [PMID: 21655255] - M Pohanka, J Pikula, K Kuca, J Kassa. Biochemical insight into soman intoxication and treatment with atropine, HI-6, trimedoxime, and K203 in a rat model.
Bratislavske lekarske listy.
2011; 112(10):539-44. doi:
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PloS one.
2011; 6(5):e17805. doi:
10.1371/journal.pone.0017805. [PMID: 21629682] - Manojkumar Valiyaveettil, Yonas Alamneh, Lionel Biggemann, Iswarduth Soojhawon, Bhupendra P Doctor, Madhusoodana P Nambiar. Efficient hydrolysis of the chemical warfare nerve agent tabun by recombinant and purified human and rabbit serum paraoxonase 1.
Biochemical and biophysical research communications.
2010 Dec; 403(1):97-102. doi:
10.1016/j.bbrc.2010.10.125. [PMID: 21040699] - Sylvia Wagner, Jürgen Kufleitner, Anja Zensi, Miriam Dadparvar, Sascha Wien, Judith Bungert, Tikva Vogel, Franz Worek, Jörg Kreuter, Hagen von Briesen. Nanoparticulate transport of oximes over an in vitro blood-brain barrier model.
PloS one.
2010 Dec; 5(12):e14213. doi:
10.1371/journal.pone.0014213. [PMID: 21151975] - Harald John, Felicitas Breyer, Jörg Oliver Thumfart, Hans Höchstetter, Horst Thiermann. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for detection and identification of albumin phosphylation by organophosphorus pesticides and G- and V-type nerve agents.
Analytical and bioanalytical chemistry.
2010 Nov; 398(6):2677-91. doi:
10.1007/s00216-010-4076-y. [PMID: 20730528] - James C Demar, Edward D Clarkson, Ruthie H Ratcliffe, Amy J Campbell, Sonia G Thangavelu, Christine A Herdman, Haim Leader, Susan M Schulz, Elizabeth Marek, Marie A Medynets, Therese C Ku, Sarah A Evans, Farhat A Khan, Roberta R Owens, Madhusoodana P Nambiar, Richard K Gordon. Pro-2-PAM therapy for central and peripheral cholinesterases.
Chemico-biological interactions.
2010 Sep; 187(1-3):191-8. doi:
10.1016/j.cbi.2010.02.015. [PMID: 20156430] - Dragomir I Draganov. Lactonases with organophosphatase activity: structural and evolutionary perspectives.
Chemico-biological interactions.
2010 Sep; 187(1-3):370-2. doi:
10.1016/j.cbi.2010.01.039. [PMID: 20122908] - Sunhee Shin, Seong Soo Joo, Dongsun Park, Jeong Hee Jeon, Tae Kyun Kim, Jeong Seon Kim, Sung Kyeong Park, Bang Yeon Hwang, Yun-Bae Kim. Ethanol extract of Angelica gigas inhibits croton oil-induced inflammation by suppressing the cyclooxygenase - prostaglandin pathway.
Journal of veterinary science.
2010 Mar; 11(1):43-50. doi:
10.4142/jvs.2010.11.1.43. [PMID: 20195064] - Maja Jelena Petek, Ana Lucić Vrdoljak, Gordan Mrsić. Qualitative GC-MS assessment of TCP and TAMORF elimination in rats.
Arhiv za higijenu rada i toksikologiju.
2010 Mar; 61(1):61-7. doi:
10.2478/10004-1254-61-2010-1985. [PMID: 20338869] - Jean-Marc Collombet, Mikael Elias, Guillaume Gotthard, Elise Four, Frédérique Renault, Aurélie Joffre, Dominique Baubichon, Daniel Rochu, Eric Chabrière. Eukaryotic DING proteins are endogenous: an immunohistological study in mouse tissues.
PloS one.
2010 Feb; 5(2):e9099. doi:
10.1371/journal.pone.0009099. [PMID: 20161715] - Robert W Read, James R Riches, Jacqueline A Stevens, Sarah J Stubbs, Robin M Black. Biomarkers of organophosphorus nerve agent exposure: comparison of phosphylated butyrylcholinesterase and phosphylated albumin after oxime therapy.
Archives of toxicology.
2010 Jan; 84(1):25-36. doi:
10.1007/s00204-009-0473-4. [PMID: 19862504] - Florian Eyer, Darren M Roberts, Nicholas A Buckley, Michael Eddleston, Horst Thiermann, Franz Worek, Peter Eyer. Extreme variability in the formation of chlorpyrifos oxon (CPO) in patients poisoned by chlorpyrifos (CPF).
Biochemical pharmacology.
2009 Sep; 78(5):531-7. doi:
10.1016/j.bcp.2009.05.004. [PMID: 19433070] - Nageswararao Chilukuri, Ellen G Duysen, Kalpana Parikh, Robert diTargiani, Bhupendra P Doctor, Oksana Lockridge, Ashima Saxena. Adenovirus-transduced human butyrylcholinesterase in mouse blood functions as a bioscavenger of chemical warfare nerve agents.
Molecular pharmacology.
2009 Sep; 76(3):612-7. doi:
10.1124/mol.109.055665. [PMID: 19542320] - Jana Zdarova Karasova, Jiri Kassa, Kamil Musilek, Miroslav Pohanka, Ladislav Novotny, Kamil Kuca. Effect of seven newly synthesized and currently available oxime cholinesterase reactivators on cyclosarin-intoxicated rats.
International journal of molecular sciences.
2009 Jul; 10(7):3065-75. doi:
10.3390/ijms10073065. [PMID: 19742125] - Tobias Kurth, Paul E de Jong, Nancy R Cook, Julie E Buring, Paul M Ridker. Kidney function and risk of cardiovascular disease and mortality in women: a prospective cohort study.
BMJ (Clinical research ed.).
2009 Jun; 338(?):b2392. doi:
10.1136/bmj.b2392. [PMID: 19564178] - Peiyuan Jia, Yuxia Wang, Ming Yu, Junhua Wu, Rifang Yang, Yu Zhao, Lijun Zhou. An organophosphorus hapten used in the preparation of monoclonal antibody and as an active immunization vaccine in the detoxication of soman poisoning.
Toxicology letters.
2009 May; 187(1):45-51. doi:
10.1016/j.toxlet.2009.01.029. [PMID: 19429243] - N Aurbek, H Thiermann, F Eyer, P Eyer, F Worek. Suitability of human butyrylcholinesterase as therapeutic marker and pseudo catalytic scavenger in organophosphate poisoning: a kinetic analysis.
Toxicology.
2009 May; 259(3):133-9. doi:
10.1016/j.tox.2009.02.014. [PMID: 19428953] - Patrick Masson, Daniel Rochu. Catalytic bioscavengers against toxic esters, an alternative approach for prophylaxis and treatments of poisonings.
Acta naturae.
2009 Apr; 1(1):68-79. doi:
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Neurotoxicology and teratology.
2009 Mar; 31(2):110-8. doi:
10.1016/j.ntt.2008.10.003. [PMID: 19026741] - William P Fawcett, Yasco Aracava, Michael Adler, Edna F R Pereira, Edson X Albuquerque. Acute toxicity of organophosphorus compounds in guinea pigs is sex- and age-dependent and cannot be solely accounted for by acetylcholinesterase inhibition.
The Journal of pharmacology and experimental therapeutics.
2009 Feb; 328(2):516-24. doi:
10.1124/jpet.108.146639. [PMID: 18984651] - Mieko Kanamori-Kataoka, Yasuo Seto. Paraoxonase activity against nerve gases measured by capillary electrophoresis and characterization of human serum paraoxonase (PON1) polymorphism in the coding region (Q192R).
Analytical biochemistry.
2009 Feb; 385(1):94-100. doi:
10.1016/j.ab.2008.09.044. [PMID: 18952040] - Ryan R Woods, Brian C Geyer, Tsafrir S Mor. Hairy-root organ cultures for the production of human acetylcholinesterase.
BMC biotechnology.
2008 Dec; 8(?):95. doi:
10.1186/1472-6750-8-95. [PMID: 19105816] - Jana Zdarova Karasova, Jiri Kassa, Young-Sik Jung, Kamil Musilek, Miroslav Pohanka, Kamil Kuca. Effect of several new and currently available oxime cholinesterase reactivators on tabun-intoxicated rats.
International journal of molecular sciences.
2008 Nov; 9(11):2243-52. doi:
10.3390/ijms9112243. [PMID: 19330072] - Leigh L Swaim, Rudolph C Johnson, Yingtao Zhou, Chris Sandlin, John R Barr. Quantification of organophosphorus nerve agent metabolites using a reduced-volume, high-throughput sample processing format and liquid chromatography-tandem mass spectrometry.
Journal of analytical toxicology.
2008 Nov; 32(9):774-7. doi:
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Protein expression and purification.
2008 Oct; 61(2):191-6. doi:
10.1016/j.pep.2008.05.021. [PMID: 18602477] - Wei Sun, Bhupendra P Doctor, David E Lenz, Ashima Saxena. Long-term effects of human butyrylcholinesterase pretreatment followed by acute soman challenge in cynomolgus monkeys.
Chemico-biological interactions.
2008 Sep; 175(1-3):428-30. doi:
10.1016/j.cbi.2008.04.036. [PMID: 18674756] - He Li, Larry Tong, Lawrence M Schopfer, Patrick Masson, Oksana Lockridge. Fast affinity purification coupled with mass spectrometry for identifying organophosphate labeled plasma butyrylcholinesterase.
Chemico-biological interactions.
2008 Sep; 175(1-3):68-72. doi:
10.1016/j.cbi.2008.04.027. [PMID: 18586231] - Julian R Haigh, Scott R Johnston, Adam Peppernay, Patrick J Mattern, Gregory E Garcia, Bhupendra P Doctor, Richard K Gordon, Paul S Aisen. Protection of red blood cell acetylcholinesterase by oral huperzine A against ex vivo soman exposure: next generation prophylaxis and sequestering of acetylcholinesterase over butyrylcholinesterase.
Chemico-biological interactions.
2008 Sep; 175(1-3):380-6. doi:
10.1016/j.cbi.2008.04.033. [PMID: 18572153] - Julian R Haigh, Lee J Lefkowitz, Benedict R Capacio, Bhupendra P Doctor, Richard K Gordon. Advantages of the WRAIR whole blood cholinesterase assay: comparative analysis to the micro-Ellman, Test-mate ChE, and Michel (DeltapH) assays.
Chemico-biological interactions.
2008 Sep; 175(1-3):417-20. doi:
10.1016/j.cbi.2008.04.032. [PMID: 18555983] - M Mastorikou, B Mackness, Y Liu, M Mackness. Glycation of paraoxonase-1 inhibits its activity and impairs the ability of high-density lipoprotein to metabolize membrane lipid hydroperoxides.
Diabetic medicine : a journal of the British Diabetic Association.
2008 Sep; 25(9):1049-55. doi:
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