CDP-ethanolamine (BioDeep_00000415769)

Main id: BioDeep_00000004450

 

natural product PANOMIX_OTCML-2023


代谢物信息卡片


CDP-ethanolamine

化学式: C11H20N4O11P2 (446.0604)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OCCN)O)O
InChI: InChI=1S/C11H20N4O11P2/c12-2-4-23-27(19,20)26-28(21,22)24-5-6-8(16)9(17)10(25-6)15-3-1-7(13)14-11(15)18/h1,3,6,8-10,16-17H,2,4-5,12H2,(H,19,20)(H,21,22)(H2,13,14,18)/t6-,8-,9-,10-/m1/s1

描述信息

A phosphoethanolamine consisting of ethanolamine having a cytidine 5-diphosphate moiety attached to the oxygen.

同义名列表

2 个代谢物同义名

CDP-ethanolamine; CDP-ethanolamine



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(2)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

5 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 CHKA, CHKB, ETNK1, PCYT2, PEBP1, PISD, SLC9A1
Peripheral membrane protein 2 PCYT1A, PISD
Endoplasmic reticulum membrane 8 CEPT1, HSP90B1, PCYT1A, PCYT2, PEMT, PTDSS1, PTDSS2, SELENOI
Mitochondrion membrane 1 PEMT
Nucleus 6 BCL6, HSP90B1, PCYT1A, PEBP1, PISD, PLCZ1
cytosol 9 CHKA, CHKB, ETNK1, HSP90B1, PCYT1A, PEBP1, PEMT, PISD, PLCZ1
mitochondrial membrane 1 PEMT
nucleoplasm 3 BCL6, PLCZ1, SLC9A1
Cell membrane 2 SLC6A8, SLC9A1
lamellipodium 1 SLC9A1
Multi-pass membrane protein 8 CEPT1, PEMT, PTDSS1, PTDSS2, SELENOI, SLC6A8, SLC9A1, SPG7
cell surface 1 SLC9A1
Golgi apparatus 4 BCL6, CEPT1, PISD, SELENOI
Golgi membrane 1 INS
mitochondrial inner membrane 2 PISD, SPG7
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 2 CHKA, PCYT1A
plasma membrane 3 CXCR5, SLC6A8, SLC9A1
Membrane 12 CEPT1, CXCR5, ETNK1, HSP90B1, PCYT1A, PEMT, PTDSS1, PTDSS2, SELENOI, SLC6A8, SLC9A1, SPG7
apical plasma membrane 2 SLC6A8, SLC9A1
basolateral plasma membrane 1 SLC9A1
extracellular exosome 3 HSP90B1, PEBP1, SLC9A1
endoplasmic reticulum 3 HSP90B1, PCYT1A, PEMT
extracellular space 1 INS
perinuclear region of cytoplasm 3 HSP90B1, PLCZ1, SLC9A1
intercalated disc 1 SLC9A1
mitochondrion 4 PEMT, PISD, SLC9A1, SPG7
protein-containing complex 1 HSP90B1
intracellular membrane-bounded organelle 1 PEMT
pronucleus 1 PLCZ1
Secreted 1 INS
extracellular region 2 HSP90B1, INS
Single-pass membrane protein 1 PISD
Nucleus membrane 1 CEPT1
nuclear membrane 1 CEPT1
external side of plasma membrane 1 CXCR5
T-tubule 1 SLC9A1
nucleolus 2 BCL6, PLCZ1
axon cytoplasm 1 SPG7
midbody 1 HSP90B1
Apical cell membrane 1 SLC6A8
Cytoplasm, perinuclear region 1 PLCZ1
Mitochondrion inner membrane 1 SPG7
Membrane raft 1 SLC9A1
focal adhesion 2 HSP90B1, SLC9A1
collagen-containing extracellular matrix 1 HSP90B1
Basolateral cell membrane 1 SLC9A1
nuclear envelope 1 PCYT1A
endosome lumen 1 INS
Lipid droplet 2 CHKA, PISD
[Isoform 1]: Endoplasmic reticulum membrane 1 PEMT
Melanosome 1 HSP90B1
sperm plasma membrane 1 HSP90B1
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 HSP90B1, INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
Sarcoplasmic reticulum lumen 1 HSP90B1
paraspeckles 1 BCL6
Intermembrane side 1 PISD
[Isoform 2]: Endoplasmic reticulum membrane 1 PEMT
endocytic vesicle lumen 1 HSP90B1
sperm head 1 PLCZ1
mitochondrial permeability transition pore complex 1 SPG7
endoplasmic reticulum chaperone complex 1 HSP90B1
cation-transporting ATPase complex 1 SLC9A1
[Isoform 1]: Lipid droplet 1 CHKA
glycogen granule 1 PCYT1A
[Isoform 2]: Mitochondrion inner membrane 1 PISD
[Isoform 1]: Mitochondrion inner membrane 1 PISD
[Phosphatidylserine decarboxylase beta chain]: Mitochondrion inner membrane 1 PISD
[Phosphatidylserine decarboxylase alpha chain]: Mitochondrion inner membrane 1 PISD
m-AAA complex 1 SPG7


文献列表

  • Zhenhua Wang, Meng Yang, Yufan Yang, Yonglin He, Hongwu Qian. Structural basis for catalysis of human choline/ethanolamine phosphotransferase 1. Nature communications. 2023 May; 14(1):2529. doi: 10.1038/s41467-023-38290-2. [PMID: 37137909]
  • Hu Xu, Weizu Li, Lei Huang, Xinyu He, Bei Xu, Xueqing He, Wentong Chen, Yaoxing Wang, Wenjun Xu, Sheng Wang, Qin Kong, Youzhi Xu, Wenjie Lu. Phosphoethanolamine cytidyltransferase ameliorates mitochondrial function and apoptosis in hepatocytes in T2DM in vitro. Journal of lipid research. 2023 Jan; ?(?):100337. doi: 10.1016/j.jlr.2023.100337. [PMID: 36716821]
  • Lance G A Nunes, Matthew W Pitts, Peter R Hoffmann. Selenoprotein I (selenoi) as a critical enzyme in the central nervous system. Archives of biochemistry and biophysics. 2022 10; 729(?):109376. doi: 10.1016/j.abb.2022.109376. [PMID: 36007576]
  • Haifang Zhao, Tao Wang. PE homeostasis rebalanced through mitochondria-ER lipid exchange prevents retinal degeneration in Drosophila. PLoS genetics. 2020 10; 16(10):e1009070. doi: 10.1371/journal.pgen.1009070. [PMID: 33064773]
  • Yi Wu, Keshi Chen, Guangsuo Xing, Linpeng Li, Bochao Ma, Zhijuan Hu, Lifan Duan, Xingguo Liu. Phospholipid remodeling is critical for stem cell pluripotency by facilitating mesenchymal-to-epithelial transition. Science advances. 2019 11; 5(11):eaax7525. doi: 10.1126/sciadv.aax7525. [PMID: 31807705]
  • Elizabeth Calzada, Ouma Onguka, Steven M Claypool. Phosphatidylethanolamine Metabolism in Health and Disease. International review of cell and molecular biology. 2016; 321(?):29-88. doi: 10.1016/bs.ircmb.2015.10.001. [PMID: 26811286]
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  • Anne Hartmann, Maria Hellmund, Richard Lucius, Dennis R Voelker, Nishith Gupta. Phosphatidylethanolamine synthesis in the parasite mitochondrion is required for efficient growth but dispensable for survival of Toxoplasma gondii. The Journal of biological chemistry. 2014 Mar; 289(10):6809-6824. doi: 10.1074/jbc.m113.509406. [PMID: 24429285]
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  • Lin Zhu, Marica Bakovic. Breast cancer cells adapt to metabolic stress by increasing ethanolamine phospholipid synthesis and CTP:ethanolaminephosphate cytidylyltransferase-Pcyt2 activity. Biochemistry and cell biology = Biochimie et biologie cellulaire. 2012 Apr; 90(2):188-99. doi: 10.1139/o11-081. [PMID: 22339418]
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