haloperidol (BioDeep_00000398998)
Main id: BioDeep_00000002293
natural product
代谢物信息卡片
Haloperidol (Haldol)
化学式: C21H23ClFNO2 (375.1401)
中文名称: 氟哌啶醇, 环氧粉末
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(CC(=O)c1ccc(cc1)F)CN1CCC(CC1)(c1ccc(cc1)Cl)O
InChI: InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
描述信息
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AD - Butyrophenone derivatives
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D002491 - Central Nervous System Agents > D018726 - Anti-Dyskinesia Agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C66883 - Dopamine Antagonist
C78272 - Agent Affecting Nervous System > C323 - Butyrophenone
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
Haloperidol is a potent dopamine D2 receptor antagonist, widely used as an antipsychotic.
同义名列表
3 个代谢物同义名
数据库引用编号
24 个数据库交叉引用编号
- ChEBI: CHEBI:5613
- KEGG: C01814
- KEGGdrug: D00136
- PubChem: 3559
- DrugBank: DB00502
- ChEMBL: CHEMBL54
- MeSH: Haloperidol
- CAS: 177716-59-5
- CAS: 52-86-8
- CAS: 61788-97-4
- MoNA: WA002251
- MoNA: WA002250
- MoNA: WA002249
- MoNA: WA002248
- MoNA: WA002247
- MoNA: FiehnHILIC001981
- MoNA: FiehnHILIC000409
- MoNA: CCMSLIB00000078346
- PubChem: 4938
- PDB-CCD: GMJ
- NIKKAJI: J1.365J
- RefMet: Haloperidol
- medchemexpress: HY-14538
- KNApSAcK: 5613
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Liwei Liu, Shen Cheng, Yufang Yang, Yuyan Chen. Clinical study on Tianma Gouteng decoction combined with haloperidol in the treatment of tic disorder in children.
Minerva pediatrics.
2024 Apr; 76(2):295-298. doi:
10.23736/s2724-5276.23.07373-1. [PMID: 37534803] - Karin Fehsel, Marie-Luise Bouvier. Sex-Specific Effects of Long-Term Antipsychotic Drug Treatment on Adipocyte Tissue and the Crosstalk to Liver and Brain in Rats.
International journal of molecular sciences.
2024 Feb; 25(4):. doi:
10.3390/ijms25042188. [PMID: 38396865] - Katerina Horska, Silje Skrede, Jan Kucera, Gabriela Kuzminova, Pavel Suchy, Vincenzo Micale, Jana Ruda-Kucerova. Olanzapine, but not haloperidol, exerts pronounced acute metabolic effects in the methylazoxymethanol rat model.
CNS neuroscience & therapeutics.
2024 02; 30(2):e14565. doi:
10.1111/cns.14565. [PMID: 38421095] - Hend A Sabry, Mai M Zahra. Icariin attenuates dopaminergic neural loss in haloperidol-induced Parkinsonism in rats via GSK-3β and tyrosine hydroxylase regulation mechanism.
Journal of chemical neuroanatomy.
2023 Dec; 136(?):102385. doi:
10.1016/j.jchemneu.2023.102385. [PMID: 38160784] - Liaqat Hussain, Ina Masood, Matloob Ahmad, Muhammad Yasir Ali, Uzma Saleem, Musaddique Hussain, Syed Haroon Khalid, Zunera Chauhdary. Pharmacological and toxicological evaluation of methyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate 1,1-dioxoide against haloperidol induced Parkinson like symptoms in animal model: In-vitro and in-vivo studies.
Toxicology and applied pharmacology.
2023 Sep; 477(?):116678. doi:
10.1016/j.taap.2023.116678. [PMID: 37683697] - Bilqis Abiola Lawal, Yusuf Oloruntoyin Ayipo, Abisola Oyindamola Adekunle, Mohammed Otuofu Amali, Umar Muhammad Badeggi, Waleed A Alananzeh, Mohd Nizam Mordi. Phytoconstituents of Datura metel extract improved motor coordination in haloperidol-induced cataleptic mice: Dual-target molecular docking and behavioural studies.
Journal of ethnopharmacology.
2023 Jan; 300(?):115753. doi:
10.1016/j.jep.2022.115753. [PMID: 36162546] - Samaresh Pal Roy, Sunil Kumar Kadiri, Vipulkumar V Karkar, Srinivasa Rao Konijeti. Antiparkinsonian activity of Tabebuia impetiginosa bark and biochemical analysis of dopamine in rat brain homogenates.
Annales pharmaceutiques francaises.
2022 Nov; 80(6):853-863. doi:
10.1016/j.pharma.2022.02.007. [PMID: 35240121] - Kenko Djoumessie Léa Blondelle, Foyet Harquin Simplice, Ngatanko Abaissou Hervé Hervé, Keugong Wado Eglantine, Rebe Nhouma Roland, Damo Kamda Jorelle Linda, Kamleu Nkwingwa Balbine, Guedang Nyayi Simon Désiré, Camdi Woumitna Guillaume, Ciobica Alin. Antidepressant, anti-amnesic and vasoprotective effect of Bombax costatum Pellegr. & Vuillet aqueous stem bark extract on chronic mild unpredictable stress induced in rat.
Journal of ethnopharmacology.
2022 Jul; 293(?):115315. doi:
10.1016/j.jep.2022.115315. [PMID: 35487448] - Ju-Tae Sohn. Haloperidol Toxicity and Lipid Emulsion Treatment.
American journal of therapeutics.
2022 07; 29(4):489-490. doi:
10.1097/mjt.0000000000001456. [PMID: 35802920] - Keisuke Takada, Yukiyoshi Sada, Masaru Samura, Masashi Matsuura, Naoki Hirose, Takenori Kurata, Fumio Nagumo, Junichi Ishii, Sakura Koshioka, Masaki Uchida, Junki Inoue, Koji Tanikawa, Hiroyuki Kunishima. A Case of Exacerbation of Haloperidol-Induced Rhabdomyolysis Following the Onset of COVID-19.
The American journal of case reports.
2022 Jun; 23(?):e936589. doi:
10.12659/ajcr.936589. [PMID: 35718989] - Rasoul Gheitaran, Abbas Afkhami, Tayyebeh Madrakian. PVP-coated silver nanocubes as RRS probe for sensitive determination of Haloperidol in real samples.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 May; 272(?):121025. doi:
10.1016/j.saa.2022.121025. [PMID: 35184030] - Angela Strain. Angioedema of the tongue due to haloperidol.
The American journal of emergency medicine.
2022 Mar; 53(?):284.e5-284.e6. doi:
10.1016/j.ajem.2021.09.039. [PMID: 34620528] - Aishwarya Vannur, Prakash R Biradar, Vishal Patil. Experimental validation of Vitex negundo leaves hydroalcoholic extract for neuroprotection in haloperidol induced parkinson's disease in rat.
Metabolic brain disease.
2022 02; 37(2):411-426. doi:
10.1007/s11011-021-00878-2. [PMID: 35023027] - Andreza Buzolin Sonego, Douglas da Silva Prado, Francisco Silveira Guimarães. PPARγ receptors are involved in the effects of cannabidiol on orofacial dyskinesia and cognitive dysfunction induced by typical antipsychotic in mice.
Progress in neuro-psychopharmacology & biological psychiatry.
2021 12; 111(?):110367. doi:
10.1016/j.pnpbp.2021.110367. [PMID: 34048863] - Han Zhou, Tao Hou, Zhenhua Gao, Xiujie Guo, Chaoran Wang, Jixia Wang, Yanfang Liu, Xinmiao Liang. Discovery of eight alkaloids with D1 and D2 antagonist activity in leaves of Nelumbo nucifera Gaertn. Using FLIPR assays.
Journal of ethnopharmacology.
2021 Oct; 278(?):114335. doi:
10.1016/j.jep.2021.114335. [PMID: 34139281] - Hanif Khan, Zhengzhong Ni, Hai Feng, Yaqi Xing, Xuejun Wu, Danmei Huang, Ling Chen, Yongdong Niu, Ganggang Shi. Combination of curcumin with N-n-butyl haloperidol iodide inhibits hepatocellular carcinoma malignant proliferation by downregulating enhancer of zeste homolog 2 (EZH2) - lncRNA H19 to silence Wnt/β-catenin signaling.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2021 Oct; 91(?):153706. doi:
10.1016/j.phymed.2021.153706. [PMID: 34517264] - Jana Osacka, Romana Koprdova, Andrej Tillinger, Zdenko Pirnik, Alexander Kiss. Haloperidol and aripiprazole impact on the BDNF and glucocorticoid receptor levels in the rat hippocampus and prefrontal cortex: effect of the chronic mild stress.
Endocrine regulations.
2021 Sep; 55(3):153-162. doi:
10.2478/enr-2021-0016. [PMID: 34523299] - Nela Zidekova, Adam Nemcek, Martina Sutovska, Juraj Mokry, Martin Kertys. Development of Sensitive and High-Throughput Liquid Chromatography-Tandem Mass Spectrometry Method for Quantification of Haloperidol in Human Plasma with Phospholipid Removal Pretreatment.
Journal of analytical toxicology.
2021 Jul; 45(6):573-580. doi:
10.1093/jat/bkaa124. [PMID: 32886781] - Armando Totomoch-Serra, Concepcion B Ibarra-Miramon, Carlos Manterola. Persistent Hiccups as Main COVID-19 Symptom.
The American journal of the medical sciences.
2021 06; 361(6):799-800. doi:
10.1016/j.amjms.2021.01.001. [PMID: 33563571] - Mao-Hsien Wang, Chih-Chuan Yang, Hsiang-Chien Tseng, Chih-Hsiang Fang, Yi-Wen Lin, Hung-Sheng Soung. Naringin Ameliorates Haloperidol-Induced Neurotoxicity and Orofacial Dyskinesia in a Rat Model of Human Tardive Dyskinesia.
Neurotoxicity research.
2021 Jun; 39(3):774-786. doi:
10.1007/s12640-021-00333-1. [PMID: 33523404] - Sua Kim, Chor Ho Jo, Gheun-Ho Kim. Psychotropic drugs upregulate aquaporin-2 via vasopressin-2 receptor/cAMP/protein kinase A signaling in inner medullary collecting duct cells.
American journal of physiology. Renal physiology.
2021 05; 320(5):F963-F971. doi:
10.1152/ajprenal.00576.2020. [PMID: 33843270] - Ragnhild Birkeland Waade, Vigdis Solhaug, Gudrun Høiseth. Impact of CYP2D6 on serum concentrations of flupentixol, haloperidol, perphenazine and zuclopenthixol.
British journal of clinical pharmacology.
2021 05; 87(5):2228-2235. doi:
10.1111/bcp.14626. [PMID: 33118660] - Samira S Valvassori, José H Cararo, Samira Menegas, Taise Possamai-Della, Jorge M Aguiar-Geraldo, Simone Lespinasse Araujo, Gustavo Antunes Mastella, João Quevedo, Alexandra I Zugno. Haloperidol elicits oxidative damage in the brain of rats submitted to the ketamine-induced model of schizophrenia.
Brain research bulletin.
2021 05; 170(?):246-253. doi:
10.1016/j.brainresbull.2021.01.021. [PMID: 33545309] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Uzma Saleem, Zujajah Gull, Ammara Saleem, Muhammad Ajmal Shah, Muhammad Furqan Akhtar, Fareeha Anwar, Bashir Ahmad, Pharkphoom Panichayupakaranant. Appraisal of anti-Parkinson activity of rhinacanthin-C in haloperidol-induced parkinsonism in mice: A mechanistic approach.
Journal of food biochemistry.
2021 04; 45(4):e13677. doi:
10.1111/jfbc.13677. [PMID: 33709527] - Youyi Peng, Qiang Zhang, William J Welsh. Novel Sigma 1 Receptor Antagonists as Potential Therapeutics for Pain Management.
Journal of medicinal chemistry.
2021 01; 64(1):890-904. doi:
10.1021/acs.jmedchem.0c01964. [PMID: 33372782] - A S Ozornin, N V Govorin, A V Sakharov, P P Tereshkov. [Changes in adipokines in the blood of patients with the first episode of schizophrenia during treatment with haloperidol and risperidone].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova.
2021; 121(9):58-62. doi:
10.17116/jnevro202112109158. [PMID: 34693690] - Deepika Gautam, Samipta Singh, Priyanka Maurya, Manjari Singh, Sapana Kushwaha, Shubhini A Saraf. Appraisal of Nano-Lipidic Astaxanthin cum Thermoreversible Gel and its Efficacy in Haloperidol Induced Parkinsonism.
Current drug delivery.
2021; 18(10):1550-1562. doi:
10.2174/1567201818666210510173524. [PMID: 33970844] - Nicolas Hoertel, Marina Sánchez-Rico, Raphaël Vernet, Anne-Sophie Jannot, Antoine Neuraz, Carlos Blanco, Cédric Lemogne, Guillaume Airagnes, Nicolas Paris, Christel Daniel, Alexandre Gramfort, Guillaume Lemaitre, Mélodie Bernaux, Ali Bellamine, Nathanaël Beeker, Frédéric Limosin. Observational study of haloperidol in hospitalized patients with COVID-19.
PloS one.
2021; 16(2):e0247122. doi:
10.1371/journal.pone.0247122. [PMID: 33606790] - Preeti Pandey, Kartikay Prasad, Amresh Prakash, Vijay Kumar. Insights into the biased activity of dextromethorphan and haloperidol towards SARS-CoV-2 NSP6: in silico binding mechanistic analysis.
Journal of molecular medicine (Berlin, Germany).
2020 12; 98(12):1659-1673. doi:
10.1007/s00109-020-01980-1. [PMID: 32965508] - Alka A Subramanyam, Hrishikesh B Nachane, Niraj N Mahajan, Snehal Shinde, Smita D Mahale, Rahul K Gajbhiye. Postpartum psychosis in mothers with SARS-CoV-2 infection: A case series from India.
Asian journal of psychiatry.
2020 Dec; 54(?):102406. doi:
10.1016/j.ajp.2020.102406. [PMID: 33271702] - Narjes Saheb Sharif-Askari, Fatemeh Saheb Sharif-Askari, Bushra Mdkhana, Saba Al Heialy, Elaref Ratemi, Malak Alghamdi, Salah Abusnana, Tarek Kashour, Qutayba Hamid, Rabih Halwani. Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue.
Archives of toxicology.
2020 12; 94(12):4037-4041. doi:
10.1007/s00204-020-02869-1. [PMID: 32808185] - Katerina Horska, Hana Kotolova, Michal Karpisek, Zuzana Babinska, Tomas Hammer, Jiri Prochazka, Tibor Stark, Vincenzo Micale, Jana Ruda-Kucerova. Metabolic profile of methylazoxymethanol model of schizophrenia in rats and effects of three antipsychotics in long-acting formulation.
Toxicology and applied pharmacology.
2020 11; 406(?):115214. doi:
10.1016/j.taap.2020.115214. [PMID: 32866524] - Xiao Yu, Xinlin Li, Sunzhao You, Yuhang Shi, Ruiqin Zhu, Ying Dong, Chuixiu Huang. Electromembrane extraction of chlorprothixene, haloperidol and risperidone from whole blood and urine.
Journal of chromatography. A.
2020 Oct; 1629(?):461480. doi:
10.1016/j.chroma.2020.461480. [PMID: 32827905] - Sol Jaworowski, Mark Weiser, Cornelius Gropp, Moria Malka. Three Cases of COVID-19-related First Onset Brief Reactive Psychosis.
The Israel Medical Association journal : IMAJ.
2020 10; 22(10):612. doi:
NULL. [PMID: 33070483] - Lin Zhao, Nan Cheng, Bo Sun, Shuzhen Wang, Anyuan Li, Zhixue Wang, Yuan Wang, Fanghua Qi. Regulatory effects of Ningdong granule on microglia-mediated neuroinflammation in a rat model of Tourette's syndrome.
Bioscience trends.
2020 Sep; 14(4):271-278. doi:
10.5582/bst.2020.03262. [PMID: 32741856] - Yelizaveta Sher, Beatrice Rabkin, José R Maldonado, Paul Mohabir. COVID-19-Associated Hyperactive Intensive Care Unit Delirium With Proposed Pathophysiology and Treatment: A Case Report.
Psychosomatics.
2020 Sep; 61(5):544-550. doi:
10.1016/j.psym.2020.05.007. [PMID: 32591212] - Mohamed Adil Shah Khoodoruth, Adeel Ahmad Khan. Anabolic steroids-induced delirium: A case report.
Medicine.
2020 Aug; 99(33):e21639. doi:
10.1097/md.0000000000021639. [PMID: 32872027] - Raahil Kajani, Austin Apramian, Arturo Vega, Nitin Ubhayakar, Prissilla Xu, Antonio Liu. Neuroleptic malignant syndrome in a COVID-19 patient.
Brain, behavior, and immunity.
2020 08; 88(?):28-29. doi:
10.1016/j.bbi.2020.05.042. [PMID: 32425332] - Gabriela Seabra, Valéria de Almeida, Guilherme Reis-de-Oliveira, Fernanda Crunfli, André Saraiva Leão Marcelo Antunes, Daniel Martins-de-Souza. Ubiquitin-proteasome system, lipid metabolism and DNA damage repair are triggered by antipsychotic medication in human oligodendrocytes: implications in schizophrenia.
Scientific reports.
2020 07; 10(1):12655. doi:
10.1038/s41598-020-69543-5. [PMID: 32724114] - Congjie Wang, Juan Zhou, Chengjuan Zong. Two cases report of epidemic stress disorder to novel coronavirus pneumonia.
Asian journal of psychiatry.
2020 Jun; 51(?):102070. doi:
10.1016/j.ajp.2020.102070. [PMID: 32325392] - Zoran Trogrlić, Mathieu van der Jagt, Robert Jan Osse, John W Devlin, Daan Nieboer, Birgit C P Koch, Ron H N van Schaik, Nicole G M Hunfeld. Pharmacogenomic response of low dose haloperidol in critically ill adults with delirium.
Journal of critical care.
2020 06; 57(?):203-207. doi:
10.1016/j.jcrc.2020.03.001. [PMID: 32208328] - Steven Lehrer, Peter H Rheinstein. SARS-CoV-2 orf1b Gene Sequence in the NTNG1 Gene on Human Chromosome 1.
In vivo (Athens, Greece).
2020 Jun; 34(3 Suppl):1629-1632. doi:
10.21873/invivo.11953. [PMID: 32503821] - Blanka Miková, Miloš Dvořák, Lenka Ryšavá, Pavel Kubáň. Hollow Fiber Liquid-Phase Microextraction At-Line Coupled to Capillary Electrophoresis for Direct Analysis of Human Body Fluids.
Analytical chemistry.
2020 05; 92(10):7171-7178. doi:
10.1021/acs.analchem.0c00697. [PMID: 32289222] - Amir Reza Naemi, Vahid Kashanitabar, Alireza Kamali, Ashkan Shiva. Comparison of the Effects of Haloperidol, Metoclopramide, Dexmedetomidine and Ginger on Postoperative Nausea and Vomiting After Laparoscopic Cholecystectomy.
Journal of medicine and life.
2020 Apr; 13(2):206-210. doi:
10.25122/jml-2019-0070. [PMID: 32742515] - Afshin Samadi, Mojataba Ziaee, Selen Yilmaz Isikhan, Nuriye Nuray Ulusu, Mahshid Samadi. Effects of treatment with haloperidol and clozapine on the plasma concentrations of thyroid hormones in rats.
Endocrine regulations.
2020 Apr; 54(2):71-76. doi:
10.2478/enr-2020-0009. [PMID: 32597158] - Joju Johns, Nigel Caulkett, George Chandy, Jacob Alexander, Syam K Venugopal, Sooryadas Surendran, Ajithkumar Sreedharannair. ORAL HALOPERIDOL PREMEDICATION TO REDUCE CAPTURE STRESS PRIOR TO XYLAZINE-KETAMINE ANESTHESIA IN CAPTIVE SPOTTED DEER (AXIS AXIS).
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians.
2020 Mar; 51(1):88-95. doi:
10.1638/2017-0034. [PMID: 32212550] - Anna Schildt, Erik F J de Vries, Antoon T M Willemsen, Bruno Lima Giacobbo, Rodrigo Moraga-Amaro, Jürgen W A Sijbesma, Aren van Waarde, Vesna Sossi, Rudi A J O Dierckx, Janine Doorduin. Effect of Dopamine D2 Receptor Antagonists on [18F]-FEOBV Binding.
Molecular pharmaceutics.
2020 03; 17(3):865-872. doi:
10.1021/acs.molpharmaceut.9b01129. [PMID: 32011892] - Amit Dahal, Rabin Neupane, Sai Hs Boddu, Jwala Renukuntla, Rahul Khupse, Richard Dudley. Percutaneous Absorption of Lorazepam, Diphenhydramine Hydrochloride, and Haloperidol from ABH Gel.
International journal of pharmaceutical compounding.
2020 Mar; 24(2):168-175. doi:
NULL. [PMID: 32196480] - Yan Li, Jun Ma, Yinghui Jin, Nan Li, Rui Zheng, Wei Mu, Jiaying Wang, Jin Hua Si, Jing Chen, Hong Cai Shang. Benzodiazepines for treatment of patients with delirium excluding those who are cared for in an intensive care unit.
The Cochrane database of systematic reviews.
2020 02; 2(?):CD012670. doi:
10.1002/14651858.cd012670.pub2. [PMID: 32108325] - Edgor Cole Tolledo, Sharon Miksys, Frank J Gonzalez, Rachel F Tyndale. Propranolol is a mechanism-based inhibitor of CYP2D and CYP2D6 in humanized CYP2D6-transgenic mice: Effects on activity and drug responses.
British journal of pharmacology.
2020 02; 177(3):701-712. doi:
10.1111/bph.14884. [PMID: 31648367] - Gayathri Nair Sekhar, Alice L Fleckney, Sevda Tomova Boyanova, Huzefa Rupawala, Rachel Lo, Hao Wang, Doaa B Farag, Khondaker Miraz Rahman, Martin Broadstock, Suzanne Reeves, Sarah Ann Thomas. Region-specific blood-brain barrier transporter changes leads to increased sensitivity to amisulpride in Alzheimer's disease.
Fluids and barriers of the CNS.
2019 Dec; 16(1):38. doi:
10.1186/s12987-019-0158-1. [PMID: 31842924] - Uzma Saleem, Zohaib Raza, Fareeha Anwar, Zunera Chaudary, Bashir Ahmad. Systems pharmacology based approach to investigate the in-vivo therapeutic efficacy of Albizia lebbeck (L.) in experimental model of Parkinson's disease.
BMC complementary and alternative medicine.
2019 Dec; 19(1):352. doi:
10.1186/s12906-019-2772-5. [PMID: 31805998] - Tanja Veselinović, Martin Scharpenberg, Martin Heinze, Joachim Cordes, Bernd Mühlbauer, Georg Juckel, Eckart Rüther, Michael Paulzen, Ekkehard Haen, Christoph Hiemke, Jürgen Timm, Gerhard Gründer. Dopamine D2 Receptor Occupancy Estimated From Plasma Concentrations of Four Different Antipsychotics and the Subjective Experience of Physical and Mental Well-Being in Schizophrenia: Results From the Randomized NeSSy Trial.
Journal of clinical psychopharmacology.
2019 Nov; 39(6):550-560. doi:
10.1097/jcp.0000000000001131. [PMID: 31688449] - Hanaa Attia Khalaf, Ekramy Elmorsy, El-Hassanin Mohamed Mahmoud, Amal Misbah Aggour, Saad A Amer. The role of oxidative stress in ovarian toxicity induced by haloperidol and clozapine-a histological and biochemical study in albino rats.
Cell and tissue research.
2019 Nov; 378(2):371-383. doi:
10.1007/s00441-019-03067-x. [PMID: 31342169] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Panpan Wang, Ting Cao, Jiaojiao Chen, Yiguo Jiang, Cheng Wang, John L Waddington, Xuechu Zhen. D2 receptor-mediated miRNA-143 expression is associated with the effects of antipsychotic drugs on phencyclidine-induced schizophrenia-related locomotor hyperactivity and with Neuregulin-1 expression in mice.
Neuropharmacology.
2019 10; 157(?):107675. doi:
10.1016/j.neuropharm.2019.107675. [PMID: 31233824] - Luc De Vries, Frédéric Finana, Claudie Cathala, Brice Ronsin, Didier Cussac. Innovative Bioluminescence Resonance Energy Transfer Assay Reveals Differential Agonist-Induced D2 Receptor Intracellular Trafficking and Arrestin-3 Recruitment.
Molecular pharmacology.
2019 09; 96(3):308-319. doi:
10.1124/mol.119.115998. [PMID: 31266815] - Afshin Samadi, Selen Yilmaz Isikhan, Mohammad Hasan Khadem Ansari, Mahshid Samadi, Suna Sabuncuoglu. Effects of clozapine and haloperidol treatment on plasma concentrations of androgen hormones and androgendependent organ changes in rats.
Indian journal of pharmacology.
2019 Jul; 51(4):269-275. doi:
10.4103/ijp.ijp_145_18. [PMID: 31571714] - Raif İlktaç, Zinar Pinar Gumus, Nur Aksuner, Hakan Coskunol. Highly sensitive and selective method for the rapid determination and preconcentration of haloperidol by using a magnetite-molecularly imprinted polymer.
Journal of separation science.
2019 Jun; 42(12):2115-2122. doi:
10.1002/jssc.201900158. [PMID: 30980609] - Cheng-Chia Tsai, Mao-Hsien Wang, Kuo-Chi Chang, Hung-Sheng Soung, Chih-Chuan Yang, Hsiang-Chien Tseng. Possible nitric oxide mechanism involved in the protective effect of L-theanine on haloperidol-induced orofacial dyskinesia.
The Chinese journal of physiology.
2019 Jan; 62(1):17-26. doi:
10.4103/cjp.cjp_8_19. [PMID: 30942195] - Xiaohong Liu, Rakesh Kumar Sharma, Anurag Mishra, Gopala Krishna Chinnaboina, Gaurav Gupta, Mahaveer Singh. Role of Aqueous Extract of the Wood Ear Mushroom, Auricularia polytricha (Agaricomycetes), in Avoidance of Haloperidol-lnduced Catalepsy via Oxidative Stress in Rats.
International journal of medicinal mushrooms.
2019; 21(4):323-330. doi:
10.1615/intjmedmushrooms.2019030351. [PMID: 31002628] - Xudong Cao, Yifang Zhang, Yin Chen, Yinli Qiu, Minquan Yu, Xiangqing Xu, Xin Liu, Bi-Feng Liu, Liangren Zhang, Guisen Zhang. Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics.
Journal of medicinal chemistry.
2018 11; 61(22):10017-10039. doi:
10.1021/acs.jmedchem.8b01096. [PMID: 30383372] - Jori Leenders, Ed Overdevest, Bart van Straten, Hanna Golab. The influence of oxygen delivery during cardiopulmonary bypass on the incidence of delirium in CABG patients; a retrospective study.
Perfusion.
2018 11; 33(8):656-662. doi:
10.1177/0267659118783104. [PMID: 29956559] - Andreza B Sonego, Douglas S Prado, Gabriel T Vale, Julia E Sepulveda-Diaz, Thiago M Cunha, Carlos R Tirapelli, Elaine A Del Bel, Rita Raisman-Vozari, Francisco S Guimarães. Cannabidiol prevents haloperidol-induced vacuos chewing movements and inflammatory changes in mice via PPARγ receptors.
Brain, behavior, and immunity.
2018 11; 74(?):241-251. doi:
10.1016/j.bbi.2018.09.014. [PMID: 30217539] - Dinesh Dhingra, Shikha Goswami, Nidhi Gahalain. Protective effect of hesperetin against haloperidol-induced orofacial dyskinesia and catalepsy in rats.
Nutritional neuroscience.
2018 Nov; 21(9):667-675. doi:
10.1080/1028415x.2017.1338549. [PMID: 28641484] - Victor Wumbor-Apin Kumbol, Wonder Kofi Mensah Abotsi, Edmund Ekuadzi, Eric Woode. Albizia zygia root extract exhibits antipsychotic-like properties in murine models of schizophrenia.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Oct; 106(?):831-841. doi:
10.1016/j.biopha.2018.07.030. [PMID: 30119253] - Gopinadh Bhyrapuneni, Jagadeesh Babu Thentu, Abdul Rasheed Mohammed, Raghupathi Reddy Aleti, Nagasurya Prakash Padala, Devender Reddy Ajjala, Ramakrishna Nirogi. Assessment of sigma-1 receptor occupancy in mice with non-radiolabelled FTC-146 as a tracer.
Journal of receptor and signal transduction research.
2018 Aug; 38(4):290-298. doi:
10.1080/10799893.2018.1478855. [PMID: 29912606] - Abderrezak Khelfi, Mohammed Azzouz, Rania Abtroun, Mohammed Reggabi, Berkahoum Alamir. Antipsychotic-induced disorders: Reported cases and prospective study on muscle biomarkers after high exposure to haloperidol.
Toxicology and applied pharmacology.
2018 08; 352(?):1-8. doi:
10.1016/j.taap.2018.05.015. [PMID: 29778398] - K F Szűcs, G Grosz, M Süle, A Sztojkov-Ivanov, E Ducza, A Márki, A Kothencz, L Balogh, R Gáspár. Detection of stress and the effects of central nervous system depressants by gastrointestinal smooth muscle electromyography in wakeful rats.
Life sciences.
2018 Jul; 205(?):1-8. doi:
10.1016/j.lfs.2018.05.015. [PMID: 29746845] - Mayra Alejandra Santillán-Urquiza, Maribel Herrera-Ruiz, Alejandro Zamilpa, Enrique Jiménez-Ferrer, Rubén Román-Ramos, Jaime Tortoriello. Pharmacological interaction of Galphimia glauca extract and natural galphimines with Ketamine and Haloperidol on different behavioral tests.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Jul; 103(?):879-888. doi:
10.1016/j.biopha.2018.04.082. [PMID: 29710504] - Kai Lei, Guo-Fang He, Cheng-Liang Zhang, Ya-Nan Liu, Juan Li, Guang-Zhao He, Xi-Ping Li, Xiu-Hua Ren, Dong Liu. Investigation of the synergistic effects of haloperidol combined with Calculus Bovis Sativus in treating MK-801-induced schizophrenia in rats.
Experimental animals.
2018 May; 67(2):163-173. doi:
10.1538/expanim.17-0091. [PMID: 29225304] - Oneka T Cummings, Erin C Strickland, Jeffrey R Enders, Gregory McIntire. Impact of β-Glucuronidase Mediated Hydrolysis on Haldol® Urinalysis.
Journal of analytical toxicology.
2018 May; 42(4):214-219. doi:
10.1093/jat/bkx103. [PMID: 29301034] - Sunayana Vikhe, Sunil Nirmal. Antiallergic and antihistaminic actions of Ceasalpinia bonducella seeds: Possible role in treatment of asthma.
Journal of ethnopharmacology.
2018 Apr; 216(?):251-258. doi:
10.1016/j.jep.2017.12.007. [PMID: 29247697] - A E Taraskina, A M Zabotina, R F Nasyrova, D N Sosin, K A Sosina, E E Ershov, M N Grunina, E M Krupitsky. [The effect of antipsychotic drug on monoamine receptors in peripheral blood mononuclear cells: affinity linked mechanism].
Biomeditsinskaia khimiia.
2018 Mar; 64(2):201-207. doi:
10.18097/pbmc20186402201. [PMID: 29723151] - Behnaz Bameri, Fatemeh Shaki, Nematollah Ahangar, Ramin Ataee, Mahedeh Samadi, Hamidreza Mohammadi. Evidence for the Involvement of the Dopaminergic System in Seizure and Oxidative Damage Induced by Tramadol.
International journal of toxicology.
2018 Mar; 37(2):164-170. doi:
10.1177/1091581817753607. [PMID: 29554822] - Dae Myung Jung, Hyun Joo Ahn, Mikyung Yang, Jie Ae Kim, Duck Kyung Kim, Sangmin Maria Lee, Joo Hyun Park. Hydroxyethyl starch is associated with early postoperative delirium in patients undergoing esophagectomy.
The Journal of thoracic and cardiovascular surgery.
2018 03; 155(3):1333-1343. doi:
10.1016/j.jtcvs.2017.10.077. [PMID: 29221748] - Cheng-Neng Chen, Kuo-Chi Chang, Mao-Hsien Wang, Hsiang-Chien Tseng, Hung-Sheng Soung. Protective Effect of L-Theanine on Haloperidol-Induced Orofacial.
The Chinese journal of physiology.
2018 Feb; 61(1):35-41. doi:
10.4077/cjp.2018.bag529. [PMID: 29374957] - Dalila Moter Benvegnú, Katiane Roversi, Raquel Cristine Silva Barcelos, Fabíola Trevizol, Camila Simonetti Pase, Hecson Jesser Segat, Verônica Tironi Dias, Ana Luiza Savian, Bruna Lopes Piccoli, Jaqueline Piccolo, Carlos Severo Dutra-Filho, Tatiana Emanuelli, Cristiane de Bona da Silva, Ruy Carlos Ruver Beck, Marilise Escobar Burger. Effects of Fish and Grape Seed Oils as Core of Haloperidol-Loaded Nanocapsules on Oral Dyskinesia in Rats.
Neurochemical research.
2018 Feb; 43(2):477-487. doi:
10.1007/s11064-017-2444-0. [PMID: 29209877] - Kazunori Suzuki, Akina Harada, Hirobumi Suzuki, Clizia Capuani, Annarosa Ugolini, Mauro Corsi, Haruhide Kimura. Combined treatment with a selective PDE10A inhibitor TAK-063 and either haloperidol or olanzapine at subeffective doses produces potent antipsychotic-like effects without affecting plasma prolactin levels and cataleptic responses in rodents.
Pharmacology research & perspectives.
2018 02; 6(1):. doi:
10.1002/prp2.372. [PMID: 29417763] - Valerie D Slooff, Desley K van den Dungen, Babette S van Beusekom, Naomi Jessurun, Erwin Ista, Dick Tibboel, Saskia N de Wildt. Monitoring Haloperidol Plasma Concentration and Associated Adverse Events in Critically Ill Children With Delirium: First Results of a Clinical Protocol Aimed to Monitor Efficacy and Safety.
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies.
2018 02; 19(2):e112-e119. doi:
10.1097/pcc.0000000000001414. [PMID: 29239979] - Emanuele Amata, Antonio Rescifina, Orazio Prezzavento, Emanuela Arena, Maria Dichiara, Valeria Pittalà, Ángeles Montilla-García, Francesco Punzo, Pedro Merino, Enrique J Cobos, Agostino Marrazzo. (+)-Methyl (1R,2S)-2-{[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]methyl}-1-phenylcyclopropanecarboxylate [(+)-MR200] Derivatives as Potent and Selective Sigma Receptor Ligands: Stereochemistry and Pharmacological Properties.
Journal of medicinal chemistry.
2018 01; 61(1):372-384. doi:
10.1021/acs.jmedchem.7b01584. [PMID: 29220177] - Peter C T Hawkins, Tobias C Wood, Anthony C Vernon, Alessandro Bertolino, Fabio Sambataro, Juergen Dukart, Emilio Merlo-Pich, Celine Risterucci, Hanna Silber-Baumann, Eamonn Walsh, Ndabezinhle Mazibuko, Fernando O Zelaya, Mitul A Mehta. An investigation of regional cerebral blood flow and tissue structure changes after acute administration of antipsychotics in healthy male volunteers.
Human brain mapping.
2018 01; 39(1):319-331. doi:
10.1002/hbm.23844. [PMID: 29058358] - A E Taraskina, R F Nasyrova, A M Zabotina, D N Sosin, К А Sosina, E E Ershov, M N Grunina, E M Krupitsky. Potential diagnostic markers of olanzapine efficiency for acute psychosis: a focus on peripheral biogenic amines.
BMC psychiatry.
2017 Dec; 17(1):394. doi:
10.1186/s12888-017-1562-1. [PMID: 29221470] - The-Vinh Tran, Eun-Joo Shin, Ji Hoon Jeong, Ji Won Lee, Youngho Lee, Choon-Gon Jang, Seung-Yeol Nah, Xin Gen Lei, Kazuya Toriumi, Kiyofumi Yamada, Toshitaka Nabeshima, Hyoung-Chun Kim. Protective Potential of the Glutathione Peroxidase-1 Gene in Abnormal Behaviors Induced by Phencyclidine in Mice.
Molecular neurobiology.
2017 11; 54(9):7042-7062. doi:
10.1007/s12035-016-0239-y. [PMID: 27796745] - Tatjana Nikolić, Milan Petronijević, Jelena Sopta, Milica Velimirović, Tihomir Stojković, Gordana Jevtić Dožudić, Milan Aksić, Nevena V Radonjić, Nataša Petronijević. Haloperidol affects bones while clozapine alters metabolic parameters - sex specific effects in rats perinatally treated with phencyclidine.
BMC pharmacology & toxicology.
2017 10; 18(1):65. doi:
10.1186/s40360-017-0171-4. [PMID: 29020988] - Catherine Lévesque, Giovanni Hernandez, Souha Mahmoudi, Frédéric Calon, Fabrizio Gasparini, Baltazar Gomez-Mancilla, Pierre J Blanchet, Daniel Lévesque. Deficient striatal adaptation in aminergic and glutamatergic neurotransmission is associated with tardive dyskinesia in non-human primates exposed to antipsychotic drugs.
Neuroscience.
2017 Oct; 361(?):43-57. doi:
10.1016/j.neuroscience.2017.07.068. [PMID: 28790021] - Ekramy Elmorsy, Ayat Al-Ghafari, Amal Misbah Aggour, Raheela Khan, Saad Amer. The role of oxidative stress in antipsychotics induced ovarian toxicity.
Toxicology in vitro : an international journal published in association with BIBRA.
2017 Oct; 44(?):190-195. doi:
10.1016/j.tiv.2017.07.008. [PMID: 28712880] - Tao Bai, Shuai Wang, Yipu Zhao, Rongtao Zhu, Weijie Wang, Yuling Sun. Haloperidol, a sigma receptor 1 antagonist, promotes ferroptosis in hepatocellular carcinoma cells.
Biochemical and biophysical research communications.
2017 09; 491(4):919-925. doi:
10.1016/j.bbrc.2017.07.136. [PMID: 28756230] - Dmitry A Sychev, Mikhail S Zastrozhin, Igor I Miroshnichenko, Natalia V Baymeeva, Valery V Smirnov, Elena A Grishina, Kristina A Ryzhikova, Karin B Mirzaev, Dmitry D Markov, Valentin Y Skryabin, Nataliya E Snalina, Polina G Nosikova, Ludmila M Savchenko, Evgeny A Bryun. Genotyping and phenotyping of CYP2D6 and CYP3A isoenzymes in patients with alcohol use disorder: correlation with haloperidol plasma concentration.
Drug metabolism and personalized therapy.
2017 09; 32(3):129-136. doi:
10.1515/dmpt-2017-0021. [PMID: 28787271] - Patrick Amoateng, Samuel Adjei, Dorcas Osei-Safo, Kennedy K E Kukuia, Thomas K Karikari, Alexander K Nyarko. An ethanolic extract of Desmodium adscendens exhibits antipsychotic-like activity in mice.
Journal of basic and clinical physiology and pharmacology.
2017 Sep; 28(5):507-518. doi:
10.1515/jbcpp-2016-0115. [PMID: 28710881] - Bart G J Dekkers, Ruben J Eck, Jan C Ter Maaten, Daniël J Touw. An acute oral intoxication with haloperidol decanoate.
The American journal of emergency medicine.
2017 Sep; 35(9):1387.e1-1387.e2. doi:
10.1016/j.ajem.2017.07.013. [PMID: 28705742] - Željka Korade, Wei Liu, Emily B Warren, Kristan Armstrong, Ned A Porter, Christine Konradi. Effect of psychotropic drug treatment on sterol metabolism.
Schizophrenia research.
2017 09; 187(?):74-81. doi:
10.1016/j.schres.2017.02.001. [PMID: 28202290] - Akintunde Jacob Kehinde. Functional Oil from Black Seed Differentially Inhibits Aldose-reductase and Ectonucleotidase Activities by Up-regulating Cellular Energy in Haloperidol-induced Hepatic Toxicity in Rat Liver.
Journal of oleo science.
2017 Sep; 66(9):1051-1060. doi:
10.5650/jos.ess17036. [PMID: 28794311] - Ruziana Masiran, Mohammad Firdaus Abdul Aziz. Hypertensive bipolar: chronic lithium toxicity in patients taking ACE inhibitor.
BMJ case reports.
2017 Aug; 2017(?):. doi:
10.1136/bcr-2017-220631. [PMID: 28847993] - Patrick Amoateng, Samuel Adjei, Dorcas Osei-Safo, Kennedy K E Kukuia, Emelia Oppong Bekoe, Thomas K Karikari, Samuel B Kombian. Extract of Synedrella nodiflora (L) Gaertn exhibits antipsychotic properties in murine models of psychosis.
BMC complementary and alternative medicine.
2017 Aug; 17(1):389. doi:
10.1186/s12906-017-1901-2. [PMID: 28784133] - Noreen Samad, Darakhshan Jabeen Haleem. Antioxidant effects of rice bran oil mitigate repeated haloperidol-induced tardive dyskinesia in male rats.
Metabolic brain disease.
2017 08; 32(4):1099-1107. doi:
10.1007/s11011-017-0002-8. [PMID: 28374238] - Sharon Miksys, Fariba Baghai Wadji, Edgor Cole Tolledo, Gary Remington, Jose N Nobrega, Rachel F Tyndale. Rat brain CYP2D enzymatic metabolism alters acute and chronic haloperidol side-effects by different mechanisms.
Progress in neuro-psychopharmacology & biological psychiatry.
2017 08; 78(?):140-148. doi:
10.1016/j.pnpbp.2017.04.030. [PMID: 28454738] - Hiroko Izumi-Nakaseko, Yuji Nakamura, Xin Cao, Takeshi Wada, Kentaro Ando, Atsushi Sugiyama. Assessment of Safety Margin of an Antipsychotic Drug Haloperidol for Torsade de Pointes Using the Chronic Atrioventricular Block Dogs.
Cardiovascular toxicology.
2017 07; 17(3):319-325. doi:
10.1007/s12012-016-9388-5. [PMID: 27738880]
