Hippuric acid (BioDeep_00000398603)

Main id: BioDeep_00000017814

Secondary id: BioDeep_00000001350, BioDeep_00000400001

PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


2-BENZAMIDOACETIC ACID

化学式: C9H9NO3 (179.0582)
中文名称: 2-苯酰胺乙酸, 马尿酸
谱图信息: 最多检出来源 Homo sapiens(blood) 24.95%

分子结构信息

SMILES: C1=CC=C(C=C1)C(=O)NCC(=O)O
InChI: InChI=1S/C9H9NO3/c11-8(12)6-10-9(13)7-4-2-1-3-5-7/h1-5H,6H2,(H,10,13)(H,11,12)

描述信息

C254 - Anti-Infective Agent > C255 - Urinary Anti-Infective Agent
An N-acylglycine in which the acyl group is specified as benzoyl.
MS2 deconvoluted using MS2Dec from all ion fragmentation data, MetaboLights identifier MTBLS1040; QIAFMBKCNZACKA-UHFFFAOYSA-N_STSL_0191_Hippuric acid_2000fmol_180831_S2_L02M02_62; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
MS2 deconvoluted using CorrDec from all ion fragmentation data, MetaboLights identifier MTBLS1040; Spectrum acquired as described in Naz et al 2017 PMID 28641411. Preparation and submission to MassBank of North America by Chaleckis R. and Tada I.
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.317
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.318
relative retention time with respect to 9-anthracene Carboxylic Acid is 0.315
Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food.
Hippuric Acid (2-Benzamidoacetic acid), an acyl glycine produced by the conjugation of benzoic acid and glycine, is a normal component in urine as a metabolite of aromatic compounds from food.

同义名列表

6 个代谢物同义名

2-BENZAMIDOACETIC ACID; N-Benzoylglycine; Hippuric acid; Benzoylglycine; Hippurate; Hippuric acid



数据库引用编号

66 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ACE, ALB, APOB, CAT, CYP1A1, CYP2E1, EGFR, GSTM1, SPINK5
Peripheral membrane protein 2 CYP1A1, CYP2E1
Endosome membrane 2 APOB, EGFR
Endoplasmic reticulum membrane 5 APOB, CYP1A1, CYP2E1, EGFR, SPINK5
Nucleus 2 ALB, EGFR
cytosol 6 ALB, APOB, CAT, GLS, GSTM1, SPINK5
centrosome 1 ALB
nucleoplasm 1 CD2
Cell membrane 5 ACE, CD2, EGFR, GPRC5A, TNF
ruffle membrane 1 EGFR
Early endosome membrane 1 EGFR
Multi-pass membrane protein 3 GPRC5A, SLC22A6, SLC22A8
Synapse 1 GLS
cell cortex 1 SPINK5
cell junction 1 EGFR
cell surface 3 CD2, EGFR, TNF
glutamatergic synapse 1 EGFR
Golgi apparatus 2 ALB, CD2
Golgi membrane 2 EGFR, INS
mitochondrial inner membrane 2 CYP1A1, CYP2E1
neuronal cell body 2 APOB, TNF
smooth endoplasmic reticulum 1 APOB
Cytoplasm, cytosol 1 GLS
Lysosome 1 ACE
endosome 2 ACE, EGFR
plasma membrane 9 ACE, APOB, CD2, EGFR, GPRC5A, REN, SLC22A6, SLC22A8, TNF
Membrane 5 ACE, CAT, EGFR, REN, SLC22A6
apical plasma membrane 2 EGFR, SLC22A8
basolateral plasma membrane 3 EGFR, SLC22A6, SLC22A8
caveola 1 SLC22A6
extracellular exosome 8 ACE, ALB, ALDH2, APOB, CAT, GPRC5A, SLC22A6, SLC22A8
endoplasmic reticulum 2 ALB, SPINK5
extracellular space 8 ACE, ALB, APOB, EGFR, IL6, INS, REN, TNF
lysosomal lumen 1 APOB
perinuclear region of cytoplasm 2 EGFR, SPINK5
mitochondrion 5 ALDH2, CAT, CYP1A1, GLS, GLYAT
protein-containing complex 5 ALB, CAT, CD2, EGFR, SLC22A6
intracellular membrane-bounded organelle 6 APOB, CAT, CYP1A1, CYP2E1, GPRC5A, SPINK5
Microsome membrane 2 CYP1A1, CYP2E1
Single-pass type I membrane protein 3 ACE, CD2, EGFR
Secreted 6 ACE, ALB, APOB, IL6, INS, REN
extracellular region 10 ACE, ALB, APOB, CAT, CD2, IL6, INS, REN, SPINK5, TNF
cytoplasmic side of plasma membrane 1 CD2
Mitochondrion matrix 1 ALDH2
mitochondrial matrix 4 ALDH2, CAT, GLS, GLYAT
anchoring junction 1 ALB
nuclear membrane 1 EGFR
external side of plasma membrane 3 ACE, CD2, TNF
chylomicron 1 APOB
low-density lipoprotein particle 1 APOB
very-low-density lipoprotein particle 1 APOB
nucleolus 1 GPRC5A
Early endosome 1 APOB
apical part of cell 1 REN
cell-cell junction 1 CD2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 GPRC5A
Mitochondrion inner membrane 2 CYP1A1, CYP2E1
Membrane raft 2 EGFR, TNF
focal adhesion 2 CAT, EGFR
Peroxisome 1 CAT
intracellular vesicle 1 EGFR
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
lateral plasma membrane 1 SLC22A8
receptor complex 2 EGFR, GPRC5A
ciliary basal body 1 ALB
phagocytic cup 1 TNF
centriole 1 ALB
[Isoform 1]: Mitochondrion 1 GLS
brush border membrane 1 ACE
spindle pole 1 ALB
blood microparticle 1 ALB
sperm midpiece 1 ACE
Basolateral cell membrane 2 SLC22A6, SLC22A8
intercellular bridge 1 GSTM1
endosome lumen 2 APOB, INS
Lipid droplet 1 APOB
Cytoplasmic vesicle membrane 1 GPRC5A
basal plasma membrane 3 ACE, EGFR, SLC22A6
synaptic membrane 1 EGFR
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, APOB, IL6, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
endoplasmic reticulum exit site 1 APOB
clathrin-coated endocytic vesicle membrane 2 APOB, EGFR
Basal cell membrane 1 SLC22A6
[Isoform 3]: Mitochondrion 1 GLS
[Glutaminase kidney isoform, mitochondrial 68 kDa chain]: Mitochondrion matrix 1 GLS
[Glutaminase kidney isoform, mitochondrial 65 kDa chain]: Mitochondrion matrix 1 GLS
multivesicular body, internal vesicle lumen 1 EGFR
Shc-EGFR complex 1 EGFR
endocytic vesicle lumen 1 APOB
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
chylomicron remnant 1 APOB
intermediate-density lipoprotein particle 1 APOB
catalase complex 1 CAT
mature chylomicron 1 APOB
interleukin-6 receptor complex 1 IL6
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
ciliary transition fiber 1 ALB
epidermal lamellar body 1 SPINK5
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Mansooreh Dehghani, Alireza Abbasi, Ziba Taherzadeh, Samaneh Dehghani. Exposure assessment of wastewater treatment plant employees to BTEX: a biological monitoring approach. Scientific reports. 2022 12; 12(1):21433. doi: 10.1038/s41598-022-25876-x. [PMID: 36509850]
  • Giulia De Simone, Claudia Balducci, Gianluigi Forloni, Roberta Pastorelli, Laura Brunelli. Hippuric acid: Could became a barometer for frailty and geriatric syndromes?. Ageing research reviews. 2021 12; 72(?):101466. doi: 10.1016/j.arr.2021.101466. [PMID: 34560280]
  • Laura Brunelli, Annalisa Davin, Giovanna Sestito, Maria Chiara Mimmi, Giulia De Simone, Claudia Balducci, Orietta Pansarasa, Gianluigi Forloni, Cristina Cereda, Roberta Pastorelli, Antonio Guaita. Plasmatic Hippuric Acid as a Hallmark of Frailty in an Italian Cohort: The Mediation Effect of Fruit-Vegetable Intake. The journals of gerontology. Series A, Biological sciences and medical sciences. 2021 11; 76(12):2081-2089. doi: 10.1093/gerona/glab244. [PMID: 34436596]
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  • Klaudia Dymek, Grzegorz Kurowski, Łukasz Kuterasiński, Roman Jędrzejczyk, Magdalena Szumera, Maciej Sitarz, Anna Pajdak, Łukasz Kurach, Anna Boguszewska-Czubara, Przemysław J Jodłowski. In Search of Effective UiO-66 Metal-Organic Frameworks for Artificial Kidney Application. ACS applied materials & interfaces. 2021 Sep; 13(38):45149-45160. doi: 10.1021/acsami.1c05972. [PMID: 34520182]
  • Jingjing Han, Huiqi Wang, Zhanfeng Li, Zonghua Wang. Preparation of chitosan-modified magnetic Schiff base network composite nanospheres for effective enrichment and detection of hippuric acid and 4-methyl hippuric acid. Journal of chromatography. A. 2021 Aug; 1652(?):462373. doi: 10.1016/j.chroma.2021.462373. [PMID: 34246963]
  • Chaw Ei Htwe Maung, Hyung Gwon Lee, Jeong-Yong Cho, Kil Yong Kim. Antifungal compound, methyl hippurate from Bacillus velezensis CE 100 and its inhibitory effect on growth of Botrytis cinerea. World journal of microbiology & biotechnology. 2021 Aug; 37(9):159. doi: 10.1007/s11274-021-03046-x. [PMID: 34420104]
  • Chun-Hui Chiu, Chi-Tsung Chen, Ming-Huei Cheng, Li-Heng Pao, Chi Wang, Gwo-Hwa Wan. Use of urinary hippuric acid and o-/p-/m-methyl hippuric acid to evaluate surgical smoke exposure in operating room healthcare personnel. Ecotoxicology and environmental safety. 2021 Jul; 217(?):112231. doi: 10.1016/j.ecoenv.2021.112231. [PMID: 33862429]
  • Yung-Chuan Lu, Cheng-Ching Wu, I-Ting Tsai, Wei-Chin Hung, Thung-Lip Lee, Chin-Feng Hsuan, Teng-Hung Yu, Ching-Ting Wei, Fu-Mei Chung, Yau-Jiunn Lee, Chao-Ping Wang. Associations among total p-cresylsulfate, indoxyl sulfate and hippuric acid levels with hemodialysis quality indicators in maintenance hemodialysis patients. Clinica chimica acta; international journal of clinical chemistry. 2021 May; 516(?):83-91. doi: 10.1016/j.cca.2021.01.015. [PMID: 33508250]
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  • Jiao-Jiao Zhao, Lei Zhang, Peng-Yu Liu, Wei-Zhe Chen, Zhi-Liang Liu, Yan-Qin Wang. Water-stable Cd(ii)/Zn(ii) coordination polymers as recyclable luminescent sensors for detecting hippuric acid in simulated urine for indexing toluene exposure with high selectivity, sensitivity and fast response. Dalton transactions (Cambridge, England : 2003). 2021 Jan; 50(2):553-561. doi: 10.1039/d0dt03648j. [PMID: 33350995]
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