4,7-Dihydroxyflavone (BioDeep_00000270166)

natural product PANOMIX_OTCML-2023 Volatile Flavor Compounds

代谢物信息卡片

7,4-dihydroxyflavone 7-O-glucoside

化学式: C15H10O4 (254.057906)
中文名称: 7,4-二羟基黄酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: c1(ccc2c(c1)oc(cc2=O)c1ccc(cc1)O)O
InChI: InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)14-8-13(18)12-6-5-11(17)7-15(12)19-14/h1-8,16-17H

描述信息

7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2. 7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 μM[1].
7,4'-Dihydroxyflavone (7,4'-DHF) is a flavonoid isolated from Glycyrrhiza uralensis, the eotaxin/CCL11 inhibitor, has the ability to consistently suppress eotaxin production and prevent dexamethasone (Dex)‐paradoxical adverse effects on eotaxin production[1]. 7,4'-Dihydroxyflavone (7,4'-DHF) inhibits MUC5AC gene expression, mucus production and secretion via regulation of NF-κB, STAT6 and HDAC2. 7,4'-Dihydroxyflavone (7,4'-DHF) decreases phorbol 12-myristate 13-acetate (PMA) stimulated NCI-H292 human airway epithelial cell MUC5AC gene expression and mucus production with IC50 value of 1.4 μM[1].

同义名列表

5 个代谢物同义名

4,7-Dihydroxyflavone; 7,4-Dihydroxyflavone; 7,4-dihydroxyflavone 7-O-glucoside; 7,4'-Dihydroxyflavone; 7,4'-Dihydroxyflavone

数据库引用编号

14 个数据库交叉引用编号

ChEBI: CHEBI:29503
KEGGdrug: D85187
PubChem: 5282073
ChEMBL: CHEMBL294878
KNApSAcK: C00003800
CAS: 2196-14-7
MoNA: PM008214
MoNA: MetaboBASE0037
MoNA: MetaboBASE0036
Flavonoid: FL3F1ANS0001
medchemexpress: HY-N2609
KEGG: C12123
PubChem: 14270
KNApSAcK: 29503

分类词条

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

45 个相关的物种来源信息

149633 - Baptisia australis:
313912 - Baptisia bracteata:
1969220 - Baptisia calycosa:
313913 - Baptisia cinerea:
1969221 - Baptisia lanceolata:
1969222 - Baptisia lecontei:
1969223 - Baptisia megacarpa:
1871516 - Baptisia perfoliata:
1969224 - Baptisia simplicifolia:
313914 - Baptisia sphaerocarpa:
1835378 - Brosimum acutifolium:
3830 - Crotalaria pallida: 10.1016/J.BMCL.2003.11.074
1142948 - Dracaena cinnabari: 10.1016/0031-9422(94)00738-F
489316 - Entada phaseoloides: 10.1002/CBDV.201100002
46348 - Glycyrrhiza echinata:
372983 - Glycyrrhiza eurycarpa:
49827 - Glycyrrhiza glabra:
74614 - Glycyrrhiza inflata:
74859 - Glycyrrhiza pallidiflora:
74613 - Glycyrrhiza uralensis:
912971 - Glycyrrhiza yunnanensis:
557660 - Inula salsoloides: 10.1002/HLCA.201000195
70968 - Medicago radiata: 10.1016/0305-1978(82)90048-5
3879 - Medicago sativa: 10.1016/0031-9422(93)85025-M
3880 - Medicago truncatula:
2715301 - Oxytropis trichophysa: 10.1007/BF00630449
33090 - Plants: -
171561 - Sophora chrysophylla:
49839 - Sophora davidii:
70607 - Sophora microphylla:
76398 - Sophora prostrata:
1196212 - Sophora viciifolia:
1196212 - Sophora viciifolia: -
114322 - Thermopsis macrophylla: 10.1016/S0031-9422(00)88458-7
2805045 - Thermopsis mollis: 10.1016/S0031-9422(00)88458-7
61122 - Thermopsis rhombifolia: 10.1016/S0031-9422(00)88458-7
114325 - Thermopsis villosa: 10.1016/S0031-9422(00)88458-7
3899 - Trifolium repens: 10.1016/S0031-9422(00)85667-8
3900 - Trifolium subterraneum: 10.1016/S0031-9422(00)85667-8
390135 - Trigonella anguina: 10.1016/0305-1978(82)90048-5
200964 - Trigonella coerulescens: 10.1016/0305-1978(82)90048-5
78534 - Trigonella foenum-graecum: 10.1016/0305-1978(82)90048-5
1210111 - Trigonella maritima: 10.1016/0305-1978(82)90048-5
119386 - Trigonella spicata: 10.1016/0305-1978(82)90048-5
3906 - Vicia faba: 10.1021/JF00002A006

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

文献列表

Safa M Shams Eldin, Mohamed M Radwan, Amira S Wanas, Abdel-Azim M Habib, Fahima F Kassem, Hala M Hammoda, Shabana I Khan, Michael L Klein, Khaled M Elokely, Mahmoud A ElSohly. Bioactivity-Guided Isolation of Potential Antidiabetic and Antihyperlipidemic Compounds from Trigonella stellata. Journal of natural products. 2018 05; 81(5):1154-1161. doi: 10.1021/acs.jnatprod.7b00707. [PMID: 29676912]
Yan Lin, Yi Kuang, Kai Li, Shuang Wang, Shuai Ji, Kuan Chen, Wei Song, Xue Qiao, Min Ye. Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl4-induced liver injury in mice. Bioorganic & medicinal chemistry. 2017 10; 25(20):5522-5530. doi: 10.1016/j.bmc.2017.08.018. [PMID: 28835349]
Yan Lin, Yi Kuang, Kai Li, Shuang Wang, Wei Song, Xue Qiao, Gulnar Sabir, Min Ye. Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata. Bioorganic & medicinal chemistry. 2017 07; 25(14):3706-3713. doi: 10.1016/j.bmc.2017.05.009. [PMID: 28522265]
Jiachun Li, Dongpo Li, Youzhi Pan, Jun-Hua Hu, Wenzhe Huang, Zhen-Zhong Wang, Wei Xiao, Yu Wang. Simultaneous determination of ten bioactive constituents of Sanjie Zhentong Capsule in rat plasma by ultra-high-performance liquid chromatography tandem mass spectrometry and its application to a pharmacokinetic study. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2017 Jun; 1054(?):20-26. doi: 10.1016/j.jchromb.2017.03.001. [PMID: 28415020]
Yelin Kang, Bong-Gyu Kim, Sunghoon Kim, Youngshim Lee, Youngdae Yoon. Inhibitory potential of flavonoids on PtdIns(3,4,5)P3 binding with the phosphoinositide-dependent kinase 1 pleckstrin homology domain. Bioorganic & medicinal chemistry letters. 2017 02; 27(3):420-426. doi: 10.1016/j.bmcl.2016.12.051. [PMID: 28049590]
Daniela Ribeiro, Marisa Freitas, Sara M Tomé, Artur M S Silva, Graça Porto, Eurico J Cabrita, M Manuel B Marques, Eduarda Fernandes. Inhibition of LOX by flavonoids: a structure-activity relationship study. European journal of medicinal chemistry. 2014 Jan; 72(?):137-45. doi: 10.1016/j.ejmech.2013.11.030. [PMID: 24368208]
Yun Li, Wei Xiao, Jianping Qin, Ying Guo, Qianqian Zhu. [Simultaneous determination of five active components in resina draconis and its extract by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2012 Apr; 37(7):929-33. doi: . [PMID: 22792791]
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Bolleddula Jayaprakasam, Srinivasulu Doddaga, Rong Wang, Daniel Holmes, Joseph Goldfarb, Xiu-Min Li. Licorice flavonoids inhibit eotaxin-1 secretion by human fetal lung fibroblasts in vitro. Journal of agricultural and food chemistry. 2009 Feb; 57(3):820-5. doi: 10.1021/jf802601j. [PMID: 19132888]
Juan Zhang, Senthil Subramanian, Gary Stacey, Oliver Yu. Flavones and flavonols play distinct critical roles during nodulation of Medicago truncatula by Sinorhizobium meliloti. The Plant journal : for cell and molecular biology. 2009 Jan; 57(1):171-83. doi: 10.1111/j.1365-313x.2008.03676.x. [PMID: 18786000]
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