leflunomide (BioDeep_00000398851)
Main id: BioDeep_00000006627
natural product
代谢物信息卡片
leflunomide
化学式: C12H9F3N2O2 (270.0616)
中文名称: 来氟米特
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1(=CC=C(C=C1)C(F)(F)F)NC(C2C=NOC=2C)=O
InChI: InChI=1S/C12H9F3N2O2/c1-7-10(6-16-19-7)11(18)17-9-4-2-8(3-5-9)12(13,14)15/h2-6H,1H3,(H,17,18)
描述信息
L - Antineoplastic and immunomodulating agents > L04 - Immunosuppressants > L04A - Immunosuppressants > L04AA - Selective immunosuppressants
C274 - Antineoplastic Agent > C1742 - Angiogenesis Inhibitor > C1971 - Angiogenesis Activator Inhibitor
C274 - Antineoplastic Agent > C186664 - Cytotoxic Chemotherapeutic Agent > C272 - Antimetabolite
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C471 - Enzyme Inhibitor > C2169 - Dihydroorotate Dehydrogenase Inhibitor
D007155 - Immunologic Factors > D007166 - Immunosuppressive Agents
D004791 - Enzyme Inhibitors
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
2 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:6402
- KEGG: C07905
- KEGGdrug: D00749
- PubChem: 3899
- DrugBank: DB01097
- ChEMBL: CHEMBL960
- MeSH: Leflunomide
- CAS: 75706-12-6
- CAS: 75706-12-6, 210165-51-8
- MoNA: CCMSLIB00000078065
- PubChem: 10107
- NIKKAJI: J227.599F
- RefMet: Leflunomide
- KNApSAcK: 6402
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Xiaoyue Ji, Junhong Chen, Chaoying You, Jing Sun, Xiulong Xu. Leflunomide alleviates obesity via activation of the TAK1-AMPK pathway and induction of lipophagy.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2023 11; 37(11):e23227. doi:
10.1096/fj.202301162r. [PMID: 37792678] - Georgia D Papadogiorgou, Cleopatra A Moraiti, David Nestel, John S Terblanche, Eleni Verykouki, Nikos T Papadopoulos. Acute cold stress and supercooling capacity of Mediterranean fruit fly populations across the Northern Hemisphere (Middle East and Europe).
Journal of insect physiology.
2023 06; 147(?):104519. doi:
10.1016/j.jinsphys.2023.104519. [PMID: 37121467] - Guangxin Lv, Chengyuan Ming. Efficacy and safety of leflunomide combined with corticosteroids for the treatment of IgA nephropathy: a Meta-analysis of randomized controlled trials.
Renal failure.
2022 Dec; 44(1):1011-1025. doi:
10.1080/0886022x.2022.2085576. [PMID: 35786300] - Mei Li, Jun Liang, Wenyou Pan, Lin Liu, Min Wu, Fuwan Ding, Huaixia Hu, Xiang Ding, Hua Wei, Yaohong Zou, Xian Qian, Meimei Wang, Jian Wu, Juan Tao, Jun Tan, Zhanyun Da, Miaojia Zhang, Jing Li, Xuebing Feng, Lihui Wen, Huayong Zhang, Lingyun Sun. Predictors of improvement in disease activity in first hospitalized patients with systemic lupus erythematosus: a multicenter retrospective study of a Chinese cohort.
Clinical rheumatology.
2022 Nov; 41(11):3355-3362. doi:
10.1007/s10067-022-06289-7. [PMID: 35849245] - Jelka Kramarič, Rok Ješe, Matija Tomšič, Žiga Rotar, Alojzija Hočevar. COVID-19 among patients with giant cell arteritis: a single-centre observational study from Slovenia.
Clinical rheumatology.
2022 Aug; 41(8):2449-2456. doi:
10.1007/s10067-022-06157-4. [PMID: 35366735] - Georgina Nakafero, Matthew J Grainge, Tim Card, Maarten W Taal, Guruprasad P Aithal, Weiya Zhang, Michael Doherty, Christopher P Fox, Christian D Mallen, Abhishek Abhishek. Development and validation of a prognostic model for leflunomide discontinuation with abnormal blood tests during long-term treatment: cohort study using data from the Clinical Practice Research Datalink Gold and Aurum.
Rheumatology (Oxford, England).
2022 07; 61(7):2783-2791. doi:
10.1093/rheumatology/keab790. [PMID: 34718430] - Chenyang Zhao, Zhao Cui, Yimiao Zhang, Fang Wang, Xin Wang, Xuyang Cheng, Liqiang Meng, Gang Liu, Minghui Zhao. Leflunomide therapy for adult patients with steroid-dependent minimal change disease or primary focal segmental glomerulosclerosis.
Chinese medical journal.
2022 04; 135(7):866-868. doi:
10.1097/cm9.0000000000001855. [PMID: 34935693] - Ning Xiao, Feng Xiao, Jinzhang Gao, Zhengkun Xu, Qianlei Wang, Jiajie Kuai, Wei Wei, Chun Wang. Effects of paeoniflorin-6'-O-benzene sulfonate on the pharmacokinetics, excretion and tissue distribution of leflunomide in rats.
Basic & clinical pharmacology & toxicology.
2022 Mar; 130(3):364-374. doi:
10.1111/bcpt.13685. [PMID: 34792845] - Nicte S Fajardo-Robledo, Heriberto Jacobo-Cuevas, Edsaul E Perez-Guerrero, Esther G Corona-Sanchez, A Miriam Saldaña-Cruz, Elba M Romero-Tejeda, N Alejandra Rodriguez-Jimenez, Sylvia E Totsuka-Sutto, Rocio I Lopez-Roa, Juan M Ponce-Guarneros, M Fabiola Alcaraz-Lopez, Sergio Cerpa-Cruz, J Francisco Muñoz-Valle, E German Cardona-Muñoz, Laura Gonzalez-Lopez, Jorge I Gamez-Nava. Therapeutic response to leflunomide in combo therapy and monotherapy is associated to serum teriflunomide (A77 1726) levels.
Scientific reports.
2022 02; 12(1):1877. doi:
10.1038/s41598-022-05644-7. [PMID: 35115601] - Mengmei Wang, Yang Zhao, Weihua Hu, Dong Zhao, Yunting Zhang, Tao Wang, Zhishui Zheng, Xiaochen Li, Shaolin Zeng, Zhenlian Liu, Li Lu, Zhihui Wan, Ke Hu. Treatment of Coronavirus Disease 2019 Patients With Prolonged Postsymptomatic Viral Shedding With Leflunomide: A Single-center Randomized Controlled Clinical Trial.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2021 12; 73(11):e4012-e4019. doi:
10.1093/cid/ciaa1417. [PMID: 32955081] - Mariam Zewail, Noha Nafee, Maged W Helmy, Nabila Boraie. Synergistic and receptor-mediated targeting of arthritic joints via intra-articular injectable smart hydrogels containing leflunomide-loaded lipid nanocarriers.
Drug delivery and translational research.
2021 12; 11(6):2496-2519. doi:
10.1007/s13346-021-00992-9. [PMID: 34013458] - Zhaohui Ni, Zhen Zhang, Zanzhe Yu, Fuming Lu, Changlin Mei, Xiaoqiang Ding, Weijie Yuan, Wei Zhang, Gengru Jiang, Min Sun, Liqun He, Yueyi Deng, Huihua Pang, Jiaqi Qian. Leflunomide plus low-dose prednisone in patients with progressive IgA nephropathy: a multicenter, prospective, randomized, open-labeled, and controlled trial.
Renal failure.
2021 Dec; 43(1):1214-1221. doi:
10.1080/0886022x.2021.1963775. [PMID: 34396911] - Georgina Nakafero, Matthew J Grainge, Tim Card, Christian D Mallen, Weiya Zhang, Michael Doherty, Maarten W Taal, Guruprasad P Aithal, Abhishek Abhishek. What is the incidence of methotrexate or leflunomide discontinuation related to cytopenia, liver enzyme elevation or kidney function decline?.
Rheumatology (Oxford, England).
2021 12; 60(12):5785-5794. doi:
10.1093/rheumatology/keab254. [PMID: 33725120] - Yebei Li, Yi Xiong, Tianlun Huang, Xin Liu, Gaosi Xu. Clinical efficacy and safety of full-dose versus half-dose corticosteroids plus leflunomide for IgA nephropathy.
BMC nephrology.
2021 11; 22(1):364. doi:
10.1186/s12882-021-02555-z. [PMID: 34736419] - Ling Hou, Zhou Zhang, Yue Du. Leflunomide therapy for IgA vasculitis with nephritis in children.
BMC pediatrics.
2021 09; 21(1):391. doi:
10.1186/s12887-021-02866-y. [PMID: 34496826] - Hardeep Kaur, Phulen Sarma, Anusuya Bhattacharyya, Saurabh Sharma, Neeraj Chhimpa, Manisha Prajapat, Ajay Prakash, Subodh Kumar, Ashutosh Singh, Rahul Singh, Pramod Avti, Prasad Thota, Bikash Medhi. Efficacy and safety of dihydroorotate dehydrogenase (DHODH) inhibitors "leflunomide" and "teriflunomide" in Covid-19: A narrative review.
European journal of pharmacology.
2021 Sep; 906(?):174233. doi:
10.1016/j.ejphar.2021.174233. [PMID: 34111397] - Michael D Wiese, Ashley M Hopkins, Catherine King, Mihir D Wechalekar, Anita Lee, Llewellyn Spargo, Robert Metcalf, Leah McWilliams, Catherine Hill, Leslie G Cleland, Susanna M Proudman. Precision Medicine With Leflunomide: Consideration of the DHODH Haplotype and Plasma Teriflunomide Concentration and Modification of Outcomes in Patients With Rheumatoid Arthritis.
Arthritis care & research.
2021 07; 73(7):983-989. doi:
10.1002/acr.24236. [PMID: 32339392] - Mengmei Wang, Ke Hu. Reply to DeVito.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2021 06; 72(12):e1165-e1166. doi:
10.1093/cid/ciaa1811. [PMID: 33274380] - Nicholas J DeVito. Concerning Trials Registration.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.
2021 06; 72(12):e1164-e1165. doi:
10.1093/cid/ciaa1808. [PMID: 33270097] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Raghad D Alamri, Mazen A Elmeligy, Ghadeer A Albalawi, Sarah M Alquayr, Samaher S Alsubhi, Sabah H El-Ghaiesh. Leflunomide an immunomodulator with antineoplastic and antiviral potentials but drug-induced liver injury: A comprehensive review.
International immunopharmacology.
2021 Apr; 93(?):107398. doi:
10.1016/j.intimp.2021.107398. [PMID: 33571819] - Huan Huang, Hao Ran, Xiaoxi Liu, Lu Yu, Li Qiu, Zhongqiang Lin, Changyi Ou, Yaru Lu, Wenhao Yang, Weibin Liu. Leflunomide ameliorates experimental autoimmune myasthenia gravis by regulating humoral and cellular immune responses.
International immunopharmacology.
2021 Apr; 93(?):107434. doi:
10.1016/j.intimp.2021.107434. [PMID: 33556668] - Yao Li, Li Yi, Sipeng Cheng, Yongshan Wang, Jiongjiong Wang, Jing Sun, Quan Zhang, Xiulong Xu. Inhibition of canine distemper virus replication by blocking pyrimidine nucleotide synthesis with A77 1726, the active metabolite of the anti-inflammatory drug leflunomide.
The Journal of general virology.
2021 03; 102(3):. doi:
10.1099/jgv.0.001534. [PMID: 33416466] - Zhijie Wan, He Li, Xiaohan Wu, Haiyun Zhao, Ran Wang, Mengmeng Li, Jing Liu, Qingfeng Liu, Rui Wang, Xiaotian Li. Hepatoprotective effect of gentiopicroside in combination with leflunomide and/or methotrexate in arthritic rats.
Life sciences.
2021 Jan; 265(?):118689. doi:
10.1016/j.lfs.2020.118689. [PMID: 33130083] - Shuwen Pei, Yan Li. Huangkui Capsule in Combination with Leflunomide Improves Immunoglobulin A Nephropathy by Inhibiting the TGF-β1/Smad3 Signaling Pathway.
Clinics (Sao Paulo, Brazil).
2021; 76(?):e2904. doi:
10.6061/clinics/2021/e2904. [PMID: 34909911] - Liyan Mei, Zhihua Yang, Xiaolin Zhang, Zehao Liu, Maojie Wang, Xiaodong Wu, Xiumin Chen, Qingchun Huang, Runyue Huang. Sustained Drug Treatment Alters the Gut Microbiota in Rheumatoid Arthritis.
Frontiers in immunology.
2021; 12(?):704089. doi:
10.3389/fimmu.2021.704089. [PMID: 34721377] - Yunhan Ma, Baiyi Xie, Junjun Guo, Yingyu Chen, Mengya Zhong, Qingru Lin, Jianyu Hua, Jiaying Zhong, Xuewei Luo, Guoliang Yan, Helong Dai, Zhongquan Qi. Leflunomide Inhibits rat-to-Mouse Cardiac Xenograft Rejection by Suppressing Adaptive Immune Cell Response and NF-κB Signaling Activation.
Cell transplantation.
2021 Jan; 30(?):9636897211054503. doi:
10.1177/09636897211054503. [PMID: 34814739] - Ke Hu, Mengmei Wang, Yang Zhao, Yunting Zhang, Tao Wang, Zhishui Zheng, Xiaochen Li, Shaolin Zeng, Dong Zhao, Honglin Li, Ke Xu, Ke Lan. A Small-Scale Medication of Leflunomide as a Treatment of COVID-19 in an Open-Label Blank-Controlled Clinical Trial.
Virologica Sinica.
2020 Dec; 35(6):725-733. doi:
10.1007/s12250-020-00258-7. [PMID: 32696396] - Yiwen Wang, Zheng Zhao, Dai Gao, Hui Wang, Simin Liao, Chongya Dong, Gui Luo, Xiaojian Ji, Yan Li, Xiuru Wang, Yurong Zhao, Kunpeng Li, Jie Zhang, Jingyu Jin, Yamei Zhang, Jian Zhu, Jianglin Zhang, Feng Huang. Additive effect of leflunomide and glucocorticoids compared with glucocorticoids monotherapy in preventing relapse of IgG4-related disease: A randomized clinical trial.
Seminars in arthritis and rheumatism.
2020 12; 50(6):1513-1520. doi:
10.1016/j.semarthrit.2020.01.010. [PMID: 32113839] - Tomotaka Yamazaki, Hiroyuki Shirai, Tamotsu Tojimbara. Use of Leflunomide as an Antiviral Agent with Everolimus for BK Virus Nephropathy Patients After Kidney Transplantation: A Case Series.
The American journal of case reports.
2020 Nov; 21(?):e927367. doi:
10.12659/ajcr.927367. [PMID: 33235184] - Yaling Guo, Xueping Wu, Lei Liu, Haifeng Zhang, Lijuan Yang, Weidong Chen. Efficacy of leflunomide combined with prednisone for the treatment of PLA2R-associated primary membranous nephropathy.
Renal failure.
2020 Nov; 42(1):122-130. doi:
10.1080/0886022x.2020.1713806. [PMID: 31957527] - Laila Schneidewind, Thomas Neumann, Desiree L Dräger, Jennifer Kranz, Oliver W Hakenberg. Leflunomide in the treatment of BK polyomavirus associated nephropathy in kidney transplanted patients - A systematic review.
Transplantation reviews (Orlando, Fla.).
2020 10; 34(4):100565. doi:
10.1016/j.trre.2020.100565. [PMID: 32611496] - Ana R Coelho, Paulo J Oliveira. Dihydroorotate dehydrogenase inhibitors in SARS-CoV-2 infection.
European journal of clinical investigation.
2020 Oct; 50(10):e13366. doi:
10.1111/eci.13366. [PMID: 32735689] - Rui Xiong, Leike Zhang, Shiliang Li, Yuan Sun, Minyi Ding, Yong Wang, Yongliang Zhao, Yan Wu, Weijuan Shang, Xiaming Jiang, Jiwei Shan, Zihao Shen, Yi Tong, Liuxin Xu, Yu Chen, Yingle Liu, Gang Zou, Dimitri Lavillete, Zhenjiang Zhao, Rui Wang, Lili Zhu, Gengfu Xiao, Ke Lan, Honglin Li, Ke Xu. Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2.
Protein & cell.
2020 10; 11(10):723-739. doi:
10.1007/s13238-020-00768-w. [PMID: 32754890] - Rachel Bush, Felicia Johns, Zachary Betty, Steven Goldstein, Biljana Horn, Lawrence Shoemaker, Kiran Upadhyay. BK virus encephalitis and end-stage renal disease in a child with hematopoietic stem cell transplantation.
Pediatric transplantation.
2020 09; 24(6):e13739. doi:
10.1111/petr.13739. [PMID: 32412694] - Yue Li, Tianhua Xu, Xiaobo Qiu, Binyao Tian, Chao Bi, Li Yao. Effectiveness of Bailing capsules in the treatment of lupus nephritis: A meta‑analysis.
Molecular medicine reports.
2020 09; 22(3):2132-2140. doi:
10.3892/mmr.2020.11293. [PMID: 32705186] - Shaozhe Cai, Wei Sun, Ming Li, Lingli Dong. A complex COVID-19 case with rheumatoid arthritis treated with tocilizumab.
Clinical rheumatology.
2020 Sep; 39(9):2797-2802. doi:
10.1007/s10067-020-05234-w. [PMID: 32562070] - Juan Zhao, Xia Ye, Zhuoli Zhang. The predictive value of serum soluble ICAM-1 and CXCL13 in the therapeutic response to TNF inhibitor in rheumatoid arthritis patients who are refractory to csDMARDs.
Clinical rheumatology.
2020 Sep; 39(9):2573-2581. doi:
10.1007/s10067-020-05043-1. [PMID: 32206975] - Jiongjiong Wang, Jing Sun, Jiao Hu, Chengming Wang, Richard A Prinz, Daxin Peng, Xiufan Liu, Xiulong Xu. A77 1726, the active metabolite of the anti-rheumatoid arthritis drug leflunomide, inhibits influenza A virus replication in vitro and in vivo by inhibiting the activity of Janus kinases.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2020 08; 34(8):10132-10145. doi:
10.1096/fj.201902793rr. [PMID: 32598086] - N Steinchen, U Müller-Ladner, U Lange. [Biological therapy after COVID-19 infection : No reactivation of a COVID-19 infection with positive SARS-CoV-2 antibody status under biological therapy].
Zeitschrift fur Rheumatologie.
2020 Aug; 79(6):574-577. doi:
10.1007/s00393-020-00824-0. [PMID: 32514854] - Jun Ni, Caifeng Zhu, Xiaoqiu Ni, Jiazhen Yin. IgA nephropathy associated with thalassemia: a case report.
BMC nephrology.
2020 05; 21(1):182. doi:
10.1186/s12882-020-01844-3. [PMID: 32410665] - Patrizia Natale, Suetonia C Palmer, Marinella Ruospo, Valeria M Saglimbene, Jonathan C Craig, Mariacristina Vecchio, Joshua A Samuels, Donald A Molony, Francesco Paolo Schena, Giovanni Fm Strippoli. Immunosuppressive agents for treating IgA nephropathy.
The Cochrane database of systematic reviews.
2020 03; 3(?):CD003965. doi:
10.1002/14651858.cd003965.pub3. [PMID: 32162319] - Gaetano Alfano, Francesco Fontana, Giovanni Guaraldi, Gianni Cappelli, Cristina Mussini. Successful treatment of BK virus associated-nephropathy in a human immunodeficiency virus-positive kidney transplant recipient.
International journal of STD & AIDS.
2020 03; 31(4):387-391. doi:
10.1177/0956462419900853. [PMID: 32075537] - Rainer Ullrich Pliquett, Christoph Lübbert, Christoph Schäfer, Matthias Girndt. Thrombotic microangiopathy and liver toxicity due to a combination therapy of leflunomide and methotrexate: a case report.
Journal of medical case reports.
2020 Feb; 14(1):26. doi:
10.1186/s13256-020-2349-4. [PMID: 32019572] - Yanying Liu, Yuxin Zhang, Wenjie Bian, Jiangnan Fu, Xing Sun, Da Chen, Jiali Chen, Xiaozhen Zhao, Yingni Li, Wen Zhang, Zhanguo Li. Efficacy and safety of iguratimod on patients with relapsed or refractory IgG4-related disease.
Clinical rheumatology.
2020 Feb; 39(2):491-497. doi:
10.1007/s10067-019-04880-z. [PMID: 31848912] - Jun Yang, Tai-Xian Li, Xiao-Yue Wang, Zhi-Peng Xue, Cheng Lyu, Hui-Zhen Li, Yuan-Fang Fan, Yi-Qun Li, Ya-Ge Tian, Wen-Jia Chen, Min-Qun Guo, Jing-Xia Wang, Hong-Yan Wu, Yan-Qiong Zhang, Chun-Yan Zhu, Na Lin. [Systematic reviews of effects of Tripterygium Glycosides Tablets on pro-inflammatory factors in rheumatoid arthritis].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2020 Feb; 45(4):764-774. doi:
10.19540/j.cnki.cjcmm.20191024.401. [PMID: 32237476] - María Martín-López, Eliseo Albert, Mario Fernández-Ruiz, Isidoro González-Álvaro, Esther Rodríguez, José M Aguado, David Navarro, José L Pablos. Torque teno virus viremia in patients with chronic arthritis: Influence of biologic therapies.
Seminars in arthritis and rheumatism.
2020 02; 50(1):166-171. doi:
10.1016/j.semarthrit.2019.06.019. [PMID: 31324467] - Xiao-Ying Liao, Qiang-Qiang Deng, Li Han, Zhi-Tao Wu, Zhao-Liang Peng, Yuan Xie, Guang-Ji Wang, Ji-Ye Aa, Guo-Yu Pan. Leflunomide increased the renal exposure of acyclovir by inhibiting OAT1/3 and MRP2.
Acta pharmacologica Sinica.
2020 Jan; 41(1):129-137. doi:
10.1038/s41401-019-0283-z. [PMID: 31341258] - Duygu Tecer, Ismihan Sunar, Ali Erhan Ozdemirel, Rabia Tural, Orhan Kucuksahin, Aylin Sepici Dincel, Sebnem Ataman. Usefullnes of atherogenic indices and Ca-LDL level to predict subclinical atherosclerosis in patients with psoriatic arthritis?.
Advances in rheumatology (London, England).
2019 11; 59(1):49. doi:
10.1186/s42358-019-0096-2. [PMID: 31727163] - Jianwei Yi, Zhihong He, Shizhang Xu, Si Feng. Efficacy and safety of leflunomide in IgA nephropathy: a systematic review and meta-analysis.
International urology and nephrology.
2019 Nov; 51(11):1987-1998. doi:
10.1007/s11255-019-02255-6. [PMID: 31515666] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Huili Li, Yuanyuan Wang, Zhangqing Zhou, Fang Tian, Huanhuan Yang, Juzhen Yan. Combination of leflunomide and benazepril reduces renal injury of diabetic nephropathy rats and inhibits high-glucose induced cell apoptosis through regulation of NF-κB, TGF-β and TRPC6.
Renal failure.
2019 Nov; 41(1):899-906. doi:
10.1080/0886022x.2019.1665547. [PMID: 31552773] - Emily Wang, Anna S Jan, Vi P Doan, Jill B Ferguson, Jason C Yeh. Leflunomide therapy for refractory cytomegalovirus infections in hematopoietic stem cell transplant recipients.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners.
2019 Oct; 25(7):1731-1737. doi:
10.1177/1078155218796188. [PMID: 30170516] - Mariam Zewail, Noha Nafee, Maged W Helmy, Nabila Boraie. Coated nanostructured lipid carriers targeting the joints - An effective and safe approach for the oral management of rheumatoid arthritis.
International journal of pharmaceutics.
2019 Aug; 567(?):118447. doi:
10.1016/j.ijpharm.2019.118447. [PMID: 31226475] - Allan Mun Fai Kwok, Tia Morosin. Leflunomide-induced colitis in association with enterocutaneous fistula in an immunosuppressed patient with renal transplant and rheumatoid arthritis.
Clinical journal of gastroenterology.
2019 Aug; 12(4):310-315. doi:
10.1007/s12328-019-00954-2. [PMID: 30820830] - Chuang Zeng, Xuejing Bai, Heping Qin, Hong Wang, Xiaofeng Rong, Jin Yan. Effect of adjuvant therapy with electroacupuncture on bone turnover markers and interleukin 17 in patients with rheumatoid arthritis.
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan.
2019 08; 39(4):582-586. doi:
". [PMID: 32186107] - Francesco Carubbi, Giovanna Picchi, Salvatore Di Bartolomeo, Alessandra Ricciardi, Paola Cipriani, Laura Marola, Alessandro Grimaldi, Roberto Giacomelli. Hepatitis E infection in a patient with rheumatoid arthritis treated with leflunomide: A case report with emphasis on geoepidemiology.
Medicine.
2019 Aug; 98(33):e16399. doi:
10.1097/md.0000000000016399. [PMID: 31415347] - Xueting Yao, Yiwen Wu, Ji Jiang, Pei Hu, Dongyang Liu, Xia Chen. Safety, Pharmacokinetics, and Pharmacogenetics of Single-Dose Teriflunomide Sodium and Leflunomide in Healthy Chinese Subjects.
Clinical drug investigation.
2019 Jul; 39(7):643-651. doi:
10.1007/s40261-019-00786-5. [PMID: 31016613] - Jennifer J Y Lee, Alhanouf Alsaleem, Grace P K Chiang, Elizaveta Limenis, Watchareewan Sontichai, Rae S M Yeung, Jonathan Akikusa, Ronald M Laxer. Hallmark trials in ANCA-associated vasculitis (AAV) for the pediatric rheumatologist.
Pediatric rheumatology online journal.
2019 Jun; 17(1):31. doi:
10.1186/s12969-019-0343-4. [PMID: 31242923] - Mei-Yi Wu, Yu-Wei Chen, Lie-Yee Hung, Chii-Hong Lee, Hsin-An Chen, Yung-Ho Hsu, Mai-Szu Wu. Successful Treatment for BK Virus Nephropathy by Leflunomide in a Kidney Transplant Patient: A Case Report.
Transplantation proceedings.
2019 Jun; 51(5):1472-1474. doi:
10.1016/j.transproceed.2019.01.146. [PMID: 31084921] - Roberto Alfaro-Lara, Hector Fabricio Espinosa-Ortega, César Alejandro Arce-Salinas. Systematic review and meta-analysis of the efficacy and safety of leflunomide and methotrexate in the treatment of rheumatoid arthritis.
Reumatologia clinica.
2019 May; 15(3):133-139. doi:
10.1016/j.reuma.2017.07.020. [PMID: 28867467] - Nicolas Keller, Simon Duquennoy, Anne Conrad, Samira Fafi-Kremer, Emmanuel Morelon, Nicolas Bouvier, Bruno Moulin, Bruno Hurault De Ligny, Sophie Caillard. Clinical utility of leflunomide for BK polyomavirus associated nephropathy in kidney transplant recipients: A multicenter retrospective study.
Transplant infectious disease : an official journal of the Transplantation Society.
2019 Apr; 21(2):e13058. doi:
10.1111/tid.13058. [PMID: 30730102] - Run-Yue Huang, Hu-Dan Pan, Jia-Qi Wu, Hua Zhou, Zhan-Guo Li, Ping Qiu, Ying-Yan Zhou, Xiu-Min Chen, Zhi-Xin Xie, Yao Xiao, Qing-Chun Huang, Liang Liu. Comparison of combination therapy with methotrexate and sinomenine or leflunomide for active rheumatoid arthritis: A randomized controlled clinical trial.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2019 Apr; 57(?):403-410. doi:
10.1016/j.phymed.2018.12.030. [PMID: 30851515] - Yuan An, Yunshan Zhou, Liqi Bi, Bo Liu, Hong Wang, Jin Lin, Danyi Xu, Mei Wang, Jing Zhang, Yongfu Wang, Yan An, Ping Zhu, Ronghua Xie, Zhiyi Zhang, Yifang Mei, Xiangyuan Liu, Xiaoli Deng, Zhongqiang Yao, Zhuoli Zhang, Yu Wang, Weiguo Xiao, Hui Shen, Xiuyan Yang, Hanshi Xu, Feng Yu, Guochun Wang, Xin Lu, Yang Li, Yingnan Li, Xiaoxia Zuo, Yisha Li, Yi Liu, Yi Zhao, Jianping Guo, Lingyun Sun, Minghui Zhao, Zhanguo Li. Combined immunosuppressive treatment (CIST) in lupus nephritis: a multicenter, randomized controlled study.
Clinical rheumatology.
2019 Apr; 38(4):1047-1054. doi:
10.1007/s10067-018-4368-8. [PMID: 30488367] - Xueting Yao, Yang Liu, Ling Song, Ji Jiang, Fei Xiao, Dongyang Liu, Pei Hu. Development of a simple HPLC-MS/MS method to simultaneously determine teriflunomide and its metabolite in human plasma and urine: Application to clinical pharmacokinetic study of teriflunomide sodium and leflunomide.
Biomedical chromatography : BMC.
2019 Mar; 33(3):e4420. doi:
10.1002/bmc.4420. [PMID: 30362147] - Mengxin Lin, Ruyi Guo, Zhijun Su, Shaopeng Ke, Dawu Zeng. Combination leflunomide and methotrexate impedes the recovery of liver fibrosis, partly through inhibition of myeloid cell admittance.
Molecular medicine reports.
2019 Mar; 19(3):1622-1628. doi:
10.3892/mmr.2019.9821. [PMID: 30628675] - Minfang Zhang, Chaojun Qi, Yan Zha, Jian Chen, Ping Luo, Li Wang, Zhuxing Sun, Jianxin Wan, Changying Xing, Song Wang, Gengru Jiang, Mindan Sun, Qinkai Chen, Jianghua Chen, Detian Li, Tianjun Guan, Zhaohui Ni. Leflunomide versus cyclophosphamide in the induction treatment of proliferative lupus nephritis in Chinese patients: a randomized trial.
Clinical rheumatology.
2019 Mar; 38(3):859-867. doi:
10.1007/s10067-018-4348-z. [PMID: 30426311] - Muhammad Ishaq, Salma Razzaque, Fadieleh Shohail, Ajeet Kumar, Jibran Sualeh Muhammad. Onset of Hypertension in Leflunamide Treated Low Socioeconomic Rheumatoid Arthritis Patients: An Unseen Iceberg.
Current rheumatology reviews.
2019; 15(3):242-245. doi:
10.2174/1573397114666171227211048. [PMID: 29283072] - Geoffrey S Rule, Alan L Rockwood, Kamisha L Johnson-Davis. LC-MS/MS Method for the Quantification of the Leflunomide Metabolite, Teriflunomide, in Human Serum/Plasma.
Methods in molecular biology (Clifton, N.J.).
2019; 1872(?):75-83. doi:
10.1007/978-1-4939-8823-5_8. [PMID: 30350281] - Yao Huang, Hui Wang, Zhe Chen, Yu Wang, Kai Qin, Ying Huang, Xin Ba, Weiji Lin, Shenghao Tu. Efficacy and safety of total glucosides of paeony combined with methotrexate and leflunomide for active rheumatoid arthritis: a meta-analysis.
Drug design, development and therapy.
2019; 13(?):1969-1984. doi:
10.2147/dddt.s207226. [PMID: 31354242] - Shasha Chen, Qing Yin, Song Ren, Xiang Zhong, Wei Wang, Guisen Li, Li Wang. A comparison of the effectiveness of cyclophosphamide, leflunomide, corticosteroids, or conservative management alone in patients with IgA nephropathy: a retrospective observational study.
Scientific reports.
2018 09; 8(1):13662. doi:
10.1038/s41598-018-31727-5. [PMID: 30209279] - Neide Tomimura Costa, Bruna Miglioranza Scavuzzi, Tatiana Mayumi Veiga Iriyoda, Marcell Alysson Batisti Lozovoy, Daniela Frizon Alfieri, Fabiano Aparecido de Medeiros, Marcelo Cândido de Sá, Pâmela Lonardoni Micheletti, Bruno Alexandre Sekiguchi, Edna Maria Vissoci Reiche, Michael Maes, Andréa Name Colado Simão, Isaias Dichi. Metabolic syndrome and the decreased levels of uric acid by leflunomide favor redox imbalance in patients with rheumatoid arthritis.
Clinical and experimental medicine.
2018 Aug; 18(3):363-372. doi:
10.1007/s10238-018-0500-y. [PMID: 29644482] - John M Thomason, Todd M Archer, Robert W Wills, Andrew J Mackin. Effects of immunosuppressive agents on the hemostatic system in normal dogs.
Journal of veterinary internal medicine.
2018 Jul; 32(4):1325-1333. doi:
10.1111/jvim.15132. [PMID: 29749651] - Le Wang, Leilei Ma, Yunfei Lin, Xing Liu, Ling Xiao, Yiting Zhang, Ye Xu, Hu Zhou, Guoyu Pan. Leflunomide Increases Hepatic Exposure to Methotrexate and Its Metabolite by Differentially Regulating Multidrug Resistance-Associated Protein Mrp2/3/4 Transporters via Peroxisome Proliferator-Activated Receptor α Activation.
Molecular pharmacology.
2018 06; 93(6):563-574. doi:
10.1124/mol.117.110593. [PMID: 29618584] - Ke Xu, Lili Zhang, Jie Ding, Suxia Wang, Baige Su, Huijie Xiao, Fang Wang, Xuhui Zhong, Yanming Li. Value of the Oxford classification of IgA nephropathy in children with Henoch-Schönlein purpura nephritis.
Journal of nephrology.
2018 04; 31(2):279-286. doi:
10.1007/s40620-017-0457-z. [PMID: 29185209] - Junhong Chen, Jing Sun, Michelle E Doscas, Jin Ye, Ashley J Williamson, Yanchun Li, Yi Li, Richard A Prinz, Xiulong Xu. Control of hyperglycemia in male mice by leflunomide: mechanisms of action.
The Journal of endocrinology.
2018 04; 237(1):43-58. doi:
10.1530/joe-17-0536. [PMID: 29496905] - Xiaoxia Yu, Lei Zhang, Lixin Wang, Weiwei Lu, Fengyan Sun, Ping Xu, Guobin Lan. MRI assessment of erosion repair in patients with long-standing rheumatoid arthritis receiving double-filtration plasmapheresis in addition to leflunomide and methotrexate: a randomized controlled trial.
Clinical rheumatology.
2018 Apr; 37(4):917-925. doi:
10.1007/s10067-017-3956-3. [PMID: 29313271] - Jose Tiago Silva, Virginia Pérez-González, Francisco Lopez-Medrano, Rodrigo Alonso-Moralejo, Mario Fernández-Ruiz, Rafael San-Juan, Patricia Brañas, María Dolores Folgueira, José María Aguado, Alicia de Pablo-Gafas. Experience with leflunomide as treatment and as secondary prophylaxis for cytomegalovirus infection in lung transplant recipients: A case series and review of the literature.
Clinical transplantation.
2018 02; 32(2):. doi:
10.1111/ctr.13176. [PMID: 29226391] - K Krüger. [Perioperative management of immunosuppressive treatment in patients undergoing joint surgery].
Zeitschrift fur Rheumatologie.
2017 Nov; 76(9):767-775. doi:
10.1007/s00393-017-0379-0. [PMID: 28913596] - I A Echenique, D Beltran, L Ramirez-Ruiz, N Najafian, N Agrawal. Ganciclovir Dosing Strategies and Development of Cytomegalovirus Resistance in a Kidney Transplant Recipient: A Case Report.
Transplantation proceedings.
2017 Sep; 49(7):1560-1564. doi:
10.1016/j.transproceed.2017.02.046. [PMID: 28838440] - Joan C Y Ng, Marianna Leung, Alissa J Wright, Mary H H Ensom. Clinical Pharmacokinetic Monitoring of Leflunomide in Renal Transplant Recipients with BK Virus Reactivation: A Review of the Literature.
Clinical pharmacokinetics.
2017 09; 56(9):1015-1031. doi:
10.1007/s40262-017-0521-9. [PMID: 28247238] - Corinna Weber-Schoendorfer, Evelin Beck, Tatjana Tissen-Diabaté, Christof Schaefer. Leflunomide - A human teratogen? A still not answered question. An evaluation of the German Embryotox pharmacovigilance database.
Reproductive toxicology (Elmsford, N.Y.).
2017 08; 71(?):101-107. doi:
10.1016/j.reprotox.2017.04.007. [PMID: 28478049] - Lulin Min, Qin Wang, Liou Cao, Wenyan Zhou, Jiangzi Yuan, Minfang Zhang, Xiajing Che, Shan Mou, Wei Fang, Leyi Gu, Mingli Zhu, Ling Wang, Zanzhe Yu, Jiaqi Qian, Zhaohui Ni. Comparison of combined leflunomide and low-dose corticosteroid therapy with full-dose corticosteroid monotherapy for progressive IgA nephropathy.
Oncotarget.
2017 Jul; 8(29):48375-48384. doi:
10.18632/oncotarget.16468. [PMID: 28415636] - Petros P Sfikakis, Vasiliki-Kalliopi Bournia, Prodromos Sidiropoulos, Dimitrios T Boumpas, Alexandros A Drosos, George D Kitas, George Konstantonis, Stamatis N Liossis, Menelaos N Manoussakis, Lazaros Sakkas, Maria Tektonidou, Athanasios G Tzioufas, Panayiotis G Vlachoyiannopoulos, Chara Kani, Panayiotis Paterakis, Panayiota Litsa, Dimitrios Vassilopoulos. Biologic treatment for rheumatic disease: real-world big data analysis from the Greek country-wide prescription database.
Clinical and experimental rheumatology.
2017 Jul; 35(4):579-585. doi:
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Transplantation proceedings.
2017 Jul; 49(6):1483-1491. doi:
10.1016/j.transproceed.2017.03.091. [PMID: 28736027] - Marie-Christine Simard-Meilleur, Paule Bodson-Clermont, Gilles St-Louis, Michel R Pâquet, Catherine Girardin, Marie-Chantal Fortin, Héloïse Cardinal, Marie-Josée Hébert, Renée Lévesque, Edith Renoult. Stabilization of renal function after the first year of follow-up in kidney transplant recipients treated for significant BK polyomavirus infection or BK polyomavirus-associated nephropathy.
Transplant infectious disease : an official journal of the Transplantation Society.
2017 Jun; 19(3):. doi:
10.1111/tid.12681. [PMID: 28207975] - Wael Talaat. Bioanalytical method for the estimation of co-administered esomeprazole, leflunomide and ibuprofen in human plasma and in pharmaceutical dosage forms using micellar liquid chromatography.
Biomedical chromatography : BMC.
2017 May; 31(5):. doi:
10.1002/bmc.3865. [PMID: 27862093] - Juli Jaw, Prue Hill, David Goodman. Combination of Leflunomide and Everolimus for treatment of BK virus nephropathy.
Nephrology (Carlton, Vic.).
2017 Apr; 22(4):326-329. doi:
10.1111/nep.12948. [PMID: 28247521] - Doyle Yang, Brandon Keys, David J Conti, Llewellyn Foulke, Kathleen Stellrecht, Linda Cook, Reynold I Lopez-Soler. JC polyomavirus nephropathy, a rare cause of transplant dysfunction: Case report and review of literature.
Transplant infectious disease : an official journal of the Transplantation Society.
2017 Apr; 19(2):. doi:
10.1111/tid.12654. [PMID: 28036142] - Su-Jin Moon, Eun-Kyung Kim, Joo Yeon Jhun, Hee Jin Lee, Weon Sun Lee, Sang-Hi Park, Mi-La Cho, Jun-Ki Min. The active metabolite of leflunomide, A77 1726, attenuates inflammatory arthritis in mice with spontaneous arthritis via induction of heme oxygenase-1.
Journal of translational medicine.
2017 02; 15(1):31. doi:
10.1186/s12967-017-1131-x. [PMID: 28193225] - Lana M Rifkin, Caroline L Minkus, Kenneth Pursell, Chaisiri Jumroendararasame, Debra A Goldstein. Utility of Leflunomide in the Treatment of Drug Resistant Cytomegalovirus Retinitis.
Ocular immunology and inflammation.
2017 Feb; 25(1):93-96. doi:
10.3109/09273948.2015.1071406. [PMID: 26652481] - Wei Zhong, Ling Zhao, Tao Liu, Zhenyu Jiang. IL-22-producing CD4+T cells in the treatment response of rheumatoid arthritis to combination therapy with methotrexate and leflunomide.
Scientific reports.
2017 01; 7(?):41143. doi:
10.1038/srep41143. [PMID: 28117352] - N V Chebotareva, I N Bobkova, S V Gulyaev. [Late-onset rheumatoid arthritis in a patient with successfully treated IgA nephropathy].
Terapevticheskii arkhiv.
2017 ; 89(8):77-79. doi:
10.17116/terarkh201789877-79. [PMID: 28914855] - Yuping Liu, Xiaolong Qu, Weidong Chen, Yan Zhang, Lei Liu. Efficacy of leflunomide combined with prednisone in the treatment of refractory nephrotic syndrome.
Renal failure.
2016 Nov; 38(10):1616-1621. doi:
10.3109/0886022x.2016.1172917. [PMID: 27819170] - Elisabeth M Hodson, Sophia C Wong, Narelle S Willis, Jonathan C Craig. Interventions for idiopathic steroid-resistant nephrotic syndrome in children.
The Cochrane database of systematic reviews.
2016 Oct; 10(?):CD003594. doi:
10.1002/14651858.cd003594.pub5. [PMID: 27726125] - Shinya Morita, Kazunobu Shinoda, Satoshi Tamaki, Hidaka Kono, Hiroshi Asanuma, Ken Nakagawa, Mototsugu Oya. Successful low-dose leflunomide treatment for ganciclovir-resistant cytomegalovirus infection with high-level antigenemia in a kidney transplant: A case report and literature review.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.
2016 09; 82(?):133-138. doi:
10.1016/j.jcv.2016.07.015. [PMID: 27494108] - Jie Wu, Shu-Wei Duan, Xue-Feng Sun, Wen-Ge Li, Ya-Ping Wang, Wen-Hu Liu, Jian-Rong Zhang, Li-De Lun, Xue-Mei Li, Chun-Hua Zhou, Ji-Jun Li, Shu-Wen Liu, Yuan-Sheng Xie, Guang-Yan Cai, Lu Ma, Wen Huang, Hua Wu, Qiang Jia, Xiang-Mei Chen. Efficacy of Leflunomide, Telmisartan, and Clopidogrel for Immunoglobulin A Nephropathy: A Randomized Controlled Trial.
Chinese medical journal.
2016 Aug; 129(16):1894-903. doi:
10.4103/0366-6999.187848. [PMID: 27503012] - Ying Chen, Jinquan Wang, Feng Xu, Caihong Zeng, Zhihong Liu. Clinicopathological features and prognosis of Kimura's disease with renal involvement in Chinese patients.
Clinical nephrology.
2016 Jun; 85(6):332-9. doi:
10.5414/cn108749. [PMID: 27142199] - Lei-lei Ma, Zhi-tao Wu, Le Wang, Xue-feng Zhang, Jing Wang, Chen Chen, Xuan Ni, Yun-fei Lin, Yi-yi Cao, Yang Luan, Guo-yu Pan. Inhibition of hepatic cytochrome P450 enzymes and sodium/bile acid cotransporter exacerbates leflunomide-induced hepatotoxicity.
Acta pharmacologica Sinica.
2016 Mar; 37(3):415-24. doi:
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