PPY 12 (BioDeep_00001867625)
Main id: BioDeep_00000003040
代谢物信息卡片
PYRROLE
化学式: C4H5N (67.0422)
中文名称: 聚吡咯, 吡咯
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1=CNC=C1
InChI: InChI=1S/C4H5N/c1-2-4-5-3-1/h1-5H
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:19203
- ChEBI: CHEBI:35556
- KEGG: C19907
- PubChem: 8027
- ChEMBL: CHEMBL16225
- MeSH: Pyrroles
- CAS: 107760-17-8
- CAS: 26120-22-9
- CAS: 30604-81-0
- CAS: 109-97-7
- PubChem: 135626373
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
4 个相关的物种来源信息
- 13443 - Coffea arabica: 10.1021/JF60160A010
- 55513 - Pistacia vera: 10.1080/10412905.1995.9698558
- 58860 - Tamarindus indica: 10.1080/10412905.1990.9697860
- 4577 - Zea mays: 10.1021/JF60220A012
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Loan Thi Thanh Nguyen, Ae Ran Park, Ve Van Le, Inmin Hwang, Jin-Cheol Kim. Exploration of a multifunctional biocontrol agent Streptomyces sp. JCK-8055 for the management of apple fire blight.
Applied microbiology and biotechnology.
2024 Dec; 108(1):49. doi:
10.1007/s00253-023-12874-w. [PMID: 38183485] - Xiang-Bo Zeng, Fa-Wen Yin, Guan-Hua Zhao, Chao Guo, De-Yang Li, Hui-Lin Liu, Lei Qin, Fereidoon Shahidi, Da-Yong Zhou. Mechanism of color change in Antarctic krill oil during storage.
Food chemistry.
2024 Jun; 444(?):138583. doi:
10.1016/j.foodchem.2024.138583. [PMID: 38309082] - Xiaoming Xu, Jing Feng, Yuying Cui, Pingjiang Li, Jianjun Dong, Lin Liao. Renal effects and safety between Asian and non-Asian chronic kidney disease and type 2 diabetes treated with nonsteroidal mineralocorticoid antagonists.
Journal of diabetes.
2024 Jun; 16(6):e13566. doi:
10.1111/1753-0407.13566. [PMID: 38753662] - Baojun Su, Gaowu Huang, Shanshan Zhu, Yaqi Wang, Qian Lan, Yue Hou, Dong Liang. N-Cinnamoylpyrrole-derived alkaloids from the genus Piper as promising agents for ischemic stroke by targeting eEF1A1.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155455. doi:
10.1016/j.phymed.2024.155455. [PMID: 38513376] - Devaraj Ezhilarasan. Deciphering the molecular pathways of saroglitazar: A dual PPAR α/γ agonist for managing metabolic NAFLD.
Metabolism: clinical and experimental.
2024 Jun; 155(?):155912. doi:
10.1016/j.metabol.2024.155912. [PMID: 38609038] - Yue Zhang, Jing Li, Hongwei Yang, Kun Li, Haolin Yuan, Ziqiao Xue, Liangfu Tang, Zhijin Fan. Fungicidal Activity of New Pyrrolo[2,3-d]thiazoles and Their Potential Action on the Tryptophan Metabolic Pathway and Wax Biosynthesis.
Journal of agricultural and food chemistry.
2024 May; 72(21):11990-12002. doi:
10.1021/acs.jafc.4c00930. [PMID: 38757490] - Haowen Luo, Qianqian Zhang, Rifang Lai, Simin Zhang, Wentao Yi, Xiangru Tang. Regulation of 2-Acetyl-1-pyrroline Content in Fragrant Rice under Different Temperatures at the Grain-Filling Stage.
Journal of agricultural and food chemistry.
2024 May; 72(18):10521-10530. doi:
10.1021/acs.jafc.3c08637. [PMID: 38656141] - Lingling Wei, Bin Chen, Jiawei Li, Pengcheng Zhang, Wenchan Chen, Wenwu Ye, Changjun Chen. Resistance mechanism of Phomopsis longicolla to fludioxonil is associated with modifications in PlOS1, PlOS4 and PlOS5.
Pesticide biochemistry and physiology.
2024 May; 201(?):105862. doi:
10.1016/j.pestbp.2024.105862. [PMID: 38685239] - Qianjun Zhuang, Aijun Liao, Qingling He, Chengxia Liu, Changqing Zheng, Xing Li, Youli Liu, Bangmao Wang, Side Liu, Yan Zhang, Rong Lin, Huixin Chen, Min Deng, Yanping Tang, Chiyi He, Weijie Dai, Haitao Tang, Lei Gong, Liangping Li, Baohong Xu, Changqing Yang, Bingxi Zhou, Dongxing Su, Qinghong Guo, Bin Li, Yongjian Zhou, Xiaoyang Wang, Sujuan Fei, Huili Wu, Sichen Wei, Zhihong Peng, Jianning Wang, Yanqing Li, Hong Wang, Tianwei Deng, Shigang Ding, Fangfang Li, Minhu Chen, Yinglian Xiao. The efficacy and safety of fexuprazan in treating erosive esophagitis: a phase III, randomized, double-blind, multicenter study.
Journal of gastroenterology and hepatology.
2024 Apr; 39(4):658-666. doi:
10.1111/jgh.16471. [PMID: 38251791] - Giuseppe Forlani, Giuseppe Sabbioni, Simone Barera, Dietmar Funck. A complex array of factors regulate the activity of Arabidopsis thaliana δ1 -pyrroline-5-carboxylate synthetase isoenzymes to ensure their specific role in plant cell metabolism.
Plant, cell & environment.
2024 Apr; 47(4):1348-1362. doi:
10.1111/pce.14817. [PMID: 38223941] - Xueru Yin, Pengfei Li, Zongwei Wang, Jing Wang, Anfei Fang, Binnian Tian, Yuheng Yang, Yang Yu, Chaowei Bi. Binding Mode and Molecular Mechanism of the Two-Component Histidine Kinase Bos1 of Botrytis cinerea to Fludioxonil and Iprodione.
Phytopathology.
2024 Apr; 114(4):770-779. doi:
10.1094/phyto-07-23-0241-r. [PMID: 38598410] - Zheng Gang, Yi-Wen Cao, Zi-Ying Zeng, Min Chen, Shu-Tong Yang, Miao-Miao Su, Yun-Liu Zeng, Qin Tian, Zhong-Hua Yang. Application of novel adsorbents synthesized with polypyrrole in magnetic solid-phase extraction of fungicides from fresh juice and environmental water.
Food chemistry.
2024 Mar; 437(Pt 2):137949. doi:
10.1016/j.foodchem.2023.137949. [PMID: 37956595] - Wenhui Liu, Wenzhe Zhang, Chen Wang, Jiarun Song, Kaiyue Li, Xia Zhang, Xinyi Wu, Hui Guo. TRPV4 antagonist suppresses retinal ganglion cell apoptosis by regulating the activation of CaMKII and TNF-α expression in a chronic ocular hypertension rat model.
International immunopharmacology.
2024 Mar; 130(?):111811. doi:
10.1016/j.intimp.2024.111811. [PMID: 38457929] - Burcu Okmen Altas, Cansu Goktas, Guliz Topcu, Nihal Aydogan. Multi-Stimuli-Responsive Tadpole-like Polymer/Lipid Janus Microrobots for Advanced Smart Material Applications.
ACS applied materials & interfaces.
2024 Mar; 16(12):15533-15547. doi:
10.1021/acsami.3c18826. [PMID: 38356451] - Ziyue Wen, Yueqi Zhang, Yun Chen, Youfu Zhao, Wenyong Shao, Zhonghua Ma. Characterization of the fludioxonil and phenamacril dual resistant mutants of Fusarium graminearum.
Pesticide biochemistry and physiology.
2024 Mar; 200(?):105815. doi:
10.1016/j.pestbp.2024.105815. [PMID: 38582573] - Qun Wang, Jinxin Wang, Dianping Yu, Qing Zhang, Hongmei Hu, Mengting Xu, Hongwei Zhang, Saisai Tian, Guangyong Zheng, Dong Lu, Jiajia Hu, Mengmeng Guo, Minchen Cai, Xiangxin Geng, Yanyan Zhang, Jianhua Xia, Xing Zhang, Ang Li, Sanhong Liu, Weidong Zhang. Benzosceptrin C induces lysosomal degradation of PD-L1 and promotes antitumor immunity by targeting DHHC3.
Cell reports. Medicine.
2024 Feb; 5(2):101357. doi:
10.1016/j.xcrm.2023.101357. [PMID: 38237597] - Zhao Ma, Zeyu Qiu, Hongming Li, Long Jiang, Zhen Qian, Bo Yuan, Runlong Hao. Multimedia Mercury Recovery from Coal-Fired Power Plants Utilizing N-Containing Conjugated Polymer Functionalized Fly Ash.
Environmental science & technology.
2024 Feb; 58(5):2574-2583. doi:
10.1021/acs.est.3c08527. [PMID: 38266484] - Ran Sun, Yali Li, Lei Lv, Weiliang Zhang, Xiaoxia Guo. Efficacy and safety of esaxerenone (CS-3150) in primary hypertension: a meta-analysis.
Journal of human hypertension.
2024 Feb; 38(2):102-109. doi:
10.1038/s41371-023-00889-9. [PMID: 38177694] - Harshal V Dhondge, Vitthal T Barvkar, Syed G Dastager, Mahesh S Dharne, Vinay Rajput, Anupama A Pable, Robert J Henry, Altafhusain B Nadaf. Genome sequencing and protein modeling unraveled the 2AP biosynthesis in Bacillus cereus DB25.
International journal of food microbiology.
2024 Jan; 413(?):110600. doi:
10.1016/j.ijfoodmicro.2024.110600. [PMID: 38281435] - Kobra Khodarahmian, Alireza Ghiasvand, Abdullah Barkhordari. Exploring the optimal electropolymerization strategy for the preparation of solid-phase microextraction fibers using pyrrole-dopamine copolymers.
Journal of chromatography. A.
2024 Jan; 1714(?):464562. doi:
10.1016/j.chroma.2023.464562. [PMID: 38065025] - Weichao Ren, Wenjiao Han, Tinghua Huan, Meiqi Zhu, Yihan Zhang, Baohua Li, Na Liu. A new point mutation (D1158N) in histidine kinase Bos1 confers high-level resistance to fludioxonil in field gray mold disease.
Pesticide biochemistry and physiology.
2024 Jan; 198(?):105750. doi:
10.1016/j.pestbp.2023.105750. [PMID: 38225093] - Ahmed E Amer, Hamdy A Ghoneim, Rania R Abdelaziz, George S G Shehatou, Ghada M Suddek. Saroglitazar mitigated NASH-associated hepatic injury in dexamethasone-treated rats via modulating autophagy, apoptosis, and necroptosis.
Toxicology and applied pharmacology.
2024 01; 482(?):116774. doi:
10.1016/j.taap.2023.116774. [PMID: 38040297] - Paolo Raggi, Farzin M Takyar, Varuna Gadiyaram, Chao Zhang, Arthur E Stillman, Amir H Davarpanah. Differential effect of atorvastatin and pravastatin on thoracic spine attenuation: A sub-analysis of a randomized clinical trial.
Atherosclerosis.
2024 Jan; 388(?):117425. doi:
10.1016/j.atherosclerosis.2023.117425. [PMID: 38109819] - GuoTong Sun, XiuWen Liang. Comparison of the efficacy and safety of Shanhuang Jiangzhi tablets and atorvastatin in the treatment of patients with hyperlipidaemia.
Journal of health, population, and nutrition.
2023 Dec; 42(1):143. doi:
10.1186/s41043-023-00482-3. [PMID: 38098069] - Seung-Ah Lee, Soon Jun Hong, Jung-Hoon Sung, Kyung-Soo Kim, Seong Hwan Kim, Jin Man Cho, Sung Wan Chun, Sang Rok Lee, Chul Sik Kim, Tae Nyun Kim, Dae Hyeok Kim, Hwan-Cheol Park, Byung Jin Kim, Hyun-Sook Kim, Ji-Yong Choi, Young Joon Hong, Joong Wha Chung, Seong Bo Yoon, Sang-Hak Lee, Cheol Whan Lee. Effectiveness of low-intensity atorvastatin 5 mg and ezetimibe 10 mg combination therapy compared with moderate-intensity atorvastatin 10 mg monotherapy: A randomized, double-blinded, multi-center, phase III study.
Medicine.
2023 Nov; 102(47):e36122. doi:
10.1097/md.0000000000036122. [PMID: 38013289] - Fengchao Gong, Qian Shi, Xiaojie Mou, Kang Wang, Qianqian Wang, Haitao Wang. Atorvastatin mitigates memory deficits and brain monocyte infiltration in chronic hypercholesterolemia.
Aging.
2023 Nov; 15(23):13669-13679. doi:
10.18632/aging.205217. [PMID: 38048213] - Shanshan Song, Miao Yang, Fei He, Xiao Zhang, Yijun Gao, Baichao An, He Ding, Shili Gai, Piaoping Yang. Multiple therapeutic mechanisms of pyrrolic N-rich g-C3N4 nanosheets with enzyme-like function in the tumor microenvironment.
Journal of colloid and interface science.
2023 Nov; 650(Pt B):1125-1137. doi:
10.1016/j.jcis.2023.06.177. [PMID: 37473473] - Nawab Singh, Raufur Rahman Khan, Weihui Xu, Steven A Whitham, Liang Dong. Plant Virus Sensor for the Rapid Detection of Bean Pod Mottle Virus Using Virus-Specific Nanocavities.
ACS sensors.
2023 10; 8(10):3902-3913. doi:
10.1021/acssensors.3c01478. [PMID: 37738225] - Yao Zheng, Cécile Cabassa-Hourton, Holger Eubel, Guillaume Chevreux, Laurent Lignieres, Emilie Crilat, Hans-Peter Braun, Sandrine Lebreton, Arnould Savouré. Pyrroline-5-carboxylate metabolism protein complex detected in Arabidopsis thaliana leaf mitochondria.
Journal of experimental botany.
2023 Oct; ?(?):. doi:
10.1093/jxb/erad406. [PMID: 37843921] - Qi Wang, Mei-Juan Li, Jia-En Zhang, Zi-Qiang Liu, Kai Yang, Hong-Ru Li, Ming-Zhu Luo. Suitable stocking density of fish in paddy field contributes positively to 2-acetyl-1-pyrroline synthesis in grain and improves rice quality.
Journal of the science of food and agriculture.
2023 Aug; 103(10):5126-5137. doi:
10.1002/jsfa.12597. [PMID: 37005496] - Sanjay Bandyopadhyay, Shambo Samrat Samajdar, Saibal Das. Effects of saroglitazar in the treatment of non-alcoholic fatty liver disease or non-alcoholic steatohepatitis: A systematic review and meta-analysis.
Clinics and research in hepatology and gastroenterology.
2023 08; 47(7):102174. doi:
10.1016/j.clinre.2023.102174. [PMID: 37380128] - Jie He, Yuanyuan Gao, Ge Bai, Jie Wang, Yongshun Sun. Network meta-analysis of multiple doses of vonoprazan for the treatment of erosive esophagitis.
Journal of comparative effectiveness research.
2023 08; 12(8):e220165. doi:
10.57264/cer-2022-0165. [PMID: 37470274] - Punitha Lakxmi Ramesh, Priyanka Khandelwal, R Lakshmy, Aditi Sinha, Arvind Bagga, Pankaj Hari. Short-term safety and efficacy of escalating doses of atorvastatin for dyslipidemia in children with predialysis chronic kidney disease stage 2-5.
Pediatric nephrology (Berlin, Germany).
2023 08; 38(8):2763-2770. doi:
10.1007/s00467-023-05887-0. [PMID: 36780007] - Guodong Fan, Qingyun Wang, Jun Xu, Pengcheng Zheng, Yonggui Robin Chi. Carbene-catalyzed chemoselective reaction of unsymmetric enedials for access to Furo[2,3-b]pyrroles.
Nature communications.
2023 Jul; 14(1):4243. doi:
10.1038/s41467-023-39988-z. [PMID: 37454112] - Tiankuan Li, Zhongqian Hu, Feifei Song, Chenyao Wu, Qizeng Miao, Zhongmin Wang, Wei Feng, Jinhe Guo, Yu Chen. Photonic Hyperthermia Synergizes with Immune-Activators to Augment Tumor-Localized Immunotherapy.
Small methods.
2023 05; 7(5):e2300116. doi:
10.1002/smtd.202300116. [PMID: 37075769] - Hyein Kim, Lina Gu, Huisu Yeo, Umji Choi, Chang-Ro Lee, Haiyang Yu, Sangho Koo. Rapid Assembly of Pyrrole-Ligated 1,3,4-Oxadiazoles and Excellent Antibacterial Activity of Iodophenol Substituents.
Molecules (Basel, Switzerland).
2023 Apr; 28(8):. doi:
10.3390/molecules28083638. [PMID: 37110872] - Bahar Arican Tarim, Francesco Fici, Istemihan Tengiz, Saadet Avunduk, Yurdaer Ozcan, Gokhan Faikoglu, Elif Ari, Nicolás Roberto Robles, Guido Grassi. Do Statins Counteract the Effect of Antidiabetic Drugs? Results of the SCEAD Study.
Yonsei medical journal.
2023 Mar; 64(3):175-180. doi:
10.3349/ymj.2022.0287. [PMID: 36825343] - Juan Jin, Yuhao Xie, Jin-Shi Zhang, Jing-Quan Wang, Shi-Jie Dai, Wen-Fang He, Shou-Ye Li, Charles R Ashby, Zhe-Sheng Chen, Qiang He. Sunitinib resistance in renal cell carcinoma: From molecular mechanisms to predictive biomarkers.
Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy.
2023 Mar; 67(?):100929. doi:
10.1016/j.drup.2023.100929. [PMID: 36739809] - S Y Cai, X Gu, P J Liu, R S Li, J J Jiang, S P Zhao, W Yao, Y N Jiang, Y H Yin, B Yu, Z Y Yuan, J A Wang. [Efficacy and safety of various doses of hybutimibe monotherapy or in combination with atorvastatin for primary hypercholesterolemia: a multicenter, randomized, double-blind, double-dummy, parallel-controlled phase Ⅲ clinical trial].
Zhonghua xin xue guan bing za zhi.
2023 Feb; 51(2):180-187. doi:
10.3760/cma.j.cn112148-20230105-00009. [PMID: 36789598] - Tarcísio Martins Meira, Mateus Matiuzzi da Costa, João José de Simoni Gouveia, Riani Ananda Nunes Soares, Márcio Rennan Santos Tavares, Antônio Wilton Cavalcante Fernandes, Gisele Veneroni Gouveia. Action of crude ethanol extract of Hymenaea martiana leaf, gallic acid, and polypyrrole (PPy) against Aeromonas hydrophila.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology].
2023 Feb; ?(?):. doi:
10.1007/s42770-023-00922-6. [PMID: 36807089] - Amina Ashraf, Ruba Munir, Gadah Albasher, Madiha Ghamkhar, Amna Muneer, Muhammad Yaseen, Tamsal Murtza, Saima Noreen. Utilization of ZnFe2O4-Polyaniline (PANI), ZnFe2O4-Polystyrene (PST), and ZnFe2O4-Polypyrrole (PPy) nanocomposites for removal of Red X-GRL and Direct Sky Blue dyes from wastewater: Equilibrium, kinetic and thermodynamic studies.
Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering.
2023; 58(11):914-934. doi:
10.1080/10934529.2023.2263323. [PMID: 37800681] - Michela Puxeddu, Jianchao Wu, Ruoli Bai, Michele D'Ambrosio, Marianna Nalli, Antonio Coluccia, Simone Manetto, Alessia Ciogli, Domiziana Masci, Andrea Urbani, Cinzia Fionda, Sonia Coni, Rosa Bordone, Gianluca Canettieri, Chiara Bigogno, Giulio Dondio, Ernest Hamel, Te Liu, Romano Silvestri, Giuseppe La Regina. Induction of Ferroptosis in Glioblastoma and Ovarian Cancers by a New Pyrrole Tubulin Assembly Inhibitor.
Journal of medicinal chemistry.
2022 12; 65(23):15805-15818. doi:
10.1021/acs.jmedchem.2c01457. [PMID: 36395526] - Magdalena Kondeva-Burdina, Emilio Mateev, Borislav Angelov, Virginia Tzankova, Maya Georgieva. In Silico Evaluation and In Vitro Determination of Neuroprotective and MAO-B Inhibitory Effects of Pyrrole-Based Hydrazones: A Therapeutic Approach to Parkinson's Disease.
Molecules (Basel, Switzerland).
2022 Dec; 27(23):. doi:
10.3390/molecules27238485. [PMID: 36500572] - María G De Los Santos, Marcos Cua-Basulto, Anallely Huepalcalco, Wendy Delit, Jesús Sandoval-Ramírez, Adolfo López-Torres, Esaú Ruiz-Sánchez, María A Fernández-Herrera. Fused Pyrroles in Cholestane and Norcholestane Side Chains: Acaricidal and Plant Growth-Promoting Effects.
Molecules (Basel, Switzerland).
2022 Dec; 27(23):. doi:
10.3390/molecules27238466. [PMID: 36500556] - Amira I Sayed, Yara E Mansour, Mohamed A Ali, Omnia Aly, Zainab M Khoder, Ahmed M Said, Samar S Fatahala, Rania H Abd El-Hameed. Novel pyrrolopyrimidine derivatives: design, synthesis, molecular docking, molecular simulations and biological evaluations as antioxidant and anti-inflammatory agents.
Journal of enzyme inhibition and medicinal chemistry.
2022 Dec; 37(1):1821-1837. doi:
10.1080/14756366.2022.2090546. [PMID: 35762086] - Rania M Hathout. Green synthesis of gold nanoparticles using plant products and plants extracts aiming for cancer therapy: helping the beauty to beat 'cure' the beast.
Artificial cells, nanomedicine, and biotechnology.
2022 Dec; 50(1):275-277. doi:
10.1080/21691401.2022.2127747. [PMID: 36191151] - Hema Murugesan, Gauthaman Cs, H Sadiqa Nasreen, Sham Santhanam, Gowrishankar M, Sailatha Ravi, Sharanya Shre Es. An Evaluation of Efficacy and Safety of Tofacitinib, A JAK Inhibitor in the Management of Hospitalized Patients with Mild to Moderate COVID-19 - An Open-Label Randomized Controlled Study.
The Journal of the Association of Physicians of India.
2022 Dec; 69(12):11-12. doi:
NULL. [PMID: 35057599] - Sizhen Wang, Zhiqiang Ma, Zhang Shi, Ying Huang, Tianheng Chen, Lei Hou, Tao Jiang, Feng Yang. Chidamide stacked in magnetic polypyrrole nano-composites counter thermotolerance and metastasis for visualized cancer photothermal therapy.
Drug delivery.
2022 Dec; 29(1):1312-1325. doi:
10.1080/10717544.2022.2068697. [PMID: 35475384] - Binli Mao, Vu Thuy Khanh Le-Trilling, Kai Wang, Denise Mennerich, Jie Hu, Zhenyu Zhao, Jiaxin Zheng, Yingying Deng, Benjamin Katschinski, Shilei Xu, Guiji Zhang, Xuefei Cai, Yuan Hu, Jianwei Wang, Mengji Lu, Ailong Huang, Ni Tang, Mirko Trilling, Yong Lin. Obatoclax inhibits SARS-CoV-2 entry by altered endosomal acidification and impaired cathepsin and furin activity in vitro.
Emerging microbes & infections.
2022 Dec; 11(1):483-497. doi:
10.1080/22221751.2022.2026739. [PMID: 34989664] - Man Zhao, Linlin Qian, Zhuoyu Chi, Xiaoli Jia, Fengjie Qi, Fengjie Yuan, Zhiqiang Liu, Yuguo Zheng. Combined Metabolomic and Quantitative RT-PCR Analyses Revealed the Synthetic Differences of 2-Acetyl-1-pyrroline in Aromatic and Non-Aromatic Vegetable Soybeans.
International journal of molecular sciences.
2022 Nov; 23(23):. doi:
10.3390/ijms232314529. [PMID: 36498856] - Sheng-Qi Zhang, Jia-Peng Wang, Feng-Mei Zhang, Lin-Lin Yao, Bing-Xian Li, Ya-Ni Li, Dong Gan, Rui-Feng Mei, Le Cai, Zhong-Tao Ding. Investigations of specialised metabolites of endophyte Diaporthe destruens hosted in Illigera orbiculata C. Y. Wu.
Phytochemistry.
2022 Nov; 203(?):113357. doi:
10.1016/j.phytochem.2022.113357. [PMID: 35970436] - Ran Niu, Yang Ding, Liang Hao, Jiaxin Ren, Jiang Gong, Jinping Qu. Plant-Mimetic Vertical-Channel Hydrogels for Synergistic Water Purification and Interfacial Water Evaporation.
ACS applied materials & interfaces.
2022 Oct; 14(40):45533-45544. doi:
10.1021/acsami.2c14773. [PMID: 36178300] - Xiao Chen, Zhuyi Jiang, Lianjing Zhang, Wei Liu, Xiaohu Ren, Luling Nie, Desheng Wu, Zhiwei Guo, Weimin Liu, Xifei Yang, Yan Wu, Zhen Liang, Peter Spencer, Jianjun Liu. Protein pyrrole adducts are associated with elevated glucose indices and clinical features of diabetic diffuse neuropathies.
Journal of diabetes.
2022 Oct; 14(10):646-657. doi:
10.1111/1753-0407.13318. [PMID: 36195541] - Maria Michela Salvatore, Antonietta Siciliano, Alessia Staropoli, Francesco Vinale, Rosario Nicoletti, Marina DellaGreca, Marco Guida, Francesco Salvatore, Mauro Iuliano, Anna Andolfi, Gaetano De Tommaso. Interaction of the Fungal Metabolite Harzianic Acid with Rare-Earth Cations (Pr3+, Eu3+, Ho3+, Tm3+).
Molecules (Basel, Switzerland).
2022 Oct; 27(19):. doi:
10.3390/molecules27196468. [PMID: 36235005] - Hui Shu, Mengjie Guo, Machongyang Wang, Mingbo Zhou, Bixiang Zhou, Ling Xu, Yutao Rao, Bangshao Yin, Atsuhiro Osuka, Jianxin Song. Efficient Synthesis of Multiply Seven-Membered-Ring Fused Porphyrins by Rhodium-Catalyzed [5+2] Annulation.
Angewandte Chemie (International ed. in English).
2022 09; 61(39):e202209594. doi:
10.1002/anie.202209594. [PMID: 35924714] - Oyunbileg Bavuu, Daiju Fukuda, Byambasuren Ganbaatar, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata. Esaxerenone, a selective mineralocorticoid receptor blocker, improves insulin sensitivity in mice consuming high-fat diet.
European journal of pharmacology.
2022 Sep; 931(?):175190. doi:
10.1016/j.ejphar.2022.175190. [PMID: 35961594] - Xiang Liu, Xueting Wang, Fengwen Zhang, Xiangfeng Yao, Zhihua Qiao, Jiahui Deng, Qin Jiao, Luo Gong, Xingyin Jiang. Toxic effects of fludioxonil on the growth, photosynthetic activity, oxidative stress, cell morphology, apoptosis, and metabolism of Chlorella vulgaris.
The Science of the total environment.
2022 Sep; 838(Pt 2):156069. doi:
10.1016/j.scitotenv.2022.156069. [PMID: 35605851] - Cátia Vilas-Boas, Logan Running, Daniela Pereira, Honorina Cidade, Marta Correia-da-Silva, Gunes Ekin Atilla-Gokcumen, Diana S Aga. Impact of Tralopyril and Triazolyl Glycosylated Chalcone in Human Retinal Cells' Lipidome.
Molecules (Basel, Switzerland).
2022 Aug; 27(16):. doi:
10.3390/molecules27165247. [PMID: 36014486] - Beatrice-Cristina Ivan, Stefania-Felicia Barbuceanu, Camelia Mia Hotnog, Adriana Iuliana Anghel, Robert Viorel Ancuceanu, Mirela Antonela Mihaila, Lorelei Irina Brasoveanu, Sergiu Shova, Constantin Draghici, Octavian Tudorel Olaru, George Mihai Nitulescu, Mihaela Dinu, Florea Dumitrascu. New Pyrrole Derivatives as Promising Biological Agents: Design, Synthesis, Characterization, In Silico, and Cytotoxicity Evaluation.
International journal of molecular sciences.
2022 Aug; 23(16):. doi:
10.3390/ijms23168854. [PMID: 36012121] - Feng Zhou, Ye-Xian Cui, Bing-Li Wang, Yu-Dong Zhou, Shi-Wang Li, Yan-Tong Zhang, Ke Zhang, Ze-Yuan Chen, Hai-Yan Hu, Cheng-Wei Li. Baseline Sensitivity and Potential Resistance Mechanisms for Fusarium pseudograminearum to Fludioxonil.
Plant disease.
2022 Aug; 106(8):2138-2144. doi:
10.1094/pdis-12-21-2626-re. [PMID: 35100030] - Hamim Zahir, Jonathan Greenberg, Ching Hsu, Thomas C Marbury, Kenneth C Lasseter, Li-An Xu, William D Tap, John H Healey, Silvia Stacchiotti, Frank LaCreta. Effect of Mild and Moderate Hepatic Impairment (Defined by Child-Pugh Classification and National Cancer Institute Organ Dysfunction Working Group Criteria) on Pexidartinib Pharmacokinetics.
Journal of clinical pharmacology.
2022 Aug; 62(8):992-1005. doi:
10.1002/jcph.2042. [PMID: 35247274] - Azza Mohammed Hafez El Medany, Sami Hussein Mahmoud Hammadi, Hoda Mahmoud Khalifa, Rasha Abdelmawla Ghazala, Hend Samir Zakaria Mohammed. The vascular impact of dapagliflozin, liraglutide, and atorvastatin alone or in combinations in type 2 diabetic rat model.
Fundamental & clinical pharmacology.
2022 Aug; 36(4):731-741. doi:
10.1111/fcp.12765. [PMID: 35106814] - Sarah J Welsh, Nicola Thompson, Anne Warren, Andrew N Priest, Tristan Barrett, Stephan Ursprung, Ferdia A Gallagher, Fulvio Zaccagna, Grant D Stewart, Kate M Fife, Athena Matakidou, Andrea J Machin, Wendi Qian, Victoria Ingleson, Jean Mullin, Antony C P Riddick, James N Armitage, Stephen Connolly, Timothy G Q Eisen. Dynamic biomarker and imaging changes from a phase II study of pre- and post-surgical sunitinib.
BJU international.
2022 08; 130(2):244-253. doi:
10.1111/bju.15600. [PMID: 34549873] - Haowen Luo, Meiyang Duan, Pipeng Xing, Huifang Xie, Xiangru Tang. Foliar application of procyanidins enhanced the biosynthesis of 2-acetyl-1-pyrroline in aromatic rice (Oryza sativa L.).
BMC plant biology.
2022 Jul; 22(1):376. doi:
10.1186/s12870-022-03775-7. [PMID: 35906561] - Clément Carbasse, Fanny Leenhardt, William Jacot, Caroline Perrier, Frederic Pinguet, Marie Viala. Oral targeted therapy dose adaptation in older patients with cancer: A real-life French cohort.
British journal of clinical pharmacology.
2022 07; 88(7):3370-3377. doi:
10.1111/bcp.15285. [PMID: 35178745] - Ramesh Boinpally, Kaifeng Lu. Single-Dose Pharmacokinetics and Safety of Ubrogepant in Adults With Hepatic Impairment: Results From an Open-Label, Phase 1 Trial.
Clinical pharmacology in drug development.
2022 Jul; 11(7):857-864. doi:
10.1002/cpdd.1066. [PMID: 35174666] - Kenichi Shikata, Sadayoshi Ito, Naoki Kashihara, Masaomi Nangaku, Takashi Wada, Yasuyuki Okuda, Tomoko Sawanobori, Kotaro Sugimoto. Reduction in the magnitude of serum potassium elevation in combination therapy with esaxerenone (CS-3150) and sodium-glucose cotransporter 2 inhibitor in patients with diabetic kidney disease: Subanalysis of two phase III studies.
Journal of diabetes investigation.
2022 Jul; 13(7):1190-1202. doi:
10.1111/jdi.13778. [PMID: 35199478] - Ling Yang, I-Hsin Lin, Lie-Chwen Lin, Jeffrey W Dalley, Tung-Hu Tsai. Biotransformation and transplacental transfer of the anti-viral remdesivir and predominant metabolite, GS-441524 in pregnant rats.
EBioMedicine.
2022 Jul; 81(?):104095. doi:
10.1016/j.ebiom.2022.104095. [PMID: 35671622] - Tao Ji, Xuejun Chen, Swamy Yeleswaram. Evaluation of drug-drug interaction potential for pemigatinib using physiologically based pharmacokinetic modeling.
CPT: pharmacometrics & systems pharmacology.
2022 07; 11(7):894-905. doi:
10.1002/psp4.12805. [PMID: 35506332] - Chen Yang, Sai Li, Taoyang Huang, Hongju Lin, Zhihui Jiang, Yongyang He, Junjie Yuan, Huijie An. Effectiveness and safety of vonoprazan-based regimen for Helicobacter pylori eradication: A meta-analysis of randomized clinical trials.
Journal of clinical pharmacy and therapeutics.
2022 Jul; 47(7):897-904. doi:
10.1111/jcpt.13637. [PMID: 35247003] - Yong Ren, Yulin Zhu, Fang Liang, Qingqing Li, Quanhu Zhao, Ying He, Xueer Lin, Xiaoyan Qin, Siren Cheng. Effect of foliar copper application on grain yield, 2-acetyl-1-Pyrroline and copper content in fragrant rice.
Plant physiology and biochemistry : PPB.
2022 Jul; 182(?):154-166. doi:
10.1016/j.plaphy.2022.04.016. [PMID: 35500526] - Arnab Mukherjee, Shinichi Tsuchiwata, Timothy Nicholas, Jack A Cook, Irene Modesto, Chinyu Su, Geert R D'Haens, William J Sandborn. Exposure-Response Characterization of Tofacitinib Efficacy in Moderate to Severe Ulcerative Colitis: Results From Phase II and Phase III Induction and Maintenance Studies.
Clinical pharmacology and therapeutics.
2022 Jul; 112(1):90-100. doi:
10.1002/cpt.2601. [PMID: 35380740] - Rene Rodriguez-Gutierrez, Jose Gerardo González, Deven Parmar, Farheen Shaikh, Pio Cruz-López. Saroglitazar is noninferior to fenofibrate in reducing triglyceride levels in hypertriglyceridemic patients in a randomized clinical trial.
Journal of lipid research.
2022 07; 63(7):100233. doi:
10.1016/j.jlr.2022.100233. [PMID: 35605678] - Le Chen, Baixin Sun, Yang Zhao, Peng Xiang, Zeyan Miao. Comparison of the Biological Characteristics and Molecular Mechanisms of Fludioxonil-Resistant Isolates of Botrytis cinerea from Tomato in Liaoning Province of China.
Plant disease.
2022 Jul; 106(7):1959-1970. doi:
10.1094/pdis-07-21-1446-re. [PMID: 35678566] - Ky V Hoang, Katherine Woolard, Ching Yang, Christian Melander, John S Gunn. Identification of a Host-Targeted Compound to Control Typhoid Fever.
Microbiology spectrum.
2022 06; 10(3):e0061922. doi:
10.1128/spectrum.00619-22. [PMID: 35579463] - Stefanie Gärtner, Angelina Graf, Carla Triunfo, Davide Laurenzi, Stefan M Schupp, Gabriele Maoloni, Giuseppe Falini, Helmut Cölfen. Turning Seashell Waste into Electrically Conductive Particles.
International journal of molecular sciences.
2022 Jun; 23(13):. doi:
10.3390/ijms23137256. [PMID: 35806261] - Andrew J Smith, Prashant Ruchaya, Robert Walmsley, Kathleen E Wright, Fiona C Lewis-McDougall, Jacquelyn Bond, Georgina M Ellison-Hughes. Receptor tyrosine kinase inhibitors negatively impact on pro-reparative characteristics of human cardiac progenitor cells.
Scientific reports.
2022 Jun; 12(1):10132. doi:
10.1038/s41598-022-13203-3. [PMID: 35710779] - Bibian M E Tullemans, Sanne L N Brouns, Frauke Swieringa, Siamack Sabrkhany, Franchette W P J van den Berkmortel, Natascha A J B Peters, Peter de Bruijn, Stijn L W Koolen, Johan W M Heemskerk, Maureen J B Aarts, Marijke J E Kuijpers. Quantitative and qualitative changes in platelet traits of sunitinib-treated patients with renal cell carcinoma in relation to circulating sunitinib levels: a proof-of-concept study.
BMC cancer.
2022 Jun; 22(1):653. doi:
10.1186/s12885-022-09676-0. [PMID: 35698081] - Qin Gu, Junqing Qiao, Ruoyi Wang, Juan Lu, Zhengqi Wang, Pingping Li, Lulu Zhang, Qurban Ali, Abdur Rashid Khan, Xuewen Gao, Huijun Wu. The Role of Pyoluteorin from Pseudomonas protegens Pf-5 in Suppressing the Growth and Pathogenicity of Pantoea ananatis on Maize.
International journal of molecular sciences.
2022 Jun; 23(12):. doi:
10.3390/ijms23126431. [PMID: 35742879] - Mengru Li, Chi-Tang Ho, Jing Wang, Yuemeng Hu, Xiaoting Zhai, Liang Zhang, Xiaochun Wan, Xiaogen Yang. Formation of Volatile Heterocyclic Compounds and Open-Chain Amides of Theanine in Model Systems with Glucose, Tea Leaves, and Tea Extract under Tea-Roasting Conditions.
Journal of agricultural and food chemistry.
2022 Jun; 70(22):6737-6746. doi:
10.1021/acs.jafc.2c02039. [PMID: 35621700] - Michal Rihacek, Iveta Selingerova, Ivo Kocak, Ilona Kocakova, Eva Rihackova, Dalibor Valik, Jaroslav Sterba. Sunitinib-Induced Elevation of Mean Corpuscular Volume (MCV)-Exploring Its Possible Clinical Relevance in Cancer Patients.
Current oncology (Toronto, Ont.).
2022 Jun; 29(6):4138-4147. doi:
10.3390/curroncol29060330. [PMID: 35735439] - Tomohiro Higuchi, Mihoko Yamade, Satoru Takahashi, Satoshi Tamura, Shinya Tani, Takuma Kagami, Takahiro Uotani, Yasushi Hamaya, Moriya Iwaizumi, Satoshi Osawa, Ken Sugimoto, Takahisa Furuta. Influence of daily versus alternate-day dosing of vonoprazan on intragastric pH, serum gastrin, and the antiplatelet function of clopidogrel : Influence of alternate-day dosing of vonoprazan.
European journal of clinical pharmacology.
2022 Jun; 78(6):955-963. doi:
10.1007/s00228-022-03313-2. [PMID: 35445847] - Jacob Wise, Raj Tiwari, Sophie O'Halloran, Lauren Fleshner, Susan Nguyen, Karen Hersey, Nazanin Fallah-Rad, Neil Fleshner. Time trends for drug specific adverse events in patients on sunitinib; implications for remote monitoring.
The Canadian journal of urology.
2022 Jun; 29(3):11136-11141. doi:
NULL. [PMID: 35691034] - Ziyue Wen, Jingrui Wang, Chen Jiao, Wenyong Shao, Zhonghua Ma. Biological and molecular characterizations of field fludioxonil-resistant isolates of Fusarium graminearum.
Pesticide biochemistry and physiology.
2022 Jun; 184(?):105101. doi:
10.1016/j.pestbp.2022.105101. [PMID: 35715040] - Khushboo A Gandhi, Amit Joshi, Parsshava Mehta, Murari Gurjar, Pallavi Rane, Jyoti Sharma, Anand Patil, Manjunath Nookala, Vanita Noronha, Kumar Prabhash, Vikram Gota. Feasibility of therapeutic drug monitoring of sunitinib and its implications on response and toxicity in patients with metastatic renal cell cancer.
Cancer chemotherapy and pharmacology.
2022 Jun; 89(6):751-759. doi:
10.1007/s00280-022-04432-4. [PMID: 35441269] - Lin Zhu, Junyi Xue, Yisheng He, Qingsu Xia, Peter P Fu, Ge Lin. Correlation Investigation between Pyrrole-DNA and Pyrrole-Protein Adducts in Male ICR Mice Exposed to Retrorsine, a Hepatotoxic Pyrrolizidine Alkaloid.
Toxins.
2022 05; 14(6):. doi:
10.3390/toxins14060377. [PMID: 35737038] - Lajos Szente, Tibor Renkecz, Dávid Sirok, János Stáhl, Gábor Hirka, István Puskás, Tamás Sohajda, Éva Fenyvesi. Comparative bioavailability study following a single dose intravenous and buccal administration of remdesivir in rabbits.
International journal of pharmaceutics.
2022 May; 620(?):121739. doi:
10.1016/j.ijpharm.2022.121739. [PMID: 35421532] - Charles N S Allen, Maryline Santerre, Sterling P Arjona, Lea J Ghaleb, Muna Herzi, Megan D Llewellyn, Natalia Shcherbik, Bassel E Sawaya. SARS-CoV-2 Causes Lung Inflammation through Metabolic Reprogramming and RAGE.
Viruses.
2022 05; 14(5):. doi:
10.3390/v14050983. [PMID: 35632725] - Zengli Liu, Jialiang Liu, Tianli Chen, Yue Wang, Anda Shi, Kangshuai Li, Xingyong Li, Bo Qiu, Lijie Zheng, Liming Zhao, Lizhuang Shu, Shuo Lian, Shaohui Huang, Zongli Zhang, Yunfei Xu. Wnt-TCF7-SOX9 axis promotes cholangiocarcinoma proliferation and pemigatinib resistance in a FGF7-FGFR2 autocrine pathway.
Oncogene.
2022 05; 41(20):2885-2896. doi:
10.1038/s41388-022-02313-x. [PMID: 35428876] - Manasa Kadagathur, Arbaz Sujat Shaikh, Biswajit Panda, Joel George, Regur Phanindranath, Dilep Kumar Sigalapalli, Nagesh A Bhale, Chandraiah Godugu, Narayana Nagesh, Nagula Shankaraiah, Neelima D Tangellamudi. Synthesis of indolo/pyrroloazepinone-oxindoles as potential cytotoxic, DNA-intercalating and Topo I inhibitors.
Bioorganic chemistry.
2022 05; 122(?):105706. doi:
10.1016/j.bioorg.2022.105706. [PMID: 35240414] - Esmeralda Zuñiga, Odin Ramírez, Carlos Martínez. Electrophysiological Recordings from Embryonic Mouse Motoneurons Cultured on Electrospun Poly-Lactic Acid (PLA) and Polypyrrole-Coated PLA Scaffolds.
Iranian biomedical journal.
2022 05; 26(3):183-92. doi:
10.52547/ibj.26.3.183. [PMID: 35373542] - Ramesh Boinpally, Abhijeet Jakate, Matthew Butler, Antonia Periclou. Atogepant and sumatriptan: no clinically relevant drug-drug interactions in a randomized, open-label, crossover trial.
Pain management.
2022 May; 12(4):499-508. doi:
10.2217/pmt-2021-0073. [PMID: 34898273] - Slobodan M Janković, Snežana V Janković. Clinical Pharmacokinetics and Pharmacodynamics of Esaxerenone, a Novel Mineralocorticoid Receptor Antagonist: A Review.
European journal of drug metabolism and pharmacokinetics.
2022 May; 47(3):291-308. doi:
10.1007/s13318-022-00760-1. [PMID: 35190999] - Lajos Markó, Anne Dörr, Peter Linz, Anton H van den Meiracker, Ingrid M Garrelds, Titus Kuehne, Ralf Dechend, A H Jan Danser, Anne Flörcken, Dominik N Müller. Effect of Sunitinib Treatment on Skin Sodium Accumulation in Patients With Renal Cancer: a Pilot Study.
Hypertension (Dallas, Tex. : 1979).
2022 05; 79(5):e103-e105. doi:
10.1161/hypertensionaha.122.19079. [PMID: 35189705] - Zhou Tian, Jing Jiang, Zhen-Hui Yan, Qing-Qing Luo, Gu Zhan, Wei Huang, Xiang Li, Bo Han. Catalytic asymmetric [3 + 2] cycloaddition of pyrazolone-derived MBH carbonate: highly stereoselective construction of the bispiro-[pyrazolone-dihydropyrrole-oxindole] skeleton.
Chemical communications (Cambridge, England).
2022 Apr; 58(35):5363-5366. doi:
10.1039/d2cc00618a. [PMID: 35411363] - Damián A Madrigal-Aguilar, Adilene Gonzalez-Silva, Blanca Rosales-Acosta, Celia Bautista-Crescencio, Jossué Ortiz-Álvarez, Carlos H Escalante, Jaime Sánchez-Navarrete, César Hernández-Rodríguez, Germán Chamorro-Cevallos, Joaquín Tamariz, Lourdes Villa-Tanaca. Antifungal Activity of Fibrate-Based Compounds and Substituted Pyrroles That Inhibit the Enzyme 3-Hydroxy-methyl-glutaryl-CoA Reductase of Candida glabrata (CgHMGR), Thus Decreasing Yeast Viability and Ergosterol Synthesis.
Microbiology spectrum.
2022 04; 10(2):e0164221. doi:
10.1128/spectrum.01642-21. [PMID: 35377226] - Myra E van Linde, Mariette Labots, Cyrillo G Brahm, Koos E Hovinga, Philip C De Witt Hamer, Richard J Honeywell, Richard de Goeij-de Haas, Alex A Henneman, Jaco C Knol, Godefridus J Peters, Henk Dekker, Sander R Piersma, Thang V Pham, William P Vandertop, Connie R Jiménez, Henk M W Verheul. Tumor Drug Concentration and Phosphoproteomic Profiles After Two Weeks of Treatment With Sunitinib in Patients with Newly Diagnosed Glioblastoma.
Clinical cancer research : an official journal of the American Association for Cancer Research.
2022 04; 28(8):1595-1602. doi:
10.1158/1078-0432.ccr-21-1933. [PMID: 35165100] - Ζografina Mavriou, Ioanna Alexandropoulou, Paraschos Melidis, Dimitrios G Karpouzas, Spyridon Ntougias. Bioprocess performance, transformation pathway, and bacterial community dynamics in an immobilized cell bioreactor treating fludioxonil-contaminated wastewater under microaerophilic conditions.
Environmental science and pollution research international.
2022 Apr; 29(20):29597-29612. doi:
10.1007/s11356-021-16452-3. [PMID: 34542817] - Daiji Nagayama, Atsuhito Saiki, Yasuhiro Watanabe, Takashi Yamaguchi, Masahiro Ohira, Naoko Sato, Mizuho Kanayama, Masao Moroi, Yoh Miyashita, Kohji Shirai, Ichiro Tatsuno. Prevention of Cardiovascular Events with Pitavastatin is Associated with Increased Serum Lipoprotein Lipase Mass Level: Subgroup Analysis of the TOHO-LIP.
Journal of atherosclerosis and thrombosis.
2022 Apr; 29(4):451-463. doi:
10.5551/jat.62141. [PMID: 33642441]
