Topiramate (BioDeep_00000397884)
Main id: BioDeep_00000001521
natural product Volatile Flavor Compounds
代谢物信息卡片
Topiramate
化学式: C12H21NO8S (339.09878260000005)
中文名称: 托吡酯
谱图信息:
最多检出来源 Homo sapiens(blood) 50%
分子结构信息
SMILES: CC1(C)O[C@@H]2CO[C@@]3(COS(=O)(=O)N)OC(C)(C)O[C@H]3[C@@H]2O1
InChI: InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)
描述信息
C78272 - Agent Affecting Nervous System > C264 - Anticonvulsant Agent
D002491 - Central Nervous System Agents > D000927 - Anticonvulsants
N - Nervous system > N03 - Antiepileptics > N03A - Antiepileptics
D007004 - Hypoglycemic Agents
CONFIDENCE standard compound; EAWAG_UCHEM_ID 3635
Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity, inhibition of kainate/AMPA receptors, inhibition of voltage-sensitive sodium and calcium channels, increases in potassium conductance, and inhibition of carbonic anhydrase[1][2][3].
同义名列表
5 个代谢物同义名
数据库引用编号
48 个数据库交叉引用编号
- ChEBI: CHEBI:63631
- KEGG: C07502
- KEGGdrug: D00537
- PubChem: 5284627
- DrugBank: DB00273
- ChEMBL: CHEMBL220492
- MeSH: Topiramate
- CAS: 97240-79-4
- CAS: 97240-79-4, 1103510-60-6
- MoNA: WA001877
- MoNA: WA001876
- MoNA: WA001875
- MoNA: WA001874
- MoNA: WA001873
- MoNA: VF-NPL-LTQ000482
- MoNA: VF-NPL-LTQ000481
- MoNA: VF-NPL-LTQ000480
- MoNA: VF-NPL-LTQ000479
- MoNA: FiehnHILIC003016
- MoNA: FiehnHILIC002370
- MoNA: FiehnHILIC001542
- MoNA: FiehnHILIC000803
- MoNA: CCMSLIB00000078944
- MoNA: CCMSLIB00000078147
- MoNA: EQ363559
- MoNA: EQ363558
- MoNA: EQ363557
- MoNA: EQ363556
- MoNA: EQ363555
- MoNA: EQ363554
- MoNA: EQ363553
- MoNA: EQ363552
- MoNA: EQ363551
- MoNA: EQ363509
- MoNA: EQ363508
- MoNA: EQ363507
- MoNA: EQ363506
- MoNA: EQ363505
- MoNA: EQ363504
- MoNA: EQ363503
- MoNA: EQ363502
- MoNA: EQ363501
- PubChem: 9705
- PDB-CCD: TOR
- NIKKAJI: J345.989F
- RefMet: Topiramate
- medchemexpress: HY-B0122
- KNApSAcK: 63631
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Qingyang Shi, Yang Wang, Qiukui Hao, Per Olav Vandvik, Gordon Guyatt, Jing Li, Zhe Chen, Shishi Xu, Yanjiao Shen, Long Ge, Feng Sun, Ling Li, Jiajie Yu, Kailei Nong, Xinyu Zou, Siyi Zhu, Cong Wang, Shengzhao Zhang, Zhi Qiao, Zhongyu Jian, Ya Li, Xinyi Zhang, Kerun Chen, Furong Qu, Yuan Wu, Yazhou He, Haoming Tian, Sheyu Li. Pharmacotherapy for adults with overweight and obesity: a systematic review and network meta-analysis of randomised controlled trials.
Lancet (London, England).
2024 04; 403(10434):e21-e31. doi:
10.1016/s0140-6736(24)00351-9. [PMID: 38582569] - Dalia M Mabrouk, Aida I El Makawy, Kawkab A Ahmed, Mohamed Fawzy Ramadan, Faten M Ibrahim. Topiramate potential neurotoxicity and mitigating role of ginger oil in mice brain.
Environmental science and pollution research international.
2022 Dec; 29(58):87184-87199. doi:
10.1007/s11356-022-21878-4. [PMID: 35802336] - Guangming Zhao, Qi Zhang, Fan Wu, Shuang Yin, Yiqi Xie, Hongyan Liu. Comparison of weight loss and adverse events of obesity drugs in children and adolescents: a systematic review and meta-analysis.
Expert review of clinical pharmacology.
2022 Sep; 15(9):1119-1125. doi:
10.1080/17512433.2022.2117152. [PMID: 36039827] - Faez Iqbal Khan, Md Tabish Rehman, Fathima Sameena, Tabish Hussain, Mohamed F AlAjmi, Dakun Lai, Md Khurshid Alam Khan. Investigating the binding mechanism of topiramate with bovine serum albumin using spectroscopic and computational methods.
Journal of molecular recognition : JMR.
2022 07; 35(7):e2958. doi:
10.1002/jmr.2958. [PMID: 35347772] - Daniel L Pelzman, Eman Kazi, Stephen V Jackman, Michelle J Semins. Urinary Metabolic Disturbances During Topiramate Use and their Reversibility Following Drug Cessation.
Urology.
2022 Jul; 165(?):139-143. doi:
10.1016/j.urology.2022.01.027. [PMID: 35093398] - Shuai Miao, Wenjing Tang, Heng Li, Bozhi Li, Chunxiao Yang, Wei Xie, Tao Wang, Wenhao Bai, Zihua Gong, Zhao Dong, Shengyuan Yu. Repeated inflammatory dural stimulation-induced cephalic allodynia causes alteration of gut microbial composition in rats.
The journal of headache and pain.
2022 Jun; 23(1):71. doi:
10.1186/s10194-022-01441-9. [PMID: 35752773] - Steven J Centola, Gregory Kaiman, Kaila Rizzo, Yekaterina Buriko, Jasper Burke. Presumptive renal tubular acidosis secondary to topiramate administration in a cat.
Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001).
2022 May; 32(3):420-425. doi:
10.1111/vec.13168. [PMID: 35142423] - Brooke L Reidy, Scott W Powers, Christopher S Coffey, Leigh A Chamberlin, Dixie J Ecklund, Elizabeth A Klingner, Jon W Yankey, Leslie L Korbee, Linda L Porter, James Peugh, Marielle A Kabbouche, Joanne Kacperski, Andrew D Hershey. Multimodal Assessment of Medication Adherence Among Youth With Migraine: An Ancillary Study of the CHAMP Trial.
Journal of pediatric psychology.
2022 04; 47(4):376-387. doi:
10.1093/jpepsy/jsab123. [PMID: 34865085] - Page B Pennell, Ashwin Karanam, Kimford J Meador, Elizabeth Gerard, Laura Kalayjian, Patricia Penovich, Abigail Matthews, Thomas M McElrath, Angela K Birnbaum. Antiseizure Medication Concentrations During Pregnancy: Results From the Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) Study.
JAMA neurology.
2022 04; 79(4):370-379. doi:
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Cephalalgia : an international journal of headache.
2022 04; 42(4-5):396-408. doi:
10.1177/03331024211047454. [PMID: 34579560] - Aaron Lazorwitz, Morgan Pena, Jeanelle Sheeder, Stephanie Teal. Effect of Topiramate on Serum Etonogestrel Concentrations Among Contraceptive Implant Users.
Obstetrics and gynecology.
2022 04; 139(4):579-587. doi:
10.1097/aog.0000000000004697. [PMID: 35594123] - Hithem Fargaly, Shobi Mathew, Noreen F Rossi. Hyperglycinuria: diagnosis in middle age.
BMJ case reports.
2022 Mar; 15(3):. doi:
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CNS drugs.
2022 03; 36(3):217-237. doi:
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Expert opinion on drug metabolism & toxicology.
2022 Mar; 18(3):219-233. doi:
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British journal of clinical pharmacology.
2022 02; 88(2):613-618. doi:
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PloS one.
2022; 17(2):e0264457. doi:
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Drug and chemical toxicology.
2022 Jan; 45(1):103-112. doi:
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International journal of clinical pharmacology and therapeutics.
2021 Dec; 59(12):784-786. doi:
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BMJ case reports.
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Advances in clinical and experimental medicine : official organ Wroclaw Medical University.
2021 Oct; 30(10):1013-1023. doi:
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The Journal of clinical endocrinology and metabolism.
2021 09; 106(10):3019-3033. doi:
10.1210/clinem/dgab408. [PMID: 34097062] - Ahmed M Kabel, Ahmed M Ashour, Dina A Ali, Hany H Arab. The immunomodulatory effects of topiramate on azoxymethane-induced colon carcinogenesis in rats: The role of the inflammatory cascade, vascular endothelial growth factor, AKT/mTOR/MAP kinase signaling and the apoptotic markers.
International immunopharmacology.
2021 Sep; 98(?):107830. doi:
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Obesity (Silver Spring, Md.).
2021 06; 29(6):985-994. doi:
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Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2021 Jun; 138(?):111446. doi:
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Acta neurologica Scandinavica.
2021 May; 143(5):558-568. doi:
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Birth defects research.
2021 04; 113(6):485-499. doi:
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BMC neurology.
2021 Feb; 21(1):93. doi:
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Epilepsia.
2021 02; 62(2):285-302. doi:
10.1111/epi.16802. [PMID: 33426641] - Sheng Feng, Brandi Bridgewater, Erin C Strickland, Gregory McIntire. A Rapid LC-MS-MS Method for the Quantitation of Antiepileptic Drugs in Urine.
Journal of analytical toxicology.
2020 Oct; 44(7):688-696. doi:
10.1093/jat/bkaa095. [PMID: 32744607] - Samuel P Callisto, Sílvia M Illamola, Angela K Birnbaum, Christopher M Barkley, Sai Praneeth R Bathena, Ilo E Leppik, Susan E Marino. Severity of Topiramate-Related Working Memory Impairment Is Modulated by Plasma Concentration and Working Memory Capacity.
Journal of clinical pharmacology.
2020 09; 60(9):1166-1176. doi:
10.1002/jcph.1611. [PMID: 32297992] - R Uribe-San-Martín, E Ciampi, J P Cruz, M Vásquez, C Cárcamo. Refractory epilepsy associated with anti-ribosomal P antibodies successfully treated with topiramate.
Journal of neuroimmunology.
2020 03; 340(?):577144. doi:
10.1016/j.jneuroim.2020.577144. [PMID: 31954282] - María Remedios Marques, Ana Garcia-Robles, Iris Usach, Maximo Vento, José Luis Poveda, José Esteban Peris, Victor Mangas-Sanjuan. Topiramate pharmacokinetics in neonates undergoing therapeutic hypothermia and proposal of an optimised dosing schedule.
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Drug and alcohol dependence.
2020 01; 206(?):107700. doi:
10.1016/j.drugalcdep.2019.107700. [PMID: 31753736] - Katarzyna Socała, Elżbieta Wyska, Małgorzata Szafarz, Dorota Nieoczym, Piotr Wlaź. Acute effect of cannabidiol on the activity of various novel antiepileptic drugs in the maximal electroshock- and 6 Hz-induced seizures in mice: Pharmacodynamic and pharmacokinetic studies.
Neuropharmacology.
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International journal of clinical pharmacy.
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Basic & clinical pharmacology & toxicology.
2019 Jul; 125(1):26-33. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2019 Jun; 1118-1119(?):93-100. doi:
10.1016/j.jchromb.2019.04.044. [PMID: 31030106] - Nobutsune Ishikawa, Hiroo Tani, Yoshiyuki Kobayashi, Akira Kato, Masao Kobayashi. High Incidence of Renal Stones in Severely Disabled Children with Epilepsy Treated with Topiramate.
Neuropediatrics.
2019 06; 50(3):160-163. doi:
10.1055/s-0038-1676287. [PMID: 30939600] - Stefano Manzini, Marco Busnelli, Cinzia Parolini, Lucia Minoli, Alice Ossoli, Elena Brambilla, Sara Simonelli, Eftychia Lekka, Andreas Persidis, Eugenio Scanziani, Giulia Chiesa. Topiramate protects apoE-deficient mice from kidney damage without affecting plasma lipids.
Pharmacological research.
2019 03; 141(?):189-200. doi:
10.1016/j.phrs.2018.12.022. [PMID: 30593851] - Aida I El Makawy, Faten M Ibrahim, Dalia M Mabrouk, Kawkab A Ahmed, Mohamed Fawzy Ramadan. Effect of antiepileptic drug (Topiramate) and cold pressed ginger oil on testicular genes expression, sexual hormones and histopathological alterations in mice.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2019 Feb; 110(?):409-419. doi:
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PloS one.
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Neonatology.
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Journal of clinical and experimental neuropsychology.
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Clinical and experimental pharmacology & physiology.
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Seizure.
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Urolithiasis.
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Croatian medical journal.
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The journal of headache and pain.
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Epilepsia.
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Archives de pediatrie : organe officiel de la Societe francaise de pediatrie.
2017 Aug; 24(8):783-787. doi:
10.1016/j.arcped.2017.05.008. [PMID: 28668216] - Hui Shen, Jie Wang, Dan Jiang, Pei Xu, Xiaolu Zhu, Yuanyuan Zhang, Xing Yu, Moo-Ho Won, Pei Qing Su, Bing Chun Yan. Topiramate Improves Neuroblast Differentiation of Hippocampal Dentate Gyrus in the D-Galactose-Induced Aging Mice via Its Antioxidant Effects.
Cellular and molecular neurobiology.
2017 Jul; 37(5):869-877. doi:
10.1007/s10571-016-0424-6. [PMID: 27734244] - Fawzia A Ibrahim, Amira F El-Yazbi, Mira M Wagih, Magda A Barary. Chromatographic determination of zonisamide, topiramate and sulpiride in plasma by a fluorescent 'turn-on' chemosensor.
Bioanalysis.
2017 Jul; 9(14):1049-1064. doi:
10.4155/bio-2017-0090. [PMID: 28737428] - Majid Motaghinejad, Manijeh Motevalian, Sulai Fatima. Mediatory role of NMDA, AMPA/kainate, GABAA and Alpha2 receptors in topiramate neuroprotective effects against methylphenidate induced neurotoxicity in rat.
Life sciences.
2017 Jun; 179(?):37-53. doi:
10.1016/j.lfs.2017.01.002. [PMID: 28082019] - Tomas Salek, Ivan Andel, Irena Kurfurstova. Topiramate induced metabolic acidosis and kidney stones - a case study.
Biochemia medica.
2017 Jun; 27(2):404-410. doi:
10.11613/bm.2017.042. [PMID: 28694730] - Majid Motaghinejad, Manijeh Motevalian, Fatemeh Babalouei, Mohammad Abdollahi, Mansour Heidari, Zahra Madjd. Possible involvement of CREB/BDNF signaling pathway in neuroprotective effects of topiramate against methylphenidate induced apoptosis, oxidative stress and inflammation in isolated hippocampus of rats: Molecular, biochemical and histological evidences.
Brain research bulletin.
2017 06; 132(?):82-98. doi:
10.1016/j.brainresbull.2017.05.011. [PMID: 28552672] - Daniela Milosheska, Robert Roškar. A novel LC-MS/MS method for the simultaneous quantification of topiramate and its main metabolites in human plasma.
Journal of pharmaceutical and biomedical analysis.
2017 May; 138(?):180-188. doi:
10.1016/j.jpba.2017.02.003. [PMID: 28214451] - Majid Motaghinejad, Manijeh Motevalian, Mohammad Abdollahi, Mansour Heidari, Zahra Madjd. Topiramate Confers Neuroprotection Against Methylphenidate-Induced Neurodegeneration in Dentate Gyrus and CA1 Regions of Hippocampus via CREB/BDNF Pathway in Rats.
Neurotoxicity research.
2017 04; 31(3):373-399. doi:
10.1007/s12640-016-9695-4. [PMID: 28078543] - Masato Takeuchi, Ikuko Yano, Satoko Ito, Mitsuhiro Sugimoto, Shota Yamamoto, Atsushi Yonezawa, Akio Ikeda, Kazuo Matsubara. Population Pharmacokinetics of Topiramate in Japanese Pediatric and Adult Patients With Epilepsy Using Routinely Monitored Data.
Therapeutic drug monitoring.
2017 04; 39(2):124-131. doi:
10.1097/ftd.0000000000000383. [PMID: 28230619] - Roberta Zilles Hahn, Marina Venzon Antunes, Priscila Costa Arnhold, Natalia Bordin Andriguetti, Simone Gasparin Verza, Rafael Linden. Determination of topiramate in dried blood spots using single-quadrupole gas chromatography-mass spectrometry after flash methylation with trimethylanilinium hydroxide.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2017 Mar; 1046(?):131-137. doi:
10.1016/j.jchromb.2017.01.047. [PMID: 28178597] - Toshihiro Jogamoto, Yoshiaki Yamamoto, Mitsumasa Fukuda, Yuka Suzuki, Katsumi Imai, Yukitoshi Takahashi, Yushi Inoue, Yoko Ohtsuka. Add-on stiripentol elevates serum valproate levels in patients with or without concomitant topiramate therapy.
Epilepsy research.
2017 02; 130(?):7-12. doi:
10.1016/j.eplepsyres.2016.12.014. [PMID: 28081475] - Yoshiaki Yamamoto, Yukitoshi Takahashi, Katsumi Imai, Yoshiyuki Kagawa, Yushi Inoue. Effect of CYP Inducers/Inhibitors on Topiramate Concentration: Clinical Value of Therapeutic Drug Monitoring.
Therapeutic drug monitoring.
2017 02; 39(1):55-61. doi:
10.1097/ftd.0000000000000367. [PMID: 27941476] - Junkichi Kanda, Nobuo Izumo, Yoshiko Kobayashi, Kenji Onodera, Taketoshi Shimakura, Noriaki Yamamoto, Hideaki E Takahashi, Hiroyuki Wakabayashi. Effects of the antiepileptic drugs topiramate and lamotrigine on bone metabolism in rats.
Biomedical research (Tokyo, Japan).
2017; 38(5):297-305. doi:
10.2220/biomedres.38.297. [PMID: 29070779] - Barry E Gidal, Annie M Clark, Bob Anders, Frank Gilliam. The application of half-life in clinical decision making: Comparison of the pharmacokinetics of extended-release topiramate (USL255) and immediate-release topiramate.
Epilepsy research.
2017 01; 129(?):26-32. doi:
10.1016/j.eplepsyres.2016.10.020. [PMID: 27883934] - Stephen D Silberstein. Topiramate in Migraine Prevention: A 2016 Perspective.
Headache.
2017 Jan; 57(1):165-178. doi:
10.1111/head.12997. [PMID: 27902848] - Majid Motaghinejad, Manijeh Motevalian, Reza Falak, Mansour Heidari, Mahshid Sharzad, Elham Kalantari. Neuroprotective effects of various doses of topiramate against methylphenidate-induced oxidative stress and inflammation in isolated rat amygdala: the possible role of CREB/BDNF signaling pathway.
Journal of neural transmission (Vienna, Austria : 1996).
2016 12; 123(12):1463-1477. doi:
10.1007/s00702-016-1619-1. [PMID: 27665547] - Mirosław Zagaja, Marta Andres-Mach, Paweł Patrzylas, Daniel Pyrka, Monika Szpringer, Magdalena Florek-Łuszczki, Dorota Żółkowska, Krystyna Skalicka-Woźniak, Jarogniew J Łuszczki. Influence of xanthotoxin (8-methoxypsoralen) on the anticonvulsant activity of various novel antiepileptic drugs against maximal electroshock-induced seizures in mice.
Fitoterapia.
2016 Dec; 115(?):86-91. doi:
10.1016/j.fitote.2016.09.020. [PMID: 27702668] - Keaton S Smetana, Aaron M Cook, Melissa L Thompson Bastin, Douglas R Oyler. Antiepileptic dosing for critically ill adult patients receiving renal replacement therapy.
Journal of critical care.
2016 12; 36(?):116-124. doi:
10.1016/j.jcrc.2016.06.023. [PMID: 27546759] - R C Crist, G A Doyle, K M Kampman, W H Berrettini. A delta-opioid receptor genetic variant is associated with abstinence prior to and during cocaine dependence treatment.
Drug and alcohol dependence.
2016 Sep; 166(?):268-71. doi:
10.1016/j.drugalcdep.2016.07.008. [PMID: 27449273] - Chittaranjan Andrade. Cardiometabolic Risks in Schizophrenia and Directions for Intervention, 3: Psychopharmacological Interventions.
The Journal of clinical psychiatry.
2016 09; 77(9):e1090-e1094. doi:
10.4088/jcp.16f11128. [PMID: 27780328] - Majid Motaghinejad, Manijeh Motevalian. Involvement of AMPA/kainate and GABAA receptors in topiramate neuroprotective effects against methylphenidate abuse sequels involving oxidative stress and inflammation in rat isolated hippocampus.
European journal of pharmacology.
2016 Aug; 784(?):181-91. doi:
10.1016/j.ejphar.2016.04.036. [PMID: 27105819] - Małgorzata Jargiełło-Baszak, Magdalena Chrościńska-Krawczyk, Marta Andres-Mach, Jarogniew J Łuszczki, Stanisław J Czuczwar. Influence of caffeine on the protective activity of gabapentin and topiramate in a mouse model of generalized tonic-clonic seizures.
Pharmacological reports : PR.
2016 08; 68(4):680-5. doi:
10.1016/j.pharep.2016.03.011. [PMID: 27116699] - Vijaykumar K Parmar, Rajesh H Parikh, Ravish J Patel. HPTLC Method for Estimation of Topiramate in Solubility Studies, Diffusion Studies, Plasma, Brain Homogenate and Pharmaceutical Formulation.
Journal of chromatographic science.
2016 Aug; 54(7):1105-14. doi:
10.1093/chromsci/bmw066. [PMID: 27406122] - A F El-Yazbi, M M Wagih, F Ibrahim, M A Barary. Spectrofluorimetric Determination of Topiramate and Levetiracetam as Single Components in Tablet Formulations and in Human Plasma and Simultaneous Fourth Derivative Synchronous Fluorescence Determination of their Co-Adminstered Mixture in Human Plasma.
Journal of fluorescence.
2016 Jul; 26(4):1225-38. doi:
10.1007/s10895-016-1810-7. [PMID: 27147226] - Farzin Rezaei, Ebrahim Ghaderi, Roya Mardani, Seiran Hamidi, Kambiz Hassanzadeh. Topiramate for the management of methamphetamine dependence: a pilot randomized, double-blind, placebo-controlled trial.
Fundamental & clinical pharmacology.
2016 Jun; 30(3):282-9. doi:
10.1111/fcp.12178. [PMID: 26751259] - Chay Ngee Lim, Angela K Birnbaum, Richard C Brundage, Ilo E Leppik, James C Cloyd, Annie Clark, Susan E Marino. Pharmacokinetic-Pharmacodynamic Modeling of Intravenous and Oral Topiramate and Its Effect on the Symbol-Digit Modalities Test in Adult Healthy Volunteers.
Journal of clinical pharmacology.
2016 06; 56(6):714-22. doi:
10.1002/jcph.646. [PMID: 26395889] - Sheridan M Hoy. Topiramate Extended Release: A Review in Epilepsy.
CNS drugs.
2016 Jun; 30(6):559-66. doi:
10.1007/s40263-016-0344-5. [PMID: 27224993] - Manuela Contin, Lucia Alberghini, Carmina Candela, Giulia Benini, Roberto Riva. Intrapatient variation in antiepileptic drug plasma concentration after generic substitution vs stable brand-name drug regimens.
Epilepsy research.
2016 May; 122(?):79-83. doi:
10.1016/j.eplepsyres.2016.02.012. [PMID: 26987080] - Scott Mintzer, Rachael Miller, Krunal Shah, Inna Chervoneva, Maromi Nei, Christopher Skidmore, Michael R Sperling. Long-term effect of antiepileptic drug switch on serum lipids and C-reactive protein.
Epilepsy & behavior : E&B.
2016 05; 58(?):127-32. doi:
10.1016/j.yebeh.2016.02.023. [PMID: 27074299] - Annie M Clark, John M Pellock, Mary Holmay, Bob Anders, James Cloyd. Clinical utility of topiramate extended-release capsules (USL255): Bioequivalence of USL255 sprinkled and intact capsule in healthy adults and an in vitro evaluation of sprinkle delivery via enteral feeding tubes.
Epilepsy & behavior : E&B.
2016 Apr; 57(Pt A):105-110. doi:
10.1016/j.yebeh.2016.01.034. [PMID: 26943947] - Simon S Evers, André van Vliet, Barbara van Vugt, Anton J W Scheurink, Gertjan van Dijk. A low TSH profile predicts olanzapine-induced weight gain and relief by adjunctive topiramate in healthy male volunteers.
Psychoneuroendocrinology.
2016 Apr; 66(?):101-10. doi:
10.1016/j.psyneuen.2015.12.024. [PMID: 26802597] - Eun-Kee Bae, Jongtae Lee, Jung-Won Shin, Jangsup Moon, Keon-Joo Lee, Yong-Won Shin, Tae-Joon Kim, Dongseong Shin, In-Jin Jang, Sang Kun Lee. Factors influencing topiramate clearance in adult patients with epilepsy: A population pharmacokinetic analysis.
Seizure.
2016 Apr; 37(?):8-12. doi:
10.1016/j.seizure.2016.02.002. [PMID: 26908152] - Leonardo Baldaçara, Hugo Cogo-Moreira, Bruna Leal Parreira, Thaynne Almeida Diniz, Jaqueline Jerônimo Milhomem, Camila Campitelli Fernandes, Acioly Luiz Tavares Lacerda. Efficacy of topiramate in the treatment of crack cocaine dependence: a double-blind, randomized, placebo-controlled trial.
The Journal of clinical psychiatry.
2016 Mar; 77(3):398-406. doi:
10.4088/jcp.14m09377. [PMID: 27046312] - Majid Motaghinejad, Manijeh Motevalian, Behnaz Shabab. Neuroprotective effects of various doses of topiramate against methylphenidate induced oxidative stress and inflammation in rat isolated hippocampus.
Clinical and experimental pharmacology & physiology.
2016 Mar; 43(3):360-71. doi:
10.1111/1440-1681.12538. [PMID: 26718459] - Huaibin Liang, Huihui Li, Yu Hu, Shaohua Li, Luxian Lü, Xueqin Song. [Effects of Topiramate for atypical antipsychotic-induced body weight gain and metabolic adversities: a systematic review and meta-analysis].
Zhonghua yi xue za zhi.
2016 Jan; 96(3):216-23. doi:
10.3760/cma.j.issn.0376-2491.2016.03.014. [PMID: 26879726] - R Allan Jhagroo, Margaret L Wertheim, Kristina L Penniston. Alkali replacement raises urinary citrate excretion in patients with topiramate-induced hypocitraturia.
British journal of clinical pharmacology.
2016 Jan; 81(1):131-6. doi:
10.1111/bcp.12751. [PMID: 26297809] - Dean C Carlow, Heng Shi, Ryan C Schofield. Simultaneous Quantitation of Lamotrigine, Levetiracetam, 10-Hydroxycarbazepine, Topiramate, and Zonisamide in Serum Using HPLC-MS/MS.
Methods in molecular biology (Clifton, N.J.).
2016; 1383(?):29-37. doi:
10.1007/978-1-4939-3252-8_4. [PMID: 26660171] - Scott T Brittain, James W Wheless. Pharmacokinetic simulations of topiramate plasma concentrations following dosing irregularities with extended-release vs. immediate-release formulations.
Epilepsy & behavior : E&B.
2015 Nov; 52(Pt A):31-6. doi:
10.1016/j.yebeh.2015.08.029. [PMID: 26409125] - Ai-Ling Shen, Hsiu-Li Lin, Yuan-Fu Tseng, Hsiu-Chen Lin, Chien-Yeh Hsu, Che-Yi Chou. Topiramate may not increase risk of urolithiasis: A nationwide population-based cohort study.
Seizure.
2015 Jul; 29(?):86-9. doi:
10.1016/j.seizure.2015.03.009. [PMID: 26076848] - Anna Sciegienka, Tami Argo, Matthew Cantrell, Bruce Alexander. Association between topiramate use and serum bicarbonate levels in a veteran population.
The Annals of pharmacotherapy.
2015 Jun; 49(6):670-3. doi:
10.1177/1060028015579197. [PMID: 25829486] - Ghada F Ahmed, Susan E Marino, Richard C Brundage, Serguei V S Pakhomov, Ilo E Leppik, James C Cloyd, Annie Clark, Angela K Birnbaum. Pharmacokinetic-pharmacodynamic modelling of intravenous and oral topiramate and its effect on phonemic fluency in adult healthy volunteers.
British journal of clinical pharmacology.
2015 May; 79(5):820-30. doi:
10.1111/bcp.12556. [PMID: 25403343] - Yang Ni, Ying Zhou, Mingzhen Xu, Xiaomeng He, Huqun Li, Satter Haseeb, Hui Chen, Weiyong Li. Simultaneous determination of phentermine and topiramate in human plasma by liquid chromatography-tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application in pharmacokinetic study.
Journal of pharmaceutical and biomedical analysis.
2015 Mar; 107(?):444-9. doi:
10.1016/j.jpba.2015.01.035. [PMID: 25668796]